Details of Drug-Drug Interaction
| Drug General Information (ID: DDIJ7ZOTR4) | |||||||||
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| Drug Name | Labetalol | Drug Info | Methoxyflurane | Drug Info | |||||
| Drug Type | Small molecule | Small molecule | |||||||
| Therapeutic Class | Antihypertensive Agents | Anesthetics | |||||||
| Structure | |||||||||
| Mechanism of Labetalol-Methoxyflurane Interaction (Severity Level: Moderate) | |||||||||
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| Additive hypotensive effects Click to Show/Hide Mechanism Graph | |||||||||
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| Drug Name | Labetalol | Methoxyflurane | |||||||
| Mechanism 1 |
Antihypertensive agent Alpha-1 adrenergic receptor Antagonist |
Antihypertensive agent | |||||||
| Key Mechanism Factor 1 | |||||||||
| Factor Name | Adrenergic receptor alpha-1 | Structure Sequence | |||||||
| Protein Family | G-protein coupled receptor 1 family | ||||||||
| Protein Function |
This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes.
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| Mechanism Description |
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| Mechanism 2 |
Antihypertensive agent Alpha-1 adrenergic receptor Antagonist |
Hypotensive effects | |||||||
| Key Mechanism Factor 2 | |||||||||
| Factor Name | Adrenergic receptor alpha-1 | Structure Sequence | |||||||
| Protein Family | G-protein coupled receptor 1 family | ||||||||
| Protein Function |
This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes.
Click to Show/Hide
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| Mechanism Description |
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| Recommended Action | |||||||||
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| Management | It is currently recommended that beta blocker therapy not be routinely withdrawn prior to surgery. However, in general, patients taking beta blockers should not be anaesthetized with methoxyflurane. Instead, an anesthetic with minimal negative inotropic activity may be considered. If methoxyflurane must be used, beta blocker therapy should be withdrawn gradually and generally completed 24 to 48 hours before anesthesia. | ||||||||