Drug General Information (ID: DDIZPGMI32)
Drug Name			Hydrocodone		Drug Info		Methoxyflurane		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Analgesics				Anesthetics
Structure

Mechanism of Hydrocodone-Methoxyflurane Interaction (Severity Level: Moderate)
Additive cardiorespiratory depression effects Click to Show/Hide Mechanism Graph
Drug Name		Hydrocodone				Methoxyflurane
Mechanism 1		Cardiorespiratory depression effects				Cardiorespiratory depression effects
Key Mechanism Factor 1
		Factor Name		Cardiorespiratory depression effects
		Factor Description		Cardiorespiratory depression is a reduction or inhibition of the normal function of the heart and lungs. The heart and lungs are the most important organs of the body's circulatory system, and when excessively depressed may result in decreased heart rate, decreased blood pressure, heart failure, slowed breathing (little to no visible chest movement), apnea, narrowed or pinpoint pupils, and seizures.
Mechanism Description		Additive cardiorespiratory depression effects by the combination of Hydrocodone and Methoxyflurane
Additive CNS depression effects Click to Show/Hide Mechanism Graph
Drug Name		Hydrocodone				Methoxyflurane
Mechanism 2		CNS depression effects				CNS depression effects
Key Mechanism Factor 2
		Factor Name		CNS depression effects
		Factor Description		CNS depressants are drugs that inhibit or suppress brain activity and can reduce mental and physical processes. Excessive CNS depression can lead to decreased heart rate, slow breathing (less than 10 breaths per minute), extreme confusion or loss of memory, nausea and vomiting, poor judgment, blue lips or fingertips, irritability and aggression, and clammy or cold skin.
Mechanism Description		Additive CNS depression effects by the combination of Hydrocodone and Methoxyflurane

Recommended Action
Management		In general, anesthesia should be titrated to clinical effect by those experienced in anesthesia technique and in the care of patients receiving opioids.

References
1	Product Information. Orlaam (levomethadyl acetate) Roxanne Laboratories Inc, Columbus, OH.
2	Product Information. Ultane (sevoflurane). Abbott Pharmaceutical, Abbott Park, IL.
3	Inagaki Y, Kuzukawa A "Effects of epidural and intravenous buprenorphine on halothane minimum alveolar anesthetic concentration and hemodynamic responses." Anesth Analg 84 (1997): 100-5