Drug General Information (ID: DDIG3JMQKZ)
Drug Name			Doxycycline		Drug Info		Methoxyflurane		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antiinflammatory Agents				Anesthetics
Structure

Mechanism of Doxycycline-Methoxyflurane Interaction (Severity Level: Major)
Increased risk of nephrotoxicity Click to Show/Hide Mechanism Graph
Drug Name		Doxycycline				Methoxyflurane
Mechanism		Nephrotoxicity				Nephrotoxicity
Key Mechanism Factor 1
		Factor Name		Nephrotoxicity
		Factor Description		The combination of drugs that can induce nephrotoxicity may increase the risk of kidney injury. When kidney injury occurs, the inability to remove excess urine and waste from the body can lead to high levels of urea nitrogen, creatinine, and electrolytes (such as potassium and magnesium) in the blood.
Mechanism Description		Increased risk of nephrotoxicity by the combination of Doxycycline and Methoxyflurane

Recommended Action
Management		This combination should be avoided if possible.

References
1	Cousins MJ, Mazze RI "Methoxyfluranne nephrotoxicity. A study of dose response in man." JAMA 225 (1973): 1611-6. [PMID: 4740737]
2	Product Information. Declomycin (demeclocycline). Lederle Laboratories, Wayne, NJ.
3	Proctor EA, Barton FL "Polyuric acute renal failure after methoxyflurane and tetracycline." Br Med J 4 (1971): 661-2.[PMID: 5134563]