Details of Drug

Drug General Information (ID: D0914)
Drug Name	Levobetaxolol (ophthalmic)
Drug Type	Small molecule
Drug Synonymous	Levobetaxolol [INN]; Betaxon (TN); (2S)-1-[4-[2-(cyclopropylmethoxy)ethyl]phenoxy]-3-(propan-2-ylamino)propan-2-ol; (2S)-1-{4-[2-(cyclopropylmethoxy)ethyl]phenoxy}-3-(propan-2-ylamino)propan-2-ol; (2s)-1-{4-[2-(cyclopropylmethoxy)ethyl]phenoxy}-3-(isopropylamino)propan-2-ol; (S)-(-)-Betaxolol; (S)-1-(isopropylamino)-3-[p-(cyclopropylmethoxyethyl)phenoxy]-2-propanol; (S)-Betaxolol Click to Show/Hide
Disease Class	9C61: Glaucoma
Therapeutic Class	Cardiotonic Agents
Structure
Structure	3D Structure		2D Structure
Formula	C18H29NO3
InChI	1S/C18H29NO3/c1-14(2)19-11-17(20)13-22-18-7-5-15(6-8-18)9-10-21-12-16-3-4-16/h5-8,14,16-17,19-20H,3-4,9-13H2,1-2H3/t17-/m0/s1
InChIKey	NWIUTZDMDHAVTP-KRWDZBQOSA-N
Canonical SMILES	CC(C)NCC(COC1=CC=C(C=C1)CCOCC2CC2)O
External Link
	Pubchem ID	60657
	CAS Number	93221-48-8
	CHEBI ID	59254
	TTD ID	D0A6CQ
	INTEDE ID	DR0932

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM017 CYP450 enzyme inhibition BM024 Competitive inhibition of metabolic enzyme BM036 Additive cardiorespiratory depression effects BM041 Additive hypertensive effects BM042 Additive hypotensive effects BM045 Additive neuromuscular blocking effects BM048 Increased risk of angioedema/anaphylactoid reactions BM049 Increased risk of atrioventricular block BM051 Increased risk of bradycardia BM052 Increased risk of cardiac depression BM057 Increased risk of hyperglycemia BM062 Increased risk of hypertriglyceridemia BM064 Increased risk of hypoglycemia BM076 Increased risk of prolong QT interval BM081 Increased risk of ventricular arrhythmias BM086 Antagonize the effect of antidiabetic agents BM089 Antagonize the effect of antihypertensive agents BM090 Antagonize the effect of bronchodilators BM101 Antagonize the effects of beta receptor blockers BM107 Attenuated pharmacological effects (Unspecific)
Relation Graph

Full list of drugs interacting with Levobetaxolol (ophthalmic)
Affected intra/extra-hepatic metabolism
Pharmacodynamic additive effects
	Additive cardiorespiratory depression effects					Drug Num: 8
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0343		Cisatracurium	C53H72N2O12+2	62887	Moderate		Inter Info	[34], [35], [36]
D0522		Doxacurium	C56H78N2O16+2	60169	Moderate		Inter Info	[34], [35], [36]
D0122		Atracurium	C53H72N2O12+2	47319	Moderate		Inter Info	[34], [35], [36]
D1080		Mivacurium	C58H80N2O14+2	5281042	Moderate		Inter Info	[34], [35], [36]
D1219		Pancuronium	C35H60N2O4+2	441289	Moderate		Inter Info	[34], [35], [36]
D1420		Rocuronium	C32H53N2O4+	441290	Moderate		Inter Info	[34], [35], [36]
D1510		Succinylcholine	C14H30N2O4+2	5314	Moderate		Inter Info	[34], [35], [36]
D1684		Vecuronium	C34H57N2O4+	39765	Moderate		Inter Info	[34], [35], [36]
	Additive hypertensive effects					Drug Num: 7
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0212		Bromocriptine	C32H40BrN5O5	31101	Moderate		Inter Info	[25], [26], [27]
D0494		Dihydroergotamine	C33H37N5O5	10531	Moderate		Inter Info	[25], [26], [27]
D0593		Ergotamine	C33H35N5O5	8223	Moderate		Inter Info	[25], [26], [27]
D1037		Methylergometrine	C20H25N3O2	8226	Moderate		Inter Info	[25], [26], [27]
D1043		Methysergide	C21H27N3O2	9681	Moderate		Inter Info	[25], [26], [27]
D1276		Phenylephrine	C9H13NO2	6041	Moderate		Inter Info	[79], [80]
D1278		Phenylephrine (ophthalmic)	C9H13NO2	6041	Moderate		Inter Info	[79], [80]
	Additive hypotensive effects					Drug Num: 35
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0010		Acebutolol	C18H28N2O4	1978	Moderate		Inter Info	[14], [15]
D0036		Alfuzosin	C19H27N5O4	2092	Moderate		Inter Info	[16], [17], [18]
D0098		Apraclonidine	C9H10Cl2N4	2216	Moderate		Inter Info	[22], [23], [24]
D0173		Betaxolol	C18H29NO3	2369	Moderate		Inter Info	[14], [15]
D0188		Bisoprolol	C18H31NO4	2405	Moderate		Inter Info	[14], [15]
D0205		Brimonidine (ophthalmic)	C11H10BrN5	2435	Moderate		Inter Info	[22], [23], [24]
D0206		Brimonidine (topical)	C11H10BrN5	2435	Moderate		Inter Info	[22], [23], [24]
D0267		Carvedilol	C24H26N2O4	2585	Moderate		Inter Info	[14], [15]
D0508		Disopyramide	C21H29N3O	3114	Moderate		Inter Info	[42], [43], [44]
D0524		Doxazosin	C23H25N5O5	3157	Moderate		Inter Info	[16], [17], [18]
D0602		Esmolol	C16H25NO4	59768	Moderate		Inter Info	[14], [15]
D0644		Fenoldopam	C16H16ClNO3	3341	Moderate		Inter Info	[53]
D0745		Guanfacine	C9H9Cl2N3O	3519	Moderate		Inter Info	[60], [8], [61]
D0853		Isocarboxazid	C12H13N3O2	3759	Moderate		Inter Info	[62], [63], [64]
D0884		Labetalol	C19H24N2O3	3869	Moderate		Inter Info	[14], [15]
D0933		Linezolid	C16H20FN3O4	441401	Moderate		Inter Info	[62], [63], [64]
D1049		Metoprolol	C15H25NO3	4171	Moderate		Inter Info	[14], [15]
D1098		Nadolol	C17H27NO4	39147	Moderate		Inter Info	[14], [15]
D1114		Nebivolol	C22H25F2NO4	71301	Moderate		Inter Info	[14], [15]
D1263		Phenelzine	C8H12N2	3675	Moderate		Inter Info	[62], [63], [64]
D1267		Phenoxybenzamine	C18H22ClNO	4768	Moderate		Inter Info	[16], [17], [18]
D1293		Pindolol	C14H20N2O2	4828	Moderate		Inter Info	[14], [15]
D1331		Prazosin	C19H21N5O4	4893	Moderate		Inter Info	[16], [17], [18]
D1345		Procarbazine	C12H19N3O	4915	Moderate		Inter Info	[62], [63], [64]
D1357		Propranolol	C16H21NO2	4946	Moderate		Inter Info	[14], [15]
D1385		Rasagiline	C12H13N	3052776	Moderate		Inter Info	[62], [63], [64]
D1393		Reserpine	C33H40N2O9	5770	Moderate		Inter Info	[62], [63], [64]
D1437		Safinamide	C17H19FN2O2	131682	Moderate		Inter Info	[62], [63], [64]
D1455		Selegiline	C13H17N	26757	Moderate		Inter Info	[62], [63], [64]
D1466		Silodosin	C25H32F3N3O4	5312125	Moderate		Inter Info	[16], [17], [18]
D1498		Sotalol	C12H20N2O3S	5253	Moderate		Inter Info	[14], [15]
D1512		Sufentanil	C22H30N2O2S	41693	Moderate		Inter Info	[82], [83], [84]
D1552		Terazosin	C19H25N5O4	5401	Moderate		Inter Info	[16], [17], [18]
D1585		Timolol	C13H24N4O3S	33624	Moderate		Inter Info	[14], [15]
D1620		Tranylcypromine	C9H11N	19493	Moderate		Inter Info	[62], [63], [64]
	Increased risk of angioedema/anaphylactoid reactions					Drug Num: 5
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1783		Ethiodized oil	NA	NA	Moderate		Inter Info	[50], [51], [52]
D1791		Gadobenic acid	C22H28GdN3O11	9852779	Moderate		Inter Info	[4], [5], [59]
D1792		Gadobutrol	C18H31GdN4O9	6102852	Moderate		Inter Info	[4], [5], [59]
D1794		Gadofosveset trisodium	C33H38GdN3Na3O14P	73049652	Moderate		Inter Info	[4], [5], [59]
D1795		Gadopentetic acid	C14H20GdN3O10	6857474	Moderate		Inter Info	[4], [5], [59]
	Increased risk of atrioventricular block					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1288		Pilocarpine	C11H16N2O2	5910	Moderate		Inter Info	[81]
D1579		Ticagrelor	C23H28F2N6O4S	9871419	Minor		Inter Info	[5], [90]
	Increased risk of bradycardia					Drug Num: 17
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0302		Ceritinib	C28H36ClN5O3S	57379345	Major		Inter Info	[4], [5], [6]
D0363		Clonidine	C9H9Cl2N3	2803	Major		Inter Info	[7], [8], [9]
D1474		Siponimod	C29H35F3N2O3	44599207	Major		Inter Info	[4], [13]
D0218		Bupivacaine	C18H28N2O	2474	Moderate		Inter Info	[31], [32], [33]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Moderate		Inter Info	[5], [37], [38]
D0491		Digoxin	C41H64O14	2724385	Moderate		Inter Info	[39], [40], [41]
D0534		Dronedarone	C31H44N2O5S	208898	Moderate		Inter Info	[48]
D0661		Fingolimod	C19H33NO2	107970	Moderate		Inter Info	[54], [55]
D0868		Ivabradine	C27H36N2O5	132999	Moderate		Inter Info	[4], [68]
D0891		Lanreotide	C54H69N11O10S2	71349	Moderate		Inter Info	[69], [70]
D0031		Alectinib	C30H34N4O2	49806720	Moderate		Inter Info	[71], [72]
D0204		Brigatinib	C29H39ClN7O2P	68165256	Moderate		Inter Info	[73]
D0897		Lasmiditan	C19H18F3N3O2	11610526	Moderate		Inter Info	[74]
D1211		Ozanimod	C23H24N4O3	52938427	Moderate		Inter Info	[75]
D1061		Midodrine	C12H18N2O4	4195	Moderate		Inter Info	[76]
D1163		Octreotide	C49H66N10O10S2	448601	Moderate		Inter Info	[69], [70]
D1230		Pasireotide	C58H66N10O9	9941444	Moderate		Inter Info	[77], [4], [78]
	Increased risk of cardiac depression					Drug Num: 12
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0497		Diltiazem	C22H26N2O4S	39186	Major		Inter Info	[10], [11], [12]
D1690		Verapamil	C27H38N2O4	2520	Major		Inter Info	[10], [11], [12]
D0069		Amlodipine	C20H25ClN2O5	2162	Moderate		Inter Info	[19], [20], [21]
D0352		Clevidipine	C21H23Cl2NO6	153994	Moderate		Inter Info	[19], [20], [21]
D0640		Felodipine	C18H19Cl2NO4	3333	Moderate		Inter Info	[19], [20], [21]
D0664		Flecainide	C17H20F6N2O3	3356	Moderate		Inter Info	[56], [57], [58]
D0865		Isradipine	C19H21N3O5	3784	Moderate		Inter Info	[19], [20], [21]
D0911		Levamlodipine	C20H25ClN2O5	9822750	Moderate		Inter Info	[19], [20], [21]
D1130		Nicardipine	C26H29N3O6	4474	Moderate		Inter Info	[19], [20], [21]
D1134		Nifedipine	C17H18N2O6	4485	Moderate		Inter Info	[19], [20], [21]
D1138		Nimodipine	C21H26N2O7	4497	Moderate		Inter Info	[19], [20], [21]
D1141		Nisoldipine	C20H24N2O6	4499	Moderate		Inter Info	[19], [20], [21]
	Increased risk of hyperglycemia					Drug Num: 6
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0217		Bumetanide	C17H20N2O5S	2471	Moderate		Inter Info	[28], [29], [30]
D0321		Chlorothiazide	C7H6ClN3O4S2	2720	Moderate		Inter Info	[28], [29], [30]
D0613		Etacrynic acid	C13H12Cl2O4	3278	Moderate		Inter Info	[28], [29], [30]
D0704		Furosemide	C12H11ClN2O5S	3440	Moderate		Inter Info	[28], [29], [30]
D0798		Indapamide	C16H16ClN3O3S	3702	Moderate		Inter Info	[28], [29], [30]
D1611		Torasemide	C16H20N4O3S	41781	Moderate		Inter Info	[28], [29], [30]
	Increased risk of ventricular arrhythmias					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1569		Thalidomide	C13H10N2O4	5426	Moderate		Inter Info	[4], [5], [86]
Pharmacodynamic antagonistic effects
	Antagonize the effect of antidiabetic agents					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1801		Glucagon	C153H225N43O49S	16132283	Minor		Inter Info	[87], [88], [89]
	Antagonize the effect of antihypertensive agents					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0517		Dopamine	C8H11NO2	681	Moderate		Inter Info	[45], [46], [47]
D0581		Epinephrine	C9H13NO3	5816	Moderate		Inter Info	[45], [46], [47]
D1153		Norepinephrine	C8H11NO3	439260	Moderate		Inter Info	[45], [46], [47]
	Antagonize the effect of bronchodilators					Drug Num: 5
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0064		Aminophylline	C16H24N10O4	9433	Major		Inter Info	[1], [2], [3]
D0544		Dyphylline	C10H14N4O4	3182	Major		Inter Info	[1], [2], [3]
D1570		Theophylline	C7H8N4O2	2153	Major		Inter Info	[1], [2], [3]
D0579		Ephedrine	C10H15NO	9294	Moderate		Inter Info	[49]
D0859		Isoprenaline	C11H17NO3	3779	Moderate		Inter Info	[65], [66], [67]
	Attenuated pharmacological effects (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1536		Tasimelteon	C15H19NO2	10220503	Moderate		Inter Info	[85]

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