Details of Drug-Drug Interaction
| Drug General Information (ID: DDIQ7INPSO) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Drug Name | Diltiazem | Drug Info | Levobetaxolol (ophthalmic) | Drug Info | |||||
| Drug Type | Small molecule | Small molecule | |||||||
| Therapeutic Class | Antihypertensive Agents | Cardiotonic Agents | |||||||
| Structure | |||||||||
| Mechanism of Diltiazem-Levobetaxolol (ophthalmic) Interaction (Severity Level: Major) | |||||||||
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| Increased risk of cardiac depression Click to Show/Hide Mechanism Graph | |||||||||
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| Drug Name | Diltiazem | Levobetaxolol (ophthalmic) | |||||||
| Mechanism | Cardiac depressant effects | Cardiac depressant effects | |||||||
| Key Mechanism Factor 1 | |||||||||
| Factor Name | Cardiac depression | ||||||||
| Factor Description | Cardiac depression may manifest as negative heart rate, negative conduction, and negative contractility. Symptoms include: excessive or more than normal sleep, irritability, loss of interest in activities, and fatigue. | ||||||||
| Mechanism Description |
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| Recommended Action | |||||||||
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| Management | Close clinical monitoring of patient hemodynamic response and tolerance is recommended if these agents are used together, and the dosage of one or both agents adjusted as necessary. Patients should be advised to promptly report any symptoms including fatigue, headache, fainting, swelling of the extremities, weight gain, shortness of breath, chest pain, increased or decreased heartbeat, or irregular heartbeat. | ||||||||