Details of Drug Interaction

Details of Drug-Drug Interaction

 Drug General Information (ID: DDI2G5JRCY)
  Drug Name Tranylcypromine Drug Info Levobetaxolol (ophthalmic) Drug Info
  Drug Type Small molecule Small molecule
  Therapeutic Class Antidepressants Cardiotonic Agents
  Structure

 Mechanism of Tranylcypromine-Levobetaxolol (ophthalmic) Interaction (Severity Level: Moderate)
     Additive hypotensive effects Click to Show/Hide Mechanism Graph
Could Not Find 2D Structure
      Drug Name Tranylcypromine Levobetaxolol (ophthalmic)
      Mechanism 1 Antihypertensive agent Antihypertensive agent
      Key Mechanism Factor 1
Factor Name Hypotensive effects
Factor Description Hypotension is a blood pressure reading below the prescribed limit (90/60 mmHg). Symptoms of hypotension may include: blurred or faded vision , dizziness or light-headedness, fainting , fatigue , difficulty concentrating, nausea.
      Mechanism Description
  • Additive hypotensive effects by the combination of Tranylcypromine and Levobetaxolol (ophthalmic) 
      Mechanism 2 Hypotensive effects Antihypertensive agent
      Key Mechanism Factor 2
Factor Name Hypotensive effects
Factor Description Hypotension is a blood pressure reading below the prescribed limit (90/60 mmHg). Symptoms of hypotension may include: blurred or faded vision , dizziness or light-headedness, fainting , fatigue , difficulty concentrating, nausea.
      Mechanism Description
  • Additive hypotensive effects by the combination of Tranylcypromine and Levobetaxolol (ophthalmic) 
      Mechanism 3 Antihypertensive agent Hypotensive effects
      Key Mechanism Factor 3
Factor Name Hypotensive effects
Factor Description Hypotension is a blood pressure reading below the prescribed limit (90/60 mmHg). Symptoms of hypotension may include: blurred or faded vision , dizziness or light-headedness, fainting , fatigue , difficulty concentrating, nausea.
      Mechanism Description
  • Additive hypotensive effects by the combination of Tranylcypromine and Levobetaxolol (ophthalmic) 
      Mechanism 4 Hypotensive effects Hypotensive effects
      Key Mechanism Factor 4
Factor Name Hypotensive effects
Factor Description Hypotension is a blood pressure reading below the prescribed limit (90/60 mmHg). Symptoms of hypotension may include: blurred or faded vision , dizziness or light-headedness, fainting , fatigue , difficulty concentrating, nausea.
      Mechanism Description
  • Additive hypotensive effects by the combination of Tranylcypromine and Levobetaxolol (ophthalmic) 
     Increased risk of bradycardia Click to Show/Hide Mechanism Graph
Could Not Find 2D Structure
      Drug Name Tranylcypromine Levobetaxolol (ophthalmic)
      Mechanism 5 Potentiate the bradycardia effect of beta blocker Bradycardia
Beta adrenergic receptor  Antagonist
      Key Mechanism Factor 5
Factor Name Adrenergic receptor beta Structure Sequence
Protein Family G-protein coupled receptor 1 family
Protein Function
Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling. Involved in the regulation of sleep/wake behaviors (PubMed:31473062).
    Click to Show/Hide
      Mechanism Description
  • Increased risk of bradycardia by the combination of Tranylcypromine and Levobetaxolol (ophthalmic) 
      Mechanism 6 Potentiate the bradycardia effect of beta blocker Bradycardia
Beta-1 adrenergic receptor  Antagonist
      Key Mechanism Factor 6
Factor Name Adrenergic receptor beta-1
×
Structure Sequence
MGAGVLVLGASEPGNLSSAAPLPDGAATAARLLVPASPPASLLPPASESPEPLSQQWTAGMGLLMALIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVVWGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARGLVCTVWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCIMAFVYLRVFREAQKQVKKIDSCERRFLGGPARPPSPSPSPVPAPAPPPGPPRPAAAAATAPLANGRAGKRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRELVPDRLFVFFNWLGYANSAFNPIIYCRSPDFRKAFQRLLCCARRAARRRHATHGDRPRASGCLARPGPPPSPGAASDDDDDDVVGATPPARLLEPWAGCNGGAAADSDSSLDEPCRPGFASESKV
Gene Name ADRB1
Uniprot ID ADRB1_HUMAN
KEGG Pathway hsa:153
Protein Family G-protein coupled receptor 1 family
Protein Function
Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling. Involved in the regulation of sleep/wake behaviors (PubMed:31473062).
    Click to Show/Hide
      Mechanism Description
  • Increased risk of bradycardia by the combination of Tranylcypromine and Levobetaxolol (ophthalmic) 

Recommended Action
      Management Caution is advised if beta-blockers, including ophthalmic formulations, are prescribed in combination with sympathetic ganglion-blocking or catecholamine-depleting agents. Patients should contact their doctor if they experience dizziness, lightheadedness, syncope, bradycardia, shortness of breath, difficulty breathing, edema, and/or chest pain.

References
1 Kronig MH, Roose SP, Walsh BT, Woodring S, Glassman AH "Blood pressure effects of phenelzine." J Clin Psychopharmacol 3 (1983): 307-10. [PMID: 6630590]
2 Product Information. Marplan (isocarboxazid) Roche Laboratories, Nutley, NJ.
3 Product Information. Matulane (procarbazine). Roche Laboratories, Nutley, NJ.