Details of Drug

Drug General Information (ID: D0623)
Drug Name	Etidronic acid
Drug Type	Small molecule
Drug Synonymous	EHDP; Etidronate; Etidronsaeure; HEDP; Osteoscan; Acetodiphosphonic acid; Acide etidronique; Acido etidronico; Acidumetidronicum; Didronel IV; Etidronic acid monohydrate; Hydroxyethanediphosphonic acid; Oxyethylidenediphosphonic acid; Turpinal SL; Dequest2010; Dequest 2015; Dequest Z 010; Ferrofos 510; RP 61; Acide etidronique [INN-French]; Acido etidronico [INN-Spanish]; Acidum etidronicum [INN-Latin]; Diphosphonate (base); Etidronic acid (USAN/INN); Etidronic acid [USAN:INN:BAN]; Hydroxyethane-1,1-diphosphonic acid; Ethane-1-hydroxy-1,1-bisphosphonate; Ethane-1-hydroxy-1,1-bisphosphonic acid; Ethane-1-hydroxy-1,1-diphosphonate; Ethane-1-hydroxy-1,1-diphosphonic acid; Phosphonic acid, 1-hydroxy-1,1-ethanediyl ester; (1-Hydroxyethylene)diphosphonic acid; (1-Hydroxyethylidene)bis(phosphonic acid); (1-Hydroxyethylidene)bisphosphonic acid; (1-Hydroxyethylidene)diphoshonic acid; (1-Hydroxyethylidene)diphosphonic acid; (1-hydroxy-1-phosphonoethyl)phosphonic acid; (1-hydroxyethane-1,1-diyl)bis(phosphonic acid); (Hydroxyethylidene)diphosphonic acid; 1,1,1-Ethanetriol diphosphonate; 1-HYDROXY-1,1-DIPHOSPHONOETHANE; 1-Hydroxyethane-1,1,-diphosphonic acid; 1-Hydroxyethane-1,1-bisphosphonic acid; 1-Hydroxyethane-1,1-diphosphonate; 1-Hydroxyethane-1,1-diphosphonic acid; 1-Hydroxyethanediphosphonic acid; 1-Hydroxyethylidene 1,1-diphosphonic acid; 1-Hydroxyethylidene-1,1-biphosphonate; 1-Hydroxyethylidene-1,1-bisphosphonate; 1-Hydroxyethylidene-1,1-diphosphonic acid; 1-Hydroxyethylidenediphosphonic acid; 1000SL Click to Show/Hide
Disease Class	FB85: Bone paget disease
Therapeutic Class	Bone Density Conservation Agents
Structure
Structure	3D Structure		2D Structure
Formula	C2H8O7P2
InChI	1S/C2H8O7P2/c1-2(3,10(4,5)6)11(7,8)9/h3H,1H3,(H2,4,5,6)(H2,7,8,9)
InChIKey	DBVJJBKOTRCVKF-UHFFFAOYSA-N
Canonical SMILES	CC(O)(P(=O)(O)O)P(=O)(O)O
External Link
	Pubchem ID	3305
	CAS Number	2809-21-4
	CHEBI ID	4907
	TTD ID	D00NNC

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM001 Affected gastrointestinal absorption AM003 Affected organization distribution AM005 Affected excretion pathways AM006 Pharmacodynamic additive effects BM003 Complex formation BM014 Interference of cell/tissue uptake BM027 Decreased renal excretion due to nephrotoxicity BM054 Increased risk of GI mucosal injury/bleeding risk BM063 Increased risk of hypocalcemia BM072 Increased risk of nephrotoxicity BM109 Increased risk of other adverse reactions (Unspecific)
Relation Graph

Full list of drugs interacting with Etidronic acid
Affected gastrointestinal absorption
	Complex formation					Drug Num: 36
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0235		Calcium acetate	C4H6CaO4	6116	Moderate		Inter Info	[24], [25], [8]
D0483		Didanosine	C10H12N4O3	135398739	Moderate		Inter Info	[24], [25], [8]
D0049		Aluminum hydroxide	AlH3O3	10176082	Moderate		Inter Info	[24], [25], [8]
D0125		Attapulgite	Al2H29Mg2O15Si4-	56842194	Moderate		Inter Info	[24], [25], [8]
D0236		Calcium carbonate	CCaO3	10112	Moderate		Inter Info	[24], [25], [8]
D0238		Calcium citrate	C12H10Ca3O14	13136	Moderate		Inter Info	[24], [25], [8]
D0239		Calcium glubionate anhydrous	C18H32CaO19	64776	Moderate		Inter Info	[24], [25], [8]
D0241		Calcium gluconate	C12H22CaO14	9290	Moderate		Inter Info	[24], [25], [8]
D0242		Calcium glycerophosphate	C3H7CaO6P	120096	Moderate		Inter Info	[24], [25], [8]
D0243		Calcium lactate	C6H10CaO6	13144	Moderate		Inter Info	[24], [25], [8]
D0244		Calcium Phosphate	Ca3O8P2	24456	Moderate		Inter Info	[24], [25], [8]
D0332		Chromium picolinate	C18H12CrN3O6	151932	Moderate		Inter Info	[24], [25], [8]
D0390		Copper gluconate	C12H22CuO14	10692	Moderate		Inter Info	[24], [25], [8]
D0649		Ferrous fumarate	C4H2FeO4	6433164	Moderate		Inter Info	[24], [25], [8]
D0650		Ferrous gluconate	C12H22FeO14	23616740	Moderate		Inter Info	[24], [25], [8]
D0651		Ferrous sulfate anhydrous	FeO4S	24393	Moderate		Inter Info	[24], [25], [8]
D0847		Iron	Fe	23925	Moderate		Inter Info	[24], [25], [8]
D0849		Iron protein succinylate	NA	NA	Moderate		Inter Info	[24], [25], [8]
D0850		Iron sucrose	C12H29Fe5Na2O23	91663255	Moderate		Inter Info	[16], [17], [24]
D0877		Kaolin	Al2H4O9Si2	56841936	Moderate		Inter Info	[24], [25], [8]
D0893		Lanthanum carbonate	C3La2O9	168924	Moderate		Inter Info	[30], [7], [31]
D0967		Magaldrate	AlHMgO5S+2	3086011	Moderate		Inter Info	[24], [25], [8]
D0968		Magnesium carbonate	CMgO3	11029	Moderate		Inter Info	[24], [25], [8]
D0969		Magnesium chloride	Cl2H12MgO6	643991	Moderate		Inter Info	[24], [25], [8]
D0970		Magnesium citrate	C12H10Mg3O14	6099959	Moderate		Inter Info	[24], [25], [8]
D0971		Magnesium gluconate	C12H22MgO14	11418570	Moderate		Inter Info	[24], [25], [8]
D0972		Magnesium glycinate	C4H8MgN2O4	84645	Moderate		Inter Info	[24], [25], [8]
D0973		Magnesium hydroxide	H2MgO2	14791	Moderate		Inter Info	[24], [25], [8]
D0974		Magnesium oxide	MgO	14792	Moderate		Inter Info	[24], [25], [8]
D1456		Selenium	Se	6326970	Moderate		Inter Info	[24], [25], [8]
D1566		Tetraferric tricitrate decahydrate	C18H32Fe4O31	90478690	Moderate		Inter Info	[24], [25], [8]
D1722		Zinc acetate	C4H6O4Zn	11192	Moderate		Inter Info	[24], [25], [8]
D1724		Zinc gluconate	C12H22O14Zn	443445	Moderate		Inter Info	[24], [25], [8]
D1725		Zinc sulfate	O4SZn	24424	Moderate		Inter Info	[24], [25], [8]
D0975		Magnesium sulfate	MgO4S	24083	Moderate		Inter Info	[24], [25], [8]
D1369		Quinapril	C25H30N2O5	54892	Moderate		Inter Info	[7], [36], [40]
Affected organization distribution
	Interference of cell/tissue uptake					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1443		Samarium (153Sm) lexidronam	Sm	23951	Moderate		Inter Info	[35], [36], [37]
Affected excretion pathways
	Decreased renal excretion due to nephrotoxicity					Drug Num: 5
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0576		Entecavir	C12H15N5O3	135398508	Moderate		Inter Info	[27]
D0668		Flucytosine	C4H4FN3O	3366	Moderate		Inter Info	[29]
D1389		Remdesivir	C27H35N6O8P	121304016	Moderate		Inter Info	[7], [32], [33]
D1193		Oxaliplatin	C8H14N2O4Pt	9887053	Moderate		Inter Info	[38]
D1241		Pemetrexed	C20H21N5O6	135410875	Moderate		Inter Info	[39]
Pharmacodynamic additive effects
	Increased risk of GI mucosal injury/bleeding risk					Drug Num: 28
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0432		Deferasirox	C21H15N3O4	214348	Major		Inter Info	[5], [6]
D0017		Acetylsalicylic acid	C9H8O4	2244	Moderate		Inter Info	[16], [17], [18]
D0210		Bromfenac	C15H12BrNO3	60726	Moderate		Inter Info	[16], [17], [18]
D0298		Celecoxib	C17H14F3N3O2S	2662	Moderate		Inter Info	[16], [17], [18]
D0476		Diclofenac	C14H11Cl2NO2	3033	Moderate		Inter Info	[16], [17], [18]
D0489		Diflunisal	C13H8F2O3	3059	Moderate		Inter Info	[16], [17], [18]
D0331		Choline salicylate	C12H19NO4	54686350	Moderate		Inter Info	[16], [17], [18]
D1272		Phenyl salicylate	C13H10O3	8361	Moderate		Inter Info	[16], [17], [18]
D1442		Salsalate	C14H10O5	5161	Moderate		Inter Info	[16], [17], [18]
D0624		Etodolac	C17H21NO3	3308	Moderate		Inter Info	[16], [17], [18]
D0645		Fenoprofen	C15H14O3	3342	Moderate		Inter Info	[16], [17], [18]
D0680		Flurbiprofen	C15H13FO2	3394	Moderate		Inter Info	[16], [17], [18]
D0786		Ibuprofen	C13H18O2	3672	Moderate		Inter Info	[16], [17], [18]
D0800		Indomethacin	C19H16ClNO4	3715	Moderate		Inter Info	[16], [17], [18]
D0881		Ketoprofen	C16H14O3	3825	Moderate		Inter Info	[16], [17], [18]
D0882		Ketorolac	C15H13NO3	3826	Moderate		Inter Info	[16], [17], [18]
D0988		Meclofenamic acid	C14H11Cl2NO2	4037	Moderate		Inter Info	[16], [17], [18]
D0991		Mefenamic acid	C15H15NO2	4044	Moderate		Inter Info	[16], [17], [18]
D0995		Meloxicam	C14H13N3O4S2	54677470	Moderate		Inter Info	[16], [17], [18]
D1097		Nabumetone	C15H16O2	4409	Moderate		Inter Info	[16], [17], [18]
D1196		Oxaprozin	C18H15NO3	4614	Moderate		Inter Info	[16], [17], [18]
D1274		Phenylbutazone	C19H20N2O2	4781	Moderate		Inter Info	[16], [17], [18]
D1300		Piroxicam	C15H13N3O4S	54676228	Moderate		Inter Info	[16], [17], [18]
D1421		Rofecoxib	C17H14O4S	5090	Moderate		Inter Info	[16], [17], [18]
D1439		Salicylic acid (sodium)	C7H6O3	338	Moderate		Inter Info	[16], [17], [18]
D1520		Sulindac	C20H17FO3S	1548887	Moderate		Inter Info	[16], [17], [18]
D1606		Tolmetin	C15H15NO3	5509	Moderate		Inter Info	[16], [17], [18]
D1674		Valdecoxib	C16H14N2O3S	119607	Moderate		Inter Info	[16], [17], [18]
	Increased risk of hypocalcemia					Drug Num: 13
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0615		Etelcalcetide	C38H73N21O10S2	71511839	Major		Inter Info	[7], [8]
D0057		Amikacin (liposome)	C22H43N5O13	37768	Moderate		Inter Info	[19], [20], [21]
D0217		Bumetanide	C17H20N2O5S	2471	Moderate		Inter Info	[8], [21]
D0613		Etacrynic acid	C13H12Cl2O4	3278	Moderate		Inter Info	[8], [21]
D0876		Kanamycin	C18H36N4O11	6032	Moderate		Inter Info	[19], [20], [21]
D1304		Plazomicin	C25H48N6O10	42613186	Moderate		Inter Info	[19], [20], [21]
D1507		Streptomycin	C21H39N7O12	19649	Moderate		Inter Info	[19], [20], [21]
D0704		Furosemide	C12H11ClN2O5S	3440	Moderate		Inter Info	[8], [21]
D0718		Gentamicin	C21H43N5O7	3467	Moderate		Inter Info	[19], [20], [21]
D1120		Neomycin	C23H46N6O13	8378	Moderate		Inter Info	[19], [20], [21]
D1126		Netilmicin	C21H41N5O7	441306	Moderate		Inter Info	[19], [20], [21]
D1597		Tobramycin	C18H37N5O9	36294	Moderate		Inter Info	[19], [20], [21]
D1611		Torasemide	C16H20N4O3S	41781	Moderate		Inter Info	[8], [21]
	Increased risk of nephrotoxicity					Drug Num: 41
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0335		Cidofovir	C8H14N3O6P	60613	Major		Inter Info	[1]
D0472		Diatrizoate	C11H9I3N2O4	2140	Major		Inter Info	[2], [3], [4]
D0761		Human botulinum neurotoxin A/B immune globulin	NA	NA	Major		Inter Info	[9], [10], [11]
D0763		Human cytomegalovirus immune globulin	NA	NA	Major		Inter Info	[9], [10], [11]
D0768		Human Rho(D) immune globulin	NA	NA	Major		Inter Info	[9], [10], [11]
D0805		Inotersen	C230H318N69O121P19S19	121492004	Major		Inter Info	[7], [12]
D0831		Iodipamide	C20H14I6N2O6	3739	Major		Inter Info	[2], [3], [4]
D0832		Iodixanol	C35H44I6N6O15	3724	Major		Inter Info	[2], [3], [4]
D0833		Iohexol	C19H26I3N3O9	3730	Major		Inter Info	[2], [3], [4]
D0834		Iopamidol	C17H22I3N3O8	65492	Major		Inter Info	[2], [3], [4]
D0836		Iopromide	C18H24I3N3O8	3736	Major		Inter Info	[2], [3], [4]
D0837		Iothalamic acid	C11H9I3N2O4	3737	Major		Inter Info	[2], [3], [4]
D0838		Ioversol	C18H24I3N3O9	3741	Major		Inter Info	[2], [3], [4]
D0839		Ioxilan	C18H24I3N3O8	3743	Major		Inter Info	[2], [3], [4]
D0765		Human immunoglobulin G (intravenous)	NA	NA	Major		Inter Info	[9], [10], [11]
D1476		Sirolimus	C51H79NO13	5284616	Major		Inter Info	[13], [14], [15]
D1526		Tacrolimus	C44H69NO12	445643	Major		Inter Info	[13], [14], [15]
D0075		Amphotericin B	C47H73NO17	5280965	Moderate		Inter Info	[19], [20], [21]
D0076		Amphotericin B (cholesteryl sulfate)	C47H73NO17	5280965	Moderate		Inter Info	[19], [20], [21]
D0078		Amphotericin B (liposomal)	C47H73NO17	5280965	Moderate		Inter Info	[19], [20], [21]
D0142		Bacitracin	C66H103N17O16S	10909430	Moderate		Inter Info	[19], [20], [21]
D0145		Balsalazide	C17H15N3O6	54585	Moderate		Inter Info	[19], [20], [21]
D0252		Capreomycin	C50H88N28O15	3000502	Moderate		Inter Info	[19], [20], [21]
D0344		Cisplatin	Cl2H6N2Pt	5702198	Moderate		Inter Info	[19], [20], [21]
D0357		Clofarabine	C10H11ClFN5O3	119182	Moderate		Inter Info	[26]
D0402		Cyclosporine	C62H111N11O12	5284373	Moderate		Inter Info	[19], [20], [21]
D0383		Colistimethate	C58H105N16O28S5-5	70789202	Moderate		Inter Info	[19], [20], [21]
D0709		Gallium nitrate	GaN3O9	61635	Moderate		Inter Info	[19], [20], [21]
D0724		Givosiran	C78H139N11O30	119058042	Moderate		Inter Info	[19], [20], [21]
D0903		Lenvatinib	C21H19ClN4O4	9823820	Moderate		Inter Info	[19], [20], [21]
D0940		Lithium carbonate	CLi2O3	11125	Moderate		Inter Info	[19], [20], [21]
D0964		Lutetium Lu 177 dotatate	C65H87LuN14O19S2	76966897	Moderate		Inter Info	[19], [20], [21]
D1091		Moxetumomab Pasudotox	NA	NA	Moderate		Inter Info	[19], [20], [21]
D1173		Olsalazine	C14H10N2O6	22419	Moderate		Inter Info	[19], [20], [21]
D1542		Telavancin	C80H106Cl2N11O27P	3081362	Moderate		Inter Info	[19], [20], [21]
D1549		Temsirolimus	C56H87NO16	6918289	Moderate		Inter Info	[19], [20], [21]
D1009		Mesalazine	C7H7NO3	4075	Moderate		Inter Info	[19], [20], [21]
D1030		Methoxyflurane	C3H4Cl2F2O	4116	Moderate		Inter Info	[19], [20], [21]
D1246		Pentamidine	C19H24N4O2	4735	Moderate		Inter Info	[19], [20], [21]
D1310		Polymyxin B	C56H98N16O13	49800004	Moderate		Inter Info	[19], [20], [21]
D1680		Vancomycin	C66H75Cl2N9O24	14969	Moderate		Inter Info	[19], [20], [21]
	Increased risk of other adverse reactions (Unspecific)					Drug Num: 5
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0177		Bevacizumab	NA	NA	Moderate		Inter Info	[22], [7], [23]
D0044		Alpelisib	C19H22F3N5O2S	56649450	Moderate		Inter Info	[7], [28]
D0443		Denosumab	NA	NA	Moderate		Inter Info	[22], [7], [23]
D1426		Romosozumab	NA	NA	Moderate		Inter Info	[34]
D1522		Sunitinib	C22H27FN4O2	5329102	Moderate		Inter Info	[22], [7], [23]

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