Drug General Information (ID: DDIVAJ7XY2)
Drug Name			Didanosine		Drug Info		Etidronic acid		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Anti-Hiv Agents				Bone Density Conservation Agents
Structure

Mechanism of Didanosine-Etidronic acid Interaction (Severity Level: Moderate)
Complex formation Click to Show/Hide Mechanism Graph
Drug Name		Didanosine				Etidronic acid
Mechanism		Polyvalent cations				Binds to polyvalent cations
Key Mechanism Factor 1
		Factor Name		Chelation
		Factor Description		Chelation is a direct drug interaction that usually involves the formation of dimers or trimers, resulting in larger complexes and poorer absorption.
Mechanism Description		Decreased absorption of Didanosine due to formation of complexes caused by Etidronic acid

Recommended Action
Management		Antacids or other oral medications containing aluminum, calcium, magnesium and other polyvalent cations should be administered at least 2 hours before or 2 hours after the bisphosphonate dose.

References
1	Product Information. Boniva (ibandronate). Roche Laboratories, Nutley, NJ.
2	Product Information. Fosamax (alendronate). Merck &amp Co, Inc, West Point, PA.
3	Product Information. Skelid (tilundronate). Sanofi Winthrop Pharmaceuticals, New York, NY.