Drug General Information (ID: DDIOYXWMSI)
Drug Name			Etidronic acid		Drug Info		Samarium (153Sm) lexidronam		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Bone Density Conservation Agents				Therapeutic Radiopharmaceuticals
Structure

Mechanism of Etidronic acid-Samarium (153Sm) lexidronam Interaction (Severity Level: Moderate)
Interference of cell/tissue uptake Click to Show/Hide Mechanism Graph
Drug Name		Etidronic acid				Samarium (153Sm) lexidronam
Mechanism		Interference with uptake of samarium sm-153 lexidronam by bone				Samarium sm-153 lexidronam
Key Mechanism Factor 1
		Factor Name		Pharmacokinetics
		Factor Description		Alters the distribution of the drug, leading to changes in the plasma concentration of the drug and affecting the pharmacological effects.
Mechanism Description		Interference of cell/tissue uptake of Samarium (153Sm) lexidronam by Etidronic acid

Recommended Action
Management		Etidronic acid should be withheld for at least 2 weeks before administration of samarium sm-153 lexidronam.

References
1	EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports.".
2	Multum Information Services, Inc. Expert Review Panel.
3	Product Information. Didronel Tablets (etidronate). Procter and Gamble Pharmaceuticals, Cincinnati, OH.