Details of Drug

Drug General Information (ID: D1443)
Drug Name	Samarium (153Sm) lexidronam
Drug Type	Small molecule
Drug Synonymous	7440-19-9; Samarium; Sm; samario; samarium atom; UNII-42OD65L39F; 62Sm; 42OD65L39F; MFCD00011233; MFCD00151299; Samarium, elemental; Samariumpowder; Samarium powder; Samarium ingot; HSDB 7863; Samarium Nanofoil; EINECS 231-128-7; Samarium foil, 3N; Samarium ingot, 3N; Samarium Nanoparticles; Samarium pieces, 3N; Samarium chunks,99.9%; Samarium powder,99.9%; Samarium powder, -40 mesh; Ultra Thin Samarium Nanofoil; Samarium Nanoparticle Dispersion; DTXSID4064688; Samarium Metal Organic Framework; Samarium Metal-Organic Framework; 1,2-Diacylglycerol-LD-SM-pool; CHEBI:33374; Samarium pieces, sublimed dendritic; AMY22263; 8996AF; AKOS024438061; DB12403; Samarium rod, 12.7mm (0.5in) dia; Samarium foil, 1.0mm (0.04in) thick; Samarium rod, 6.35mm (0.25in) dia; BP-21451; Samarium foil, 0.1mm (0.004in) thick; Samarium foil, 0.25mm (0.01in) thick; Samarium foil, 0.75mm (0.03in) thick; Samarium pieces, 12mm (0.47in) & down; Samarium foil, 0.62mm (0.024in) thick; Samarium powder (99.9% REO) 325 mesh; Q1819; Samarium foil, 0.025mm (0.001in) thick; Samarium foil, 0.127mm (0.005in) thick; D78246; Lanthanum Vanadium (LaVO3) Sputtering Targets; Samarium ingot/button, ca. 50.8mm (2.0in) dia; Samarium, chips, 99.9% trace rare earth metals basis; Samarium, ingot, 99.9% trace rare earth metals basis; Samarium, rod, 100mm, diameter 6.35mm, cast, 99%; Samarium, rod, 50mm, diameter 6.35mm, cast, 99%; Samarium, -40 mesh, 99% trace rare earth metals basis; Samarium, AAS standard solution, Specpure?, Sm 1000?g/ml; Samarium, foil, 25x25mm, thickness 0.1mm, as rolled, 99%; Samarium, foil, 25x25mm, thickness 0.25mm, as rolled, 99%; Samarium, foil, 50x50mm, thickness 0.1mm, as rolled, 99%; Samarium, foil, 50x50mm, thickness 0.25mm, as rolled, 99%; Samarium, plasma standard solution, Specpure?, Sm 1000?g/ml; Samarium, foil, thickness 0.5 mm, 15 mm diameter, purity 99%; Samarium, foil, thickness 0.7 mm, 15 mm diameter, purity 99%; Samarium, lump, 25 mm max. lump size, weight 10 g, purity 99.9%; Samarium, lump, 25 mm max. lump size, weight 20 g, purity 99.9%; Samarium, lump, 25 mm max. lump size, weight 50 g, purity 99.9%; Samarium, plasma standard solution, Specpure?, Sm 10,000?g/ml; Samarium hydride, 99.9%, - 325 mesh SmH2 -3, Hydrogen level may vary; Samarium, foil, thickness 1 mm, 99.9% trace rare earth metals basis; AA Grade Samarium 1,000 mg/L inverted exclamation markA 2% in 2% HNO3, 100 ml; Samarium, foil, not light tested, 25x25mm, thickness 0.005mm, as rolled, 99%; Samarium, foil, not light tested, 25x25mm, thickness 0.025mm, as rolled, 99%; Samarium, foil, not light tested, 50x50mm, thickness 0.025mm, as rolled, 99%; Samarium, powder, 500 max. part. size (micron), weight 10 g, purity 99.9%; Samarium, powder, 500 max. part. size (micron), weight 20 g, purity 99.9%; Samarium, powder, max. particle size 500 micron, weight 50 g, purity 99.9% Click to Show/Hide
Therapeutic Class	Therapeutic Radiopharmaceuticals
Structure
Structure	3D Structure		2D Structure
Formula	Sm
InChI	InChI=1S/Sm
InChIKey	KZUNJOHGWZRPMI-UHFFFAOYSA-N
Canonical SMILES	[Sm]
External Link
External Link	Pubchem ID	23951

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM003 Affected organization distribution AM006 Pharmacodynamic additive effects BM014 Interference of cell/tissue uptake BM043 Additive immunosuppressive effects BM044 Additive myelosuppressive effects BM063 Increased risk of hypocalcemia
Relation Graph

Full list of drugs interacting with Samarium (153Sm) lexidronam
Affected organization distribution
	Interference of cell/tissue uptake					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0623		Etidronic acid	C2H8O7P2	3305	Moderate		Inter Info	[6], [7], [8]
Pharmacodynamic additive effects
	Additive immunosuppressive effects					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0348		Cladribine	C10H12ClN5O3	20279	Major		Inter Info	[2], [3]
D1162		Ocrelizumab	NA	NA	Moderate		Inter Info	[14]
	Additive myelosuppressive effects					Drug Num: 144
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0030		Aldesleukin	NA	NA	Major		Inter Info	[1]
D0033		Alemtuzumab	NA	NA	Major		Inter Info	[1]
D0048		Altretamine	C9H18N6	2123	Major		Inter Info	[1]
D0134		Azacitidine	C8H12N4O5	9444	Major		Inter Info	[1]
D0136		Azathioprine	C9H7N7O2S	2265	Major		Inter Info	[1]
D0153		Belinostat	C15H14N2O4S	6918638	Major		Inter Info	[1]
D0177		Bevacizumab	NA	NA	Major		Inter Info	[1]
D0178		Bexarotene	C24H28O2	82146	Major		Inter Info	[1]
D0190		Bleomycin	C55H84N17O21S3+	5360373	Major		Inter Info	[1]
D0193		Bortezomib	C19H25BN4O4	387447	Major		Inter Info	[1]
D0223		Busulfan	C6H14O6S2	2478	Major		Inter Info	[1]
D0260		Carboplatin	C6H12N2O4Pt	426756	Major		Inter Info	[1]
D0264		Carmustine	C5H9Cl2N3O2	2578	Major		Inter Info	[1]
D0312		Chlorambucil	C14H19Cl2NO2	2708	Major		Inter Info	[1]
D0344		Cisplatin	Cl2H6N2Pt	5702198	Major		Inter Info	[1]
D0357		Clofarabine	C10H11ClFN5O3	119182	Major		Inter Info	[1]
D0370		Clozapine	C18H19ClN4	135398737	Major		Inter Info	[2], [4], [5]
D0376		Cobimetinib	C21H21F3IN3O2	16222096	Major		Inter Info	[1]
D0400		Cyclophosphamide	C7H15Cl2N2O2P	2907	Major		Inter Info	[1]
D0404		Cytarabine	C9H13N3O5	6253	Major		Inter Info	[1]
D0407		Dacarbazine	C6H10N6O	135398738	Major		Inter Info	[1]
D0410		Dactinomycin	C62H86N12O16	457193	Major		Inter Info	[1]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Major		Inter Info	[1]
D0429		Daunorubicin	C27H29NO10	30323	Major		Inter Info	[1]
D0430		Daunorubicin (liposomal)	C27H29NO10	30323	Major		Inter Info	[1]
D0431		Decitabine	C8H12N4O4	451668	Major		Inter Info	[1]
D0511		Docetaxel	C43H53NO14	148124	Major		Inter Info	[1]
D0528		Doxorubicin	C27H29NO11	31703	Major		Inter Info	[1]
D0529		Doxorubicin (liposomal)	C27H29NO11	31703	Major		Inter Info	[1]
D0584		Epirubicin	C27H29NO11	41867	Major		Inter Info	[1]
D0627		Etoposide	C29H32O13	36462	Major		Inter Info	[1]
D0666		Floxuridine	C9H11FN2O5	5790	Major		Inter Info	[1]
D0669		Fludarabine	C10H12FN5O4	657237	Major		Inter Info	[1]
D0675		Fluorouracil	C4H3FN2O2	3385	Major		Inter Info	[1]
D0714		Gemcitabine	C9H11F2N3O4	60750	Major		Inter Info	[1]
D0717		Gemtuzumab ozogamicin	NA	NA	Major		Inter Info	[1]
D0780		Hydroxyurea	CH4N2O2	3657	Major		Inter Info	[1]
D0784		Ibritumomab tiuxetan	NA	NA	Major		Inter Info	[1]
D0788		Idarubicin	C26H27NO9	42890	Major		Inter Info	[1]
D0793		Imatinib	C29H31N7O	5291	Major		Inter Info	[1]
D0821		Interferon alfa-2a, Recombinant	NA	NA	Major		Inter Info	[1]
D0822		Interferon alfa-2b	C16H17Cl3I2N3NaO5S	71306834	Major		Inter Info	[1]
D0824		Interferon alfa-n1	NA	NA	Major		Inter Info	[1]
D0823		Interferon alfacon-1	NA	NA	Major		Inter Info	[1]
D0828		Interferon gamma-1b	NA	NA	Major		Inter Info	[1]
D0845		Irinotecan	C33H38N4O6	60838	Major		Inter Info	[1]
D0846		Irinotecan (liposomal)	C33H38N4O6	60838	Major		Inter Info	[1]
D0873		Ixabepilone	C27H42N2O5S	6445540	Major		Inter Info	[1]
D0902		Lenalidomide	C13H13N3O3	216326	Major		Inter Info	[1]
D0945		Lomustine	C9H16ClN3O2	3950	Major		Inter Info	[1]
D0996		Melphalan	C13H18Cl2N2O2	460612	Major		Inter Info	[1]
D1007		Mercaptopurine	C5H4N4S	667490	Major		Inter Info	[1]
D1025		Methotrexate	C20H22N8O5	126941	Major		Inter Info	[1]
D1077		Mitomycin	C15H18N4O5	5746	Major		Inter Info	[1]
D1079		Mitoxantrone	C22H28N4O6	4212	Major		Inter Info	[1]
D1118		Nelarabine	C11H15N5O5	3011155	Major		Inter Info	[1]
D1136		Nilotinib	C28H22F3N7O	644241	Major		Inter Info	[1]
D1174		Omacetaxine mepesuccinate	C29H39NO9	285033	Major		Inter Info	[1]
D1193		Oxaliplatin	C8H14N2O4Pt	9887053	Major		Inter Info	[1]
D1213		Paclitaxel (protein-bound)	C47H51NO14	36314	Major		Inter Info	[1]
D1237		Peginterferon alfa-2a	NA	NA	Major		Inter Info	[1]
D1238		Peginterferon alfa-2b	NA	NA	Major		Inter Info	[1]
D1241		Pemetrexed	C20H21N5O6	135410875	Major		Inter Info	[1]
D1250		Pentostatin	C11H16N4O4	439693	Major		Inter Info	[1]
D1345		Procarbazine	C12H19N3O	4915	Major		Inter Info	[1]
D1416		Rituximab	NA	NA	Major		Inter Info	[1]
D0006		Abemaciclib	C27H32F2N8	46220502	Major		Inter Info	[1]
D0027		Aflibercept	NA	NA	Major		Inter Info	[1]
D0129		Avapritinib	C26H27FN10	118023034	Major		Inter Info	[1]
D0132		Axicabtagene ciloleucel	NA	NA	Major		Inter Info	[1]
D0146		Baricitinib	C16H17N7O2S	44205240	Major		Inter Info	[1]
D0150		Belantamab mafodotin	NA	NA	Major		Inter Info	[1]
D0157		Bendamustine	C16H21Cl2N3O2	65628	Major		Inter Info	[1]
D0191		Blinatumomab	NA	NA	Major		Inter Info	[1]
D0195		Bosutinib	C26H29Cl2N5O3	5328940	Major		Inter Info	[1]
D0199		Brentuximab vedotin	NA	NA	Major		Inter Info	[1]
D0203		Brexucabtagene autoleucel	NA	NA	Major		Inter Info	[1]
D0227		Cabazitaxel	C45H57NO14	9854073	Major		Inter Info	[1]
D0261		Carfilzomib	C40H57N5O7	11556711	Major		Inter Info	[1]
D0389		Copanlisib	C23H28N8O4	135565596	Major		Inter Info	[1]
D0422		Daratumumab	NA	NA	Major		Inter Info	[1]
D0501		Dinutuximab	NA	NA	Major		Inter Info	[1]
D0543		Duvelisib	C22H17ClN6O	50905713	Major		Inter Info	[1]
D0560		Elotuzumab	NA	NA	Major		Inter Info	[1]
D0571		Enfortumab vedotin	NA	NA	Major		Inter Info	[1]
D0594		Eribulin	C40H59NO11	11354606	Major		Inter Info	[1]
D0785		Ibrutinib	C25H24N6O2	24821094	Major		Inter Info	[1]
D0789		Idelalisib	C22H18FN7O	11625818	Major		Inter Info	[1]
D0806		Inotuzumab ozogamicin	NA	NA	Major		Inter Info	[1]
D0829		Iobenguane (I-131)	C8H10IN3	60860	Major		Inter Info	[1]
D0851		Isatuximab	NA	NA	Major		Inter Info	[1]
D0874		Ixazomib	C14H19BCl2N2O4	25183872	Major		Inter Info	[1]
D0939		Lisocabtagene maraleucel	NA	NA	Major		Inter Info	[1]
D0962		Lurbinectedin	C41H44N4O10S	57327016	Major		Inter Info	[1]
D0964		Lutetium Lu 177 dotatate	C65H87LuN14O19S2	76966897	Major		Inter Info	[1]
D1062		Midostaurin	C35H30N4O4	9829523	Major		Inter Info	[1]
D1083		Mogamulizumab	NA	NA	Major		Inter Info	[1]
D1113		Naxitamab	NA	NA	Major		Inter Info	[1]
D1140		Niraparib	C19H20N4O	24958200	Major		Inter Info	[1]
D1161		Obinutuzumab	NA	NA	Major		Inter Info	[1]
D1164		Ofatumumab	NA	NA	Major		Inter Info	[1]
D1167		Olaparib	C24H23FN4O3	23725625	Major		Inter Info	[1]
D1190		Osimertinib	C28H33N7O2	71496458	Major		Inter Info	[1]
D1214		Palbociclib	C24H29N7O2	5330286	Major		Inter Info	[1]
D1221		Panobinostat	C21H23N3O2	6918837	Major		Inter Info	[1]
D1232		Pazopanib	C21H23N7O2S	10113978	Major		Inter Info	[1]
D1305		Plicamycin	C52H76O24	163659	Major		Inter Info	[1]
D1306		Polatuzumab vedotin	NA	NA	Major		Inter Info	[1]
D1312		Pomalidomide	C13H11N3O4	134780	Major		Inter Info	[1]
D1313		Ponatinib	C29H27F3N6O	24826799	Major		Inter Info	[1]
D1323		Pralatrexate	C23H23N7O5	148121	Major		Inter Info	[1]
D1398		Ribociclib	C23H30N8O	44631912	Major		Inter Info	[1]
D1424		Romidepsin	C24H36N4O6S2	5352062	Major		Inter Info	[1]
D1432		Rucaparib	C19H18FN3O	9931954	Major		Inter Info	[1]
D1448		Satralizumab	NA	NA	Major		Inter Info	[1]
D1458		Selinexor	C17H11F6N7O	71481097	Major		Inter Info	[1]
D1529		Tafasitamab	NA	NA	Major		Inter Info	[1]
D1532		Talazoparib	C19H14F2N6O	135565082	Major		Inter Info	[1]
D1594		Tisagenlecleucel	NA	NA	Major		Inter Info	[1]
D1600		Tofacitinib	C16H20N6O	9926791	Major		Inter Info	[1]
D1622		Trastuzumab deruxtecan	NA	NA	Major		Inter Info	[1]
D1666		Upadacitinib	C17H19F3N6O	58557659	Major		Inter Info	[1]
D1688		Venetoclax	C45H50ClN7O7S	49846579	Major		Inter Info	[1]
D1718		Zanubrutinib	C27H29N5O3	135565884	Major		Inter Info	[1]
D1508		Streptozocin	C8H15N3O7	29327	Major		Inter Info	[1]
D1548		Temozolomide	C6H6N6O2	5394	Major		Inter Info	[1]
D1551		Teniposide	C32H32O13S	452548	Major		Inter Info	[1]
D1569		Thalidomide	C13H10N2O4	5426	Major		Inter Info	[1]
D1575		Thiotepa	C6H12N3PS	5453	Major		Inter Info	[1]
D1589		Tioguanine	C5H5N5S	2723601	Major		Inter Info	[1]
D1610		Topotecan	C23H23N3O5	60700	Major		Inter Info	[1]
D1613		Tositumomab	NA	NA	Major		Inter Info	[1]
D1614		Tositumomab (I-131)	NA	NA	Major		Inter Info	[1]
D1615		Trabectedin	C39H43N3O11S	108150	Major		Inter Info	[1]
D1621		Trastuzumab	NA	NA	Major		Inter Info	[1]
D1639		Trifluridine	C10H11F3N2O5	6256	Major		Inter Info	[1]
D1646		Trimetrexate	C19H23N5O3	5583	Major		Inter Info	[1]
D1667		Uracil mustard	C8H11Cl2N3O2	6194	Major		Inter Info	[1]
D1697		Vinblastine	C46H58N4O9	13342	Major		Inter Info	[1]
D1698		Vincristine	C46H56N4O10	5978	Major		Inter Info	[1]
D1699		Vincristine (liposome)	C46H56N4O10	5978	Major		Inter Info	[1]
D1700		Vinorelbine	C45H54N4O8	5311497	Major		Inter Info	[1]
D0710		Ganciclovir	C9H13N5O4	135398740	Moderate		Inter Info	[12], [2], [13]
D1676		Valganciclovir	C14H22N6O5	135413535	Moderate		Inter Info	[12], [2], [13]
	Increased risk of hypocalcemia					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0694		Foscarnet	CH3O5P	3415	Moderate		Inter Info	[9], [10], [11]

References
1	Product Information. Quadramet (samarium sm 153 lexidronam) Berlex Laboratories, Richmond, CA.
2	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
3	Product Information. Leustatin (cladribine). Ortho Biotech Inc, Raritan, NJ.
4	Product Information. Clozaril (clozapine). Novartis Pharmaceuticals, East Hanover, NJ.
5	Canadian Pharmacists Association "e-CPS."
6	EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports.".
7	Multum Information Services, Inc. Expert Review Panel.
8	Product Information. Didronel Tablets (etidronate). Procter and Gamble Pharmaceuticals, Cincinnati, OH.
9	Foscarnet: a review. Drugs 41 (1991): 106-29. [PMID: 1706982]
10	Product Information. Foscavir (foscarnet). Astra USA, Westborough, MA.
11	Youle M, Clarbour J, Gazzard B, Chanas A "Severe hypocalcemia in AIDS patients treated with foscarnet and pentamidine." Lancet 1 (1988): 1455-6. [PMID: 2898602]
12	Cerner Multum, Inc. "Australian Product Information.".
13	Product Information. Valcyte (valganciclovir) Roche Laboratories, Nutley, NJ.
14	Product Information. Ocrevus (ocrelizumab). Genentech, South San Francisco, CA.

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