Details of Drug

Drug General Information (ID: D0509)
Drug Name	Disulfiram
Drug Type	Small molecule
Drug Synonymous	Abstenisil; Abstinil; Abstinyl; Alcophobin; Antabus; Antabuse; Antadix; Antaenyl; Antaethan; Antaethyl; Antaetil; Antalcol; Antetan; Antethyl; Antetil; Anteyl; Anthethyl; Antiaethan; Anticol; Antietanol; Antiethanol; Antietil; Antikol; Antivitium; Aversan; Averzan; Bonibal; Contralin; Contrapot; Cronetal; Dicupral; Disetil; Disulfan; Disulfirame; Disulfiramo; Disulfiramum; Disulfirm; Disulfram; Disulfuram; Disulphuram; Ephorran; Espenal; Esperal; Etabus; Ethyldithiourame; Ethyldithiurame; Exhoran; Exhorran; Gababentin; Hoca; Krotenal; Nocbin; Nocceler; Noxal; Refusal; Stopaethyl; Stopethyl; Stopety; Stopetyl; TATD; TETD; THIOCID; TTD; TTS; Tenurid; Tenutex; Tetidis; Tetradin; Tetradine; Tetraethylthiuram; Tetraetil; Teturam; Teturamin; Thireranide; Thiuranide; Tillram; Tiuram; Accel TET; Akrochem TETD; Ancazide ET; Antab use; Disulfirame [DCIT]; Ekagom DTET; Ekagom TEDS; Ekagom TETDS; Ekaland TETD; Esperal [France]; Eta bus; Ethyl Thiram; Ethyl Thiudad; Ethyl Thiurad; Ethyl Tuads Rodform; Ethyl Tuex; Ethyl tuads; Etyl Tuex; Nocceler TET; Perkacit TETD; Perkait TETD; Robac TET; Sanceler TET; Soxinol TET; TTS x; Tet raethylthiuram; Thiuram E; Dupon 4472; T 1132; Accel TET-R; Alk-aubs; Antabus (TN); Antabuse (TN); Anti-ethyl; Antivitium (Spain); ENT 27,340; Nocceler TET-G; Noxal (VAN); Ro-sulfiram; Sanceler TET-G; Tuads, ethyl; Usaf B-33; Ro-Sulfram-500 (USA) Click to Show/Hide
Disease Class	6C40: Substance abuse
Therapeutic Class	Alcohol Deterrents
Structure
Structure	3D Structure		2D Structure
Formula	C10H20N2S4
InChI	1S/C10H20N2S4/c1-5-11(6-2)9(13)15-16-10(14)12(7-3)8-4/h5-8H2,1-4H3
InChIKey	AUZONCFQVSMFAP-UHFFFAOYSA-N
Canonical SMILES	CCN(CC)C(=S)SSC(=S)N(CC)CC
External Link
	Pubchem ID	3117
	CAS Number	97-77-8
	CHEBI ID	4659
	TTD ID	D0X5SD
	INTEDE ID	DR0519
	VARIDT ID	DR00310

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects BM017 CYP450 enzyme inhibition BM018 Non-CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM024 Competitive inhibition of metabolic enzyme BM038 Additive CNS depression effects BM040 Additive dopaminergic effects BM055 Increased risk of hepatotoxicity BM074 Increased risk of peripheral neuropathy BM109 Increased risk of other adverse reactions (Unspecific)
Relation Graph

Full list of drugs interacting with Disulfiram
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 16
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0194		Bosentan	C27H29N5O6S	104865	Moderate		Inter Info	[44]
D0298		Celecoxib	C17H14F3N3O2S	2662	Moderate		Inter Info	[45]
D0327		Chlorzoxazone	C7H4ClNO2	2733	Moderate		Inter Info	[46]
D0064		Aminophylline	C16H24N10O4	9433	Moderate		Inter Info	[48], [49]
D0545		Echinacea	NA	NA	Moderate		Inter Info	[53]
D0697		Fosphenytoin	C16H15N2O6P	56339	Moderate		Inter Info	[54], [15], [16], [55], [56], [57]
D1201		Oxtriphylline	C12H21N5O3	656652	Moderate		Inter Info	[48], [49]
D1299		Pirfenidone	C12H11NO	40632	Moderate		Inter Info	[16], [66], [67]
D1682		Vardenafil	C23H32N6O4S	135400189	Moderate		Inter Info	[72], [73]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Moderate		Inter Info	[15], [16]
D0621		Ethotoin	C11H12N2O2	3292	Moderate		Inter Info	[54], [15], [16], [55], [56], [57]
D1003		Mephenytoin	C12H14N2O2	4060	Moderate		Inter Info	[54], [15], [16], [55], [56], [57]
D1283		Phenytoin	C15H12N2O2	1775	Moderate		Inter Info	[54], [15], [16], [55], [56], [57]
D1570		Theophylline	C7H8N4O2	2153	Moderate		Inter Info	[48], [49]
D1674		Valdecoxib	C16H14N2O3S	119607	Moderate		Inter Info	[86]
D0231		Caffeine	C8H10N4O2	2519	Minor		Inter Info	[87]
	Non-CYP450 enzyme inhibition					Drug Num: 4
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0081		Amprenavir (oral solution)	C25H35N3O6S	65016	Major		Inter Info	[1], [2], [3], [4]
D1224		Paraldehyde	C6H12O3	31264	Major		Inter Info	[15], [16], [17], [18]
D1461		Sertraline	C17H17Cl2N	68617	Major		Inter Info	[18], [20]
D1592		Tipranavir	C31H33F3N2O5S	54682461	Major		Inter Info	[21], [7], [18], [22], [8], [9]
	CYP450 enzyme induction					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0901		Lemborexant	C22H20F2N4O2	56944144	Moderate		Inter Info	[15], [60]
	Competitive inhibition of metabolic enzyme					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0001		Abacavir	C14H18N6O	441300	Minor		Inter Info	[88]
Pharmacodynamic additive effects
	Additive CNS depression effects					Drug Num: 16
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0045		Alprazolam	C17H13ClN4	2118	Moderate		Inter Info	[27], [28], [29]
D0317		Chlordiazepoxide	C16H14ClN3O	2712	Moderate		Inter Info	[27], [28], [29]
D0356		Clobazam	C16H13ClN2O2	2789	Moderate		Inter Info	[27], [28], [29]
D0365		Clorazepic acid	C16H11ClN2O3	2809	Moderate		Inter Info	[27], [28], [29]
D0362		Clonazepam	C15H10ClN3O3	2802	Moderate		Inter Info	[27], [28], [29]
D0473		Diazepam	C16H13ClN2O	3016	Moderate		Inter Info	[27], [28], [29]
D0604		Estazolam	C16H11ClN4	3261	Moderate		Inter Info	[27], [28], [29]
D1367		Quazepam	C17H11ClF4N2S	4999	Moderate		Inter Info	[27], [28], [29]
D1391		Remimazolam	C21H19BrN4O2	9867812	Moderate		Inter Info	[27], [28], [29]
D1632		Triazolam	C17H12Cl2N4	5556	Moderate		Inter Info	[27], [28], [29]
D0679		Flurazepam	C21H23ClFN3O	3393	Moderate		Inter Info	[27], [28], [29]
D0748		Halazepam	C17H12ClF3N2O	31640	Moderate		Inter Info	[27], [28], [29]
D1060		Midazolam	C18H13ClFN3	4192	Moderate		Inter Info	[27], [28], [29]
D1172		Olopatadine (nasal)	C21H23NO3	5281071	Moderate		Inter Info	[80], [81], [82]
D1547		Temazepam	C16H13ClN2O2	5391	Moderate		Inter Info	[27], [28], [29]
D1596		Tizanidine	C9H8ClN5S	5487	Moderate		Inter Info	[85]
	Additive dopaminergic effects					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0858		Isoniazid	C6H7N3O	3767	Moderate		Inter Info	[59]
	Increased risk of hepatotoxicity					Drug Num: 21
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0900		Leflunomide	C12H9F3N2O2	3899	Major		Inter Info	[10], [11], [12]
D0944		Lomitapide	C39H37F6N3O2	9853053	Major		Inter Info	[13]
D1073		Mipomersen	C230H324N67O122P19S19	118984467	Major		Inter Info	[14]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Major		Inter Info	[19]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Major		Inter Info	[10], [11], [12]
D0114		Asparaginase Escherichia coli	NA	NA	Moderate		Inter Info	[30], [31], [32], [15], [16], [33], [34], [35], [36], [37], [38], [39], [40]
D0357		Clofarabine	C10H11ClFN5O3	119182	Moderate		Inter Info	[47]
D0113		Asparaginase Erwinia chrysanthemi	NA	NA	Moderate		Inter Info	[30], [31], [32], [15], [16], [33], [34], [35], [36], [37], [38], [39], [40]
D0149		Bedaquiline	C32H31BrN2O2	5388906	Moderate		Inter Info	[50]
D0232		Calaspargase pegol	NA	NA	Moderate		Inter Info	[30], [31], [32], [15], [16], [33], [34], [35], [36], [37], [38], [39], [40]
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[58]
D1239		Peginterferon beta-1a	NA	NA	Moderate		Inter Info	[62], [63], [64], [65]
D1389		Remdesivir	C27H35N6O8P	121304016	Moderate		Inter Info	[15], [16], [68], [69], [70]
D0554		Efavirenz	C14H9ClF3NO2	64139	Moderate		Inter Info	[75], [76]
D0584		Epirubicin	C27H29NO11	41867	Moderate		Inter Info	[15], [16], [77]
D0826		Interferon beta-1a	NA	NA	Moderate		Inter Info	[62], [63], [64], [65]
D0827		Interferon beta-1b	NA	NA	Moderate		Inter Info	[62], [63], [64], [65]
D1025		Methotrexate	C20H22N8O5	126941	Moderate		Inter Info	[16], [78]
D1106		Naltrexone	C20H23NO4	5360515	Moderate		Inter Info	[79]
D1234		Pegaspargase	C14H19NO	436058	Moderate		Inter Info	[30], [31], [32], [15], [16], [33], [34], [35], [36], [37], [38], [39], [40]
D1589		Tioguanine	C5H5N5S	2723601	Moderate		Inter Info	[83], [84]
	Increased risk of peripheral neuropathy					Drug Num: 75
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0023		Adalimumab	NA	NA	Moderate		Inter Info	[24], [25], [26]
D0193		Bortezomib	C19H25BN4O4	387447	Moderate		Inter Info	[41], [42], [43]
D0303		Cerivastatin	C26H34FNO5	446156	Moderate		Inter Info	[24], [25], [26]
D0313		Chloramphenicol	C11H12Cl2N2O5	5959	Moderate		Inter Info	[24], [25], [26]
D0320		Chloroquine	C18H26ClN3	2719	Moderate		Inter Info	[24], [25], [26]
D0344		Cisplatin	Cl2H6N2Pt	5702198	Moderate		Inter Info	[24], [25], [26]
D0419		Dapsone	C12H12N2O2S	2955	Moderate		Inter Info	[24], [25], [26]
D0066		Amiodarone	C25H29I2NO3	2157	Moderate		Inter Info	[24], [25], [26]
D0120		Atorvastatin	C33H35FN2O5	60823	Moderate		Inter Info	[24], [25], [26]
D0126		Auranofin	C20H34AuO9PS	24199313	Moderate		Inter Info	[24], [25], [26]
D0127		Aurothioglucose	C6H11AuO5S	454937	Moderate		Inter Info	[24], [25], [26]
D0199		Brentuximab vedotin	NA	NA	Moderate		Inter Info	[24], [51], [52]
D0227		Cabazitaxel	C45H57NO14	9854073	Moderate		Inter Info	[24], [25], [26]
D0260		Carboplatin	C6H12N2O4Pt	426756	Moderate		Inter Info	[24], [25], [26]
D0261		Carfilzomib	C40H57N5O7	11556711	Moderate		Inter Info	[24], [25], [26]
D0304		Certolizumab pegol	NA	NA	Moderate		Inter Info	[24], [25], [26]
D0380		Colchicine	C22H25NO6	6167	Moderate		Inter Info	[24], [25], [26]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Moderate		Inter Info	[24], [25], [26]
D0483		Didanosine	C10H12N4O3	135398739	Moderate		Inter Info	[24], [25], [26]
D0496		Diiodohydroxyquinoline	C9H5I2NO	3728	Moderate		Inter Info	[24], [25], [26]
D0501		Dinutuximab	NA	NA	Moderate		Inter Info	[24], [25], [26]
D0511		Docetaxel	C43H53NO14	148124	Moderate		Inter Info	[24], [25], [26]
D0560		Elotuzumab	NA	NA	Moderate		Inter Info	[24], [25], [26]
D0571		Enfortumab vedotin	NA	NA	Moderate		Inter Info	[24], [25], [26]
D0594		Eribulin	C40H59NO11	11354606	Moderate		Inter Info	[24], [25], [26]
D0628		Etravirine	C20H15BrN6O	193962	Moderate		Inter Info	[24], [25], [26]
D0669		Fludarabine	C10H12FN5O4	657237	Moderate		Inter Info	[24], [25], [26]
D0686		Fluvastatin	C24H26FNO4	446155	Moderate		Inter Info	[24], [25], [26]
D0736		Golimumab	NA	NA	Moderate		Inter Info	[24], [25], [26]
D0770		Hydralazine	C8H8N4	3637	Moderate		Inter Info	[24], [25], [26]
D0779		Hydroxychloroquine	C18H26ClN3O	3652	Moderate		Inter Info	[24], [25], [26]
D0841		Ipilimumab	NA	NA	Moderate		Inter Info	[24], [25], [26]
D0873		Ixabepilone	C27H42N2O5S	6445540	Moderate		Inter Info	[24], [25], [26]
D0874		Ixazomib	C14H19BCl2N2O4	25183872	Moderate		Inter Info	[24], [25], [26]
D0918		Levodopa	C9H11NO4	6047	Moderate		Inter Info	[24], [25], [26]
D1113		Naxitamab	NA	NA	Moderate		Inter Info	[24], [25], [26]
D1118		Nelarabine	C11H15N5O5	3011155	Moderate		Inter Info	[24], [25], [26]
D1212		Paclitaxel	C47H51NO14	36314	Moderate		Inter Info	[24], [25], [26]
D1213		Paclitaxel (protein-bound)	C47H51NO14	36314	Moderate		Inter Info	[24], [25], [26]
D1301		Pitavastatin	C25H24FNO4	5282452	Moderate		Inter Info	[24], [25], [26]
D1306		Polatuzumab vedotin	NA	NA	Moderate		Inter Info	[24], [25], [26]
D1312		Pomalidomide	C13H11N3O4	134780	Moderate		Inter Info	[24], [25], [26]
D1313		Ponatinib	C29H27F3N6O	24826799	Moderate		Inter Info	[24], [25], [26]
D1430		Rosuvastatin	C22H28FN3O6S	446157	Moderate		Inter Info	[24], [25], [26]
D1452		Secnidazole	C7H11N3O3	71815	Moderate		Inter Info	[24], [25], [26]
D1479		Sodium aurothiomalate	C4H3AuNa2O4S	22318	Moderate		Inter Info	[24], [25], [26]
D1543		Telbivudine	C10H14N2O5	159269	Moderate		Inter Info	[24], [25], [26]
D1569		Thalidomide	C13H10N2O4	5426	Moderate		Inter Info	[41], [15], [16], [71]
D1599		Tocilizumab	NA	NA	Moderate		Inter Info	[24], [25], [26]
D1615		Trabectedin	C39H43N3O11S	108150	Moderate		Inter Info	[24], [25], [26]
D1623		Trastuzumab emtansine	NA	NA	Moderate		Inter Info	[24], [25], [26]
D1715		Zalcitabine	C9H13N3O3	24066	Moderate		Inter Info	[41], [74]
D0614		Etanercept	NA	NA	Moderate		Inter Info	[24], [25], [26]
D0616		Ethambutol	C10H24N2O2	14052	Moderate		Inter Info	[24], [25], [26]
D1731		Ethionamide	C8H10N2S	2761171	Moderate		Inter Info	[24], [25], [26]
D0627		Etoposide	C29H32O13	36462	Moderate		Inter Info	[24], [25], [26]
D0802		Infliximab	NA	NA	Moderate		Inter Info	[24], [25], [26]
D0821		Interferon alfa-2a, Recombinant	NA	NA	Moderate		Inter Info	[24], [25], [26]
D0822		Interferon alfa-2b	C16H17Cl3I2N3NaO5S	71306834	Moderate		Inter Info	[24], [25], [26]
D0824		Interferon alfa-n1	NA	NA	Moderate		Inter Info	[24], [25], [26]
D0823		Interferon alfacon-1	NA	NA	Moderate		Inter Info	[24], [25], [26]
D0956		Lovastatin	C24H36O5	53232	Moderate		Inter Info	[24], [25], [26]
D1145		Nitrofurantoin	C8H6N4O5	6604200	Moderate		Inter Info	[24], [25], [26]
D1193		Oxaliplatin	C8H14N2O4Pt	9887053	Moderate		Inter Info	[24], [25], [26]
D1237		Peginterferon alfa-2a	NA	NA	Moderate		Inter Info	[24], [25], [26]
D1238		Peginterferon alfa-2b	NA	NA	Moderate		Inter Info	[24], [25], [26]
D1329		Pravastatin	C23H36O7	54687	Moderate		Inter Info	[24], [25], [26]
D1473		Simvastatin	C25H38O5	54454	Moderate		Inter Info	[24], [25], [26]
D1504		Stavudine	C10H12N2O4	18283	Moderate		Inter Info	[24], [25], [26]
D1551		Teniposide	C32H32O13S	452548	Moderate		Inter Info	[24], [25], [26]
D1697		Vinblastine	C46H58N4O9	13342	Moderate		Inter Info	[24], [25], [26]
D1698		Vincristine	C46H56N4O10	5978	Moderate		Inter Info	[24], [25], [26]
D1699		Vincristine (liposome)	C46H56N4O10	5978	Moderate		Inter Info	[24], [25], [26]
D1700		Vinorelbine	C45H54N4O8	5311497	Moderate		Inter Info	[24], [25], [26]
D1714		Zafirlukast	C31H33N3O6S	5717	Moderate		Inter Info	[24], [25], [26]
	Increased risk of other adverse reactions (Unspecific)					Drug Num: 6
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0162		Benznidazole	C12H12N4O3	31593	Major		Inter Info	[3], [5], [6]
D0617		Ethanol	C2H6O	702	Major		Inter Info	[7], [8], [9]
D1051		Metronidazole	C6H9N3O3	4173	Major		Inter Info	[3], [5], [6]
D1415		Ritonavir	C37H48N6O5S2	392622	Major		Inter Info	[18], [23], [8]
D1052		Metronidazole (topical)	C6H9N3O3	4173	Moderate		Inter Info	[3], [6], [61]
D1587		Tinidazole	C8H13N3O4S	5479	Moderate		Inter Info	[3], [6], [61]

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37	Product Information. Elspar (asparaginase). Merck & Co, Inc, West Point, PA.
38	Product Information. Erwinaze (asparaginase Erwinia chrysanthemi). EUSA Pharma, Newtown, PA.
39	Product Information. Oncaspar (pegaspargase). Rhone-Poulenc Rorer, Collegeville, PA.
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63	Product Information. Betaseron (interferon beta-1b). Berlex, Richmond, CA.
64	Product Information. Plegridy (peginterferon beta-1a). Biogen Idec Inc, Cambridge, MA.
65	Product Information. Rebif (interferon beta-1a). Serono Laboratories Inc, Norwell, MA.
66	Product Information. Esbriet (pirfenidone). Intermune Inc, Brisbane, CA.
67	Product Information. Varubi (rolapitant). Tesaro Inc., Waltham, MA.
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74	Product Information. Hivid (zalcitabine). Roche Laboratories, Nutley, NJ.
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77	Product Information. Ellence (epirubicin) Pharmacia and Upjohn, Kalamazoo, MI.
78	Product Information. Methotrexate (methotrexate). Lederle Laboratories, Wayne, NJ.
79	Product Information. ReVia (naltrexone). DuPont Pharmaceuticals, Wilmington, DE.
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83	Product Information. Aubagio (teriflunomide). Genzyme Corporation, Cambridge, MA.
84	Product Information. Tabloid (thioguanine). Prasco Laboratories, Cincinnati, OH.
85	Product Information. Zanaflex (tizanidine). Acorda Therapeutics, Hawthorne, NY.
86	Product Information. Bextra (valdecoxib). Pharmacia Corporation, Peapack, NJ.
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88	Product Information. Ziagen (abacavir). Glaxo Wellcome, Research Triangle Pk, NC.

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