Details of Drug Interaction

Details of Drug-Drug Interaction

 Drug General Information (ID: DDIPZ8HMVI)
  Drug Name Disulfiram Drug Info Abacavir Drug Info
  Drug Type Small molecule Small molecule
  Therapeutic Class Alcohol Deterrents Anti-Hiv Agents
  Structure

 Mechanism of Disulfiram-Abacavir Interaction (Severity Level: Minor)
     Competitive inhibition of metabolic enzyme Click to Show/Hide Mechanism Graph
Could Not Find 2D Structure
      Drug Name Disulfiram Abacavir
      Mechanism 1 Alcohol dehydrogenase substrate Alcohol dehydrogenase substrate
      Key Mechanism Factor 1
Factor Name Alcohol dehydrogenase Structure Sequence
Protein Family Zinc-containing alcohol dehydrogenase family
Protein Function
Alcohol dehydrogenase (PubMed:2738060). Oxidizes primary as well as secondary alcohols. Ethanol is a very poor substrate (PubMed:2738060).
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      Mechanism Description
  • Increased plasma concentrations of Disulfiram and Abacavir due to competitive inhibition of the same metabolic pathway
      Mechanism 2 UGT substrate UGT substrate
      Key Mechanism Factor 2
Factor Name UDP-glucuronosyltransferase Structure Sequence
Protein Family UDP-glycosyltransferase family
Protein Function
[Isoform 1]: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:12181437, PubMed:15472229, PubMed:18004206, PubMed:18004212, PubMed:18719240, PubMed:19830808, PubMed:23288867). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:12181437, PubMed:18004206, PubMed:18004212). Catalyzes the glucuronidation of endogenous estrogen hormones such as estradiol, estrone and estriol (PubMed:15472229, PubMed:18719240, PubMed:23288867). Involved in the glucuronidation of bilirubin, a degradation product occurring in the normal catabolic pathway that breaks down heme in vertebrates (PubMed:17187418, PubMed:18004206, PubMed:19830808). Also catalyzes the glucuronidation the isoflavones genistein, daidzein, glycitein, formononetin, biochanin A and prunetin, which are phytoestrogens with anticancer and cardiovascular properties (PubMed:18052087, PubMed:19545173). Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonist losartan, a drug which can inhibit the effect of angiotensin II (PubMed:18674515). Involved in the biotransformation of 7-ethyl-10-hydroxycamptothecin (SN-38), the pharmacologically active metabolite of the anticancer drug irinotecan (PubMed:12181437, PubMed:18004212, PubMed:20610558).
    Click to Show/Hide
      Mechanism Description
  • Increased plasma concentrations of Disulfiram and Abacavir due to competitive inhibition of the same metabolic pathway

References
1 Product Information. Ziagen (abacavir). Glaxo Wellcome, Research Triangle Pk, NC.