Drug General Information (ID: DDIBUJH10Y)
Drug Name			Disulfiram		Drug Info		Diazepam		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Alcohol Deterrents				Benzodiazepine Anticonvulsants
Structure

Mechanism of Disulfiram-Diazepam Interaction (Severity Level: Moderate)
Additive CNS depression effects Click to Show/Hide Mechanism Graph
Drug Name		Disulfiram				Diazepam
Mechanism 1		Increase the CNS depressant effects combined with benzodiazepine				Benzodiazepines
Key Mechanism Factor 1
		Factor Name		CNS depression effects
		Factor Description		CNS depressants are drugs that inhibit or suppress brain activity and can reduce mental and physical processes. Excessive CNS depression can lead to decreased heart rate, slow breathing (less than 10 breaths per minute), extreme confusion or loss of memory, nausea and vomiting, poor judgment, blue lips or fingertips, irritability and aggression, and clammy or cold skin.
Mechanism Description		Additive CNS depression effects by the combination of Disulfiram and Diazepam
Mechanism 2		Increase the CNS depressant effects combined with benzodiazepine				Benzodiazepine
Key Mechanism Factor 2
		Factor Name		CNS depression effects
		Factor Description		CNS depressants are drugs that inhibit or suppress brain activity and can reduce mental and physical processes. Excessive CNS depression can lead to decreased heart rate, slow breathing (less than 10 breaths per minute), extreme confusion or loss of memory, nausea and vomiting, poor judgment, blue lips or fingertips, irritability and aggression, and clammy or cold skin.
Mechanism Description		Additive CNS depression effects by the combination of Disulfiram and Diazepam

Recommended Action
Management		The benzodiazepine dosage may require reduction. Patients should be monitored for excessive and prolonged sedation.

References
1	Hardman M, Biniwale A, Clarke CE "Temazepam toxicity precipitated by disulfiram." Lancet 344 (1994): 1231-2
2	MacLeod SM, Sellers EM, Giles HG, et al "Interaction of disulfiram with benzodiazepines." Clin Pharmacol Ther 24 (1978): 583-9
3	Sellers EM, Giles HG, Greenblatt DJ, Naranjo CA "Differential effects on benzodiazepine disposition by disulfiram and ethanol." Arzneimittelforschung 30 (1980): 882-6