Details of Drug Interaction

Details of Drug-Drug Interaction

 Drug General Information (ID: DDIIF3OJHX)
  Drug Name Temazepam Drug Info Disulfiram Drug Info
  Drug Type Small molecule Small molecule
  Therapeutic Class Anxiolytics/Sedatives/Hypnotics Alcohol Deterrents
  Structure

 Mechanism of Temazepam-Disulfiram Interaction (Severity Level: Moderate)
     Additive CNS depression effects Click to Show/Hide Mechanism Graph
Could Not Find 2D Structure
      Drug Name Temazepam Disulfiram
      Mechanism 1 Benzodiazepines Increase the CNS depressant effects combined with benzodiazepine
      Key Mechanism Factor 1
Factor Name CNS depression effects
Factor Description CNS depressants are drugs that inhibit or suppress brain activity and can reduce mental and physical processes. Excessive CNS depression can lead to decreased heart rate, slow breathing (less than 10 breaths per minute), extreme confusion or loss of memory, nausea and vomiting, poor judgment, blue lips or fingertips, irritability and aggression, and clammy or cold skin.
      Mechanism Description
  • Additive CNS depression effects by the combination of Temazepam and Disulfiram 
      Mechanism 2 Benzodiazepine Increase the CNS depressant effects combined with benzodiazepine
      Key Mechanism Factor 2
Factor Name CNS depression effects
Factor Description CNS depressants are drugs that inhibit or suppress brain activity and can reduce mental and physical processes. Excessive CNS depression can lead to decreased heart rate, slow breathing (less than 10 breaths per minute), extreme confusion or loss of memory, nausea and vomiting, poor judgment, blue lips or fingertips, irritability and aggression, and clammy or cold skin.
      Mechanism Description
  • Additive CNS depression effects by the combination of Temazepam and Disulfiram 

Recommended Action
      Management The benzodiazepine dosage may require reduction. Patients should be monitored for excessive and prolonged sedation.

References
1 Hardman M, Biniwale A, Clarke CE "Temazepam toxicity precipitated by disulfiram." Lancet 344 (1994): 1231-2
2 MacLeod SM, Sellers EM, Giles HG, et al "Interaction of disulfiram with benzodiazepines." Clin Pharmacol Ther 24 (1978): 583-9
3 Sellers EM, Giles HG, Greenblatt DJ, Naranjo CA "Differential effects on benzodiazepine disposition by disulfiram and ethanol." Arzneimittelforschung 30 (1980): 882-6