Details of Drug

Drug General Information (ID: D1492)
Drug Name	Solriamfetol
Drug Type	Small molecule
Drug Synonymous	JZP-110; (R)-2-Amino-3-phenylpropyl carbamate; UNII-939U7C91AI; 939U7C91AI; (2R)-2-amino-3-phenylpropyl carbamate; Solriamfetol [USAN]; Adx-N05 free base; SCHEMBL2739637; O-Carbamoyl-(D)-phenylalaninol; UCTRAOBQFUDCSR-SECBINFHSA-N; ZINC34278783; (R)-2-amino-3-phenylpropyl carbamate; Benzenepropanol, beta-amino-, 1-carbamate, (betaR)-; Benzenepropanol, beta-amino-, carbamate (ester), (R)-; 178429-62-4 Click to Show/Hide
Disease Class	7A20: Narcolepsy; MG42: Somnolence
Therapeutic Class	Cns Agents
Structure
Structure	3D Structure		2D Structure
Formula	C10H14N2O2
InChI	1S/C10H14N2O2/c11-9(7-14-10(12)13)6-8-4-2-1-3-5-8/h1-5,9H,6-7,11H2,(H2,12,13)/t9-/m1/s1
InChIKey	UCTRAOBQFUDCSR-SECBINFHSA-N
Canonical SMILES	C1=CC=C(C=C1)CC(COC(=O)N)N
External Link
	Pubchem ID	10130337
	CAS Number	178429-62-4
	TTD ID	D0M3CV

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM006 Pharmacodynamic additive effects BM040 Additive dopaminergic effects BM041 Additive hypertensive effects BM078 Increased risk of rapid heart rate
Relation Graph

Full list of drugs interacting with Solriamfetol
Pharmacodynamic additive effects
	Additive dopaminergic effects					Drug Num: 22
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0853		Isocarboxazid	C12H13N3O2	3759	Major		Inter Info	[1]
D0933		Linezolid	C16H20FN3O4	441401	Major		Inter Info	[1]
D1036		Methylene blue	C16H18ClN3S	6099	Major		Inter Info	[1]
D1211		Ozanimod	C23H24N4O3	52938427	Major		Inter Info	[1]
D1263		Phenelzine	C8H12N2	3675	Major		Inter Info	[1]
D1345		Procarbazine	C12H19N3O	4915	Major		Inter Info	[1]
D1385		Rasagiline	C12H13N	3052776	Major		Inter Info	[1]
D1437		Safinamide	C17H19FN2O2	131682	Major		Inter Info	[1]
D1455		Selegiline	C13H17N	26757	Major		Inter Info	[1]
D1620		Tranylcypromine	C9H11N	19493	Major		Inter Info	[1]
D0051		Amantadine	C10H17N	2130	Moderate		Inter Info	[1]
D0097		Apomorphine	C17H17NO2	6005	Moderate		Inter Info	[1]
D0212		Bromocriptine	C32H40BrN5O5	31101	Moderate		Inter Info	[1]
D0228		Cabergoline	C26H37N5O2	54746	Moderate		Inter Info	[1]
D0258		Carbidopa	C10H14N2O4	34359	Moderate		Inter Info	[1]
D0575		Entacapone	C14H15N3O5	5281081	Moderate		Inter Info	[1]
D0918		Levodopa	C9H11NO4	6047	Moderate		Inter Info	[1]
D1182		Opicapone	C15H10Cl2N4O6	135565903	Moderate		Inter Info	[1]
D1255		Pergolide	C19H26N2S	47811	Moderate		Inter Info	[1]
D1325		Pramipexole	C10H17N3S	119570	Moderate		Inter Info	[1]
D1427		Ropinirole	C16H24N2O	5095	Moderate		Inter Info	[1]
D1604		Tolcapone	C14H11NO5	4659569	Moderate		Inter Info	[1]
	Additive hypertensive effects					Drug Num: 55
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0074		Amphetamine	C9H13N	3007	Moderate		Inter Info	[1]
D0103		Arformoterol	C19H24N2O4	3083544	Moderate		Inter Info	[1]
D0465		Dextroamphetamine	C9H13N	5826	Moderate		Inter Info	[1]
D0505		Dipivefrin (ophthalmic)	C19H29NO5	3105	Moderate		Inter Info	[1]
D0510		Dobutamine	C18H23NO3	36811	Moderate		Inter Info	[1]
D0517		Dopamine	C8H11NO2	681	Moderate		Inter Info	[1]
D0538		Droxidopa	C9H11NO5	92974	Moderate		Inter Info	[1]
D0539		Duloxetine	C18H19NOS	60835	Moderate		Inter Info	[1]
D0579		Ephedrine	C10H15NO	9294	Moderate		Inter Info	[1]
D0580		Ephedrine (nasal)	C10H15NO	9294	Moderate		Inter Info	[1]
D0581		Epinephrine	C9H13NO3	5816	Moderate		Inter Info	[1]
D0582		Epinephrine (ophthalmic)	C9H13NO3	5816	Moderate		Inter Info	[1]
D0583		Epinephrine (topical)	C9H13NO3	5816	Moderate		Inter Info	[1]
D0691		Formoterol	C19H24N2O4	3410	Moderate		Inter Info	[1]
D0778		Hydroxyamphetamine (ophthalmic)	C9H13NO	3651	Moderate		Inter Info	[1]
D0797		Indacaterol	C24H28N2O3	6918554	Moderate		Inter Info	[1]
D0854		Isoetharine	C13H21NO3	3762	Moderate		Inter Info	[1]
D0857		Isometheptene	C9H19N	22297	Moderate		Inter Info	[1]
D0859		Isoprenaline	C11H17NO3	3779	Moderate		Inter Info	[1]
D0879		Ketamine	C13H16ClNO	3821	Moderate		Inter Info	[2], [3], [4]
D0913		Levmetamfetamine (nasal)	C10H15N	36604	Moderate		Inter Info	[1]
D0920		Levomilnacipran	C15H22N2O	6917779	Moderate		Inter Info	[1]
D0921		Levonordefrin	C9H13NO3	164739	Moderate		Inter Info	[1]
D0924		Levosalbutamol	C13H21NO3	123600	Moderate		Inter Info	[1]
D0937		Lisdexamfetamine	C15H25N3O	11597698	Moderate		Inter Info	[1]
D0981		Mazindol	C16H13ClN2O	4020	Moderate		Inter Info	[1]
D1002		Mephentermine	C11H17N	3677	Moderate		Inter Info	[1]
D1013		Metaraminol	C9H13NO2	5906	Moderate		Inter Info	[1]
D1027		Methoxamine	C11H17NO3	6082	Moderate		Inter Info	[1]
D1061		Midodrine	C12H18N2O4	4195	Moderate		Inter Info	[1]
D1066		Milnacipran	C15H22N2O	65833	Moderate		Inter Info	[1]
D1107		Naphazoline (nasal)	C14H14N2	4436	Moderate		Inter Info	[1]
D1153		Norepinephrine	C8H11NO3	439260	Moderate		Inter Info	[1]
D1171		Olodaterol	C21H26N2O5	11504295	Moderate		Inter Info	[1]
D1185		Orciprenaline	C11H17NO3	4086	Moderate		Inter Info	[1]
D1204		Oxymetazoline (nasal)	C16H24N2O	4636	Moderate		Inter Info	[1]
D1205		Oxymetazoline (ophthalmic)	C16H24N2O	4636	Moderate		Inter Info	[1]
D1206		Oxymetazoline (topical)	C16H24N2O	4636	Moderate		Inter Info	[1]
D1277		Phenylephrine (nasal)	C9H13NO2	6041	Moderate		Inter Info	[1]
D1278		Phenylephrine (ophthalmic)	C9H13NO2	6041	Moderate		Inter Info	[1]
D1280		Phenylephrine (topical)	C9H13NO2	6041	Moderate		Inter Info	[1]
D1298		Pirbuterol	C12H20N2O3	4845	Moderate		Inter Info	[1]
D1358		Propylhexedrine (nasal)	C10H21N	7558	Moderate		Inter Info	[1]
D1363		Pseudoephedrine	C10H15NO	7028	Moderate		Inter Info	[1]
D1374		Racepinephrine	C9H13NO3	838	Moderate		Inter Info	[1]
D1414		Ritodrine	C17H21NO3	33572	Moderate		Inter Info	[1]
D1438		Salbutamol	C13H21NO3	2083	Moderate		Inter Info	[1]
D1440		Salmeterol	C25H37NO4	5152	Moderate		Inter Info	[1]
D1535		Tapentadol	C14H23NO	9838022	Moderate		Inter Info	[1]
D1554		Terbutaline	C12H19NO3	5403	Moderate		Inter Info	[1]
D1567		Tetryzoline (nasal)	C13H16N2	5419	Moderate		Inter Info	[1]
D1568		Tetryzoline (ophthalmic)	C13H16N2	5419	Moderate		Inter Info	[1]
D1689		Venlafaxine	C17H27NO2	5656	Moderate		Inter Info	[1]
D1695		Vilanterol	C24H33Cl2NO5	10184665	Moderate		Inter Info	[1]
D1712		Xylometazoline (nasal)	C16H24N2	5709	Moderate		Inter Info	[1]

References
1	Product Information. Sunosi (solriamfetol). Jazz Pharmaceuticals, Palo Alto, CA.
2	Cerner Multum, Inc. "Australian Product Information.".
3	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
4	Product Information. Ketalar (ketamine). JHP Pharmaceuticals, Saddle River, NJ.

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