Drug General Information (ID: DDISTY5GJV)
Drug Name			Mazindol		Drug Info		Solriamfetol		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Cns Stimulants				Cns Agents
Structure

Mechanism of Mazindol-Solriamfetol Interaction (Severity Level: Moderate)
Additive hypertensive effects Click to Show/Hide Mechanism Graph
Drug Name		Mazindol				Solriamfetol
Mechanism 1		Hypertensive effects				Hypertensive effects
Key Mechanism Factor 1
		Factor Name		Hypertensive effects
		Factor Description		Hypertension is defined as a blood pressure reading above a prescribed limit (130/90 mmHg). Most people with hypertension have no signs or symptoms; others may experience: severe headache, shortness of breath, nosebleeds, severe anxiety, and feeling a tingling sensation in the neck or head.
Mechanism Description		Additive hypertensive effects by the combination of Mazindol and Solriamfetol
Increased risk of rapid heart rate Click to Show/Hide Mechanism Graph
Drug Name		Mazindol				Solriamfetol
Mechanism 2		Increased heart rate				Increased heart rate
Key Mechanism Factor 2
		Factor Name		Tachycardia
		Factor Description		A faster-than-normal heart rate, but the heart is beating normally. Tachycardia may not cause any symptoms or complications, but if left untreated, some forms of tachycardia can lead to serious health problems, including heart failure, stroke, or sudden cardiac death.
Mechanism Description		Increased risk of rapid heart rate by the combination of Mazindol and Solriamfetol

Recommended Action
Management		Caution is advised if solriamfetol is used with other drugs that increase blood pressure and/or heart rate. Blood pressure should be monitored prior to initiating solriamfetol therapy and regularly during treatment. In addition, hypertension should be controlled prior to treatment, and any new-onset hypertension or exacerbations of pre-existing hypertension that occur during solriamfetol therapy should be treated. Discontinuation of solriamfetol should be considered in patients who experience an increase in blood pressure or heart rate that cannot be managed with dose reduction of solriamfetol or other appropriate medical intervention.

References
1	Product Information. Sunosi (solriamfetol). Jazz Pharmaceuticals, Palo Alto, CA.