Details of Drug

Drug General Information (ID: D0981)
Drug Name	Mazindol
Drug Type	Small molecule
Drug Synonymous	mazindol; Mazanor; Sanorex; Teronac; Mazildene; 22232-71-9; Magrilon; Dimagrir; Mazindolum; Mazindole; Mazindolum [INN-Latin]; Terenac; AN 448; Mazindol [USAN:BAN:INN]; SAH 42548; CCRIS 3152; DEA No 1605; 5-(4-Chlorophenyl)-3,5-dihydro-2H-imidazo[2,1-a]isoindol-5-ol; 5-(4-Chlorophenyl)-2,5-dihydro-3H-imidazo[2,1-a]isoindol-5-ol; HSDB 3112; SA 42-548; 5-(4-Chlorophenyl)-2,3-dihydro-5-hydroxy-5H-imidazo[2,1-a]isoindole; EINECS 244-857-0; S 42548; CHEMBL781; 5-p-Chlorophenyl-2,3-dihydro-5H-imidazo(2,1-a)isoindol-5-ol; BRN 0546547; Diestet; Sanjorex; Solucaps; Teronak; Mazindol Medix Brand; Mazindol Novartis Brand; Mazindol Searle Brand; Mazindol Wyeth Brand; Medix Brand of Mazindol; Novartis Brand of Mazindol; Searle Brand of Mazindol; Wyeth Brand of Mazindol; AN 448;AN448; AN-448; Mazanor (TN); SANOREX (TN); Sanorex (TN); Mazindol (JAN/USP/INN); (+-)-5-(p-Chlorophenyl)-2,5-dihydro-3H-imidazo(2,1-a)isoindol-5-ol; 5-(4-Chlorophenyl)-2,3-dihydro-5-hydroxy-5H-imidazo(2,1-a)isoindole; 5-(4-chlorophenyl)-2,3-dihydroimidazo[1,2-b]isoindol-5-ol; 5-(p-Chlorophenyl)-2,5-dihydro-3H-imidazo(2,1-a)isoindol-5-ol; 5H-Imidazo(2,1-a)isoindol-5-ol, 5-(4-chlorophenyl)-2,3-dihydro; [3H]mazindol Click to Show/Hide
Disease Class	5B80-5B81: Obesity
Therapeutic Class	Cns Stimulants
Structure
Structure	3D Structure		2D Structure
Formula	C16H13ClN2O
InChI	1S/C16H13ClN2O/c17-12-7-5-11(6-8-12)16(20)14-4-2-1-3-13(14)15-18-9-10-19(15)16/h1-8,20H,9-10H2
InChIKey	ZPXSCAKFGYXMGA-UHFFFAOYSA-N
Canonical SMILES	C1CN2C(=N1)C3=CC=CC=C3C2(C4=CC=C(C=C4)Cl)O
External Link
	Pubchem ID	4020
	CAS Number	22232-71-9
	CHEBI ID	6702
	TTD ID	D0H8QL
	VARIDT ID	DR00850

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM003 Affected organization distribution AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM014 Interference of cell/tissue uptake BM018 Non-CYP450 enzyme inhibition BM038 Additive CNS depression effects BM041 Additive hypertensive effects BM046 Additive serotonergic effects BM061 Increased risk of hyperpyrexia BM064 Increased risk of hypoglycemia BM069 Increased risk of lowers seizure threshold BM078 Increased risk of rapid heart rate BM081 Increased risk of ventricular arrhythmias BM083 Potentiated the pharmacological effects (Unspecific) BM089 Antagonize the effect of antihypertensive agents BM093 Antagonize the effect of dopaminergic agents BM109 Increased risk of other adverse reactions (Unspecific)
Relation Graph

Full list of drugs interacting with Mazindol
Affected organization distribution
	Interference of cell/tissue uptake					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0829		Iobenguane (I-131)	C8H10IN3	60860	Major		Inter Info	[27]
D1821		Iobenguane (I-123)	C8H10IN3	60860	Moderate		Inter Info	[112], [113], [114]
Affected intra/extra-hepatic metabolism
	Non-CYP450 enzyme inhibition					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1437		Safinamide	C17H19FN2O2	131682	Moderate		Inter Info	[127], [33], [34], [25], [22], [128], [36], [37], [38], [129], [39], [120], [43], [130], [51], [131], [126], [132], [54]
Pharmacodynamic additive effects
	Additive CNS depression effects					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0617		Ethanol	C2H6O	702	Moderate		Inter Info	[59], [103], [57]
	Additive hypertensive effects					Drug Num: 52
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0345		Citalopram	C20H21FN2O	2771	Major		Inter Info	[1], [2], [3]
D0539		Duloxetine	C18H19NOS	60835	Major		Inter Info	[1], [2], [3]
D0676		Fluoxetine	C17H18F3NO	3386	Major		Inter Info	[1], [2], [3]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Major		Inter Info	[1], [2], [3]
D0377		Cocaine (nasal)	C17H21NO4	446220	Major		Inter Info	[22], [23], [24]
D0378		Cocaine (topical)	C17H21NO4	446220	Major		Inter Info	[22], [23], [24]
D0451		Desvenlafaxine	C16H25NO2	125017	Major		Inter Info	[1], [2], [3]
D0600		Esketamine	C13H16ClNO	182137	Major		Inter Info	[25], [26]
D0920		Levomilnacipran	C15H22N2O	6917779	Major		Inter Info	[1], [2], [3]
D1066		Milnacipran	C15H22N2O	65833	Major		Inter Info	[1], [2], [3]
D1229		Paroxetine	C19H20FNO3	43815	Major		Inter Info	[1], [2], [3]
D1461		Sertraline	C17H17Cl2N	68617	Major		Inter Info	[1], [2], [3]
D1464		Sibutramine	C17H26ClN	5210	Major		Inter Info	[1], [2], [3]
D1535		Tapentadol	C14H23NO	9838022	Major		Inter Info	[1], [2], [3]
D1696		Vilazodone	C26H27N5O2	6918314	Major		Inter Info	[1], [2], [3]
D1708		Vortioxetine	C18H22N2S	9966051	Major		Inter Info	[1], [2], [3]
D1689		Venlafaxine	C17H27NO2	5656	Major		Inter Info	[1], [2], [3]
D0068		Amitriptyline	C20H23N	2160	Moderate		Inter Info	[60], [61], [62]
D0072		Amoxapine	C17H16ClN3O	2170	Moderate		Inter Info	[60], [61], [62]
D0795		Imipramine	C19H24N2	3696	Moderate		Inter Info	[60], [61], [62]
D0103		Arformoterol	C19H24N2O4	3083544	Moderate		Inter Info	[46], [48], [101]
D0361		Clomipramine	C19H23ClN2	2801	Moderate		Inter Info	[60], [61], [62]
D0446		Desipramine	C18H22N2	2995	Moderate		Inter Info	[60], [61], [62]
D0510		Dobutamine	C18H23NO3	36811	Moderate		Inter Info	[46], [48], [101]
D0517		Dopamine	C8H11NO2	681	Moderate		Inter Info	[46], [48], [101]
D0525		Doxepin	C19H21NO	667477	Moderate		Inter Info	[60], [61], [62]
D0526		Doxepin (topical)	C19H21NO	667477	Moderate		Inter Info	[60], [61], [62]
D0538		Droxidopa	C9H11NO5	92974	Moderate		Inter Info	[102]
D0579		Ephedrine	C10H15NO	9294	Moderate		Inter Info	[46], [48], [101]
D0581		Epinephrine	C9H13NO3	5816	Moderate		Inter Info	[46], [48], [101]
D0691		Formoterol	C19H24N2O4	3410	Moderate		Inter Info	[46], [48], [101]
D0797		Indacaterol	C24H28N2O3	6918554	Moderate		Inter Info	[46], [48], [101]
D0857		Isometheptene	C9H19N	22297	Moderate		Inter Info	[46], [48], [101]
D0859		Isoprenaline	C11H17NO3	3779	Moderate		Inter Info	[46], [48], [101]
D0921		Levonordefrin	C9H13NO3	164739	Moderate		Inter Info	[46], [48], [101]
D0924		Levosalbutamol	C13H21NO3	123600	Moderate		Inter Info	[46], [48], [101]
D1171		Olodaterol	C21H26N2O5	11504295	Moderate		Inter Info	[46], [48], [101]
D1185		Orciprenaline	C11H17NO3	4086	Moderate		Inter Info	[46], [48], [101]
D1298		Pirbuterol	C12H20N2O3	4845	Moderate		Inter Info	[46], [48], [101]
D1363		Pseudoephedrine	C10H15NO	7028	Moderate		Inter Info	[46], [48], [101]
D1385		Rasagiline	C12H13N	3052776	Moderate		Inter Info	[33], [117], [34], [22], [118], [35], [36], [119], [38], [39], [120], [40], [121], [122], [41], [123], [42], [124], [125], [49], [50], [52], [126], [53], [54]
D1438		Salbutamol	C13H21NO3	2083	Moderate		Inter Info	[46], [48], [101]
D1440		Salmeterol	C25H37NO4	5152	Moderate		Inter Info	[46], [48], [101]
D1492		Solriamfetol	C10H14N2O2	10130337	Moderate		Inter Info	[133]
D1554		Terbutaline	C12H19NO3	5403	Moderate		Inter Info	[46], [48], [101]
D1647		Trimipramine	C20H26N2	5584	Moderate		Inter Info	[60], [61], [62]
D1695		Vilanterol	C24H33Cl2NO5	10184665	Moderate		Inter Info	[46], [48], [101]
D1061		Midodrine	C12H18N2O4	4195	Moderate		Inter Info	[22], [134]
D1153		Norepinephrine	C8H11NO3	439260	Moderate		Inter Info	[46], [48], [101]
D1158		Nortriptyline	C19H21N	4543	Moderate		Inter Info	[60], [61], [62]
D1276		Phenylephrine	C9H13NO2	6041	Moderate		Inter Info	[46], [48], [101]
D1361		Protriptyline	C19H21N	4976	Moderate		Inter Info	[60], [61], [62]
	Additive serotonergic effects					Drug Num: 9
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0466		Dextromethorphan	C18H25NO	5360696	Moderate		Inter Info	[90], [91], [83]
D0035		Alfentanil	C21H32N6O3	51263	Moderate		Inter Info	[90], [91], [83]
D0467		Dextropropoxyphene	C22H29NO2	10100	Moderate		Inter Info	[90], [91], [83]
D0646		Fentanyl	C22H28N2O	3345	Moderate		Inter Info	[90], [91], [83]
D1247		Pentazocine	C19H27NO	441278	Moderate		Inter Info	[90], [91], [83]
D1390		Remifentanil	C20H28N2O5	60815	Moderate		Inter Info	[90], [91], [83]
D1512		Sufentanil	C22H30N2O2S	41693	Moderate		Inter Info	[90], [91], [83]
D1001		Meperidine	C15H21NO2	4058	Moderate		Inter Info	[90], [91], [83]
D1017		Methadone	C21H27NO	4095	Moderate		Inter Info	[90], [91], [83]
	Increased risk of hyperpyrexia					Drug Num: 7
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0853		Isocarboxazid	C12H13N3O2	3759	Major		Inter Info	[33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54]
D0933		Linezolid	C16H20FN3O4	441401	Major		Inter Info	[33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54]
D1036		Methylene blue	C16H18ClN3S	6099	Major		Inter Info	[33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54]
D1263		Phenelzine	C8H12N2	3675	Major		Inter Info	[33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54]
D1345		Procarbazine	C12H19N3O	4915	Major		Inter Info	[33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54]
D1455		Selegiline	C13H17N	26757	Major		Inter Info	[33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54]
D1620		Tranylcypromine	C9H11N	19493	Major		Inter Info	[34], [42], [44]
	Increased risk of hypoglycemia					Drug Num: 35
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0009		Acarbose	C25H43NO18	41774	Moderate		Inter Info	[57], [58], [59]
D0727		Glimepiride	C24H34N4O5S	3476	Moderate		Inter Info	[57], [58], [59]
D0811		Insulin glargine	C267H404N72O78S6	118984454	Moderate		Inter Info	[57], [58], [59]
D0814		Insulin human (inhalation, rapid acting)	C257H383N65O77S6	118984375	Moderate		Inter Info	[57], [58], [59]
D0815		Insulin human (isophane)	C257H383N65O77S6	118984375	Moderate		Inter Info	[57], [58], [59]
D0816		Insulin human (regular)	C257H383N65O77S6	118984375	Moderate		Inter Info	[57], [58], [59]
D0817		Insulin human (zinc extended)	C257H383N65O77S6	118984375	Moderate		Inter Info	[57], [58], [59]
D0818		Insulin human (zinc)	C257H383N65O77S6	118984375	Moderate		Inter Info	[57], [58], [59]
D0819		Insulin lispro	C257H389N65O77S6	16132438	Moderate		Inter Info	[57], [58], [59]
D0029		Albiglutide	C148H224N40O45	145994868	Moderate		Inter Info	[57], [58], [59]
D0042		Alogliptin	C18H21N5O2	11450633	Moderate		Inter Info	[57], [58], [59]
D0245		Canagliflozin	C24H25FO5S	24812758	Moderate		Inter Info	[57], [58], [59]
D0325		Chlorpropamide	C10H13ClN2O3S	2727	Moderate		Inter Info	[57], [58], [59]
D0418		Dapagliflozin	C21H25ClO6	9887712	Moderate		Inter Info	[57], [58], [59]
D0565		Empagliflozin	C23H27ClO7	11949646	Moderate		Inter Info	[57], [58], [59]
D0728		Glipizide	C21H27N5O4S	3478	Moderate		Inter Info	[57], [58], [59]
D0730		Glyburide	C23H28ClN3O5S	3488	Moderate		Inter Info	[57], [58], [59]
D0808		Insulin aspart (aspart)	C256H381N65O79S6	118984445	Moderate		Inter Info	[57], [58], [59]
D0809		Insulin degludec	C274H411N65O81S6	118984462	Moderate		Inter Info	[57], [58], [59]
D0810		Insulin detemir	C267H402N64O76S6	16137271	Moderate		Inter Info	[57], [58], [59]
D0812		Insulin glulisine	C258H384N64O78S6	16136701	Moderate		Inter Info	[57], [58], [59]
D0930		Linagliptin	C25H28N8O2	10096344	Moderate		Inter Info	[57], [58], [59]
D0936		Liraglutide	C172H265N43O51	16134956	Moderate		Inter Info	[57], [58], [59]
D0941		Lixisenatide	C215H347N61O65S	90472060	Moderate		Inter Info	[57], [58], [59]
D1112		Nateglinide	C19H27NO3	5311309	Moderate		Inter Info	[57], [58], [59]
D1294		Pioglitazone	C19H20N2O3S	4829	Moderate		Inter Info	[57], [58], [59]
D1326		Pramlintide	C171H267N51O53S2	70691388	Moderate		Inter Info	[57], [58], [59]
D1392		Repaglinide	C27H36N2O4	65981	Moderate		Inter Info	[57], [58], [59]
D1449		Saxagliptin	C18H25N3O2	11243969	Moderate		Inter Info	[57], [58], [59]
D1477		Sitagliptin	C16H15F6N5O	4369359	Moderate		Inter Info	[57], [58], [59]
D1601		Tolazamide	C14H21N3O3S	5503	Moderate		Inter Info	[57], [58], [59]
D1603		Tolbutamide	C12H18N2O3S	5505	Moderate		Inter Info	[57], [58], [59]
D1015		Metformin	C4H11N5	4091	Moderate		Inter Info	[57], [58], [59]
D1064		Miglitol	C8H17NO5	441314	Moderate		Inter Info	[57], [58], [59]
D1429		Rosiglitazone	C18H19N3O3S	77999	Moderate		Inter Info	[57], [58], [59]
	Increased risk of lowers seizure threshold					Drug Num: 10
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0220		Bupropion	C13H18ClNO	444	Major		Inter Info	[7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21]
D0833		Iohexol	C19H26I3N3O9	3730	Major		Inter Info	[28], [29], [30], [31], [32]
D0834		Iopamidol	C17H22I3N3O8	65492	Major		Inter Info	[28], [29], [30], [31], [32]
D1616		Tramadol	C16H25NO2	33741	Major		Inter Info	[55], [20], [19], [56]
D0932		Lindane	C6H6Cl6	727	Moderate		Inter Info	[96], [97], [98]
D0054		Amifampridine	C5H7N3	5918	Moderate		Inter Info	[99], [100]
D0722		Ginkgo biloba	NA	NA	Moderate		Inter Info	[104], [105], [106], [107], [108], [109], [110], [111]
D1287		Picosulfuric acid	C18H15NO8S2	5243	Moderate		Inter Info	[115], [116], [22]
D1308		Polyethylene glycol (3350 with electrolytes)	C2H6O2	174	Moderate		Inter Info	[115], [116], [22]
D1488		Sodium sulfate	Na2O4S	24436	Moderate		Inter Info	[115], [116], [22]
	Potentiated the pharmacological effects (Unspecific)					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0925		Levothyroxine	C15H11I4NO4	5819	Moderate		Inter Info	[93], [94], [95]
D0934		Liothyronine	C15H12I3NO4	5920	Moderate		Inter Info	[93], [94], [95]
D1577		Thyroid, porcine	NA	NA	Moderate		Inter Info	[93], [94], [95]
	Increased risk of other adverse reactions (Unspecific)					Drug Num: 8
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0641		Fenfluramine	C12H16F3N	3337	Major		Inter Info	[4], [5], [6]
D0165		Benzphetamine	C17H21N	5311017	Major		Inter Info	[4], [5], [6]
D0486		Diethylpropion	C13H19NO	7029	Major		Inter Info	[4], [5], [6]
D0952		Lorcaserin	C11H14ClN	11658860	Major		Inter Info	[4], [5], [6]
D1012		Metamfetamine	C10H15N	10836	Major		Inter Info	[4], [5], [6]
D1262		Phendimetrazine	C12H17NO	30487	Major		Inter Info	[4], [5], [6]
D1270		Phentermine	C10H15N	4771	Major		Inter Info	[4], [5], [6]
D1281		Phenylpropanolamine	C9H13NO	26934	Major		Inter Info	[4], [5], [6]
Pharmacodynamic antagonistic effects
	Antagonize the effect of antihypertensive agents					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1393		Reserpine	C33H40N2O9	5770	Moderate		Inter Info	[135], [136], [137]
	Antagonize the effect of dopaminergic agents					Drug Num: 8
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0324		Chlorpromazine	C17H19ClN2S	2726	Moderate		Inter Info	[63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [42], [75], [76], [77], [78], [44], [79], [80], [45], [57], [81], [46], [82], [47], [83], [84], [49], [85], [86], [87], [88], [89]
D0750		Haloperidol	C21H23ClFNO2	3559	Moderate		Inter Info	[63], [64], [92], [65], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [44], [49], [85], [86], [87], [88], [89]
D1010		Mesoridazine	C21H26N2OS2	4078	Moderate		Inter Info	[72], [42], [85]
D1257		Perphenazine	C21H26ClN3OS	4748	Moderate		Inter Info	[63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [42], [75], [76], [77], [78], [44], [79], [80], [45], [57], [81], [46], [82], [47], [83], [84], [49], [85], [86], [87], [88], [89]
D1352		Promethazine	C17H20N2S	4927	Moderate		Inter Info	[63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [42], [75], [76], [77], [78], [44], [79], [80], [45], [57], [81], [46], [82], [47], [83], [84], [49], [85], [86], [87], [88], [89]
D1574		Thioridazine	C21H26N2S2	5452	Moderate		Inter Info	[72], [42], [85]
D1637		Trifluoperazine	C21H24F3N3S	5566	Moderate		Inter Info	[63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [42], [75], [76], [77], [78], [44], [79], [80], [45], [57], [81], [46], [82], [47], [83], [84], [49], [85], [86], [87], [88], [89]
D1346		Prochlorperazine	C20H24ClN3S	4917	Moderate		Inter Info	[63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [42], [75], [76], [77], [78], [44], [79], [80], [45], [57], [81], [46], [82], [47], [83], [84], [49], [85], [86], [87], [88], [89]

References
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