Drug General Information (ID: DDIMEZJAI6)
Drug Name			Phentermine		Drug Info		Mazindol		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Appetite Depressants				Cns Stimulants
Structure

Mechanism of Phentermine-Mazindol Interaction (Severity Level: Major)
Increased risk of other adverse reactions (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Phentermine				Mazindol
Mechanism		Risk of valvular heart disease				Risk of valvular heart disease
Key Mechanism Factor 1
		Factor Name		Adverse reactions
		Factor Description		An adverse reaction is an unexpected negative reaction to a medication or treatment that happens even when it's used correctly.
Mechanism Description		Increased risk of adverse reactions by the combination of Phentermine and Mazindol

Recommended Action
Management		Centrally--acting appetite suppressants should not be used in combination with other anorectic agents, including prescription, over-the-counter, and herbal preparations. In addition, they are not recommended for patients who have used any anorectic agents within the prior year. The potential risk of possible serious adverse effects such as valvular heart disease and pulmonary hypertension should be assessed carefully against the benefit of weight loss, and baseline cardiac evaluation should be considered to detect preexisting valvular heart diseases or pulmonary hypertension prior to initiating treatment. These agents are not recommended for use in patients with known heart murmur or valvular heart disease, severe hypertension, or symptomatic cardiovascular disease including arrhythmias.

References
1	Product Information. Meridia (sibutramine). Knoll Pharmaceutical Company, Whippany, NJ.
2	Product Information. Diethylpropion Hydrochloride SR (diethylpropion). Watson Pharmaceuticals, Parsippany, NJ.
3	Product Information. Phendimetrazine Tartrate SR (phendimetrazine). Sandoz Inc, Broomfield, CO.