Details of Drug Interaction | MecDDI

Drug General Information (ID: DDI6KU49JA)
Drug Name			Opicapone		Drug Info		Solriamfetol		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Dopaminergic Antiparkinsonism Agents				Cns Agents
Structure

Mechanism of Opicapone-Solriamfetol Interaction (Severity Level: Moderate)
Additive dopaminergic effects Click to Show/Hide Mechanism Graph

Drug Name		Opicapone				Solriamfetol
Mechanism		Dopaminergic effects Catechol-O-methyl-transferase Inhibitor				Dopaminergic effects Dopamine transporter Inhibitor
Key Mechanism Factor 1
		Factor Name		Catechol-O-methyl-transferase				× Structure Sequence MPEAPPLLLAAVLLGLVLLVVLLLLLRHWGWGLCLIGWNEFILQPIHNLLMGDTKEQRILNHVLQHAEPGNAQSVLEAIDTYCEQKEWAMNVGDKKGKIVDAVIQEHQPSVLLELGAYCGYSAVRMARLLSPGARLITIEINPDCAAITQRMVDFAGVKDKVTLVVGASQDIIPQLKKKYDVDTLDMVFLDHWKDRYLPDTLLLEECGLLRKGTVLLADNVICPGAPDFLAHVRGSSCFECTHYQSFLEYREVVDGLEKAIYKGPGSEAGP
		Gene Name		COMT
		Uniprot ID		COMT_HUMAN
		KEGG Pathway		hsa:1312
		Protein Family		Class I-like SAM-binding methyltransferase superfamily
		Protein Function		Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol. Click to Show/Hide
Key Mechanism Factor 2
		Factor Name		Dopamine transporter				× Structure Sequence MSKSKCSVGLMSSVVAPAKEPNAVGPKEVELILVKEQNGVQLTSSTLTNPRQSPVEAQDRETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELALGQFNREGAAGVWKICPILKGVGFTVILISLYVGFFYNVIIAWALHYLFSSFTTELPWIHCNNSWNSPNCSDAHPGDSSGDSSGLNDTFGTTPAAEYFERGVLHLHQSHGIDDLGPPRWQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAIDGIRAYLSVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIVTTSINSLTSFSSGFVVFSFLGYMAQKHSVPIGDVAKDGPGLIFIIYPEAIATLPLSSAWAVVFFIMLLTLGIDSAMGGMESVITGLIDEFQLLHRHRELFTLFIVLATFLLSLFCVTNGGIYVFTLLDHFAAGTSILFGVLIEAIGVAWFYGVGQFSDDIQQMTGQRPSLYWRLCWKLVSPCFLLFVVVVSIVTFRPPHYGAYIFPDWANALGWVIATSSMAMVPIYAAYKFCSLPGSFREKLAYAIAPEKDRELVDRGEVRQFTLRHWLKV
		Gene Name		SLC6A3
		Uniprot ID		SC6A3_HUMAN
		KEGG Pathway		hsa:6531
		Protein Family		Sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family
		Protein Function		Amine transporter (PubMed:1406597, PubMed:8302271, PubMed:15505207). Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals (By similarity). Regulator of light-dependent retinal hyaloid vessel regression, downstream of OPN5 signaling (By similarity). Click to Show/Hide
Mechanism Description		Additive dopaminergic effects by the combination of Opicapone and Solriamfetol

Recommended Action
Management		Caution is advised if solriamfetol is administered concomitantly with other dopaminergic drugs. Dosage adjustments and close patient monitoring should be considered whenever solriamfetol is used with other dopaminergic drugs.

References
1	Product Information. Sunosi (solriamfetol). Jazz Pharmaceuticals, Palo Alto, CA.