Drug General Information (ID: D1181)
  Drug Name
Ondansetron
  Drug Type Small molecule
  Drug Synonymous
DESMETHYLONDANSETRON; Zofran; Zophren; Zudan; Sandoz ondansetron; ZOFRAN IN PLASTIC CONTAINER; Zofran ODT; GR 38032; GR 38032X; GR38032F; Apo-ondansetron; GR-38032F; Novo-ondansetron; Ondansetron (Zofran); PHL-ondansetron; PMS-ondansetron; Ratio-ondansetron; SN-307; Zofran (TN); Zofran ODT (TN); Ondansetron [USAN:INN:BAN]; Ondansetron (JAN/USP/INN); Ondansetron, (+,-)-Isomer; (RS)-1,2,3,9-Tetrahydro-9-methyl-3-(2-methylimidazol-1-ylmethyl)carbazol-4-one; 1,2,3,9-Tetrahydro-9-methyl-3-((2-methyl-1H-imidazol-1-yl)methyl)-4H-carbazol-4-one; 9-Methyl-3-(2-methyl-imidazol-1-ylmethyl)-1,2,3,9-tetrahydro-carbazol-4-one; 9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-1,2,3,9-tetrahydro-4H-carbazol-4-one; 9-methyl-3-[(2-methylimidazol-1-yl)methyl]-2,3-dihydro-1H-carbazol-4-one
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  Disease Class MD90: Nausea/vomiting; 6C40: Substance abuse
  Therapeutic Class Antiemetics
  Structure Could Not Find 2D Structure
3D Structure 2D Structure
  Formula C18H19N3O
  InChI 1S/C18H19N3O/c1-12-19-9-10-21(12)11-13-7-8-16-17(18(13)22)14-5-3-4-6-15(14)20(16)2/h3-6,9-10,13H,7-8,11H2,1-2H3
  InChIKey FELGMEQIXOGIFQ-UHFFFAOYSA-N
  Canonical SMILES CC1=NC=CN1CC2CCC3=C(C2=O)C4=CC=CC=C4N3C
  External Link
Pubchem ID 4595
CAS Number 99614-02-5
CHEBI ID 7773
TTD ID D0K7WK
INTEDE ID DR1200
VARIDT ID DR00909

Drug-Drug Interaction Network
  Sunburst Graph
AM002  Affected cellular transport
AM004  Affected intra/extra-hepatic metabolism
AM006  Pharmacodynamic additive effects
BM010  Transporter inhibition
BM017  CYP450 enzyme inhibition
BM022  CYP450 enzyme induction
BM038  Additive CNS depression effects
BM042  Additive hypotensive effects
BM046  Additive serotonergic effects
BM049  Increased risk of atrioventricular block
BM076  Increased risk of prolong QT interval
BM081  Increased risk of ventricular arrhythmias
  Relation Graph
 Full list of drugs interacting with Ondansetron
      Affected cellular transport
      Affected intra/extra-hepatic metabolism
   CYP450 enzyme inhibition Drug Num:  17
Drug ID
 
Drug Name
Formula Pubchem ID Severity Level Interaction Detail REF
D0298
 
Celecoxib
 
C17H14F3N3O2S
 
2662 
Moderate    Inter Info   
[210]
D0386
 
Conivaptan
 
C32H26N4O2
 
151171 
Moderate    Inter Info   
[212]
D0793
 
Imatinib
 
C29H31N7O
 
5291 
Moderate    Inter Info   
[216]
D0002
 
Abametapir (topical)
 
C12H12N2
 
15664 
Moderate    Inter Info   
[256]
D0426
 
Darunavir
 
C27H37N3O7S
 
213039 
Moderate    Inter Info   
[268]
D0432
 
Deferasirox
 
C21H15N3O4
 
214348 
Moderate    Inter Info   
[270], [271]
D0543
 
Duvelisib
 
C22H17ClN6O
 
50905713 
Moderate    Inter Info   
[273]
D0545
 
Echinacea
 
NA
 
NA
Moderate    Inter Info   
[274]
D0699
 
Fostamatinib
 
C23H26FN6O9P
 
11671467 
Moderate    Inter Info   
[279]
D0732
 
Glycerol phenylbutyrate
 
C33H38O6
 
10482134 
Moderate    Inter Info   
[3], [284]
D0789
 
Idelalisib
 
C22H18FN7O
 
11625818 
Moderate    Inter Info   
[285]
D0852
 
Isavuconazonium
 
C35H35F2N8O5S+
 
6918606 
Moderate    Inter Info   
[3], [287]
D0896
 
Larotrectinib
 
C21H22F2N6O2
 
46188928 
Moderate    Inter Info   
[2], [3], [288]
D0906
 
Letermovir
 
C29H28F4N4O4
 
45138674 
Moderate    Inter Info   
[289]
D0946
 
Lonafarnib
 
C27H31Br2ClN4O2
 
148195 
Moderate    Inter Info   
[298]
D1505
 
Stiripentol
 
C14H18O3
 
5311454 
Moderate    Inter Info   
[2], [3], [314], [36]
D1553
 
Terbinafine
 
C21H25N
 
1549008 
Moderate    Inter Info   
[342], [343], [344], [345]
   CYP450 enzyme induction Drug Num:  21
Drug ID
 
Drug Name
Formula Pubchem ID Severity Level Interaction Detail REF
D0194
 
Bosentan
 
C27H29N5O6S
 
104865 
Moderate    Inter Info   
[168]
D0255
 
Carbamazepine
 
C15H12N2O
 
2554 
Moderate    Inter Info   
[3], [209]
D1128
 
Nevirapine
 
C15H14N4O
 
4463 
Moderate    Inter Info   
[2], [3], [253], [254]
D0204
 
Brigatinib
 
C29H39ClN7O2P
 
68165256 
Moderate    Inter Info   
[265]
D0300
 
Cenobamate
 
C10H10ClN5O2
 
11962412 
Moderate    Inter Info   
[266]
D0406
 
Dabrafenib
 
C23H20F3N5O2S2
 
44462760 
Moderate    Inter Info   
[3], [267]
D1167
 
Olaparib
 
C24H23FN4O3
 
23725625 
Moderate    Inter Info   
[2], [3], [38]
D1302
 
Pitolisant
 
C17H26ClNO
 
9948102 
Moderate    Inter Info   
[3], [304]
D1400
 
Rifampicin
 
C43H58N4O12
 
135398735 
Moderate    Inter Info   
[309]
D1401
 
Rifapentine
 
C47H64N4O12
 
135403821 
Moderate    Inter Info   
[309]
D1433
 
Rufinamide
 
C10H8F2N4O
 
129228 
Moderate    Inter Info   
[3], [310]
D1493
 
Somapacitan
 
C54H95N13O20S2
 
129894493 
Moderate    Inter Info   
[2], [3], [312]
D1495
 
Somatrem
 
C43H72N14O14
 
5487805 
Moderate    Inter Info   
[2], [3], [313], [312]
D1546
 
Telotristat ethyl
 
C27H26ClF3N6O3
 
25181577 
Moderate    Inter Info   
[3], [319]
D1556
 
Teriflunomide
 
C12H9F3N2O2
 
54684141 
Moderate    Inter Info   
[2], [3], [320]
D1198
 
Oxcarbazepine
 
C15H12N2O2
 
34312 
Moderate    Inter Info   
[324], [325], [326]
D1283
 
Phenytoin
 
C15H12N2O2
 
1775 
Moderate    Inter Info   
[3], [209]
D1399
 
Rifabutin
 
C46H62N4O11
 
135398743 
Moderate    Inter Info   
[309]
D1494
 
Somatotropin
 
NA
 
NA
Moderate    Inter Info   
[2], [3], [312]
D1081
 
Modafinil
 
C15H15NO2S
 
4236 
Minor    Inter Info   
[346], [347], [348], [349], [350]
D0106
 
Armodafinil
 
C15H15NO2S
 
9690109 
Minor    Inter Info   
[346], [347], [348], [349], [350]
      Pharmacodynamic additive effects
   Additive CNS depression effects Drug Num:  15
Drug ID
 
Drug Name
Formula Pubchem ID Severity Level Interaction Detail REF
D0226
 
Butorphanol
 
C21H29NO2
 
5361092 
Moderate    Inter Info   
[169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204], [205], [206], [207], [208]
D0379
 
Codeine
 
C18H21NO3
 
5284371 
Moderate    Inter Info   
[169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204], [205], [206], [207], [208]
D0776
 
Hydromorphone
 
C17H19NO3
 
5284570 
Moderate    Inter Info   
[169], [173], [186], [171], [195], [170], [175], [202], [176], [182], [203], [174], [185], [187], [190], [177], [205], [204], [191], [193], [181], [179], [183], [206], [189], [188], [196], [200], [207], [192], [208], [201], [172], [178], [180], [184], [194], [197], [198], [199]
D0923
 
Levorphanol
 
C17H23NO
 
5359272 
Moderate    Inter Info   
[169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204], [205], [206], [207], [208]
D1089
 
Morphine
 
C17H19NO3
 
5288826 
Moderate    Inter Info   
[169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204], [205], [206], [207], [208]
D1090
 
Morphine (liposomal)
 
C17H19NO3
 
5288826 
Moderate    Inter Info   
[169], [170], [171]
D1100
 
Nalbuphine
 
C21H27NO4
 
5311304 
Moderate    Inter Info   
[169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204], [205], [206], [207], [208]
D0161
 
Benzhydrocodone
 
C25H25NO4
 
49836084 
Moderate    Inter Info   
[169], [170], [171]
D0452
 
Deutetrabenazine
 
C19H27NO3
 
73437646 
Moderate    Inter Info   
[272]
D0470
 
Dezocine
 
C16H23NO
 
3033053 
Moderate    Inter Info   
[169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204], [205], [206], [207], [208]
D0493
 
Dihydrocodeine
 
C18H23NO3
 
5284543 
Moderate    Inter Info   
[169], [170], [171]
D0772
 
Hydrocodone
 
C18H21NO3
 
5284569 
Moderate    Inter Info   
[169], [173], [186], [171], [195], [170], [175], [202], [176], [182], [203], [174], [185], [187], [190], [177], [205], [204], [191], [193], [181], [179], [183], [206], [189], [188], [196], [200], [207], [192], [208], [201], [172], [178], [180], [184], [194], [197], [198], [199]
D1208
 
Oxymorphone
 
C17H19NO4
 
5284604 
Moderate    Inter Info   
[169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204], [205], [206], [207], [208]
D1673
 
Valbenazine
 
C24H38N2O4
 
24795069 
Moderate    Inter Info   
[323]
D1203
 
Oxycodone
 
C18H21NO4
 
5284603 
Moderate    Inter Info   
[169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204], [205], [206], [207], [208]
   Additive hypotensive effects Drug Num:  1
Drug ID
 
Drug Name
Formula Pubchem ID Severity Level Interaction Detail REF
D0942
 
Lofexidine
 
C11H12Cl2N2O
 
30668 
Moderate    Inter Info   
[1], [2], [3], [297], [38]
   Additive serotonergic effects Drug Num:  38
Drug ID
 
Drug Name
Formula Pubchem ID Severity Level Interaction Detail REF
D0035
 
Alfentanil
 
C21H32N6O3
 
51263 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7]
D0222
 
Buspirone
 
C21H31N5O2
 
2477 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7]
D0466
 
Dextromethorphan
 
C18H25NO
 
5360696 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7]
D0539
 
Duloxetine
 
C18H19NOS
 
60835 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7]
D0557
 
Eletriptan
 
C22H26N2O2S
 
77993 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7]
D0641
 
Fenfluramine
 
C12H16F3N
 
3337 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7]
D0646
 
Fentanyl
 
C22H28N2O
 
3345 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7]
D0933
 
Linezolid
 
C16H20FN3O4
 
441401 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7]
D1001
 
Meperidine
 
C15H21NO2
 
4058 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7]
D0041
 
Almotriptan
 
C17H25N3O2S
 
123606 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7]
D0220
 
Bupropion
 
C13H18ClNO
 
444 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7]
D0451
 
Desvenlafaxine
 
C16H25NO2
 
125017 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7]
D0457
 
Dexfenfluramine
 
C12H16F3N
 
66265 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7]
D0526
 
Doxepin (topical)
 
C19H21NO
 
667477 
Major    Inter Info   
[2], [3], [4]
D0702
 
Frovatriptan
 
C14H17N3O
 
77992 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7]
D0853
 
Isocarboxazid
 
C12H13N3O2
 
3759 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7]
D0897
 
Lasmiditan
 
C19H18F3N3O2
 
11610526 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7]
D0920
 
Levomilnacipran
 
C15H22N2O
 
6917779 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7]
D1036
 
Methylene blue
 
C16H18ClN3S
 
6099 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7]
D1066
 
Milnacipran
 
C15H22N2O
 
65833 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7]
D1110
 
Naratriptan
 
C17H25N3O2S
 
4440 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7]
D1117
 
Nefazodone
 
C25H32ClN5O2
 
4449 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7]
D1200
 
Oxitriptan
 
C11H12N2O3
 
439280 
Major    Inter Info   
[2], [3], [4]
D1345
 
Procarbazine
 
C12H19N3O
 
4915 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7]
D1419
 
Rizatriptan
 
C15H19N5
 
5078 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7]
D1464
 
Sibutramine
 
C17H26ClN
 
5210 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7]
D1502
 
St. John's Wort
 
NA
 
NA
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7]
D1535
 
Tapentadol
 
C14H23NO
 
9838022 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7]
D1696
 
Vilazodone
 
C26H27N5O2
 
6918314 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7]
D1708
 
Vortioxetine
 
C18H22N2S
 
9966051 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7]
D1247
 
Pentazocine
 
C19H27NO
 
441278 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7]
D1263
 
Phenelzine
 
C8H12N2
 
3675 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7]
D1390
 
Remifentanil
 
C20H28N2O5
 
60815 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7]
D1512
 
Sufentanil
 
C22H30N2O2S
 
41693 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7]
D1521
 
Sumatriptan
 
C14H21N3O2S
 
5358 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7]
D1620
 
Tranylcypromine
 
C9H11N
 
19493 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7]
D1658
 
Tryptophan
 
C11H12N2O2
 
6305 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7]
D1728
 
Zolmitriptan
 
C16H21N3O2
 
60857 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7]
   Increased risk of atrioventricular block Drug Num:  1
Drug ID
 
Drug Name
Formula Pubchem ID Severity Level Interaction Detail REF
D0992
 
Mefloquine
 
C17H16F6N2O
 
4046 
Moderate    Inter Info   
[3], [110], [252]
   Increased risk of prolong QT interval Drug Num:  182
Drug ID
 
Drug Name
Formula Pubchem ID Severity Level Interaction Detail REF
D0068
 
Amitriptyline
 
C20H23N
 
2160 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7]
D0072
 
Amoxapine
 
C17H16ClN3O
 
2170 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7]
D0084
 
Anagrelide
 
C10H7Cl2N3O
 
135409400 
Major    Inter Info   
[1], [2], [3], [8]
D0097
 
Apomorphine
 
C17H17NO2
 
6005 
Major    Inter Info   
[5], [6], [9]
D0320
 
Chloroquine
 
C18H26ClN3
 
2719 
Major    Inter Info   
[10], [3], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28]
D0342
 
Cisapride
 
C23H29ClFN3O4
 
6917698 
Major    Inter Info   
[1], [2], [3], [29], [30], [31]
D0345
 
Citalopram
 
C20H21FN2O
 
2771 
Major    Inter Info   
[1], [2], [3], [32], [33], [34], [4], [5], [6], [35], [7], [36]
D0370
 
Clozapine
 
C18H19ClN4
 
135398737 
Major    Inter Info   
[1], [2], [3], [37], [38]
D0508
 
Disopyramide
 
C21H29N3O
 
3114 
Major    Inter Info   
[1], [2], [3], [39], [40], [41], [42], [43], [44], [45], [46], [47], [38]
D0513
 
Dofetilide
 
C19H27N3O5S2
 
71329 
Major    Inter Info   
[1], [2], [3], [48]
D0514
 
Dolasetron
 
C19H20N2O3
 
3033818 
Major    Inter Info   
[1], [2], [3], [6]
D0535
 
Droperidol
 
C22H22FN3O2
 
3168 
Major    Inter Info   
[1], [2], [3], [49], [50], [38]
D0554
 
Efavirenz
 
C14H9ClF3NO2
 
64139 
Major    Inter Info   
[51]
D0676
 
Fluoxetine
 
C17H18F3NO
 
3386 
Major    Inter Info   
[1], [2], [3], [32], [33], [34], [4], [5], [6], [35], [7], [36]
D0687
 
Fluvoxamine
 
C15H21F3N2O2
 
5324346 
Major    Inter Info   
[1], [2], [3], [32], [33], [34], [4], [5], [6], [35], [7], [36]
D0740
 
Grepafloxacin
 
C19H22FN3O3
 
72474 
Major    Inter Info   
[52], [1], [2], [3], [53], [54], [55]
D0750
 
Haloperidol
 
C21H23ClFNO2
 
3559 
Major    Inter Info   
[1], [2], [3], [56], [57], [58], [59], [60], [61], [38]
D0787
 
Ibutilide
 
C20H36N2O3S
 
60753 
Major    Inter Info   
[1], [2], [3], [62]
D0795
 
Imipramine
 
C19H24N2
 
3696 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7]
D1017
 
Methadone
 
C21H27NO
 
4095 
Major    Inter Info   
[1], [2], [3], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [38]
D1063
 
Mifepristone
 
C29H35NO2
 
55245 
Major    Inter Info   
[1], [2], [3], [73]
D1075
 
Mirtazapine
 
C17H19N3
 
4205 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7]
D1092
 
Moxifloxacin
 
C21H24FN3O4
 
152946 
Major    Inter Info   
[74], [52], [75], [1], [2], [3], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95]
D1158
 
Nortriptyline
 
C19H21N
 
4543 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7]
D0066
 
Amiodarone
 
C25H29I2NO3
 
2157 
Major    Inter Info   
[1], [2], [3], [39], [40], [41], [42], [43], [44], [45], [46], [47], [38]
D0067
 
Amisulpride
 
C17H27N3O4S
 
2159 
Major    Inter Info   
[96]
D0149
 
Bedaquiline
 
C32H31BrN2O2
 
5388906 
Major    Inter Info   
[99]
D0170
 
Bepridil
 
C24H34N2O
 
2351 
Major    Inter Info   
[1], [2], [3], [39], [40], [41], [42], [43], [44], [45], [46], [47], [38]
D0230
 
Cabozantinib
 
C28H24FN3O5
 
25102847 
Major    Inter Info   
[3], [100]
D0302
 
Ceritinib
 
C28H36ClN5O3S
 
57379345 
Major    Inter Info   
[1], [2], [3], [101]
D0361
 
Clomipramine
 
C19H23ClN2
 
2801 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7]
D0393
 
Crizotinib
 
C21H22Cl2FN5O
 
11626560 
Major    Inter Info   
[102]
D0446
 
Desipramine
 
C18H22N2
 
2995 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7]
D0525
 
Doxepin
 
C19H21NO
 
667477 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7]
D0534
 
Dronedarone
 
C31H44N2O5S
 
208898 
Major    Inter Info   
[1], [2], [3], [103]
D0599
 
Escitalopram
 
C20H21FN2O
 
146570 
Major    Inter Info   
[1], [2], [3], [32], [33], [34], [4], [5], [6], [35], [7], [36]
D0712
 
Gatifloxacin
 
C19H22FN3O4
 
5379 
Major    Inter Info   
[74], [52], [75], [1], [2], [3], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95]
D0749
 
Halofantrine
 
C26H30Cl2F3NO
 
37393 
Major    Inter Info   
[106], [1], [2], [3], [107], [108], [109], [110], [111]
D0779
 
Hydroxychloroquine
 
C18H26ClN3O
 
3652 
Major    Inter Info   
[10], [3], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28]
D0791
 
Iloperidone
 
C24H27FN2O4
 
71360 
Major    Inter Info   
[1], [2], [3], [112], [38]
D0872
 
Ivosidenib
 
C28H22ClF3N6O3
 
71657455 
Major    Inter Info   
[115]
D0899
 
Lefamulin
 
C28H45NO5S
 
25185057 
Major    Inter Info   
[116]
D0909
 
Levacetylmethadol
 
C23H31NO2
 
15130 
Major    Inter Info   
[3], [117], [38]
D0940
 
Lithium carbonate
 
CLi2O3
 
11125 
Major    Inter Info   
[2], [6], [7]
D0960
 
Lumefantrine
 
C30H32Cl3NO
 
6437380 
Major    Inter Info   
[2], [3], [118]
D0965
 
Macimorelin
 
C26H30N6O3
 
9804938 
Major    Inter Info   
[119]
D0979
 
Maprotiline
 
C20H23N
 
4011 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7]
D1010
 
Mesoridazine
 
C21H26N2OS2
 
4078 
Major    Inter Info   
[1], [2], [3], [120], [38]
D1136
 
Nilotinib
 
C28H22F3N7O
 
644241 
Major    Inter Info   
[1], [2], [3], [121]
D1169
 
Oliceridine
 
C22H30N2O2S
 
66553195 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7]
D1190
 
Osimertinib
 
C28H33N7O2
 
71496458 
Major    Inter Info   
[122]
D1221
 
Panobinostat
 
C21H23N3O2
 
6918837 
Major    Inter Info   
[124]
D1223
 
Papaverine
 
C20H21NO4
 
4680 
Major    Inter Info   
[125], [126], [127], [128], [129], [130], [131], [132]
D1230
 
Pasireotide
 
C58H66N10O9
 
9941444 
Major    Inter Info   
[1], [2], [3], [133]
D1292
 
Pimozide
 
C28H29F2N3O
 
16362 
Major    Inter Info   
[3], [49], [134], [38]
D1343
 
Procainamide
 
C13H21N3O
 
4913 
Major    Inter Info   
[1], [2], [3], [39], [40], [41], [42], [43], [44], [45], [46], [47], [38]
D1371
 
Quinidine
 
C20H24N2O2
 
441074 
Major    Inter Info   
[1], [2], [3], [39], [40], [41], [42], [43], [44], [45], [46], [47], [38]
D1398
 
Ribociclib
 
C23H30N8O
 
44631912 
Major    Inter Info   
[1], [2], [3], [49], [80], [135], [136], [38]
D1459
 
Selpercatinib
 
C29H31N7O3
 
134436906 
Major    Inter Info   
[3], [137]
D1461
 
Sertraline
 
C17H17Cl2N
 
68617 
Major    Inter Info   
[1], [2], [3], [32], [33], [34], [4], [5], [6], [35], [7], [36]
D1499
 
Sparfloxacin
 
C19H22F2N4O3
 
60464 
Major    Inter Info   
[52], [1], [2], [3], [139], [140], [78], [80], [82], [141], [83], [84], [142], [86], [87], [88], [89], [143], [93], [55], [144]
D1681
 
Vandetanib
 
C22H24BrFN4O2
 
3081361 
Major    Inter Info   
[1], [2], [3], [145]
D1687
 
Vemurafenib
 
C23H18ClF2N3O3S
 
42611257 
Major    Inter Info   
[1], [2], [3], [146]
D1229
 
Paroxetine
 
C19H20FNO3
 
43815 
Major    Inter Info   
[1], [2], [3], [32], [33], [34], [4], [5], [6], [35], [7], [36]
D1361
 
Protriptyline
 
C19H21N
 
4976 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7]
D1498
 
Sotalol
 
C12H20N2O3S
 
5253 
Major    Inter Info   
[1], [2], [3], [39], [40], [41], [42], [43], [44], [45], [46], [47], [38]
D1574
 
Thioridazine
 
C21H26N2S2
 
5452 
Major    Inter Info   
[1], [2], [3], [147], [49], [148], [149], [150], [38]
D1612
 
Toremifene
 
C26H28ClNO
 
3005573 
Major    Inter Info   
[1], [2], [3], [151]
D1616
 
Tramadol
 
C16H25NO2
 
33741 
Major    Inter Info   
[1], [2], [3], [152], [4], [5], [6], [7]
D1624
 
Trazodone
 
C19H22ClN5O
 
5533 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7]
D1647
 
Trimipramine
 
C20H26N2
 
5584 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7]
D1689
 
Venlafaxine
 
C17H27NO2
 
5656 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7]
D1726
 
Ziprasidone
 
C21H21ClN4OS
 
60854 
Major    Inter Info   
[1], [2], [3], [49], [153], [38]
D0003
 
Abarelix
 
C72H95ClN14O14
 
16131215 
Moderate    Inter Info   
[3], [154], [155], [156], [157], [158], [159], [160]
D0036
 
Alfuzosin
 
C19H27N5O4
 
2092 
Moderate    Inter Info   
[1], [2], [3], [167], [38]
D0115
 
Astemizole
 
C28H31FN4O
 
2247 
Moderate    Inter Info   
[1], [2], [3], [49], [80], [136], [38]
D0119
 
Atomoxetine
 
C17H21NO
 
54841 
Moderate    Inter Info   
[1], [2], [3], [49], [80], [136], [38]
D0139
 
Azithromycin
 
C38H72N2O12
 
447043 
Moderate    Inter Info   
[1], [2], [3], [49], [80], [136], [38]
D0324
 
Chlorpromazine
 
C17H19ClN2S
 
2726 
Moderate    Inter Info   
[1], [2], [3], [49], [80], [136], [38]
D0341
 
Ciprofloxacin
 
C17H18FN3O3
 
2764 
Moderate    Inter Info   
[1], [2], [3], [49], [80], [136], [38]
D0358
 
Clofazimine
 
C27H22Cl2N4
 
2794 
Moderate    Inter Info   
[211]
D0429
 
Daunorubicin
 
C27H29NO10
 
30323 
Moderate    Inter Info   
[1], [2], [3], [49], [80], [136], [38]
D0430
 
Daunorubicin (liposomal)
 
C27H29NO10
 
30323 
Moderate    Inter Info   
[80], [136], [38]
D0467
 
Dextropropoxyphene
 
C22H29NO2
 
10100 
Moderate    Inter Info   
[80], [136], [38]
D0584
 
Epirubicin
 
C27H29NO11
 
41867 
Moderate    Inter Info   
[1], [2], [3], [49], [80], [136], [38]
D0597
 
Erythromycin
 
C37H67NO13
 
12560 
Moderate    Inter Info   
[1], [2], [3], [49], [80], [136], [38]
D0667
 
Fluconazole
 
C13H12F2N6O
 
3365 
Moderate    Inter Info   
[1], [2], [3], [49], [80], [136], [38]
D0678
 
Fluphenazine
 
C22H26F3N3OS
 
3372 
Moderate    Inter Info   
[1], [2], [3], [49], [80], [136], [38]
D0682
 
Flutamide
 
C11H11F3N2O3
 
3397 
Moderate    Inter Info   
[3], [154], [155], [156], [157], [158], [159], [160]
D0694
 
Foscarnet
 
CH3O5P
 
3415 
Moderate    Inter Info   
[1], [2], [3], [49], [80], [136], [38]
D0737
 
Goserelin
 
C59H84N18O14
 
5311128 
Moderate    Inter Info   
[3], [154], [155], [156], [157], [158], [159], [160]
D0781
 
Hydroxyzine
 
C21H27ClN2O2
 
3658 
Moderate    Inter Info   
[1], [2], [3], [49], [80], [136], [38]
D0908
 
Leuprolide
 
C59H84N16O12
 
657181 
Moderate    Inter Info   
[3], [154], [155], [156], [157], [158], [159], [160]
D0947
 
Loperamide
 
C29H33ClN2O2
 
3955 
Moderate    Inter Info   
[250], [251]
D1137
 
Nilutamide
 
C12H10F3N3O4
 
4493 
Moderate    Inter Info   
[3], [154], [155], [156], [157], [158], [159], [160]
D1166
 
Olanzapine
 
C17H20N4S
 
135398745 
Moderate    Inter Info   
[2], [3], [255]
D0007
 
Abiraterone
 
C24H31NO
 
132971 
Moderate    Inter Info   
[3], [154], [155], [156], [157], [158], [159], [160]
D0037
 
Alimemazine
 
C18H22N2S
 
5574 
Moderate    Inter Info   
[80], [136], [38]
D0095
 
Apalutamide
 
C21H15F4N5O2S
 
24872560 
Moderate    Inter Info   
[3], [154], [155], [156], [157], [158], [159], [160]
D0105
 
Aripiprazole
 
C23H27Cl2N3O2
 
60795 
Moderate    Inter Info   
[2], [3], [257], [258], [259], [260], [261], [262]
D0112
 
Asenapine
 
C17H16ClNO
 
3036780 
Moderate    Inter Info   
[1], [2], [3], [263], [38]
D0180
 
Bicalutamide
 
C18H14F4N2O4S
 
2375 
Moderate    Inter Info   
[3], [154], [155], [156], [157], [158], [159], [160]
D0195
 
Bosutinib
 
C26H29Cl2N5O3
 
5328940 
Moderate    Inter Info   
[3], [264]
D0219
 
Buprenorphine
 
C29H41NO4
 
644073 
Moderate    Inter Info   
[1], [2], [3], [49], [80], [136], [38]
D0336
 
Cilostazol
 
C20H27N5O2
 
2754 
Moderate    Inter Info   
[1], [2], [3], [49], [80], [136], [38]
D0349
 
Clarithromycin
 
C38H69NO13
 
84029 
Moderate    Inter Info   
[1], [2], [3], [49], [80], [136], [38]
D0428
 
Dasatinib
 
C22H26ClN7O2S
 
3062316 
Moderate    Inter Info   
[269]
D0437
 
Degarelix
 
C82H103ClN18O16
 
16136245 
Moderate    Inter Info   
[3], [154], [155], [156], [157], [158], [159], [160]
D0528
 
Doxorubicin
 
C27H29NO11
 
31703 
Moderate    Inter Info   
[1], [2], [3], [49], [80], [136], [38]
D0529
 
Doxorubicin (liposomal)
 
C27H29NO11
 
31703 
Moderate    Inter Info   
[80], [136], [38]
D0569
 
Encorafenib
 
C22H27ClFN7O4S
 
50922675 
Moderate    Inter Info   
[275]
D0577
 
Entrectinib
 
C31H34F2N6O2
 
25141092 
Moderate    Inter Info   
[2], [3], [276]
D0578
 
Enzalutamide
 
C21H16F4N4O2S
 
15951529 
Moderate    Inter Info   
[3], [154], [155], [156], [157], [158], [159], [160]
D0594
 
Eribulin
 
C40H59NO11
 
11354606 
Moderate    Inter Info   
[1], [2], [3], [277]
D0632
 
Ezogabine
 
C16H18FN3O2
 
121892 
Moderate    Inter Info   
[1], [2], [3], [49], [80], [136], [38]
D0636
 
Famotidine
 
C8H15N7O2S3
 
5702160 
Moderate    Inter Info   
[2], [3], [278]
D0664
 
Flecainide
 
C17H20F6N2O3
 
3356 
Moderate    Inter Info   
[1], [2], [3], [49], [80], [136], [38]
D0700
 
Fostemsavir
 
C25H26N7O8P
 
11319217 
Moderate    Inter Info   
[280]
D0716
 
Gemifloxacin
 
C18H20FN5O4
 
9571107 
Moderate    Inter Info   
[52], [82], [83], [88], [281]
D0720
 
Gilteritinib
 
C29H44N8O3
 
49803313 
Moderate    Inter Info   
[282]
D0725
 
Glasdegib
 
C21H22N6O
 
25166913 
Moderate    Inter Info   
[283]
D0751
 
Halothane
 
C2HBrClF3
 
3562 
Moderate    Inter Info   
[1], [2], [3], [49], [80], [136], [38]
D0758
 
Histrelin
 
C66H86N18O12
 
25077993 
Moderate    Inter Info   
[3], [154], [155], [156], [157], [158], [159], [160]
D0788
 
Idarubicin
 
C26H27NO9
 
42890 
Moderate    Inter Info   
[1], [2], [3], [49], [80], [136], [38]
D0806
 
Inotuzumab ozogamicin
 
NA
 
NA
Moderate    Inter Info   
[3], [286]
D0880
 
Ketoconazole
 
C26H28Cl2N4O4
 
456201 
Moderate    Inter Info   
[1], [2], [3], [49], [80], [136], [38]
D0894
 
Lapatinib
 
C29H26ClFN4O4S
 
208908 
Moderate    Inter Info   
[1], [2], [3], [49], [80], [136], [38]
D0903
 
Lenvatinib
 
C21H19ClN4O4
 
9823820 
Moderate    Inter Info   
[1], [2], [3], [49], [80], [136], [38]
D0919
 
Levofloxacin
 
C18H20FN3O4
 
149096 
Moderate    Inter Info   
[52], [1], [2], [3], [78], [79], [80], [290], [291], [83], [84], [292], [85], [293], [86], [87], [88], [89], [294], [295], [296], [93], [55]
D0937
 
Lisdexamfetamine
 
C15H25N3O
 
11597698 
Moderate    Inter Info   
[3]
D0943
 
Lomefloxacin
 
C17H19F2N3O3
 
3948 
Moderate    Inter Info   
[1], [2], [3], [49], [80], [136], [38]
D0948
 
Lopinavir
 
C37H48N4O5
 
92727 
Moderate    Inter Info   
[1], [2], [299]
D1026
 
Methotrimeprazine
 
C19H24N2OS
 
72287 
Moderate    Inter Info   
[1], [2], [3], [49], [80], [136], [38]
D1062
 
Midostaurin
 
C35H30N4O4
 
9829523 
Moderate    Inter Info   
[1], [2], [3], [49], [80], [136], [38]
D1155
 
Norfloxacin
 
C16H18FN3O3
 
4539 
Moderate    Inter Info   
[52], [1], [2], [3], [78], [79], [80], [290], [291], [83], [84], [292], [85], [293], [86], [87], [88], [89], [294], [295], [296], [93], [55]
D1165
 
Ofloxacin
 
C18H20FN3O4
 
4583 
Moderate    Inter Info   
[52], [1], [2], [3], [78], [79], [80], [290], [291], [83], [84], [292], [85], [293], [86], [87], [88], [89], [294], [295], [296], [93], [55]
D1189
 
Osilodrostat
 
C13H10FN3
 
44139752 
Moderate    Inter Info   
[3], [300]
D1215
 
Paliperidone
 
C23H27FN4O3
 
115237 
Moderate    Inter Info   
[1], [2], [3], [49], [80], [136], [38]
D1232
 
Pazopanib
 
C21H23N7O2S
 
10113978 
Moderate    Inter Info   
[1], [2], [3], [49], [80], [136], [38]
D1290
 
Pimavanserin
 
C25H34FN3O2
 
10071196 
Moderate    Inter Info   
[303]
D1315
 
Posaconazole
 
C37H42F2N8O4
 
468595 
Moderate    Inter Info   
[1], [2], [3], [49], [80], [136], [38]
D1339
 
Primaquine
 
C15H21N3O
 
4908 
Moderate    Inter Info   
[1], [2], [3], [49], [80], [136], [38]
D1342
 
Probucol
 
C31H48O2S2
 
4912 
Moderate    Inter Info   
[1], [2], [3], [49], [80], [136], [38]
D1352
 
Promethazine
 
C17H20N2S
 
4927 
Moderate    Inter Info   
[1], [2], [3], [49], [80], [136], [38]
D1353
 
Propafenone
 
C21H27NO3
 
4932 
Moderate    Inter Info   
[1], [2], [3], [49], [80], [136], [38]
D1368
 
Quetiapine
 
C21H25N3O2S
 
5002 
Moderate    Inter Info   
[1], [2], [3], [49], [305], [306], [307], [308], [38]
D1388
 
Relugolix
 
C29H27F2N7O5S
 
10348973 
Moderate    Inter Info   
[3], [154], [155], [156], [157], [158], [159], [160]
D1404
 
Rilpivirine
 
C22H18N6
 
6451164 
Moderate    Inter Info   
[1], [2], [3], [49], [80], [136], [38]
D1424
 
Romidepsin
 
C24H36N4O6S2
 
5352062 
Moderate    Inter Info   
[1], [2], [3], [49], [80], [136], [38]
D1432
 
Rucaparib
 
C19H18FN3O
 
9931954 
Moderate    Inter Info   
[1], [2], [3], [49], [80], [136], [38]
D1463
 
Sevoflurane
 
C4H3F7O
 
5206 
Moderate    Inter Info   
[1], [2], [3], [311]
D1491
 
Solifenacin
 
C23H26N2O2
 
154059 
Moderate    Inter Info   
[1], [2], [3], [49], [80], [136], [38]
D1522
 
Sunitinib
 
C22H27FN4O2
 
5329102 
Moderate    Inter Info   
[1], [2], [3], [315]
D1542
 
Telavancin
 
C80H106Cl2N11O27P
 
3081362 
Moderate    Inter Info   
[1], [2], [3], [49], [80], [136], [38]
D1544
 
Telithromycin
 
C43H65N5O10
 
3002190 
Moderate    Inter Info   
[1], [2], [3], [316], [317], [318]
D1560
 
Tetrabenazine
 
C19H27NO3
 
6018 
Moderate    Inter Info   
[1], [2], [3], [321], [38]
D1634
 
Triclabendazole
 
C14H9Cl3N2OS
 
50248 
Moderate    Inter Info   
[1], [2], [3], [49], [80], [136], [38]
D1651
 
Triptorelin
 
C64H82N18O13
 
25074470 
Moderate    Inter Info   
[3], [154], [155], [156], [157], [158], [159], [160]
D1193
 
Oxaliplatin
 
C8H14N2O4Pt
 
9887053 
Moderate    Inter Info   
[1], [2], [3], [49], [80], [136], [38]
D1210
 
Oxytocin
 
C43H66N12O12S2
 
439302 
Moderate    Inter Info   
[1], [2], [3], [49], [80], [136], [38]
D1216
 
Palonosetron
 
C19H24N2O
 
6337614 
Moderate    Inter Info   
[1], [2], [3], [49], [80], [136], [38]
D1246
 
Pentamidine
 
C19H24N4O2
 
4735 
Moderate    Inter Info   
[1], [2], [3], [49], [80], [136], [38]
D1254
 
Perflutren
 
C3F8
 
6432 
Moderate    Inter Info   
[327], [328]
D1257
 
Perphenazine
 
C21H26ClN3OS
 
4748 
Moderate    Inter Info   
[1], [2], [3], [49], [80], [136], [38]
D1346
 
Prochlorperazine
 
C20H24ClN3S
 
4917 
Moderate    Inter Info   
[1], [2], [3], [49], [80], [136], [38]
D1351
 
Promazine
 
C17H20N2S
 
4926 
Moderate    Inter Info   
[1], [2], [3], [49], [80], [136], [38]
D1356
 
Propofol
 
C12H18O
 
4943 
Moderate    Inter Info   
[329], [330], [331], [332], [333], [334], [335], [336], [337], [338]
D1372
 
Quinine
 
C20H24N2O2
 
3034034 
Moderate    Inter Info   
[1], [2], [3], [49], [80], [136], [38]
D1383
 
Ranolazine
 
C24H33N3O4
 
56959 
Moderate    Inter Info   
[339], [340]
D1413
 
Risperidone
 
C23H27FN4O2
 
5073 
Moderate    Inter Info   
[1], [2], [3], [49], [80], [136], [38]
D1497
 
Sorafenib
 
C21H16ClF3N4O3
 
216239 
Moderate    Inter Info   
[1], [2], [3], [341]
D1526
 
Tacrolimus
 
C44H69NO12
 
445643 
Moderate    Inter Info   
[1], [2], [3], [49], [80], [136], [38]
D1533
 
Tamoxifen
 
C26H29NO
 
2733526 
Moderate    Inter Info   
[1], [2], [3], [49], [80], [136], [38]
D1555
 
Terfenadine
 
C32H41NO2
 
5405 
Moderate    Inter Info   
[1], [2], [3], [49], [80], [136], [38]
D1596
 
Tizanidine
 
C9H8ClN5S
 
5487 
Moderate    Inter Info   
[1], [2], [3], [49], [80], [136], [38]
D1637
 
Trifluoperazine
 
C21H24F3N3S
 
5566 
Moderate    Inter Info   
[1], [2], [3], [49], [80], [136], [38]
D1638
 
Triflupromazine
 
C18H19F3N2S
 
5568 
Moderate    Inter Info   
[1], [2], [3], [49], [80], [136], [38]
D1682
 
Vardenafil
 
C23H32N6O4S
 
135400189 
Moderate    Inter Info   
[1], [2], [3], [49], [80], [136], [38]
D1683
 
Vasopressin
 
C46H65N15O12S2
 
644077 
Moderate    Inter Info   
[1], [2], [3], [49], [80], [136], [38]
D1706
 
Voriconazole
 
C16H14F3N5O
 
71616 
Moderate    Inter Info   
[1], [2], [3], [49], [80], [136], [38]
D1051
 
Metronidazole
 
C6H9N3O3
 
4173 
Minor    Inter Info   
[2], [351], [352], [353]
D1516
 
Sulfamethoxazole
 
C10H11N3O3S
 
5329 
Minor    Inter Info   
[1], [2], [3], [354], [355], [356], [357]
   Increased risk of ventricular arrhythmias Drug Num:  39
Drug ID
 
Drug Name
Formula Pubchem ID Severity Level Interaction Detail REF
D0107
 
Arsenic trioxide
 
As2O3
 
14888 
Major    Inter Info   
[97], [98]
D0661
 
Fingolimod
 
C19H33NO2
 
107970 
Major    Inter Info   
[1], [2], [3], [104], [105]
D0868
 
Ivabradine
 
C27H36N2O5
 
132999 
Major    Inter Info   
[3], [113], [114]
D1211
 
Ozanimod
 
C23H24N4O3
 
52938427 
Major    Inter Info   
[123]
D1474
 
Siponimod
 
C29H35F3N2O3
 
44599207 
Major    Inter Info   
[2], [138]
D0025
 
Adenosine
 
C10H13N5O4
 
60961 
Moderate    Inter Info   
[1], [161], [2], [3], [162], [163], [164], [29], [165], [166]
D0516
 
Donepezil
 
C24H29NO3
 
3152 
Moderate    Inter Info   
[1], [2], [3], [213], [214], [215]
D0707
 
Galantamine
 
C17H21NO3
 
9651 
Moderate    Inter Info   
[1], [2], [3], [213], [214], [215]
D0854
 
Isoetharine
 
C13H21NO3
 
3762 
Moderate    Inter Info   
[217], [218], [219], [220], [221], [222], [223], [224], [225], [226], [227], [228], [229], [230], [231], [232], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246]
D0888
 
Lactulose
 
C12H22O11
 
11333 
Moderate    Inter Info   
[1], [2], [3], [247], [248], [249]
D0103
 
Arformoterol
 
C19H24N2O4
 
3083544 
Moderate    Inter Info   
[217], [218], [219], [220], [221], [222], [223], [224], [225], [226], [227], [228], [229], [230], [231], [232], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246]
D0184
 
Bisacodyl
 
C22H19NO4
 
2391 
Moderate    Inter Info   
[1], [2], [3], [247], [248], [249]
D0269
 
Castor oil
 
C57H104O9
 
14030006 
Moderate    Inter Info   
[1], [2], [3], [247], [248], [249]
D0691
 
Formoterol
 
C19H24N2O4
 
3410 
Moderate    Inter Info   
[217], [218], [219], [220], [221], [222], [223], [224], [225], [226], [227], [228], [229], [230], [231], [232], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246]
D0701
 
Frangula purshiana bark
 
NA
 
NA
Moderate    Inter Info   
[2], [3], [249]
D0731
 
Glycerin
 
C3H8O3
 
753 
Moderate    Inter Info   
[1], [2], [3], [247], [248], [249]
D0797
 
Indacaterol
 
C24H28N2O3
 
6918554 
Moderate    Inter Info   
[217], [218], [219], [220], [221], [222], [223], [224], [225], [226], [227], [228], [229], [230], [231], [232], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246]
D0859
 
Isoprenaline
 
C11H17NO3
 
3779 
Moderate    Inter Info   
[230], [240], [243]
D0887
 
Lactitol
 
C12H24O11
 
157355 
Moderate    Inter Info   
[1], [2], [3], [247], [248], [249]
D0924
 
Levosalbutamol
 
C13H21NO3
 
123600 
Moderate    Inter Info   
[230], [240], [243]
D0970
 
Magnesium citrate
 
C12H10Mg3O14
 
6099959 
Moderate    Inter Info   
[1], [2], [3], [247], [248], [249]
D0973
 
Magnesium hydroxide
 
H2MgO2
 
14791 
Moderate    Inter Info   
[1], [2], [3], [247], [248], [249]
D1069
 
Mineral oil
 
NA
 
NA
Moderate    Inter Info   
[1], [2], [3], [247], [248], [249]
D1171
 
Olodaterol
 
C21H26N2O5
 
11504295 
Moderate    Inter Info   
[217], [218], [219], [220], [221], [222], [223], [224], [225], [226], [227], [228], [229], [230], [231], [232], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246]
D1266
 
Phenolphthalein
 
C20H14O4
 
4764 
Moderate    Inter Info   
[1], [2], [3], [247], [248], [249]
D1287
 
Picosulfuric acid
 
C18H15NO8S2
 
5243 
Moderate    Inter Info   
[3], [301], [302]
D1298
 
Pirbuterol
 
C12H20N2O3
 
4845 
Moderate    Inter Info   
[217], [218], [219], [220], [221], [222], [223], [224], [225], [226], [227], [228], [229], [230], [231], [232], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246]
D1308
 
Polyethylene glycol (3350 with electrolytes)
 
C2H6O2
 
174 
Moderate    Inter Info   
[3], [301], [302]
D1309
 
Polyethylene glycol (3350)
 
C2H6O2
 
174 
Moderate    Inter Info   
[2], [3], [249]
D1418
 
Rivastigmine
 
C14H22N2O2
 
77991 
Moderate    Inter Info   
[1], [2], [3], [213], [214], [215]
D1438
 
Salbutamol
 
C13H21NO3
 
2083 
Moderate    Inter Info   
[230], [240], [243]
D1440
 
Salmeterol
 
C25H37NO4
 
5152 
Moderate    Inter Info   
[217], [218], [219], [220], [221], [222], [223], [224], [225], [226], [227], [228], [229], [230], [231], [232], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246]
D1488
 
Sodium sulfate
 
Na2O4S
 
24436 
Moderate    Inter Info   
[3], [301], [302]
D1569
 
Thalidomide
 
C13H10N2O4
 
5426 
Moderate    Inter Info   
[2], [3], [322]
D1695
 
Vilanterol
 
C24H33Cl2NO5
 
10184665 
Moderate    Inter Info   
[230], [240], [243]
D1185
 
Orciprenaline
 
C11H17NO3
 
4086 
Moderate    Inter Info   
[230], [240], [243]
D1414
 
Ritodrine
 
C17H21NO3
 
33572 
Moderate    Inter Info   
[217], [218], [219], [220], [221], [222], [223], [224], [225], [226], [227], [228], [229], [230], [231], [232], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246]
D1525
 
Tacrine
 
C13H14N2
 
1935 
Moderate    Inter Info   
[1], [2], [3], [213], [214], [215]
D1554
 
Terbutaline
 
C12H19NO3
 
5403 
Moderate    Inter Info   
[217], [218], [219], [220], [221], [222], [223], [224], [225], [226], [227], [228], [229], [230], [231], [232], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246]
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101 Product Information. Zykadia (ceritinib). Novartis Pharmaceuticals, East Hanover, NJ.
102 Product Information. Xalkori (crizotinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
103 Product Information. Multaq (dronedarone). sanofi-aventis , Bridgewater, NJ.
104 Product Information. Gilenya (fingolimod). Novartis Pharmaceuticals, East Hanover, NJ.
105 FDA. U.S. Food and Drug Administration "FDA Drug Safety Communication: Revised recommendations for cardiovascular monitoring and use of multiple sclerosis drug Gilenya (fingolimod).".
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117 Product Information. Orlaam (levomethadyl acetate) Roxanne Laboratories Inc, Columbus, OH.
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119 Product Information. Macrilen (macimorelin). Aeterna Zentaris, Charleston, SC.
120 Product Information. Serentil (mesoridazine) Boehringer-Ingelheim, Ridgefield, CT.
121 Product Information. Tasigna (nilotinib). Novartis Pharmaceuticals, East Hanover, NJ.
122 Product Information. Tagrisso (osimertinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
123 Product Information. Zeposia (ozanimod). Celgene Corporation, Summit, NJ.
124 Product Information. Farydak (panobinostat). Novartis Pharmaceuticals, East Hanover, NJ.
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134 Product Information. Orap Tablets (pimozide). Gate Pharmaceuticals, Sellersville, PA.
135 Product Information. Kisqali (ribociclib). Novartis Pharmaceuticals, East Hanover, NJ.
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146 Product Information. Zelboraf (vemurafenib). Genentech, South San Francisco, CA.
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154 Product Information. Eligard (leuprolide). Sanofi Winthrop Pharmaceuticals, New York, NY.
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156 Product Information. Lupron (leuprolide). TAP Pharmaceuticals Inc, Deerfield, IL.
157 Product Information. Plenaxis (abarelix). Praecis Pharmaceuticals Inc, Waltham, MA.
158 Product Information. Trelstar (triptorelin) Pharmacia and Upjohn, Kalamazoo, MI.
159 Product Information. Vantas (histrelin). Endo Pharmaceuticals (formally Indevus Pharmaceuticals Inc), Lexington, MA.
160 Product Information. Zoladex (goserelin). Zeneca Pharmaceuticals, Wilmington, DE.
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214 Product Information. Exelon (rivastigmine) Novartis Pharmaceuticals, East Hanover, NJ.
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232 Product Information. Brovana (arformoterol). Sepracor Inc, Marlborough, MA.
233 Product Information. Foradil (formoterol) Novartis Pharmaceuticals, East Hanover, NJ.
234 Product Information. Maxair (pirbuterol). 3M Pharmaceuticals, St. Paul, MN.
235 Product Information. Proventil (albuterol). Schering Laboratories, Kenilworth, NJ.
236 Product Information. Severent (salmeterol). Glaxo Wellcome, Research Triangle Park, NC.
237 Product Information. Striverdi Respimat (olodaterol). Boehringer Ingelheim, Ridgefield, CT.
238 Product Information. Xopenex (levalbuterol). Sepracor, Marlborough, MA.
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254 Product Information. Viramune XR (nevirapine). Boehringer Ingelheim, Ridgefield, CT.
255 Product Information. Zyprexa (olanzapine). Lilly, Eli and Company, Indianapolis, IN.
256 Product Information. Xeglyze (abametapir topical). Dr. Reddy's Laboratories Inc, Upper Saddle River, NJ.
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262 Product Information. Abilify (aripiprazole). Bristol-Myers Squibb, Princeton, NJ.
263 Product Information. Saphris (asenapine). Schering-Plough Corporation, Kenilworth, NJ.
264 Abbas R, Hug BA, Leister C, Sonnichsen D "A randomized, crossover, placebo- and moxifloxacin-controlled study to evaluate the effects of bosutinib (SKI-606), a dual Src/Abl tyrosine kinase inhibitor, on cardiac repolarization in healthy adult subjects." Int J Cancer 131 (2012): Epub. [PMID: 22065400]
265 Product Information. Alunbrig (brigatinib). Ariad Pharmaceuticals Inc, Cambridge, MA.
266 Product Information. Xcopri (cenobamate). SK Life Science, Inc., Paramus, NJ.
267 Product Information. Tafinlar (dabrafenib). GlaxoSmithKline, Research Triangle Park, NC.
268 Product Information. Prezista (darunavir). Ortho Biotech Inc, Bridgewater, NJ.
269 Product Information. Sprycel (dasatinib). Bristol-Myers Squibb, Princeton, NJ.
270 Product Information. Exjade (deferasirox). Novartis Pharmaceuticals, East Hanover, NJ.
271 Skerjanec A, Wang J, Maren K, Rojkjaer L "Investigation of the pharmacokinetic interactions of deferasirox, a once-daily oral iron chelator, with midazolam, rifampin, and repaglinide in healthy volunteers." J Clin Pharmacol 50 (2010): 205-13. [PMID: 19940232]
272 Product Information. Austedo (deutetrabenazine). Teva Pharmaceuticals USA, North Wales, PA.
273 Product Information. Copiktra (duvelisib). Verastem, Inc., Needham, MA.
274 Gorski JC, Huang SM, Pinto A, et al. "The effect of echinacea (Echinacea purpurea root) on cytochrome P450 activity in vivo." Clin Pharmacol Ther 75 (2004): 89-100. [PMID: 14749695]
275 Product Information. Braftovi (encorafenib). Array BioPharma Inc., Boulder, CO.
276 Product Information. Rozlytrek (entrectinib). Genentech, South San Francisco, CA.
277 Product Information. Halaven (eribulin). Eisai Inc, Teaneck, NJ.
278 Product Information. Pepcid (famotidine). Merck & Co, Inc, West Point, PA.
279 Product Information. Tavalisse (fostamatinib). Rigel Pharmaceuticals, South San Francisco, CA.
280 Product Information. Rukobia (fostemsavir). ViiV Healthcare, Research Triangle Park, NC.
281 Product Information. Factive (gemifloxacin). GeneSoft Inc, San Francisco, CA.
282 Product Information. Xospata (gilteritinib). Astellas Pharma US, Inc, Deerfield, IL.
283 Product Information. Daurismo (glasdegib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
284 Product Information. Ravicti (glycerol phenylbutyrate). Hyperion Therapeutics Inc, South San Francisco, CA.
285 Product Information. Zydelig (idelalisib). Gilead Sciences, Foster City, CA.
286 Product Information. Besponsa (inotuzumab ozogamicin). Wyeth Laboratories, Philadelphia, PA.
287 Product Information. Cresemba (isavuconazonium). Astellas Pharma US, Inc, Deerfield, IL.
288 Product Information. Vitrakvi (larotrectinib). Bayer Pharmaceutical Inc, West Haven, CT.
289 Product Information. Prevymis (letermovir). Merck & Company Inc, Whitehouse Station, NJ.
290 Iannini PB, Doddamani S, Byazrova E, Curciumaru I, Kramer H "Risk of torsades de pointes with non-cardiac drugs. Prolongation of QT interval is probably a class effect of fluoroquinolones." Br Med J 322 (2001): 46-7. [PMID: 11141163]
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294 Product Information. Floxin (ofloxacin). Ortho Pharmaceutical Corporation, Raritan, NJ.
295 Product Information. Levaquin (levofloxacin). Ortho Pharmaceutical Corporation, Raritan, NJ.
296 Samaha FF "QTC interval prolongation and polymorphic ventricular tachycardia in association with levofloxacin." Am J Med 107 (1999): 528-9. [PMID: 10569314]
297 Product Information. Lucemyra (lofexidine). US WorldMeds LLC, Louisville , KY.
298 Product Information. Zokinvy (lonafarnib). Eiger BioPharmaceuticals, Palo Alto, CA.
299 Product Information. Kaletra (lopinavir-ritonavir) Abbott Pharmaceutical, Abbott Park, IL.
300 Product Information. Isturisa (osilodrostat). Recordati Rare Diseases Inc, Lebanon, NJ.
301 Product Information. Suclear (polyethylene glycol 3350 with electrolytes). Braintree Laboratories, Braintree, MA.
302 Product Information. Suprep Bowel Prep Kit (magnesium/potassium/sodium sulfates). Braintree Laboratories, Braintree, MA.
303 Product Information. Nuplazid (pimavanserin). Accelis Pharma, East Windsor, NJ.
304 Product Information. Wakix (pitolisant). Harmony Biosciences, LLC, Plymouth Meeting, PA.
305 Product Information. Seroquel (quetiapine). Zeneca Pharmaceuticals, Wilmington, DE.
306 Sala M, Vicentini A, Brambilla P, et al. "QT interval prolongation related to psychoactive drug treatment: a comparison of monotherapy versus polytherapy." Ann Gen Psychiatry 4 (2005): 1. [PMID: 15845138]
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310 Product Information. Banzel (rufinamide). Eisai Inc, Teaneck, NJ.
311 Product Information. Ultane (sevoflurane). Abbott Pharmaceutical, Abbott Park, IL.
312 Product Information. Zorbtive (somatropin). Serono Laboratories Inc, Rockland, MA.
313 Product Information. Humatrope (somatropin). Lilly, Eli and Company, Indianapolis, IN.
314 Product Information. Diacomit (stiripentol). Biocodex Inc, Creswell, OR.
315 Product Information. Sutent (sunitinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
316 Demolis JL, Vacheron F, Cardus S, Funck-Brentano C "Effect of single and repeated oral doses of telithromycin on cardiac QT interval in healthy subjects." Clin Pharmacol Ther 73 (2003): 242-52. [PMID: 12621389]
317 Product Information. Ketek (telithromycin). Aventis Pharmaceuticals, Bridgewater, NJ.
318 European Agency for the Evaluation of Medicinal Products. Committee for Proprietary Medicinal Products "European Public Assessment Report Ketek (telithromycin) (Rev. 2) ".
319 Product Information. Xermelo (telotristat ethyl). Lexicon Pharmaceuticals, Inc., The Woodlands, TX.
320 Product Information. Aubagio (teriflunomide). Genzyme Corporation, Cambridge, MA.
321 Product Information. Xenazine (tetrabenazine). Prestwick Pharmaceuticals Inc, Washington DC, VA.
322 Product Information. Thalomid (thalidomide). Celgene Corporation, Warren, NJ.
323 Product Information. Ingrezza (valbenazine). Neurocrine Biosciences, Inc., San Diego, CA.
324 Product Information. Trileptal (oxcarbazepine) Novartis Pharmaceuticals, East Hanover, NJ.
325 Rosche J, Froscher W, Abendroth D, Liebel J "Possible oxcarbazepine interaction with cyclosporine serum levels: A single case study." Clin Neuropharmacol 24 (2001): 113-6. [PMID: 11307049]
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327 Product Information. Definity (perflutren). Lantheus Medical Imaging Inc, North Billerica, MA.
328 Product Information. Optison (perflutren). Mallinckrodt Medical Inc, St. Louis, MO.
329 Hanci V, Aydin M, Yurtlu BS, et.al "Anesthesia induction with sevoflurane and propofol: evaluation of P-wave dispersion, QT and corrected QT intervals." Kaohsiung J Med Sci 26 (2010): 470-7. [PMID: 20837343]
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339 European Medicines Agency "CHMP Assessment Report for Latixa. International nonproprietary name: ranolazine.".
340 Product Information. Ranexa (ranolazine). Calmoseptine Inc, Huntington Beach, CA.
341 Product Information. Nexavar (sorafenib). Bayer Pharmaceutical Inc, West Haven, CT.
342 AbdelRahman SM, Gotschall RR, Kauffman RE, Leeder JS, Kearns GL "Investigation of terbinafine as a CYP2D6 inhibitor in vivo." Clin Pharmacol Ther 65 (1999): 465-72. [PMID: 10340911]
343 Gupta AK, Katz HI, Shear NH "Terbinafine and potential drug interactions - Reply." J Am Acad Dermatol 43 (2000): 883-4. [PMID: 11050604]
344 Product Information. Lamisil (terbinafine). Sandoz Pharmaceuticals Corporation, East Hanover, NJ.
345 Van der Kuy PH, Hooymans PM, Verkaaik AJ "Nortriptyline intoxication induced by terbinafine." BMJ 316 (1998): 441. [PMID: 9492672]
346 Doherty MM, Charman WN "The mucosa of the small intestine: how clinically relevant as an organ of drug metabolism?" Clin Pharmacokinet 41 (2002): 235-53. [PMID: 11978143]
347 Product Information. Nuvigil (armodafinil). Cephalon Inc, West Chester, PA.
348 Product Information. Provigil (modafinil). Cephalon, Inc, West Chester, PA.
349 Robertson P Jr, Hellriegel ET, Arora S, Nelson M "Effect of modafinil on the pharmacokinetics of ethinyl estradiol and triazolam in healthy volunteers." Clin Pharmacol Ther 71 (2002): 46-56. [PMID: 11823757]
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352 Product Information. Flagyl (metronidazole). Searle, Skokie, IL.
353 Product Information. Pylera (bismuth subcitrate potassium/metronidazo/TCN). Aptalis Pharma, Birmingham, AL.
354 Crouch MA, Limon L, Cassano AT "Clinical relevance and management of drug-related QT interval prolongation." Pharmacotherapy 23 (2003): 881-908. [PMID: 12885102]
355 Darpo B "Spectrum of drugs prolonging QT interval and the incidence of torsades de pointes." Eur Heart J Suppl 3(Suppl K) (2001): K70-80.
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