Drug General Information (ID: DDI2HEKVUT)
Drug Name			Apomorphine		Drug Info		Ondansetron		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Dopaminergic Antiparkinsonism Agents				Antiemetics
Structure

Mechanism of Apomorphine-Ondansetron Interaction (Severity Level: Major)
Increased risk of prolong QT interval Click to Show/Hide Mechanism Graph
Drug Name		Apomorphine				Ondansetron
Mechanism		Prolong QT interval				Prolong QT interval
Key Mechanism Factor 1
		Factor Name		QT interval
		Factor Description		Long QT syndrome is a heart signaling disorder that can cause a fast, chaotic heartbeat (arrhythmia). Many people may not exhibit symptoms, and usually the condition is detected during routine medical tests. In others, the most common symptoms include: sudden fainting, palpitations, dizziness, seizures, sudden death.
Mechanism Description		Increased risk of prolong QT interval by the combination of Apomorphine and Ondansetron

Recommended Action
Management		The concomitant use of apomorphine and 5-HT3 antagonists is contraindicated by the manufacturer.

References
1	Product Information. Aloxi (palonosetron). MGI Pharma Inc, Minnetonka, MN.
2	Product Information. Anzemet (dolasetron). Hoechst Marion-Roussel Inc, Kansas City, MO.
3	Product Information. Apokyn (apomorphine). Mylan Pharmaceuticals Inc, Morgantown, WV.