Drug General Information (ID: DDIZWT142G)
Drug Name			Ondansetron		Drug Info		Sevoflurane		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antiemetics				Anesthetics
Structure

Mechanism of Ondansetron-Sevoflurane Interaction (Severity Level: Moderate)
Increased risk of prolong QT interval Click to Show/Hide Mechanism Graph
Drug Name		Ondansetron				Sevoflurane
Mechanism		Prolong QT interval				Prolong QT interval
Key Mechanism Factor 1
		Factor Name		QT interval
		Factor Description		Long QT syndrome is a heart signaling disorder that can cause a fast, chaotic heartbeat (arrhythmia). Many people may not exhibit symptoms, and usually the condition is detected during routine medical tests. In others, the most common symptoms include: sudden fainting, palpitations, dizziness, seizures, sudden death.
Mechanism Description		Increased risk of prolong QT interval by the combination of Ondansetron and Sevoflurane

Recommended Action
Management		Caution is recommended if sevoflurane is used in combination with other drugs that can prolong the QT interval. The patient's cardiovascular status and serum electrolytes should be closely monitored.

References
1	Canadian Pharmacists Association.
2	Cerner Multum, Inc. "Australian Product Information.".
3	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
4	Product Information. Ultane (sevoflurane). Abbott Pharmaceutical, Abbott Park, IL.