Details of Drug

Drug General Information (ID: D1154)
Drug Name	Norethisterone
Drug Type	Small molecule
Drug Synonymous	Activella; Anhydrohydroxynorprogesterone; Anovulatorio; Anovule; Brevicon; Brevinor; Camila; Ciclovulan; Conceplan;Conludaf; Conludag; Demulen; Errin; Estrinor; Ethinylnortestosterone; Ethynylmortestosterone; Ethynylnortestosterone; Gencept; Genora; Gestest; Jenest; Loestrin; Menzol; Microneth; Micronett; Micronor; Micronovum; Milli; Minovlar; Nelova; Nodiol; Noraethisteronum; Noralutin; Norcept; Norcolut; Norcolute; Noresthisterone; Norethadrone; Norethin; Norethindirone; Norethisteron; Norethisterone; Norethisteronum; Norethyndron; Norethynodron; Norethynodrone; Noretisterona; Noretisterone; Norfor; Norgestin; Noriday; Norluten; Norlutin; Norluton; Normapause; Norpregneninlone; Norpregneninolone; Norpregneninotone; Orlest; Proluteasi; Synphase; Triella; Utovlan; Utovlar; Component of Noriday; Norethindrone Norethisterone; Norethindrone [USAN]; Norethisterone [Progestins]; Noretisterone [DCIT]; Primolut N; Brevinor 21; Brevinor 28; Noriday 28; Ortho 1 35; Ortho 7 7 7; Ovysmen 1 35; SC 4640; Synphasic 28; Trinovum 21; Brevinor-1 21; Brevinor-1 28; Camila (TN); Jenest-28; Micronor (TN); Mini-Pe; Mini-pill; Nor-QD; Nora-BE; Norcept-E; Norethin 1/35 E; Norethin 1/50 M; Norethindrone (USP); Norethisterone (JP15); Norethisteronum [INN-Latin]; Noretisterona [INN-Spanish]; Ortho-Novum 1 35; Ortho-Novum 1 50; Ortho-Novum 7 7 7; Ovysmen 0.5 35; Primolut-N; Tri-Norinyl; Ethinyl-19-nortestosterone; Nor-Q.D; Primolut-N (TN); Nor-Q.D.; 17-Ethinyl-19-nortestosterone; 17-Ethynyl-17-hydroxyestr-4-en-3-one; 17-alpha-Ethynyl-19-nortestosterone; 17-alpha-Ethynyl-4-estren-17-ol-3-one; 17-ethynyl-17beta-hydroxyestr-4-en-3-one; 17.alpha.-Ethinyl-19-nortestosterone; 17.alpha.-Ethynyl-19-nortestosterone; 17.alpha.-Ethynyl-4-estren-17-ol-3-one; 17alpha-Ethinyl-19-nortestosterone; 17alpha-Ethynyl-19-nortestosterone; 17alpha-Ethynyl-4-estren-17-ol-3-one; 19-Nor-17-alpha-ethynyltestosterone; 19-Nor-17-ethinyltestosterone; 19-Nor-17.alpha.-ethynyltestosterone; 19-Nor-17alpa-ethynyltestosterone; 19-Nor-17alpha-ethynyltestosterone; 19-Nor-ethindrone; 19-Nor-ethinyl-4,5-testosterone; 19-Norethindrone; 19-Norethinyltestosterone; 19-Norethisterone; 4-Estren-17alpha-ethynyl-17beta-ol-3-one Click to Show/Hide
Disease Class	2A00-2F9Z: Solid tumour/cancer
Therapeutic Class	Contraceptive Agents
Structure
Structure	3D Structure		2D Structure
Formula	C20H26O2
InChI	1S/C20H26O2/c1-3-20(22)11-9-18-17-6-4-13-12-14(21)5-7-15(13)16(17)8-10-19(18,20)2/h1,12,15-18,22H,4-11H2,2H3/t15-,16+,17+,18-,19-,20-/m0/s1
InChIKey	VIKNJXKGJWUCNN-XGXHKTLJSA-N
Canonical SMILES	CC12CCC3C(C1CCC2(C#C)O)CCC4=CC(=O)CCC34
External Link
	Pubchem ID	6230
	CAS Number	68-22-4
	CHEBI ID	7627
	TTD ID	D0GL7U

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM001 Affected gastrointestinal absorption AM004 Affected intra/extra-hepatic metabolism AM005 Affected excretion pathways AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM003 Complex formation BM009 Altered absorption (Unspecific) BM016 Altered formation of CYP450 enzymes BM017 CYP450 enzyme inhibition BM019 UGT inhibition BM020 Decreased metabolism due to hepatotoxicity BM022 CYP450 enzyme induction BM023 UGT induction BM024 Competitive inhibition of metabolic enzyme BM025 Decreased metabolism (Unspecific) BM032 Decreased renal excretion (Unspecific) BM047 Additive thrombogenic effects BM079 Increased risk of skin rash BM086 Antagonize the effect of antidiabetic agents BM089 Antagonize the effect of antihypertensive agents BM107 Attenuated pharmacological effects (Unspecific)
Relation Graph

Full list of drugs interacting with Norethisterone
Affected gastrointestinal absorption
	Complex formation					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0382		Colestipol	C11H28ClN5O	62816	Moderate		Inter Info	[55], [56], [57]
D0329		Cholestyramine	C27H47ClN2	137699107	Moderate		Inter Info	[55], [56], [57]
D0381		Colesevelam	C31H67Cl3N4O	160051	Moderate		Inter Info	[22], [13], [83]
	Altered absorption (Unspecific)					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0929		Linaclotide	C59H79N15O21S6	16158208	Moderate		Inter Info	[19], [108], [109]
D1068		Miltefosine	C21H46NO4P	3599	Moderate		Inter Info	[22], [13], [114]
D1362		Prucalopride	C18H26ClN3O3	3052762	Moderate		Inter Info	[47], [19], [122]
Affected intra/extra-hepatic metabolism
	Altered formation of CYP450 enzymes					Drug Num: 18
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0023		Adalimumab	NA	NA	Moderate		Inter Info	[40], [41], [42]
D0032		Alefacept	NA	NA	Moderate		Inter Info	[40], [41], [42]
D0085		Anakinra	C20H23N5O7S2	146171046	Moderate		Inter Info	[40], [41], [42]
D0614		Etanercept	NA	NA	Moderate		Inter Info	[40], [41], [42]
D0802		Infliximab	NA	NA	Moderate		Inter Info	[40], [41], [42]
D0246		Canakinumab	NA	NA	Moderate		Inter Info	[40], [41], [42]
D0304		Certolizumab pegol	NA	NA	Moderate		Inter Info	[40], [41], [42]
D0564		Emapalumab	NA	NA	Moderate		Inter Info	[40], [41], [42]
D0736		Golimumab	NA	NA	Moderate		Inter Info	[40], [41], [42]
D0747		Guselkumab	NA	NA	Moderate		Inter Info	[40], [41], [42]
D0875		Ixekizumab	NA	NA	Moderate		Inter Info	[40], [41], [42]
D1403		Rilonacept	NA	NA	Moderate		Inter Info	[40], [41], [42]
D1447		Sarilumab	NA	NA	Moderate		Inter Info	[40], [41], [42]
D1448		Satralizumab	NA	NA	Moderate		Inter Info	[40], [41], [42]
D1454		Secukinumab	NA	NA	Moderate		Inter Info	[40], [41], [42]
D1467		Siltuximab	NA	NA	Moderate		Inter Info	[40], [41], [42]
D1599		Tocilizumab	NA	NA	Moderate		Inter Info	[40], [41], [42]
D1671		Ustekinumab	NA	NA	Moderate		Inter Info	[40], [41], [42]
	CYP450 enzyme inhibition					Drug Num: 46
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0692		Fosamprenavir	C25H36N3O9PS	131536	Major		Inter Info	[22], [13], [23]
D0367		Clotrimazole	C22H17ClN2	2812	Moderate		Inter Info	[52], [53], [54]
D0497		Diltiazem	C22H26N2O4S	39186	Moderate		Inter Info	[58], [59], [60]
D0597		Erythromycin	C37H67NO13	12560	Moderate		Inter Info	[47], [19], [4]
D0667		Fluconazole	C13H12F2N6O	3365	Moderate		Inter Info	[52], [53], [54]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Moderate		Inter Info	[63], [64], [65]
D0740		Grepafloxacin	C19H22FN3O3	72474	Moderate		Inter Info	[66]
D0793		Imatinib	C29H31N7O	5291	Moderate		Inter Info	[47], [19], [67]
D0002		Abametapir (topical)	C12H12N2	15664	Moderate		Inter Info	[74]
D0116		Atazanavir	C38H52N6O7	148192	Moderate		Inter Info	[22], [13], [81]
D0171		Berotralstat	C30H26F4N6O	137528262	Moderate		Inter Info	[82]
D0349		Clarithromycin	C38H69NO13	84029	Moderate		Inter Info	[47], [19], [4]
D0386		Conivaptan	C32H26N4O2	151171	Moderate		Inter Info	[13], [84]
D0413		Dalfopristin	C34H50N4O9S	6323289	Moderate		Inter Info	[85]
D0426		Darunavir	C27H37N3O7S	213039	Moderate		Inter Info	[86], [32]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Moderate		Inter Info	[47], [87]
D0534		Dronedarone	C31H44N2O5S	208898	Moderate		Inter Info	[89], [90]
D0543		Duvelisib	C22H17ClN6O	50905713	Moderate		Inter Info	[91]
D0638		Fedratinib	C27H36N6O3S	16722836	Moderate		Inter Info	[22], [13], [95]
D0699		Fostamatinib	C23H26FN6O9P	11671467	Moderate		Inter Info	[98]
D0852		Isavuconazonium	C35H35F2N8O5S+	6918606	Moderate		Inter Info	[19], [89], [100]
D0867		Itraconazole	C35H38Cl2N8O4	55283	Moderate		Inter Info	[52], [53], [54]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Moderate		Inter Info	[52], [53], [54]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Moderate		Inter Info	[102], [103], [65]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Moderate		Inter Info	[47], [19], [104]
D0899		Lefamulin	C28H45NO5S	25185057	Moderate		Inter Info	[102], [105], [65]
D0906		Letermovir	C29H28F4N4O4	45138674	Moderate		Inter Info	[47], [19], [107]
D0944		Lomitapide	C39H37F6N3O2	9853053	Moderate		Inter Info	[13], [110]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Moderate		Inter Info	[111]
D1050		Metreleptin	NA	NA	Moderate		Inter Info	[22], [13], [112]
D1057		Miconazole	C18H14Cl4N2O	4189	Moderate		Inter Info	[52], [53], [54]
D1117		Nefazodone	C25H32ClN5O2	4449	Moderate		Inter Info	[102], [115], [65]
D1136		Nilotinib	C28H22F3N7O	644241	Moderate		Inter Info	[117], [65]
D1315		Posaconazole	C37H42F2N8O4	468595	Moderate		Inter Info	[52], [53], [54]
D1432		Rucaparib	C19H18FN3O	9931954	Moderate		Inter Info	[123]
D1444		Saquinavir	C38H50N6O5	441243	Moderate		Inter Info	[47], [124], [125]
D1455		Selegiline	C13H17N	26757	Moderate		Inter Info	[126], [127], [128]
D1459		Selpercatinib	C29H31N7O3	134436906	Moderate		Inter Info	[129], [65]
D1505		Stiripentol	C14H18O3	5311454	Moderate		Inter Info	[108], [89], [133]
D1544		Telithromycin	C43H65N5O10	3002190	Moderate		Inter Info	[135], [65], [136]
D1660		Tucatinib	C26H24N8O2	51039094	Moderate		Inter Info	[138]
D1709		Voxelotor	C19H19N3O3	71602803	Moderate		Inter Info	[22], [13], [140]
D1706		Voriconazole	C16H14F3N5O	71616	Moderate		Inter Info	[52], [53], [54]
D0439		Delavirdine	C22H28N6O3S	5625	Minor		Inter Info	[148], [149], [150]
D0799		Indinavir	C36H47N5O4	5362440	Minor		Inter Info	[151], [152]
D0120		Atorvastatin	C33H35FN2O5	60823	Minor		Inter Info	[153], [154]
	Decreased metabolism due to hepatotoxicity					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0114		Asparaginase Escherichia coli	NA	NA	Moderate		Inter Info	[47], [19], [48]
D0113		Asparaginase Erwinia chrysanthemi	NA	NA	Moderate		Inter Info	[47], [19], [48]
D1234		Pegaspargase	C14H19NO	436058	Moderate		Inter Info	[47], [19], [48]
	CYP450 enzyme induction					Drug Num: 67
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0080		Amprenavir	C25H35N3O6S	65016	Major		Inter Info	[1], [2], [3]
D0178		Bexarotene	C24H28O2	82146	Major		Inter Info	[4], [5], [6]
D0194		Bosentan	C27H29N5O6S	104865	Major		Inter Info	[4], [7], [6]
D0255		Carbamazepine	C15H12N2O	2554	Major		Inter Info	[8], [9], [10]
D0741		Griseofulvin	C17H17ClO6	441140	Major		Inter Info	[11], [1], [12]
D0192		Boceprevir	C27H45N5O5	10324367	Major		Inter Info	[4], [16], [17]
D0204		Brigatinib	C29H39ClN7O2P	68165256	Major		Inter Info	[13], [18]
D0406		Dabrafenib	C23H20F3N5O2S2	44462760	Major		Inter Info	[4], [20], [6]
D0569		Encorafenib	C22H27ClFN7O4S	50922675	Major		Inter Info	[13], [21]
D0601		Eslicarbazepine	C15H14N2O2	9881504	Major		Inter Info	[8], [9], [10]
D0639		Felbamate	C11H14N2O4	3331	Major		Inter Info	[8], [9], [10]
D0697		Fosphenytoin	C16H15N2O6P	56339	Major		Inter Info	[8], [9], [10]
D0958		Lumacaftor	C24H18F2N2O5	16678941	Major		Inter Info	[19], [4], [24]
D1198		Oxcarbazepine	C15H12N2O2	34312	Major		Inter Info	[8], [9], [10]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Major		Inter Info	[25], [6], [12]
D1265		Phenobarbital	C12H12N2O3	4763	Major		Inter Info	[8], [9], [10]
D1340		Primidone	C12H14N2O2	4909	Major		Inter Info	[8], [9], [10]
D1400		Rifampicin	C43H58N4O12	135398735	Major		Inter Info	[26], [27], [28]
D1401		Rifapentine	C47H64N4O12	135403821	Major		Inter Info	[26], [27], [28]
D1502		St. John's Wort	NA	NA	Major		Inter Info	[29], [30], [31]
D1541		Telaprevir	C36H53N7O6	3010818	Major		Inter Info	[4], [16], [17]
D1399		Rifabutin	C46H62N4O11	135398743	Major		Inter Info	[26], [27], [28]
D0061		Aminoglutethimide	C13H16N2O2	2145	Moderate		Inter Info	[43], [44], [12]
D0100		Aprepitant	C23H21F7N4O3	135413536	Moderate		Inter Info	[4], [45], [46]
D0224		Butabarbital	C10H16N2O3	2479	Moderate		Inter Info	[43], [49], [50]
D0225		Butalbital	C11H16N2O3	2481	Moderate		Inter Info	[43], [49], [50]
D0356		Clobazam	C16H13ClN2O2	2789	Moderate		Inter Info	[4], [13], [51]
D0554		Efavirenz	C14H9ClF3NO2	64139	Moderate		Inter Info	[4], [61], [62]
D1078		Mitotane	C14H10Cl4	4211	Moderate		Inter Info	[43], [44], [12]
D1099		Nafcillin	C21H22N2O5S	8982	Moderate		Inter Info	[43], [44], [12]
D1119		Nelfinavir	C32H45N3O4S	64143	Moderate		Inter Info	[19], [4], [71]
D1128		Nevirapine	C15H14N4O	4463	Moderate		Inter Info	[72], [4], [73]
D0071		Amobarbital	C11H18N2O3	2164	Moderate		Inter Info	[43], [49], [50]
D0095		Apalutamide	C21H15F4N5O2S	24872560	Moderate		Inter Info	[43], [44], [12]
D0106		Armodafinil	C15H15NO2S	9690109	Moderate		Inter Info	[4], [78], [79]
D0108		Artemether	C16H26O5	68911	Moderate		Inter Info	[4], [13], [80]
D0300		Cenobamate	C10H10ClN5O2	11962412	Moderate		Inter Info	[43], [44], [12]
D0432		Deferasirox	C21H15N3O4	214348	Moderate		Inter Info	[13], [88]
D0545		Echinacea	NA	NA	Moderate		Inter Info	[47], [92]
D0555		Elagolix	C32H30F5N3O5	11250647	Moderate		Inter Info	[43], [44], [12]
D0568		Enasidenib	C19H17F6N7O	89683805	Moderate		Inter Info	[22], [13], [94]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Moderate		Inter Info	[43], [44], [12]
D0693		Fosaprepitant	C23H22F7N4O6P	135413538	Moderate		Inter Info	[4], [45], [46]
D0732		Glycerol phenylbutyrate	C33H38O6	10482134	Moderate		Inter Info	[19], [99]
D0872		Ivosidenib	C28H22ClF3N6O3	71657455	Moderate		Inter Info	[13], [101]
D0901		Lemborexant	C22H20F2N4O2	56944144	Moderate		Inter Info	[43], [44], [12]
D0905		Lesinurad	C17H14BrN3O2S	53465279	Moderate		Inter Info	[22], [13], [106]
D0953		Lorlatinib	C21H19FN6O2	71731823	Moderate		Inter Info	[43], [44], [12]
D1040		Methylphenobarbital	C13H14N2O3	8271	Moderate		Inter Info	[43], [49], [50]
D1081		Modafinil	C15H15NO2S	4236	Moderate		Inter Info	[4], [78], [79]
D1167		Olaparib	C24H23FN4O3	23725625	Moderate		Inter Info	[19], [4], [118]
D1253		Perampanel	C23H15N3O	9924495	Moderate		Inter Info	[19], [4], [102]
D1274		Phenylbutazone	C19H20N2O2	4781	Moderate		Inter Info	[4], [119], [120]
D1302		Pitolisant	C17H26ClNO	9948102	Moderate		Inter Info	[19], [4], [121]
D1433		Rufinamide	C10H8F2N4O	129228	Moderate		Inter Info	[19], [4], [102]
D1493		Somapacitan	C54H95N13O20S2	129894493	Moderate		Inter Info	[47], [19], [132]
D1495		Somatrem	C43H72N14O14	5487805	Moderate		Inter Info	[47], [19], [132]
D1518		Sulfinpyrazone	C23H20N2O3S	5342	Moderate		Inter Info	[43], [44], [12]
D1538		Tazemetostat	C34H44N4O4	66558664	Moderate		Inter Info	[13], [134]
D1546		Telotristat ethyl	C27H26ClF3N6O3	25181577	Moderate		Inter Info	[19], [137]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Moderate		Inter Info	[43], [44], [12]
D1248		Pentobarbital	C11H18N2O3	4737	Moderate		Inter Info	[43], [49], [50]
D1453		Secobarbital	C12H18N2O3	5193	Moderate		Inter Info	[43], [49], [50]
D1494		Somatotropin	NA	NA	Moderate		Inter Info	[47], [19], [132]
D1652		Troglitazone	C24H27NO5S	5591	Moderate		Inter Info	[141], [142], [143]
D0208		Brivaracetam	C11H20N2O2	9837243	Minor		Inter Info	[155], [156], [157]
D1294		Pioglitazone	C19H20N2O3S	4829	Minor		Inter Info	[141], [160], [161]
	UGT induction					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1677		Valproic acid	C8H16O2	3121	Moderate		Inter Info	[144], [145], [146], [147]
	Competitive inhibition of metabolic enzyme					Drug Num: 5
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0696		Fosnetupitant	C31H35F6N4O5P	71544786	Moderate		Inter Info	[47], [96], [97]
D1127		Netupitant	C30H32F6N4O	6451149	Moderate		Inter Info	[47], [96], [97]
D1476		Sirolimus	C51H79NO13	5284616	Moderate		Inter Info	[130], [131], [65]
D1526		Tacrolimus	C44H69NO12	445643	Moderate		Inter Info	[130], [131], [65]
D1549		Temsirolimus	C56H87NO16	6918289	Moderate		Inter Info	[130], [131], [65]
	Decreased metabolism (Unspecific)					Drug Num: 4
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0064		Aminophylline	C16H24N10O4	9433	Moderate		Inter Info	[75], [76], [77]
D1201		Oxtriphylline	C12H21N5O3	656652	Moderate		Inter Info	[75], [76], [77]
D1570		Theophylline	C7H8N4O2	2153	Moderate		Inter Info	[75], [76], [77]
D0617		Ethanol	C2H6O	702	Minor		Inter Info	[22], [13], [158]
Affected excretion pathways
	Decreased renal excretion (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1110		Naratriptan	C17H25N3O2S	4440	Minor		Inter Info	[22], [13], [159]
Pharmacodynamic additive effects
	Additive thrombogenic effects					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0261		Carfilzomib	C40H57N5O7	11556711	Major		Inter Info	[4], [19]
D1619		Tranexamic acid	C8H15NO2	5526	Major		Inter Info	[34], [35], [36]
	Increased risk of skin rash					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0558		Elexacaftor	C26H34F3N7O4S	134587348	Moderate		Inter Info	[19], [13], [93]
Pharmacodynamic antagonistic effects
	Antagonize the effect of antidiabetic agents					Drug Num: 38
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0009		Acarbose	C25H43NO18	41774	Moderate		Inter Info	[37], [38], [39]
D0013		Acetohexamide	C15H20N2O4S	1989	Moderate		Inter Info	[37], [38], [39]
D0325		Chlorpropamide	C10H13ClN2O3S	2727	Moderate		Inter Info	[37], [38], [39]
D0727		Glimepiride	C24H34N4O5S	3476	Moderate		Inter Info	[37], [38], [39]
D0811		Insulin glargine	C267H404N72O78S6	118984454	Moderate		Inter Info	[37], [38], [39]
D0813		Insulin human	C257H383N65O77S6	118984375	Moderate		Inter Info	[37], [38], [39]
D0814		Insulin human (inhalation, rapid acting)	C257H383N65O77S6	118984375	Moderate		Inter Info	[37], [38], [39]
D0815		Insulin human (isophane)	C257H383N65O77S6	118984375	Moderate		Inter Info	[37], [38], [39]
D0816		Insulin human (regular)	C257H383N65O77S6	118984375	Moderate		Inter Info	[37], [38], [39]
D0817		Insulin human (zinc extended)	C257H383N65O77S6	118984375	Moderate		Inter Info	[37], [38], [39]
D0818		Insulin human (zinc)	C257H383N65O77S6	118984375	Moderate		Inter Info	[37], [38], [39]
D0819		Insulin lispro	C257H389N65O77S6	16132438	Moderate		Inter Info	[37], [38], [39]
D0820		Insulin lispro (protamine)	C257H389N65O77S6	16132438	Moderate		Inter Info	[37], [38], [39]
D1015		Metformin	C4H11N5	4091	Moderate		Inter Info	[37], [38], [39]
D1064		Miglitol	C8H17NO5	441314	Moderate		Inter Info	[37], [38], [39]
D0029		Albiglutide	C148H224N40O45	145994868	Moderate		Inter Info	[37], [38], [39]
D0042		Alogliptin	C18H21N5O2	11450633	Moderate		Inter Info	[37], [38], [39]
D0245		Canagliflozin	C24H25FO5S	24812758	Moderate		Inter Info	[37], [38], [39]
D0418		Dapagliflozin	C21H25ClO6	9887712	Moderate		Inter Info	[37], [38], [39]
D0565		Empagliflozin	C23H27ClO7	11949646	Moderate		Inter Info	[37], [38], [39]
D0728		Glipizide	C21H27N5O4S	3478	Moderate		Inter Info	[37], [38], [39]
D0730		Glyburide	C23H28ClN3O5S	3488	Moderate		Inter Info	[37], [38], [39]
D0807		Insulin aspart (aspart protamine)	C256H381N65O79S6	118984445	Moderate		Inter Info	[37], [38], [39]
D0808		Insulin aspart (aspart)	C256H381N65O79S6	118984445	Moderate		Inter Info	[37], [38], [39]
D0809		Insulin degludec	C274H411N65O81S6	118984462	Moderate		Inter Info	[37], [38], [39]
D0810		Insulin detemir	C267H402N64O76S6	16137271	Moderate		Inter Info	[37], [38], [39]
D0812		Insulin glulisine	C258H384N64O78S6	16136701	Moderate		Inter Info	[37], [38], [39]
D0930		Linagliptin	C25H28N8O2	10096344	Moderate		Inter Info	[37], [38], [39]
D0936		Liraglutide	C172H265N43O51	16134956	Moderate		Inter Info	[37], [38], [39]
D0941		Lixisenatide	C215H347N61O65S	90472060	Moderate		Inter Info	[37], [38], [39]
D1112		Nateglinide	C19H27NO3	5311309	Moderate		Inter Info	[37], [38], [39]
D1326		Pramlintide	C171H267N51O53S2	70691388	Moderate		Inter Info	[37], [38], [39]
D1392		Repaglinide	C27H36N2O4	65981	Moderate		Inter Info	[37], [38], [39]
D1449		Saxagliptin	C18H25N3O2	11243969	Moderate		Inter Info	[37], [38], [39]
D1477		Sitagliptin	C16H15F6N5O	4369359	Moderate		Inter Info	[37], [38], [39]
D1601		Tolazamide	C14H21N3O3S	5503	Moderate		Inter Info	[37], [38], [39]
D1603		Tolbutamide	C12H18N2O3S	5505	Moderate		Inter Info	[37], [38], [39]
D1429		Rosiglitazone	C18H19N3O3S	77999	Moderate		Inter Info	[37], [38], [39]
	Antagonize the effect of antihypertensive agents					Drug Num: 4
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1779		Dulaglutide	NA	NA	Moderate		Inter Info	[37], [38], [39]
D1782		Ertugliflozin	C22H25ClO7	44814423	Moderate		Inter Info	[37], [38], [39]
D1784		Exenatide	C184H282N50O60S	45588096	Moderate		Inter Info	[37], [38], [39]
D1887		Semaglutide	C187H291N45O59	56843331	Moderate		Inter Info	[37], [38], [39]
	Attenuated pharmacological effects (Unspecific)					Drug Num: 7
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1094		Mycophenolate mofetil	C23H31NO7	5281078	Major		Inter Info	[13], [14], [15]
D1095		Mycophenolic acid	C17H20O6	446541	Major		Inter Info	[13], [14], [15]
D1894		Sugammadex	C72H112O48S8	6918585	Major		Inter Info	[19], [32], [33]
D0890		Lamotrigine	C9H7Cl2N5	3878	Moderate		Inter Info	[68], [69], [70]
D1063		Mifepristone	C29H35NO2	55245	Moderate		Inter Info	[22], [13], [113]
D1124		Neratinib	C30H29ClN6O3	9915743	Moderate		Inter Info	[116], [47]
D1664		Ulipristal	C28H35NO3	13559281	Moderate		Inter Info	[19], [139], [32]

References
1	FFPRHC Guidance (April 2005). Drug interactions with hormonal contraception. J Fam Plann Reprod Health Care 31 (2005): 139-51. [PMID: 15921558]
2	Product Information. Agenerase (amprenavir). Glaxo Wellcome, Research Triangle Pk, NC.
3	Durant J, Clevenbergh P, Garraffo R, Halfon P, Icard S, DelGiudice P, Montagne N, Schapiro JM, Dellamonica P "Importance of protease inhibitor plasma levels in HIV-infected patients treated with genotypic-guided therapy: pharmacological data from the Viradapt Study." Aids 14 (2000): 1333-9.[PMID: 10930147]
4	Faculty of Sexual & Reproductive Healthcare "FSRH Clinical Guidance: Drug Interactions with Hormonal Contraception.".
5	Product Information. Targretin (bexarotene) Ligand Pharmaceuticals, San Diego, CA.
6	Strayhorn VA, Baciewicz AM, Self TH "Update on rifampin drug interactions, III." Arch Intern Med 157 (1997): 2453-8. [PMID: 9385296]
7	Product Information. Tracleer (bosentan). Acetelion Pharmaceuticals US, Inc, South San Francisco, CA.
8	Back DJ, Grimmer SF, Orme ML, Proudlove D, Mann RD, Breckenridge AM "Evaluation of Committee on Safety of Medicines yellow card reports on oral contraceptive-drug interactions with anticonvulsants and antibiotics." Br J Clin Pharmacol 25 (1988): 527-32. [PMID: 3408633]
9	Fattore C, Cipolla G, Gatti G, Limido GL, Sturm Y, Bernasconi C, Perucca E "Induction of ethinylestradiol and levonorgestrel metabolism by oxcarbazepine in healthy women." Epilepsia 40 (1999): 783-7. [PMID: 10368079]
10	Odlind V, Olsson SE "Enhanced metabolism of levonorgestrel during phenytoin treatment in a woman with norplant implants." Contraception 33 (1986): 257-61. [PMID: 3087695]
11	Cote J "Interaction of griseofulvin and oral contraceptives." J Am Acad Dermatol 22 (1990): 124-5. [PMID: 2298948]
12	van Dijke CP, Weber JC "Interaction between oral contraceptives and griseofulvin." Br Med J (Clin Res Ed) 288 (1984): 1125-6. [PMID: 2143563]
13	Gunston GD, Mehta U "Potentially serious drug interactions with grapefruit juice." S Afr Med J 90 (2000): 41. [PMID: 10721388]
14	Product Information. CellCept (mycophenolate mofetil). Roche Laboratories, Nutley, NJ.
15	Product Information. Myfortic (mycophenolic acid). Novartis Pharmaceuticals, East Hanover, NJ.
16	Product Information. Incivek (telaprevir). Vertex Pharmaceuticals, Cambridge, MA.
17	Product Information. Victrelis (boceprevir). Schering-Plough Corporation, Kenilworth, NJ.
18	Product Information. Alunbrig (brigatinib). Ariad Pharmaceuticals Inc, Cambridge, MA.
19	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
20	Product Information. Tafinlar (dabrafenib). GlaxoSmithKline, Research Triangle Park, NC.
21	Product Information. Braftovi (encorafenib). Array BioPharma Inc., Boulder, CO.
22	Bailey DG, Arnold JMO, Spence JD "Grapefruit juice and drugs - how significant is the interaction." Clin Pharmacokinet 26 (1994): 91-8. [PMID: 8162660]
23	Product Information. Lexiva (fosamprenavir). GlaxoSmithKline, Research Triangle Park, NC.
24	Product Information. Orkambi (ivacaftor-lumacaftor). Vertex Pharmaceuticals, Cambridge, MA.
25	Product Information. Turalio (pexidartinib). Daiichi Sankyo, Inc., Parsippany, NJ.
26	Back DJ, Breckenridge AM, Crawford F, et al. "The effect of rifampicin on norethisterone pharmacokinetics." Eur J Clin Pharmacol 15 (1979): 193-7. [PMID: 37091]
27	Product Information. Priftin (rifapentine). Hoechst Marion-Roussel Inc, Kansas City, MO.
28	Venkatesan K "Pharmacokinetic drug interactions with rifampicin." Clin Pharmacokinet 22 (1992): 47-65. [PMID: 1559307]
29	Ernst E "Second thoughts about safety of St John's wort." Lancet 354 (1999): 2014-6. [PMID: 10636361]
30	Fugh-Berman A "Herb-drug interactions." Lancet 355 (2000): 134-8. [PMID: 10675182]
31	Roby CA, Anderson GD, Kantor E, Dryer DA, Burstein AH "St John's Wort: Effect on CYP3A4 activity." Clin Pharmacol Ther 67 (2000): 451-7. [PMID: 10824623]
32	Schubert W, Eriksson U, Edgar B, Cullberg G, Hedner T "Flavonoids in grapefruit juice inhibit the in vitro hepatic metabolism of 17B-estradiol." Eur J Drug Metab Pharmacokinet 20 (1995): 219-24. [PMID: 8751044]
33	Product Information. Bridion (sugammadex). Merck &amp Company Inc, Whitehouse Station, NJ.
34	Product Information. LYSTEDA (tranexamic acid). Xanodyne Pharmaceuticals Inc, Newport, KY.
35	van Hylckama Vlieg A, Helmerhorst FM, Vandenbroucke JP, Doggen CJ, Rosendaal FR "The venous thrombotic risk of oral contraceptives, effects of oestrogen dose and progestogen type: results of the MEGA case-control study." BMJ 339 (2009): b2921.[PMID: 19679614]
36	Lidegaard O, Lokkegaard E, Svendsen AL, Agger C "Hormonal contraception and risk of venous thromboembolism: national follow-up study." BMJ 339 (2009): b2890.[PMID: 19679613]
37	Jori A, Carrara MC "On the mechanism of the hyperglycaemic effect of chlorpromazine." J Pharm Pharmacol 18 (1966): 623-4. [PMID: 4381950]
38	Product Information. Dymelor (acetohexamide) Lilly, Eli and Company, Indianapolis, IN.
39	Product Information. Thorazine (chlorpromazine). SmithKline Beecham, Philadelphia, PA.
40	Product Information. Cosentyx (secukinumab). Novartis Pharmaceuticals, East Hanover, NJ.
41	Product Information. Ilaris (canakinumab). Novartis Pharmaceuticals, East Hanover, NJ.
42	Product Information. Skyrizi (risankizumab). AbbVie US LLC, North Chicago, IL.
43	Back DJ, Breckenridge AM, Crawford FE, MacIver M, Orne ML, Rowe PH "Interindividual variation and drug interactions with hormonal steroid contraceptives." Drugs 21 (1981): 46-61. [PMID: 7009137]
44	Dickinson BD, Altman RD, Nielsen NH, Sterling ML "Drug interactions between oral contraceptives and antibiotics." Obstet Gynecol 98(5 Pt 1) (2001): 853-60. [PMID: 11704183]
45	Product Information. Emend (aprepitant). Merck &amp Company Inc, West Point, PA.
46	Product Information. Emend for Injection (fosaprepitant). Merck &amp Company Inc, West Point, PA.
47	Cerner Multum, Inc. "Australian Product Information.".
48	Product Information. Asparlas (calaspargase pegol). Servier, Boston, MA.
49	O'Brien MD, Guillebaud J "Contraception for women with epilepsy." Epilepsia 47 (2006): 1419-22. [PMID: 16981856]
50	Product Information. Norplant System (levonorgestrel) Wyeth-Ayerst Laboratories, Philadelphia, PA.
51	Product Information. Onfi (clobazam). Lundbeck Inc, Deerfield, IL.
52	Lazar JD, Wilner KD "Drug interactions with fluconazole." Rev Infect Dis 12 Suppl 3 (1990): s327-33. [PMID: 2330488]
53	Pillans PI, Sparrow MJ "Pregnancy associated with a combined oral contraceptive and itraconazole." N Z Med J 106 (1993): 436. [PMID: 8414287]
54	Weisberg E "Interactions between oral contraceptives and antifungals antibacterials - Is contraceptive failure the result?." Clin Pharmacokinet 36 (1999): 309-13. [PMID: 10384856]
55	Cerner Multum, Inc. "Canadian Product Information.".
56	Product Information. Questran (cholestyramine). Par Pharmaceutical Inc, Chestnut Ridge, NY.
57	Underhill KL, Rotter BA, Thompson BK, Prelusky DB, Trenholm HL "Effectiveness of cholestyramine in the detoxification of zearalenone as determined in mice." Bull Environ Contam Toxicol 54 (1995): 128-34. [PMID: 7756775]
58	Renton KW "Inhibition of hepatic microsomal drug metabolism by the calcium channel blockers diltiazem and verapamil." Biochem Pharmacol 34 (1985): 2549-53. [PMID: 4015695]
59	Sakai H, Kobayashi S, Hamada K, et al "The effects of diltiazem on hepatic drug metabolizing enzymes in man using antipyrine, trimethadione and debrisoquine as model substrates." Br J Clin Pharmacol 31 (1991): 353-5. [PMID: 2054276]
60	Sutton D, Butler AM, Nadin L, Murray M "Role of CYP3A4 in human hepatic diltiazem N-demethylation: inhibition of CYP3A4 activity by oxidized diltiazem metabolites." J Pharmacol Exp Ther 282 (1997): 294-300. [PMID: 9223567]
61	Lakhi N, Govind A "Implanon failure in patients on antiretroviral medication: the importance of disclosure." J Fam Plann Reprod Health Care 36 (2010): 181-2. [PMID: 20659385]
62	Product Information. Sustiva (efavirenz). DuPont Pharmaceuticals, Wilmington, DE.
63	Damkier P, Hansen LL, Brosen K "Effect of fluvoxamine on the pharmacokinetics of quinidine." Eur J Clin Pharmacol 55 (1999): 451-6. [PMID: 10492058]
64	Product Information. Luvox (fluvoxamine). Solvay Pharmaceuticals Inc, Marietta, GA.
65	Warrington SJ, Ankier SI, Turner P "Evaluation of possible interactions between ethanol and trazodone or amitriptyline." Neuropsychobiology 15 (1986): 31-7. [PMID: 3725002]
66	Product Information. Raxar (grepafloxacin). Glaxo Wellcome, Research Triangle Park, NC.
67	Product Information. Gleevec (imatinib mesylate). Novartis Pharmaceuticals, East Hanover, NJ.
68	Wilbur K, Ensom MHH "Pharmacokinetic drug interactions between oral contraceptives and second-generation anticonvulsants." Clin Pharmacokinet 38 (2000): 355-65. [PMID: 10803456]
69	Ohman I, Vitols S, Tomson T "Lamotrigine in pregnancy: pharmacokinetics during delivery, in the neonate, and during lactation." Epilepsia 41 (2000): 706-13
70	Sidhu J, Job S, Singh S, Philipson R. The pharmacokinetic and pharmacodynamic consequences of the co-administration of lamotrigine and a combined oral contraceptive in healthy female subjects. Br J Clin Pharmacol. 2006 Feb;61(2):191-9.
71	Product Information. Viracept (nelfinavir). Agouron Pharma Inc, La Jolla, CA.
72	Back D, Gibbons S, Khoo S "Pharmacokinetic drug interactions with nevirapine." J Acquir Immune Defic Syndr 34 Suppl 1 (2003): S8-14. [PMID: 14562853]
73	Product Information. Viramune (nevirapine). Boehringer-Ingelheim, Ridgefield, CT.
74	Product Information. Xeglyze (abametapir topical). Dr. Reddy's Laboratories Inc, Upper Saddle River, NJ.
75	Gardner MJ, Tornatore KM, Jusko WJ, Kanarkowski R "Effects of tobacco smoking and oral contraceptive use on theophylline disposition." Br J Clin Pharmacol 16 (1983): 271-80. [PMID: 6626419]
76	Roberts RK, Grice J, McGuffie, Heilbronn L "Oral contraceptive steroids impair the elimination of theophylline." J Lab Clin Med 101 (1983): 821-25. [PMID: 6854122]
77	Tornatore KM, Kanarkowski R, McCarthy TL, et al "Effect of chronic oral contraceptive steroids on theophylline disposition." Eur J Clin Pharmacol 23 (1982): 129-34. [PMID: 7140802]
78	Product Information. Nuvigil (armodafinil). Cephalon Inc, West Chester, PA.
79	Product Information. Provigil (modafinil). Cephalon, Inc, West Chester, PA.
80	Product Information. Coartem (artemether-lumefantrine). Novartis Pharmaceuticals, East Hanover, NJ.
81	Product Information. Reyataz (atazanavir). Bristol-Myers Squibb, Princeton, NJ.
82	Product Information. Orladeyo (berotralstat). BioCryst Pharmaceuticals Inc, Durham, NC.
83	Product Information. Welchol (colesevelam) Daiichi Sankyo, Inc., Parsippany, NJ.
84	Product Information. Vaprisol (conivaptan). Cumberland Pharmaceuticals Inc, Nashville, TN.
85	Product Information. Synercid (dalfopristin-quinupristin) Rhone-Poulenc Rorer, Collegeville, PA.
86	Product Information. Prezista (darunavir). Ortho Biotech Inc, Bridgewater, NJ.
87	Product Information. Sprycel (dasatinib). Bristol-Myers Squibb, Princeton, NJ.
88	Product Information. Desferal (deferoxamine). Novartis Pharmaceuticals, East Hanover, NJ.
89	Product Information. Ambien (zolpidem). sanofi-aventis, Bridgewater, NJ.
90	Product Information. Multaq (dronedarone). sanofi-aventis , Bridgewater, NJ.
91	Product Information. Copiktra (duvelisib). Verastem, Inc., Needham, MA.
92	Gorski JC, Huang SM, Pinto A, et al. "The effect of echinacea (Echinacea purpurea root) on cytochrome P450 activity in vivo." Clin Pharmacol Ther 75 (2004): 89-100. [PMID: 14749695]
93	Product Information. Trikafta (elexacaftor/ivacaftor/tezacaftor). Vertex Pharmaceuticals, Cambridge, MA.
94	Product Information. Idhifa (enasidenib). Celgene Corporation, Summit, NJ.
95	Product Information. Inrebic (fedratinib). Celgene Corporation, Summit, NJ.
96	Product Information. Akynzeo (netupitant-palonosetron). Eisai Inc, Woodcliff Lake, NJ.
97	Product Information. Akynzeo for Injection (fosnetupitant-palonosetron). Helsinn Therapeutics Inc, Woodbridge Township, NJ.
98	Product Information. Tavalisse (fostamatinib). Rigel Pharmaceuticals, South San Francisco, CA.
99	Product Information. Ravicti (glycerol phenylbutyrate). Hyperion Therapeutics Inc, South San Francisco, CA.
100	Product Information. Cresemba (isavuconazonium). Astellas Pharma US, Inc, Deerfield, IL.
101	Product Information. Tibsovo (ivosidenib). Agios Pharmaceuticals, Cambridge, MA.
102	Product Information. Fycompa (perampanel). Eisai Inc, Teaneck, NJ.
103	Product Information. Tykerb (lapatinib). Novartis Pharmaceuticals, East Hanover, NJ.
104	Product Information. Vitrakvi (larotrectinib). Bayer Pharmaceutical Inc, West Haven, CT.
105	Product Information. Xenleta (lefamulin). Nabriva Therapeutics US, Inc., King of Prussia, PA.
106	Product Information. Zurampic (lesinurad). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
107	Product Information. Prevymis (letermovir). Merck &amp Company Inc, Whitehouse Station, NJ.
108	EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports.".
109	Product Information. Linzess (linaclotide). Forest Pharmaceuticals, St. Louis, MO.
110	Product Information. Juxtapid (lomitapide). Aegerion Pharmaceuticals Inc, Cambridge, MA.
111	Product Information. Zokinvy (lonafarnib). Eiger BioPharmaceuticals, Palo Alto, CA.
112	Product Information. Myalept (metreleptin). Bristol-Myers Squibb, Princeton, NJ.
113	Product Information. Korlym (mifepristone). Corcept Therapeutics Incorporated, Menlo Park, CA.
114	Product Information. Impavido (miltefosine). Paladin Therapeutics Inc, Wilmington, DE.
115	Product Information. Serzone (nefazodone). Bristol-Myers Squibb, Princeton, NJ.
116	Abbas R, Hug BA, Leister C, Burns J, Sonnichsen D "Pharmacokinetics of oral neratinib during co-administration of ketoconazole in healthy subjects." Br J Clin Pharmacol 71 (2011): 522-7. [PMID: 21395644]
117	Product Information. Tasigna (nilotinib). Novartis Pharmaceuticals, East Hanover, NJ.
118	Product Information. Lynparza (olaparib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
119	Kleier DJ, Tucker JE "Oral contraceptive failure secondary to dentally prescribed drugs: fact or fiction?" J Colo Dent Assoc 66 (1987): 5-6. [PMID: 3478352]
120	Product Information. NuvaRing (ethinyl estradiol-etonogestrel). Organon, West Orange, NJ.
121	Product Information. Wakix (pitolisant). Harmony Biosciences, LLC, Plymouth Meeting, PA.
122	Product Information. Resotran (prucalopride). Janssen Pharmaceuticals, Titusville, NJ.
123	EMA. European Medicines Agency. European Union "EMA - List of medicines under additional monitoring.".
124	Product Information. Fortovase (saquinavir) Roche Laboratories, Nutley, NJ.
125	Product Information. Invirase (saquinavir). Roche Laboratories, Nutley, NJ.
126	Ito D, Amano T, Sato H, Fukuuchi Y "Paroxysmal hypertensive crises induced by selegiline in a patient with Parkinson's disease." J Neurol 248 (2001): 533-4. [PMID: 11499649]
127	Laine K, Anttila M, Helminen A, Karnani H, Huupponen R "Dose linearity study of selegiline pharmacokinetics after oral administration: evidence for strong drug interaction with female sex steroids." Br J Clin Pharmacol 47 (1999): 249-54. [PMID: 10215747]
128	McGrath PJ, Stewart JW, Quitkin FM "A possible L-deprenyl induced hypertensive reaction." J Clin Psychopharmacol 9 (1989): 310-1. [PMID: 2504782]
129	Product Information. Retevmo (selpercatinib). Lilly, Eli and Company, Indianapolis, IN.
130	Product Information. Prograf (tacrolimus). Fujisawa, Deerfield, IL.
131	Product Information. Rapamune (sirolimus) Wyeth-Ayerst Laboratories, Philadelphia, PA.
132	Product Information. Zorbtive (somatropin). Serono Laboratories Inc, Rockland, MA.
133	Yamreudeewong W, Henann NE, Fazio A, Lower DL, Cassidy TG "Drug-food interactions in clinical practice." J Fam Pract 40 (1995): 376-84. [PMID: 7699352]
134	Product Information. Tazverik (tazemetostat). Epizyme, Inc, Cambridge, MA.
135	Product Information. Ketek (telithromycin). Aventis Pharmaceuticals, Bridgewater, NJ.
136	European Agency for the Evaluation of Medicinal Products. Committee for Proprietary Medicinal Products "European Public Assessment Report Ketek (telithromycin) (Rev. 2) ".
137	Product Information. Xermelo (telotristat ethyl). Lexicon Pharmaceuticals, Inc., The Woodlands, TX.
138	Product Information. Tukysa (tucatinib). Seattle Genetics Inc, Bothell, WA.
139	Product Information. ella (ulipristal). Afaxys Inc., Charleston, SC.
140	Product Information. Oxbryta (voxelotor). Global Blood Therapeutics, Inc., South San Francisco, CA.
141	Loi CM, Stern R, Koup JR, Vassos AB, Knowlton P, Sedman AJ "Effect of troglitazone on the pharmacokinetics of an oral contraceptive agent." J Clin Pharmacol 39 (1999): 410-7. [PMID: 10197300]
142	Product Information. Rezulin (troglitazone). Parke-Davis, Morris Plains, NJ.
143	Sahi J, Black CB, Hamilton GA, et al. "Comparative Effects of Thiazolidinediones on in Vitro P450 Enzyme Induction and Inhibition." Drug Metab Dispos 31 (2003): 439-446. [PMID: 12642470]
144	Product Information. Depakote (divalproex sodium). Abbott Pharmaceutical, Abbott Park, IL.
145	Product Information. Depacon (valproic acid). Abbott Pharmaceutical, Abbott Park, IL.
146	Herzog AG, Farina EL, Blum AS "Serum valproate levels with oral contraceptive use." Epilepsia 46 (2005): 970-1.
147	Reimers A, Brodtkorb E, Sabers A. "Interactions between hormonal contraception and antiepileptic drugs: Clinical and mechanistic considerations." Seizure. 2015;28:66-70.
148	Cheng CL, Smith DE, Carver PL, Cox SR, Watkins PB, Blake DS, Kauffman CA, Meyer KM, Amidon GL, Stetson PL "Steady-state pharmacokinetics of delavirdine in HIV-positive patients: Effect on erythromycin breath test." Clin Pharmacol Ther 61 (1997): 531-43. [PMID: 9164415]
149	Fichtenbaum CJ, Gerber JG "Interactions between antiretroviral drugs and drugs used for the therapy of the metabolic complications encountered during HIV infection." Clin Pharmacokinet 41 (2002): 1195-211. [PMID: 12405866]
150	vonMoltke LL, Greenblatt DJ, Granda BW, Giancarlo GM, Duan SX, Daily JP, Harmatz JS, Shader RI "Inhibition of human cytochrome P450 isoforms by nonnucleoside reverse transcriptase inhibitors." J Clin Pharmacol 41 (2001): 85-91. [PMID: 11225565]
151	Product Information. Crixivan (indinavir). Merck &amp Co, Inc, West Point, PA.
152	Shelton MJ, Wynn HE, Newitt RG, DiFrancesco R "Effects of grapefruit juice on pharmacokinetic exposure to indinavir in HIV-positive subjects." J Clin Pharmacol 41 (2001): 435-42. [PMID: 11304900]
153	Product Information. Lipitor (atorvastatin). Parke-Davis, Morris Plains, NJ.
154	Richter WO, Jacob BG, Schwandt P "Interaction between fibre and lovastatin." Lancet 338 (1991): 706. [PMID: 1679514]
155	Product Information. Briviact (brivaracetam). UCB Pharma Inc, Smyrna, GA.
156	Stockis A, Rolan P "Effect of brivaracetam (400 mg/day) on the pharmacokinetics and pharmacodynamics of a combination oral contraceptive in healthy women." J Clin Pharmacol 53 (2013): 1313-21. [PMID: 24386664]
157	Stockis A, Watanabe S, Fauchoux N "Interaction between brivaracetam (100 mg/day) and a combination oral contraceptive: a randomized, double-blind, placebo-controlled study." Epilepsia 55 (2014): e27-31. [PMID: 24512385]
158	Hobbes J, Boutagy J, Shenfield GM "Interactions between ethanol and oral contraceptive steroids." Clin Pharmacol Ther 38 (1985): 371-80. [PMID: 4042520]
159	Product Information. Amerge (naratriptan). Glaxo Wellcome, Research Triangle Park, NC.
160	Nowak SN, Edwards DJ, Clarke A, Anderson GD, Jaber LA "Pioglitazone: effect on CYP3A4 activity." J Clin Pharmacol 42 (2002): 1299-302. [PMID: 12463723]
161	Product Information. Avandia (rosiglitazone) SmithKline Beecham, Philadelphia, PA.

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