Drug General Information (ID: DDI3LQREVU)
Drug Name			Norethisterone		Drug Info		Sugammadex		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Contraceptive Agents				Anesthetics
Structure

Mechanism of Norethisterone-Sugammadex Interaction (Severity Level: Major)
Attenuated pharmacological effects (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Norethisterone				Sugammadex
Mechanism		Hormonal contraceptives				Reduce the therapeutic efficacy of hormonal contraceptives
Key Mechanism Factor 1
		Factor Name		Pharmacodynamics
		Factor Description		Reduced pharmacological effects leading to insufficient efficacy and/or treatment failure.
Mechanism Description		Attenuated pharmacological effects of  Norethisterone when combined with Sugammadex

Recommended Action
Management		Female patients of reproductive potential receiving hormonal contraceptives (whether oral or non-oral) should use an additional, nonhormonal contraceptive method or backup method of contraception (e.g., condoms and spermicides) for 7 days after sugammadex administration.

References
1	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
2	Schubert W, Eriksson U, Edgar B, Cullberg G, Hedner T "Flavonoids in grapefruit juice inhibit the in vitro hepatic metabolism of 17B-estradiol." Eur J Drug Metab Pharmacokinet 20 (1995): 219-24. [PMID: 8751044]
3	Product Information. Bridion (sugammadex). Merck &amp Company Inc, Whitehouse Station, NJ.