Details of Drug

Details of Drug

 Drug General Information (ID: D1894)
  Drug Name
Sugammadex
  Drug Type Small molecule
  Drug Synonymous
Sugammadex|343306-71-8|Bridion|UNII-361LPM2T56|361LPM2T56|ORG-25969|Sugammadex [USAN:INN:BAN]|SCHEMBL13917069|CHEBI:90953|DTXSID90895043|DB06206|C74763|6A,6B,6C,6D,6E,6F,6G,6H-Octakis-S-(2-carboxyethyl)-6A,6B,6C,6D,6E,6F,6G,6H-octathio-|A-cyclodextrin|WURCS=2.0/1,8,8/[a2122h-1a_1-5_6*SCCCO/5=O]/1-1-1-1-1-1-1-1/a1-h4_a4-b1_b4-c1_c4-d1_d4-e1_e4-f1_f4-g1_g4-h1
    Click to Show/Hide
  Therapeutic Class Anesthetics
  Structure Could Not Find 2D Structure
3D Structure 2D Structure
  Formula C72H112O48S8
  InChI InChI=1S/C72H112O48S8/c73-33(74)1-9-121-17-25-57-41(89)49(97)65(105-25)114-58-26(18-122-10-2-34(75)76)107-67(51(99)43(58)91)116-60-28(20-124-12-4-36(79)80)109-69(53(101)45(60)93)118-62-30(22-126-14-6-38(83)84)111-71(55(103)47(62)95)120-64-32(24-128-16-8-40(87)88)112-72(56(104)48(64)96)119-63-31(23-127-15-7-39(85)86)110-70(54(102)46(63)94)117-61-29(21-125-13-5-37(81)82)108-68(52(100)44(61)92)115-59-27(19-123-11-3-35(77)78)106-66(113-57)50(98)42(59)90/h25-32,41-72,89-104H,1-24H2,(H,73,74)(H,75,76)(H,77,78)(H,79,80)(H,81,82)(H,83,84)(H,85,86)(H,87,88)/t25-,26-,27-,28-,29-,30-,31-,32-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65-,66-,67-,68-,69-,70-,71-,72-/m1/s1
  InChIKey WHRODDIHRRDWEW-VTHZAVIASA-N
  Canonical SMILES C(CSC[C@@H]1[C@@H]2[C@@H]([C@H]([C@H](O1)O[C@@H]3[C@H](O[C@@H]([C@@H]([C@H]3O)O)O[C@@H]4[C@H](O[C@@H]([C@@H]([C@H]4O)O)O[C@@H]5[C@H](O[C@@H]([C@@H]([C@H]5O)O)O[C@@H]6[C@H](O[C@@H]([C@@H]([C@H]6O)O)O[C@@H]7[C@H](O[C@@H]([C@@H]([C@H]7O)O)O[C@@H]8[C@H](O[C@@H]([C@@H]([C@H]8O)O)O[C@@H]9[C@H](O[C@H](O2)[C@@H]([C@H]9O)O)CSCCC(=O)O)CSCCC(=O)O)CSCCC(=O)O)CSCCC(=O)O)CSCCC(=O)O)CSCCC(=O)O)CSCCC(=O)O)O)O)C(=O)O
  External Link
Pubchem ID 6918585

Drug-Drug Interaction Network
  Sunburst Graph
AM006  Pharmacodynamic additive effects
AM007  Pharmacodynamic antagonistic effects
BM050  Increased risk of bleeding
BM107  Attenuated pharmacological effects (Unspecific)
  Relation Graph
 Full list of drugs interacting with Sugammadex
      Pharmacodynamic additive effects
   Increased risk of bleeding Drug Num:  20
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0087
 
Anisindione
 
C16H12O3
 
2197 
Moderate    Inter Info   
[1], [3]
D0102
 
Ardeparin
 
C26H42N2O37S5
 
772 
Moderate    Inter Info   
[1], [3]
D0104
 
Argatroban
 
C23H36N6O5S
 
92722 
Moderate    Inter Info   
[1], [3]
D0189
 
Bivalirudin
 
C98H138N24O33
 
16129704 
Moderate    Inter Info   
[1], [3]
D0481
 
Dicoumarol
 
C19H12O6
 
54676038 
Moderate    Inter Info   
[1], [3]
D0574
 
Enoxaparin
 
C26H42N2O37S5
 
772 
Moderate    Inter Info   
[1], [3]
D0690
 
Fondaparinux
 
C31H53N3O49S8
 
5282448 
Moderate    Inter Info   
[1], [3]
D0753
 
Heparin
 
C26H42N2O37S5
 
772 
Moderate    Inter Info   
[1], [3]
D0904
 
Lepirudin
 
C287H440N80O111S6
 
118856773 
Moderate    Inter Info   
[1], [3]
D0092
 
Antithrombin Alfa
 
NA
 
NA
Moderate    Inter Info   
[1], [3]
D0093
 
Antithrombin III human
 
NA
 
NA
Moderate    Inter Info   
[1], [3]
D0096
 
Apixaban
 
C25H25N5O4
 
10182969 
Moderate    Inter Info   
[1], [3]
D0176
 
Betrixaban
 
C23H22ClN5O3
 
10275777 
Moderate    Inter Info   
[1], [3]
D0414
 
Dalteparin
 
C26H42N2O37S5
 
772 
Moderate    Inter Info   
[1], [3]
D0415
 
Danaparoid
 
NA
 
NA
Moderate    Inter Info   
[1], [3]
D0447
 
Desirudin
 
C287H440N80O110S6
 
16129703 
Moderate    Inter Info   
[1], [3]
D0551
 
Edoxaban
 
C24H30ClN7O4S
 
10280735 
Moderate    Inter Info   
[1], [3]
D1417
 
Rivaroxaban
 
C19H18ClN3O5S
 
9875401 
Moderate    Inter Info   
[1], [3]
D1588
 
Tinzaparin
 
C26H42N2O37S5
 
772 
Moderate    Inter Info   
[1], [3]
D1711
 
Warfarin
 
C19H16O4
 
54678486 
Moderate    Inter Info   
[1], [3]
      Pharmacodynamic antagonistic effects
   Attenuated pharmacological effects (Unspecific) Drug Num:  11
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0450
 
Desogestrel
 
C22H30O
 
40973 
Major    Inter Info   
[1], [2], [3]
D0536
 
Drospirenone
 
C24H30O3
 
68873 
Major    Inter Info   
[1], [2], [3]
D0626
 
Etonogestrel
 
C22H28O2
 
6917715 
Major    Inter Info   
[1], [2], [3]
D0922
 
Levonorgestrel
 
C21H28O2
 
13109 
Major    Inter Info   
[1], [2], [3]
D0990
 
Medroxyprogesterone acetate
 
C24H34O4
 
6279 
Major    Inter Info   
[1], [2], [3]
D1154
 
Norethisterone
 
C20H26O2
 
6230 
Major    Inter Info   
[1], [2], [3]
D1156
 
Norgestimate
 
C23H31NO3
 
6540478 
Major    Inter Info   
[1], [2], [3]
D0485
 
Dienogest
 
C20H25NO2
 
68861 
Major    Inter Info   
[1], [2], [3]
D1152
 
Norelgestromin
 
C21H29NO2
 
9568628 
Major    Inter Info   
[1], [2], [3]
D1157
 
Norgestrel
 
C21H28O2
 
13109 
Major    Inter Info   
[1], [2], [3]
D1612
 
Toremifene
 
C26H28ClNO
 
3005573 
Moderate    Inter Info   
[1], [4], [3]
References
1 Cerner Multum, Inc. "UK Summary of Product Characteristics.".
2 Schubert W, Eriksson U, Edgar B, Cullberg G, Hedner T "Flavonoids in grapefruit juice inhibit the in vitro hepatic metabolism of 17B-estradiol." Eur J Drug Metab Pharmacokinet 20 (1995): 219-24. [PMID: 8751044]
3 Product Information. Bridion (sugammadex). Merck &amp Company Inc, Whitehouse Station, NJ.
4 Product Information. Fareston (toremifene). Schering Laboratories, Kenilworth, NJ.