Drug General Information (ID: DDI5BCRHMY)
Drug Name			Toremifene		Drug Info		Sugammadex		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antineoplastics				Anesthetics
Structure

Mechanism of Toremifene-Sugammadex Interaction (Severity Level: Moderate)
Attenuated pharmacological effects (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Toremifene				Sugammadex
Mechanism		Reduce the therapeutic efficacy of sugammadex				Sugammadex
Key Mechanism Factor 1
		Factor Name		Pharmacodynamics
		Factor Description		Reduced pharmacological effects leading to insufficient efficacy and/or treatment failure.
Mechanism Description		Attenuated pharmacological effects of  Sugammadex when combined with Toremifene

Recommended Action
Management		Clinicians should be aware that toremifene may delay the reversal of neuromuscular blockade in patients receiving sugammadex. Patients should be closely monitored for signs of recurrence of neuromuscular blockade, and appropriate steps taken to provide adequate ventilation as necessary.

References
1	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
2	Product Information. Fareston (toremifene). Schering Laboratories, Kenilworth, NJ.
3	Product Information. Bridion (sugammadex). Merck &amp Company Inc, Whitehouse Station, NJ.