Details of Drug

Drug General Information (ID: D1612)
Drug Name	Toremifene
Drug Type	Small molecule
Drug Synonymous	Acapodene; Estrimex; Farestone; Toremifeno; Toremifenum; Toremifene Base; Toremifeno [Spanish]; Toremifenum [Latin]; GTx 006; Acapodene (TN); FC-1157a; Fareston (TN); GTx-006; Toremifene (INN); Toremifene [INN:BAN]; Z-Toremifene; GTX-006 (Acapodene); Toremifene Citrate (1:1); {2-[4-(4-Chloro-1,2-diphenyl-but-1-enyl)-phenoxy]-ethyl}-dimethyl-amine; (Z)-2-(4-(4-Chloro-1,2-diphenyl-1-butenyl)phenoxy)-N,N-dimethylethanamine; 2-(p-[(Z)-4-chloro-1,2-diphenyl-1-butenyl]-phenoxy)-N,N-dimethyl-ethylamine citrate(1:1); 2-(para-((Z)-4-Chloro-1,2-diphenyl-1-butenyl)phenoxy)-N,N-dimethylethylamine (IUPAC); 2-({4-[(1Z)-4-chloro-1,2-diphenylbut-1-en-1-yl]phenyl}oxy)-N,N-dimethylethanamine; 2-[4-[(Z)-4-chloro-1,2-diphenylbut-1-enyl]phenoxy]-N,N-dimethylethanamine; 2-{4-[(1Z)-4-chloro-1,2-diphenylbut-1-en-1-yl]phenoxy}-N,N-dimethylethanamine Click to Show/Hide
Disease Class	2C60-2C6Y: Breast cancer
Therapeutic Class	Antineoplastics
Structure
Structure	3D Structure		2D Structure
Formula	C26H28ClNO
InChI	1S/C26H28ClNO/c1-28(2)19-20-29-24-15-13-23(14-16-24)26(22-11-7-4-8-12-22)25(17-18-27)21-9-5-3-6-10-21/h3-16H,17-20H2,1-2H3/b26-25-
InChIKey	XFCLJVABOIYOMF-QPLCGJKRSA-N
Canonical SMILES	CN(C)CCOC1=CC=C(C=C1)C(=C(CCCl)C2=CC=CC=C2)C3=CC=CC=C3
External Link
	Pubchem ID	3005573
	CAS Number	89778-26-7
	CHEBI ID	9635
	TTD ID	D04VFJ
	VARIDT ID	DR01170

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM002 Affected cellular transport AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM010 Transporter inhibition BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM024 Competitive inhibition of metabolic enzyme BM047 Additive thrombogenic effects BM076 Increased risk of prolong QT interval BM081 Increased risk of ventricular arrhythmias BM107 Attenuated pharmacological effects (Unspecific) BM108 Increased risk of hypercalcemia
Relation Graph

Full list of drugs interacting with Toremifene
Affected cellular transport
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 58
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0799		Indinavir	C36H47N5O4	5362440	Major		Inter Info	[13]
D1119		Nelfinavir	C32H45N3O4S	64143	Major		Inter Info	[13]
D1415		Ritonavir	C37H48N6O5S2	392622	Major		Inter Info	[13]
D0080		Amprenavir	C25H35N3O6S	65016	Major		Inter Info	[13]
D0116		Atazanavir	C38H52N6O7	148192	Major		Inter Info	[13]
D0192		Boceprevir	C27H45N5O5	10324367	Major		Inter Info	[13]
D0349		Clarithromycin	C38H69NO13	84029	Major		Inter Info	[13]
D0375		Cobicistat	C40H53N7O5S2	25151504	Major		Inter Info	[13]
D0386		Conivaptan	C32H26N4O2	151171	Major		Inter Info	[13]
D0439		Delavirdine	C22H28N6O3S	5625	Major		Inter Info	[13]
D0692		Fosamprenavir	C25H36N3O9PS	131536	Major		Inter Info	[13]
D0789		Idelalisib	C22H18FN7O	11625818	Major		Inter Info	[13]
D0867		Itraconazole	C35H38Cl2N8O4	55283	Major		Inter Info	[13]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Major		Inter Info	[13]
D0899		Lefamulin	C28H45NO5S	25185057	Major		Inter Info	[42]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Major		Inter Info	[13]
D1117		Nefazodone	C25H32ClN5O2	4449	Major		Inter Info	[13]
D1398		Ribociclib	C23H30N8O	44631912	Major		Inter Info	[1], [2], [3], [64], [65], [66], [7]
D1541		Telaprevir	C36H53N7O6	3010818	Major		Inter Info	[13]
D1544		Telithromycin	C43H65N5O10	3002190	Major		Inter Info	[13]
D1653		Troleandomycin	C41H67NO15	202225	Major		Inter Info	[13]
D1660		Tucatinib	C26H24N8O2	51039094	Major		Inter Info	[13]
D1706		Voriconazole	C16H14F3N5O	71616	Major		Inter Info	[13]
D0337		Cimetidine	C10H16N6S	2756	Moderate		Inter Info	[13]
D0367		Clotrimazole	C22H17ClN2	2812	Moderate		Inter Info	[13]
D0402		Cyclosporine	C62H111N11O12	5284373	Moderate		Inter Info	[13]
D0481		Dicoumarol	C19H12O6	54676038	Moderate		Inter Info	[2], [3], [122]
D0497		Diltiazem	C22H26N2O4S	39186	Moderate		Inter Info	[13]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Moderate		Inter Info	[13]
D1087		Montelukast	C35H36ClNO3S	5281040	Moderate		Inter Info	[126], [127]
D1611		Torasemide	C16H20N4O3S	41781	Moderate		Inter Info	[132], [133], [134]
D0002		Abametapir (topical)	C12H12N2	15664	Moderate		Inter Info	[135]
D0087		Anisindione	C16H12O3	2197	Moderate		Inter Info	[2], [3], [136], [13], [137], [138], [122]
D0100		Aprepitant	C23H21F7N4O3	135413536	Moderate		Inter Info	[13]
D0171		Berotralstat	C30H26F4N6O	137528262	Moderate		Inter Info	[13]
D0413		Dalfopristin	C34H50N4O9S	6323289	Moderate		Inter Info	[153], [13]
D0416		Danazol	C22H27NO2	28417	Moderate		Inter Info	[13]
D0426		Darunavir	C27H37N3O7S	213039	Moderate		Inter Info	[13]
D0543		Duvelisib	C22H17ClN6O	50905713	Moderate		Inter Info	[13]
D0638		Fedratinib	C27H36N6O3S	16722836	Moderate		Inter Info	[13]
D0686		Fluvastatin	C24H26FNO4	446155	Moderate		Inter Info	[2], [3], [156], [157]
D0693		Fosaprepitant	C23H22F7N4O6P	135413538	Moderate		Inter Info	[13]
D0699		Fostamatinib	C23H26FN6O9P	11671467	Moderate		Inter Info	[158]
D0793		Imatinib	C29H31N7O	5291	Moderate		Inter Info	[13]
D0852		Isavuconazonium	C35H35F2N8O5S+	6918606	Moderate		Inter Info	[13]
D0858		Isoniazid	C6H7N3O	3767	Moderate		Inter Info	[13]
D0869		Ivacaftor	C24H28N2O3	16220172	Moderate		Inter Info	[13]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Moderate		Inter Info	[13]
D0905		Lesinurad	C17H14BrN3O2S	53465279	Moderate		Inter Info	[159]
D0906		Letermovir	C29H28F4N4O4	45138674	Moderate		Inter Info	[13]
D1057		Miconazole	C18H14Cl4N2O	4189	Moderate		Inter Info	[13]
D1112		Nateglinide	C19H27NO3	5311309	Moderate		Inter Info	[162], [163]
D1134		Nifedipine	C17H18N2O6	4485	Moderate		Inter Info	[13]
D1505		Stiripentol	C14H18O3	5311454	Moderate		Inter Info	[13]
D1690		Verapamil	C27H38N2O4	2520	Moderate		Inter Info	[13]
D1709		Voxelotor	C19H19N3O3	71602803	Moderate		Inter Info	[13]
D1711		Warfarin	C19H16O4	54678486	Moderate		Inter Info	[2], [3], [136], [13], [137], [138], [122]
D1714		Zafirlukast	C31H33N3O6S	5717	Moderate		Inter Info	[13]
	CYP450 enzyme induction					Drug Num: 52
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1283		Phenytoin	C15H12N2O2	1775	Major		Inter Info	[16], [2], [3], [17], [13]
D0095		Apalutamide	C21H15F4N5O2S	24872560	Major		Inter Info	[16], [2], [3], [17], [13]
D0255		Carbamazepine	C15H12N2O	2554	Major		Inter Info	[16], [2], [3], [17], [13]
D0453		Dexamethasone	C22H29FO5	5743	Major		Inter Info	[16], [2], [3], [17], [13]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Major		Inter Info	[16], [2], [3], [17], [13]
D0697		Fosphenytoin	C16H15N2O6P	56339	Major		Inter Info	[16], [2], [3], [17], [13]
D0958		Lumacaftor	C24H18F2N2O5	16678941	Major		Inter Info	[16], [2], [3]
D1078		Mitotane	C14H10Cl4	4211	Major		Inter Info	[16], [2], [3], [17], [13]
D1265		Phenobarbital	C12H12N2O3	4763	Major		Inter Info	[16], [2], [3], [17], [13]
D1340		Primidone	C12H14N2O2	4909	Major		Inter Info	[16], [2], [3], [17], [13]
D1399		Rifabutin	C46H62N4O11	135398743	Major		Inter Info	[16], [2], [3], [17], [13]
D1400		Rifampicin	C43H58N4O12	135398735	Major		Inter Info	[16], [2], [3]
D1502		St. John's Wort	NA	NA	Major		Inter Info	[16], [2], [3], [17], [13]
D0061		Aminoglutethimide	C13H16N2O2	2145	Moderate		Inter Info	[16], [2], [3], [17], [13]
D0178		Bexarotene	C24H28O2	82146	Moderate		Inter Info	[16], [2], [3], [17], [13]
D0224		Butabarbital	C10H16N2O3	2479	Moderate		Inter Info	[16], [2], [3], [17], [13]
D0225		Butalbital	C11H16N2O3	2481	Moderate		Inter Info	[16], [2], [3], [17], [13]
D0741		Griseofulvin	C17H17ClO6	441140	Moderate		Inter Info	[16], [2], [3], [17], [13]
D1128		Nevirapine	C15H14N4O	4463	Moderate		Inter Info	[16], [2], [3], [17], [13]
D1248		Pentobarbital	C11H18N2O3	4737	Moderate		Inter Info	[16], [2], [3], [17], [13]
D1453		Secobarbital	C12H18N2O3	5193	Moderate		Inter Info	[16], [2], [3], [17], [13]
D1494		Somatotropin	NA	NA	Moderate		Inter Info	[2], [3], [13]
D0071		Amobarbital	C11H18N2O3	2164	Moderate		Inter Info	[16], [2], [3], [17], [13]
D0106		Armodafinil	C15H15NO2S	9690109	Moderate		Inter Info	[16], [2], [3], [17], [13]
D0194		Bosentan	C27H29N5O6S	104865	Moderate		Inter Info	[16], [2], [3], [17], [13]
D0204		Brigatinib	C29H39ClN7O2P	68165256	Moderate		Inter Info	[16], [2], [3], [17], [13]
D0300		Cenobamate	C10H10ClN5O2	11962412	Moderate		Inter Info	[16], [2], [3], [17], [13]
D0406		Dabrafenib	C23H20F3N5O2S2	44462760	Moderate		Inter Info	[3], [152]
D0432		Deferasirox	C21H15N3O4	214348	Moderate		Inter Info	[16], [2], [3], [17], [13]
D0545		Echinacea	NA	NA	Moderate		Inter Info	[2], [154]
D0555		Elagolix	C32H30F5N3O5	11250647	Moderate		Inter Info	[16], [2], [3], [17], [13]
D0601		Eslicarbazepine	C15H14N2O2	9881504	Moderate		Inter Info	[16], [2], [3], [17], [13]
D0628		Etravirine	C20H15BrN6O	193962	Moderate		Inter Info	[16], [2], [3], [17], [13]
D0639		Felbamate	C11H14N2O4	3331	Moderate		Inter Info	[16], [2], [3], [17], [13]
D0901		Lemborexant	C22H20F2N4O2	56944144	Moderate		Inter Info	[2], [3], [13]
D0953		Lorlatinib	C21H19FN6O2	71731823	Moderate		Inter Info	[16], [2], [3], [17], [13]
D1040		Methylphenobarbital	C13H14N2O3	8271	Moderate		Inter Info	[2], [3], [13]
D1050		Metreleptin	NA	NA	Moderate		Inter Info	[16], [2], [3], [17], [13]
D1081		Modafinil	C15H15NO2S	4236	Moderate		Inter Info	[16], [2], [3], [17], [13]
D1099		Nafcillin	C21H22N2O5S	8982	Moderate		Inter Info	[16], [2], [3], [17], [13]
D1186		Oritavancin	C86H97Cl3N10O26	16136912	Moderate		Inter Info	[16], [2], [3], [17], [13]
D1198		Oxcarbazepine	C15H12N2O2	34312	Moderate		Inter Info	[16], [2], [3], [17], [13]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Moderate		Inter Info	[16], [2], [3], [17], [13]
D1274		Phenylbutazone	C19H20N2O2	4781	Moderate		Inter Info	[16], [2], [3], [17], [13]
D1294		Pioglitazone	C19H20N2O3S	4829	Moderate		Inter Info	[164]
D1433		Rufinamide	C10H8F2N4O	129228	Moderate		Inter Info	[16], [2], [3], [17], [13]
D1493		Somapacitan	C54H95N13O20S2	129894493	Moderate		Inter Info	[2], [3], [13]
D1495		Somatrem	C43H72N14O14	5487805	Moderate		Inter Info	[16], [2], [3], [17], [13]
D1518		Sulfinpyrazone	C23H20N2O3S	5342	Moderate		Inter Info	[16], [2], [3], [17], [13]
D1538		Tazemetostat	C34H44N4O4	66558664	Moderate		Inter Info	[16], [2], [3], [17], [13]
D1546		Telotristat ethyl	C27H26ClF3N6O3	25181577	Moderate		Inter Info	[2], [3], [13]
D1652		Troglitazone	C24H27NO5S	5591	Moderate		Inter Info	[16], [2], [3], [17], [13]
	Competitive inhibition of metabolic enzyme					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1476		Sirolimus	C51H79NO13	5284616	Moderate		Inter Info	[175], [176]
D1549		Temsirolimus	C56H87NO16	6918289	Moderate		Inter Info	[175], [176]
Pharmacodynamic additive effects
	Additive thrombogenic effects					Drug Num: 7
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0902		Lenalidomide	C13H13N3O3	216326	Major		Inter Info	[3], [14], [15]
D0261		Carfilzomib	C40H57N5O7	11556711	Major		Inter Info	[2], [28], [3]
D1312		Pomalidomide	C13H11N3O4	134780	Major		Inter Info	[13], [62], [63]
D1569		Thalidomide	C13H10N2O4	5426	Major		Inter Info	[3], [13], [112]
D1619		Tranexamic acid	C8H15NO2	5526	Major		Inter Info	[118], [119], [120]
D0385		Conestat alfa	NA	NA	Moderate		Inter Info	[148], [149], [150], [151]
D0762		Human C1-esterase inhibitor	NA	NA	Moderate		Inter Info	[148], [150], [151]
	Increased risk of prolong QT interval					Drug Num: 177
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0003		Abarelix	C72H95ClN14O14	16131215	Major		Inter Info	[1], [2], [3], [4]
D0036		Alfuzosin	C19H27N5O4	2092	Major		Inter Info	[1], [2], [3], [4]
D0068		Amitriptyline	C20H23N	2160	Major		Inter Info	[1], [2], [3], [4]
D0084		Anagrelide	C10H7Cl2N3O	135409400	Major		Inter Info	[1], [2], [3], [4]
D0119		Atomoxetine	C17H21NO	54841	Major		Inter Info	[1], [2], [3], [4]
D0139		Azithromycin	C38H72N2O12	447043	Major		Inter Info	[1], [2], [3], [4]
D0324		Chlorpromazine	C17H19ClN2S	2726	Major		Inter Info	[1], [2], [3], [4]
D0341		Ciprofloxacin	C17H18FN3O3	2764	Major		Inter Info	[1], [2], [3], [4]
D0345		Citalopram	C20H21FN2O	2771	Major		Inter Info	[1], [2], [3], [5], [6], [7], [8]
D0370		Clozapine	C18H19ClN4	135398737	Major		Inter Info	[1], [2], [3], [4]
D0508		Disopyramide	C21H29N3O	3114	Major		Inter Info	[1], [2], [3], [4]
D0513		Dofetilide	C19H27N3O5S2	71329	Major		Inter Info	[1], [2], [3], [4]
D0535		Droperidol	C22H22FN3O2	3168	Major		Inter Info	[1], [2], [3], [4]
D0584		Epirubicin	C27H29NO11	41867	Major		Inter Info	[1], [2], [3], [4]
D0597		Erythromycin	C37H67NO13	12560	Major		Inter Info	[1], [2], [3], [4]
D0667		Fluconazole	C13H12F2N6O	3365	Major		Inter Info	[1], [2], [3], [4]
D0676		Fluoxetine	C17H18F3NO	3386	Major		Inter Info	[1], [2], [3], [4]
D0682		Flutamide	C11H11F3N2O3	3397	Major		Inter Info	[1], [2], [3], [4]
D0694		Foscarnet	CH3O5P	3415	Major		Inter Info	[1], [2], [3], [4]
D0737		Goserelin	C59H84N18O14	5311128	Major		Inter Info	[1], [2], [3], [4]
D0740		Grepafloxacin	C19H22FN3O3	72474	Major		Inter Info	[9], [1], [2], [3], [10], [11], [12]
D0750		Haloperidol	C21H23ClFNO2	3559	Major		Inter Info	[1], [2], [3], [4]
D0787		Ibutilide	C20H36N2O3S	60753	Major		Inter Info	[1], [2], [3], [4]
D0795		Imipramine	C19H24N2	3696	Major		Inter Info	[1], [2], [3], [4]
D0908		Leuprolide	C59H84N16O12	657181	Major		Inter Info	[1], [2], [3], [4]
D0992		Mefloquine	C17H16F6N2O	4046	Major		Inter Info	[1], [2], [3], [4]
D1017		Methadone	C21H27NO	4095	Major		Inter Info	[1], [2], [3], [4]
D1075		Mirtazapine	C17H19N3	4205	Major		Inter Info	[1], [2], [3], [4]
D1092		Moxifloxacin	C21H24FN3O4	152946	Major		Inter Info	[1], [2], [3], [4]
D1193		Oxaliplatin	C8H14N2O4Pt	9887053	Major		Inter Info	[1], [2], [3], [4]
D1210		Oxytocin	C43H66N12O12S2	439302	Major		Inter Info	[1], [2], [3], [4]
D1216		Palonosetron	C19H24N2O	6337614	Major		Inter Info	[1], [2], [3], [4]
D1346		Prochlorperazine	C20H24ClN3S	4917	Major		Inter Info	[1], [2], [3], [4]
D1351		Promazine	C17H20N2S	4926	Major		Inter Info	[1], [2], [3], [4]
D1361		Protriptyline	C19H21N	4976	Major		Inter Info	[1], [2], [3], [4]
D1372		Quinine	C20H24N2O2	3034034	Major		Inter Info	[1], [2], [3], [4]
D1383		Ranolazine	C24H33N3O4	56959	Major		Inter Info	[1], [2], [3], [4]
D1497		Sorafenib	C21H16ClF3N4O3	216239	Major		Inter Info	[1], [2], [3], [4]
D1498		Sotalol	C12H20N2O3S	5253	Major		Inter Info	[1], [2], [3], [4]
D1555		Terfenadine	C32H41NO2	5405	Major		Inter Info	[1], [2], [3], [4]
D0007		Abiraterone	C24H31NO	132971	Major		Inter Info	[1], [2], [3], [4]
D0037		Alimemazine	C18H22N2S	5574	Major		Inter Info	[1], [2], [25]
D0066		Amiodarone	C25H29I2NO3	2157	Major		Inter Info	[1], [2], [3], [4]
D0067		Amisulpride	C17H27N3O4S	2159	Major		Inter Info	[1], [2], [3], [4]
D0072		Amoxapine	C17H16ClN3O	2170	Major		Inter Info	[1], [2], [3], [4]
D0097		Apomorphine	C17H17NO2	6005	Major		Inter Info	[1], [2], [3], [4]
D0112		Asenapine	C17H16ClNO	3036780	Major		Inter Info	[1], [2], [3], [4]
D0115		Astemizole	C28H31FN4O	2247	Major		Inter Info	[1], [2], [3], [4]
D0149		Bedaquiline	C32H31BrN2O2	5388906	Major		Inter Info	[1], [2], [3], [4]
D0170		Bepridil	C24H34N2O	2351	Major		Inter Info	[1], [2], [3], [4]
D0180		Bicalutamide	C18H14F4N2O4S	2375	Major		Inter Info	[1], [2], [3], [4]
D0195		Bosutinib	C26H29Cl2N5O3	5328940	Major		Inter Info	[1], [2], [3], [4]
D0219		Buprenorphine	C29H41NO4	644073	Major		Inter Info	[1], [2], [3], [4]
D0230		Cabozantinib	C28H24FN3O5	25102847	Major		Inter Info	[1], [2], [3], [4]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Major		Inter Info	[1], [2], [3], [4]
D0320		Chloroquine	C18H26ClN3	2719	Major		Inter Info	[1], [2], [3], [4]
D0336		Cilostazol	C20H27N5O2	2754	Major		Inter Info	[1], [2], [3], [4]
D0342		Cisapride	C23H29ClFN3O4	6917698	Major		Inter Info	[1], [2], [3], [22], [29], [30]
D0358		Clofazimine	C27H22Cl2N4	2794	Major		Inter Info	[1], [2], [3], [4]
D0361		Clomipramine	C19H23ClN2	2801	Major		Inter Info	[1], [2], [3], [4]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Major		Inter Info	[1], [2], [3], [4]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Major		Inter Info	[1], [2], [3], [4]
D0429		Daunorubicin	C27H29NO10	30323	Major		Inter Info	[1], [2], [3], [4]
D0430		Daunorubicin (liposomal)	C27H29NO10	30323	Major		Inter Info	[1], [2], [25]
D0437		Degarelix	C82H103ClN18O16	16136245	Major		Inter Info	[1], [2], [3], [4]
D0446		Desipramine	C18H22N2	2995	Major		Inter Info	[1], [2], [3], [4]
D0452		Deutetrabenazine	C19H27NO3	73437646	Major		Inter Info	[1], [2], [3], [4]
D0467		Dextropropoxyphene	C22H29NO2	10100	Major		Inter Info	[1], [2], [25]
D0514		Dolasetron	C19H20N2O3	3033818	Major		Inter Info	[1], [2], [3], [4]
D0525		Doxepin	C19H21NO	667477	Major		Inter Info	[1], [2], [3], [4]
D0528		Doxorubicin	C27H29NO11	31703	Major		Inter Info	[1], [2], [3], [4]
D0529		Doxorubicin (liposomal)	C27H29NO11	31703	Major		Inter Info	[1], [2], [25]
D0534		Dronedarone	C31H44N2O5S	208898	Major		Inter Info	[1], [2], [3], [31]
D0554		Efavirenz	C14H9ClF3NO2	64139	Major		Inter Info	[1], [2], [3], [4]
D0569		Encorafenib	C22H27ClFN7O4S	50922675	Major		Inter Info	[1], [2], [3], [4]
D0577		Entrectinib	C31H34F2N6O2	25141092	Major		Inter Info	[1], [2], [3], [4]
D0594		Eribulin	C40H59NO11	11354606	Major		Inter Info	[1], [2], [3], [4]
D0599		Escitalopram	C20H21FN2O	146570	Major		Inter Info	[1], [2], [3], [4]
D0632		Ezogabine	C16H18FN3O2	121892	Major		Inter Info	[1], [2], [3], [4]
D0664		Flecainide	C17H20F6N2O3	3356	Major		Inter Info	[1], [2], [3], [4]
D0678		Fluphenazine	C22H26F3N3OS	3372	Major		Inter Info	[1], [2], [3], [4]
D0700		Fostemsavir	C25H26N7O8P	11319217	Major		Inter Info	[1], [2], [3], [4]
D0712		Gatifloxacin	C19H22FN3O4	5379	Major		Inter Info	[1], [2], [3], [4]
D0716		Gemifloxacin	C18H20FN5O4	9571107	Major		Inter Info	[1], [2], [3], [4]
D0720		Gilteritinib	C29H44N8O3	49803313	Major		Inter Info	[1], [2], [3], [4]
D0725		Glasdegib	C21H22N6O	25166913	Major		Inter Info	[1], [2], [3], [4]
D0738		Granisetron	C18H24N4O	5284566	Major		Inter Info	[1], [2], [3], [4]
D0749		Halofantrine	C26H30Cl2F3NO	37393	Major		Inter Info	[33], [1], [2], [3], [34], [35], [36], [37], [38]
D0751		Halothane	C2HBrClF3	3562	Major		Inter Info	[1], [2], [3], [4]
D0758		Histrelin	C66H86N18O12	25077993	Major		Inter Info	[1], [2], [3], [4]
D0779		Hydroxychloroquine	C18H26ClN3O	3652	Major		Inter Info	[1], [2], [3], [4]
D0781		Hydroxyzine	C21H27ClN2O2	3658	Major		Inter Info	[1], [2], [3], [4]
D0788		Idarubicin	C26H27NO9	42890	Major		Inter Info	[1], [2], [3], [4]
D0791		Iloperidone	C24H27FN2O4	71360	Major		Inter Info	[1], [2], [3], [4]
D0806		Inotuzumab ozogamicin	NA	NA	Major		Inter Info	[1], [2], [3], [4]
D0872		Ivosidenib	C28H22ClF3N6O3	71657455	Major		Inter Info	[1], [2], [3], [4]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Major		Inter Info	[1], [2], [3], [4]
D0903		Lenvatinib	C21H19ClN4O4	9823820	Major		Inter Info	[1], [2], [3], [4]
D0909		Levacetylmethadol	C23H31NO2	15130	Major		Inter Info	[3], [43], [7]
D0937		Lisdexamfetamine	C15H25N3O	11597698	Major		Inter Info	[1], [2], [3], [4]
D0940		Lithium carbonate	CLi2O3	11125	Major		Inter Info	[1], [2], [25]
D0942		Lofexidine	C11H12Cl2N2O	30668	Major		Inter Info	[1], [2], [3], [4]
D0943		Lomefloxacin	C17H19F2N3O3	3948	Major		Inter Info	[1], [2], [3], [4]
D0960		Lumefantrine	C30H32Cl3NO	6437380	Major		Inter Info	[2], [3], [25]
D0965		Macimorelin	C26H30N6O3	9804938	Major		Inter Info	[44]
D0979		Maprotiline	C20H23N	4011	Major		Inter Info	[1], [2], [3], [4]
D1010		Mesoridazine	C21H26N2OS2	4078	Major		Inter Info	[1], [2], [3], [45], [7]
D1026		Methotrimeprazine	C19H24N2OS	72287	Major		Inter Info	[1], [2], [3], [4]
D1062		Midostaurin	C35H30N4O4	9829523	Major		Inter Info	[1], [2], [3], [4]
D1063		Mifepristone	C29H35NO2	55245	Major		Inter Info	[1], [2], [3], [46]
D1136		Nilotinib	C28H22F3N7O	644241	Major		Inter Info	[1], [2], [3], [4]
D1137		Nilutamide	C12H10F3N3O4	4493	Major		Inter Info	[1], [2], [3], [4]
D1155		Norfloxacin	C16H18FN3O3	4539	Major		Inter Info	[1], [2], [3], [4]
D1158		Nortriptyline	C19H21N	4543	Major		Inter Info	[1], [2], [3], [4]
D1165		Ofloxacin	C18H20FN3O4	4583	Major		Inter Info	[1], [2], [3], [4]
D1169		Oliceridine	C22H30N2O2S	66553195	Major		Inter Info	[1], [2], [3], [4]
D1181		Ondansetron	C18H19N3O	4595	Major		Inter Info	[1], [2], [3], [4]
D1189		Osilodrostat	C13H10FN3	44139752	Major		Inter Info	[1], [2], [3], [4]
D1190		Osimertinib	C28H33N7O2	71496458	Major		Inter Info	[1], [2], [3], [4]
D1211		Ozanimod	C23H24N4O3	52938427	Major		Inter Info	[1], [2], [3], [4]
D1215		Paliperidone	C23H27FN4O3	115237	Major		Inter Info	[1], [2], [3], [4]
D1221		Panobinostat	C21H23N3O2	6918837	Major		Inter Info	[1], [2], [3], [4]
D1223		Papaverine	C20H21NO4	4680	Major		Inter Info	[47], [48], [49], [50], [51], [52], [53], [54]
D1230		Pasireotide	C58H66N10O9	9941444	Major		Inter Info	[1], [2], [3], [4]
D1232		Pazopanib	C21H23N7O2S	10113978	Major		Inter Info	[1], [2], [3], [4]
D1246		Pentamidine	C19H24N4O2	4735	Major		Inter Info	[1], [2], [3], [4]
D1254		Perflutren	C3F8	6432	Major		Inter Info	[55], [56]
D1257		Perphenazine	C21H26ClN3OS	4748	Major		Inter Info	[1], [2], [3], [4]
D1290		Pimavanserin	C25H34FN3O2	10071196	Major		Inter Info	[1], [2], [3], [4]
D1292		Pimozide	C28H29F2N3O	16362	Major		Inter Info	[3], [60], [61], [7]
D1302		Pitolisant	C17H26ClNO	9948102	Major		Inter Info	[1], [2], [3], [4]
D1315		Posaconazole	C37H42F2N8O4	468595	Major		Inter Info	[1], [2], [3], [4]
D1339		Primaquine	C15H21N3O	4908	Major		Inter Info	[1], [2], [3], [4]
D1342		Probucol	C31H48O2S2	4912	Major		Inter Info	[1], [2], [3], [4]
D1343		Procainamide	C13H21N3O	4913	Major		Inter Info	[1], [2], [3], [4]
D1352		Promethazine	C17H20N2S	4927	Major		Inter Info	[1], [2], [3], [4]
D1353		Propafenone	C21H27NO3	4932	Major		Inter Info	[1], [2], [3], [4]
D1368		Quetiapine	C21H25N3O2S	5002	Major		Inter Info	[1], [2], [3], [4]
D1371		Quinidine	C20H24N2O2	441074	Major		Inter Info	[1], [2], [3], [4]
D1388		Relugolix	C29H27F2N7O5S	10348973	Major		Inter Info	[1], [2], [3], [4]
D1404		Rilpivirine	C22H18N6	6451164	Major		Inter Info	[1], [2], [3], [4]
D1413		Risperidone	C23H27FN4O2	5073	Major		Inter Info	[1], [2], [3], [4]
D1424		Romidepsin	C24H36N4O6S2	5352062	Major		Inter Info	[1], [2], [3], [4]
D1432		Rucaparib	C19H18FN3O	9931954	Major		Inter Info	[1], [2], [3], [4]
D1444		Saquinavir	C38H50N6O5	441243	Major		Inter Info	[91], [92], [1], [2], [3], [93], [94]
D1459		Selpercatinib	C29H31N7O3	134436906	Major		Inter Info	[1], [2], [3], [4]
D1461		Sertraline	C17H17Cl2N	68617	Major		Inter Info	[1], [2], [3], [4]
D1463		Sevoflurane	C4H3F7O	5206	Major		Inter Info	[1], [2], [3], [4]
D1491		Solifenacin	C23H26N2O2	154059	Major		Inter Info	[1], [2], [3], [4]
D1499		Sparfloxacin	C19H22F2N4O3	60464	Major		Inter Info	[9], [1], [2], [3], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [12], [111]
D1522		Sunitinib	C22H27FN4O2	5329102	Major		Inter Info	[1], [2], [3], [4]
D1526		Tacrolimus	C44H69NO12	445643	Major		Inter Info	[1], [2], [3], [4]
D1542		Telavancin	C80H106Cl2N11O27P	3081362	Major		Inter Info	[1], [2], [3], [4]
D1560		Tetrabenazine	C19H27NO3	6018	Major		Inter Info	[1], [2], [3], [4]
D1574		Thioridazine	C21H26N2S2	5452	Major		Inter Info	[1], [2], [3], [113], [60], [114], [115], [116], [7]
D1596		Tizanidine	C9H8ClN5S	5487	Major		Inter Info	[1], [2], [3], [4]
D1624		Trazodone	C19H22ClN5O	5533	Major		Inter Info	[1], [2], [3], [4]
D1634		Triclabendazole	C14H9Cl3N2OS	50248	Major		Inter Info	[1], [2], [3], [4]
D1637		Trifluoperazine	C21H24F3N3S	5566	Major		Inter Info	[1], [2], [3], [4]
D1647		Trimipramine	C20H26N2	5584	Major		Inter Info	[1], [2], [3], [4]
D1651		Triptorelin	C64H82N18O13	25074470	Major		Inter Info	[1], [2], [3], [4]
D1673		Valbenazine	C24H38N2O4	24795069	Major		Inter Info	[1], [2], [3], [4]
D1681		Vandetanib	C22H24BrFN4O2	3081361	Major		Inter Info	[117]
D1682		Vardenafil	C23H32N6O4S	135400189	Major		Inter Info	[1], [2], [3], [4]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Major		Inter Info	[1], [2], [3], [4]
D1616		Tramadol	C16H25NO2	33741	Major		Inter Info	[1], [2], [3], [4]
D1638		Triflupromazine	C18H19F3N2S	5568	Major		Inter Info	[1], [2], [3], [4]
D1683		Vasopressin	C46H65N15O12S2	644077	Major		Inter Info	[1], [2], [3], [4]
D1689		Venlafaxine	C17H27NO2	5656	Major		Inter Info	[1], [2], [3], [4]
D1726		Ziprasidone	C21H21ClN4OS	60854	Major		Inter Info	[1], [2], [3], [60], [121], [7]
D1166		Olanzapine	C17H20N4S	135398745	Moderate		Inter Info	[2], [3], [128]
D0105		Aripiprazole	C23H27Cl2N3O2	60795	Moderate		Inter Info	[2], [3], [139], [140], [141], [142], [143], [144]
D0636		Famotidine	C8H15N7O2S3	5702160	Moderate		Inter Info	[2], [3], [155]
D0947		Loperamide	C29H33ClN2O2	3955	Moderate		Inter Info	[160], [161]
D1356		Propofol	C12H18O	4943	Moderate		Inter Info	[165], [166], [167], [168], [169], [170], [171], [172], [173], [174]
D1051		Metronidazole	C6H9N3O3	4173	Minor		Inter Info	[2], [178], [179], [180]
D1516		Sulfamethoxazole	C10H11N3O3S	5329	Minor		Inter Info	[1], [2], [3], [181], [182], [183], [184]
	Increased risk of ventricular arrhythmias					Drug Num: 36
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0025		Adenosine	C10H13N5O4	60961	Major		Inter Info	[18], [3], [19], [20], [21], [22], [23], [24]
D0107		Arsenic trioxide	As2O3	14888	Major		Inter Info	[26], [27]
D0661		Fingolimod	C19H33NO2	107970	Major		Inter Info	[1], [2], [3], [32], [8]
D0859		Isoprenaline	C11H17NO3	3779	Major		Inter Info	[39], [40], [41]
D1185		Orciprenaline	C11H17NO3	4086	Major		Inter Info	[39], [40], [41]
D1287		Picosulfuric acid	C18H15NO8S2	5243	Major		Inter Info	[57], [58], [59]
D1308		Polyethylene glycol (3350 with electrolytes)	C2H6O2	174	Major		Inter Info	[57], [58], [59]
D1414		Ritodrine	C17H21NO3	33572	Major		Inter Info	[39], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [40], [85], [86], [87], [88], [41], [89], [90]
D1474		Siponimod	C29H35F3N2O3	44599207	Major		Inter Info	[2], [95]
D1488		Sodium sulfate	Na2O4S	24436	Major		Inter Info	[57], [58], [59]
D1554		Terbutaline	C12H19NO3	5403	Major		Inter Info	[39], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [40], [85], [86], [87], [88], [41], [89], [90]
D0854		Isoetharine	C13H21NO3	3762	Moderate		Inter Info	[39], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [123], [124], [79], [80], [81], [82], [83], [125], [84], [40], [85], [86], [87], [88], [41], [89], [90]
D1525		Tacrine	C13H14N2	1935	Moderate		Inter Info	[1], [2], [3], [129], [130], [131]
D0103		Arformoterol	C19H24N2O4	3083544	Moderate		Inter Info	[39], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [123], [124], [79], [80], [81], [82], [83], [125], [84], [40], [85], [86], [87], [88], [41], [89], [90]
D0184		Bisacodyl	C22H19NO4	2391	Moderate		Inter Info	[1], [2], [3], [145], [146], [147]
D0269		Castor oil	C57H104O9	14030006	Moderate		Inter Info	[1], [2], [3], [145], [146], [147]
D0516		Donepezil	C24H29NO3	3152	Moderate		Inter Info	[1], [2], [3], [129], [130], [131]
D0691		Formoterol	C19H24N2O4	3410	Moderate		Inter Info	[39], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [123], [124], [79], [80], [81], [82], [83], [125], [84], [40], [85], [86], [87], [88], [41], [89], [90]
D0701		Frangula purshiana bark	NA	NA	Moderate		Inter Info	[2], [3], [147]
D0707		Galantamine	C17H21NO3	9651	Moderate		Inter Info	[1], [2], [3], [129], [130], [131]
D0731		Glycerin	C3H8O3	753	Moderate		Inter Info	[1], [2], [3], [145], [146], [147]
D0797		Indacaterol	C24H28N2O3	6918554	Moderate		Inter Info	[39], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [123], [124], [79], [80], [81], [82], [83], [125], [84], [40], [85], [86], [87], [88], [41], [89], [90]
D0887		Lactitol	C12H24O11	157355	Moderate		Inter Info	[1], [2], [3], [145], [146], [147]
D0888		Lactulose	C12H22O11	11333	Moderate		Inter Info	[1], [2], [3], [145], [146], [147]
D0924		Levosalbutamol	C13H21NO3	123600	Moderate		Inter Info	[123], [85], [88]
D0970		Magnesium citrate	C12H10Mg3O14	6099959	Moderate		Inter Info	[1], [2], [3], [145], [146], [147]
D0973		Magnesium hydroxide	H2MgO2	14791	Moderate		Inter Info	[1], [2], [3], [145], [146], [147]
D1069		Mineral oil	NA	NA	Moderate		Inter Info	[1], [2], [3], [145], [146], [147]
D1171		Olodaterol	C21H26N2O5	11504295	Moderate		Inter Info	[39], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [123], [124], [79], [80], [81], [82], [83], [125], [84], [40], [85], [86], [87], [88], [41], [89], [90]
D1266		Phenolphthalein	C20H14O4	4764	Moderate		Inter Info	[1], [2], [3], [145], [146], [147]
D1298		Pirbuterol	C12H20N2O3	4845	Moderate		Inter Info	[39], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [123], [124], [79], [80], [81], [82], [83], [125], [84], [40], [85], [86], [87], [88], [41], [89], [90]
D1309		Polyethylene glycol (3350)	C2H6O2	174	Moderate		Inter Info	[2], [3], [147]
D1418		Rivastigmine	C14H22N2O2	77991	Moderate		Inter Info	[1], [2], [3], [129], [130], [131]
D1438		Salbutamol	C13H21NO3	2083	Moderate		Inter Info	[71], [77], [82]
D1440		Salmeterol	C25H37NO4	5152	Moderate		Inter Info	[39], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [123], [124], [79], [80], [81], [82], [83], [125], [84], [40], [85], [86], [87], [88], [41], [89], [90]
D1695		Vilanterol	C24H33Cl2NO5	10184665	Moderate		Inter Info	[123], [85], [88]
	Increased risk of hypercalcemia					Drug Num: 10
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0158		Bendroflumethiazide	C15H14F3N3O4S2	2315	Moderate		Inter Info	[13], [63]
D0326		Chlorthalidone	C14H11ClN2O4S	2732	Moderate		Inter Info	[13], [63]
D1048		Metolazone	C16H16ClN3O3S	4170	Moderate		Inter Info	[13], [63]
D0166		Benzthiazide	C15H14ClN3O4S3	2343	Moderate		Inter Info	[13], [63]
D0321		Chlorothiazide	C7H6ClN3O4S2	2720	Moderate		Inter Info	[13], [63]
D0771		Hydrochlorothiazide	C7H8ClN3O4S2	3639	Moderate		Inter Info	[13], [63]
D0775		Hydroflumethiazide	C8H8F3N3O4S2	3647	Moderate		Inter Info	[13], [63]
D0798		Indapamide	C16H16ClN3O3S	3702	Moderate		Inter Info	[13], [63]
D1311		Polythiazide	C11H13ClF3N3O4S3	4870	Moderate		Inter Info	[13], [63]
D1633		Trichlormethiazide	C8H8Cl3N3O4S2	5560	Moderate		Inter Info	[13], [63]
Pharmacodynamic antagonistic effects
	Attenuated pharmacological effects (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1894		Sugammadex	C72H112O48S8	6918585	Moderate		Inter Info	[3], [13], [177]

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175	Product Information. Prograf (tacrolimus). Fujisawa, Deerfield, IL.
176	Product Information. Rapamune (sirolimus) Wyeth-Ayerst Laboratories, Philadelphia, PA.
177	Product Information. Bridion (sugammadex). Merck &amp Company Inc, Whitehouse Station, NJ.
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179	Product Information. Flagyl (metronidazole). Searle, Skokie, IL.
180	Product Information. Pylera (bismuth subcitrate potassium/metronidazo/TCN). Aptalis Pharma, Birmingham, AL.
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