Drug General Information (ID: DDIGWX92DJ)
Drug Name			Norethisterone		Drug Info		Elexacaftor		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Contraceptive Agents				Cftr Combinations
Structure

Mechanism of Norethisterone-Elexacaftor Interaction (Severity Level: Moderate)
Increased risk of skin rash Click to Show/Hide Mechanism Graph
Drug Name		Norethisterone				Elexacaftor
Mechanism		Hormonal contraceptives				Increase the risk of skin rash combined with hormonal contraceptives
Key Mechanism Factor 1
		Factor Name		Skin rash
		Factor Description		Skin rashes are the body's reaction to a certain drug. The type of rash that occurs depends on the drug that causes the rash and your reaction to it. Medications are associated with every type of rash, from mild to life-threatening. The timing of the rash may also vary.
Mechanism Description		Increased risk of skin rash by the combination of Norethisterone and Elexacaftor

Recommended Action
Management		Monitor for rash in patients taking both medications. Consider interrupting IVA/TEZ/ELX and hormonal contraceptives in patients who develop rash. Once the rash clears, IVA/TEZ/ELX may be restarted without the hormonal contraceptives. If rash does not recur, resumption of hormonal contraceptives can be considered.

References
1	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
2	Gunston GD, Mehta U "Potentially serious drug interactions with grapefruit juice." S Afr Med J 90 (2000): 41. [PMID: 10721388]
3	Product Information. Trikafta (elexacaftor/ivacaftor/tezacaftor). Vertex Pharmaceuticals, Cambridge, MA.