Details of Drug

Details of Drug

 Drug General Information (ID: D0558)
  Drug Name
Elexacaftor
  Drug Type Small molecule
  Drug Synonymous
Elexacaftor; 2216712-66-0; VX-445; UNII-RRN67GMB0V; RRN67GMB0V; Elexacaftor (USAN); Elexacaftor [USAN]; (S)-N-((1,3-dimethyl-1H-pyrazol-4-yl)sulfonyl)-6-(3-(3,3,3-trifluoro-2,2-dimethylpropoxy)-1H-pyrazol-1-yl)-2-(2,2,4-trimethylpyrrolidin-1-yl)nicotinamide; N-(1,3-dimethylpyrazol-4-yl)sulfonyl-6-[3-(3,3,3-trifluoro-2,2-dimethylpropoxy)pyrazol-1-yl]-2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide; 3-Pyridinecarboxamide, N-((1,3-dimethyl-1H-pyrazol-4-yl)sulfonyl)-6-(3-(3,3,3-trifluoro-2,2-dimethylpropoxy)-1H-pyrazol-1-yl)-2-((4S)-2,2,4-trimethyl-1-pyrrolidinyl)-; Elexacaftor (VX-445); Elexacaftor/Ivacaftor/Tezacaftor; CHEMBL4298128; SCHEMBL20239811; GTPL10552; EX-A3637; s8851; VX-445VX-445; WHO 11180; AT16051; DB15444; Compound 1 [WO2018107100A1]; HY-111772; CS-0090942; D11507; A930250
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  Therapeutic Class Cftr Combinations
  Structure Could Not Find 2D Structure
3D Structure 2D Structure
  Formula C26H34F3N7O4S
  InChI InChI=1S/C26H34F3N7O4S/c1-16-12-25(5,6)35(13-16)22-18(23(37)33-41(38,39)19-14-34(7)31-17(19)2)8-9-20(30-22)36-11-10-21(32-36)40-15-24(3,4)26(27,28)29/h8-11,14,16H,12-13,15H2,1-7H3,(H,33,37)/t16-/m0/s1
  InChIKey MVRHVFSOIWFBTE-INIZCTEOSA-N
  Canonical SMILES C[C@H]1CC(N(C1)C2=C(C=CC(=N2)N3C=CC(=N3)OCC(C)(C)C(F)(F)F)C(=O)NS(=O)(=O)C4=CN(N=C4C)C)(C)C
  External Link
Pubchem ID 134587348

Drug-Drug Interaction Network
  Sunburst Graph
AM002  Affected cellular transport
AM006  Pharmacodynamic additive effects
BM010  Transporter inhibition
BM079  Increased risk of skin rash
  Relation Graph
 Full list of drugs interacting with Elexacaftor
      Affected cellular transport
   Transporter inhibition Drug Num:  16
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0053
 
Ambrisentan
 
C22H22N2O4
 
6918493 
Moderate    Inter Info   
[1], [2], [3]
D0120
 
Atorvastatin
 
C33H35FN2O5
 
60823 
Moderate    Inter Info   
[1], [2], [3]
D0194
 
Bosentan
 
C27H29N5O6S
 
104865 
Moderate    Inter Info   
[1], [2], [3]
D0565
 
Empagliflozin
 
C23H27ClO7
 
11949646 
Moderate    Inter Info   
[1], [2], [3]
D0631
 
Ezetimibe
 
C24H21F2NO3
 
150311 
Moderate    Inter Info   
[1], [2], [3]
D0956
 
Lovastatin
 
C24H36O5
 
53232 
Moderate    Inter Info   
[1], [2], [3]
D1170
 
Olmesartan
 
C24H26N6O3
 
158781 
Moderate    Inter Info   
[1], [2], [3]
D1301
 
Pitavastatin
 
C25H24FNO4
 
5282452 
Moderate    Inter Info   
[1], [2], [3]
D1329
 
Pravastatin
 
C23H36O7
 
54687 
Moderate    Inter Info   
[1], [2], [3]
D1392
 
Repaglinide
 
C27H36N2O4
 
65981 
Moderate    Inter Info   
[1], [2], [3]
D1396
 
Revefenacin
 
C35H43N5O4
 
11753673 
Moderate    Inter Info   
[6], [7], [8]
D1430
 
Rosuvastatin
 
C22H28FN3O6S
 
446157 
Moderate    Inter Info   
[1], [2], [3]
D1457
 
Selexipag
 
C26H32N4O4S
 
9913767 
Moderate    Inter Info   
[1], [2], [3]
D1471
 
Simeprevir
 
C38H47N5O7S2
 
24873435 
Moderate    Inter Info   
[1], [2], [3]
D1473
 
Simvastatin
 
C25H38O5
 
54454 
Moderate    Inter Info   
[1], [2], [3]
D1679
 
Valsartan
 
C24H29N5O3
 
60846 
Moderate    Inter Info   
[1], [2], [3]
      Pharmacodynamic additive effects
   Increased risk of skin rash Drug Num:  5
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0536
 
Drospirenone
 
C24H30O3
 
68873 
Moderate    Inter Info   
[4], [5], [3]
D0619
 
Ethinylestradiol
 
C20H24O2
 
5991 
Moderate    Inter Info   
[4], [5], [3]
D0922
 
Levonorgestrel
 
C21H28O2
 
13109 
Moderate    Inter Info   
[4], [5], [3]
D1154
 
Norethisterone
 
C20H26O2
 
6230 
Moderate    Inter Info   
[4], [5], [3]
D1157
 
Norgestrel
 
C21H28O2
 
13109 
Moderate    Inter Info   
[4], [5], [3]
References
1 Product Information. Cozaar (losartan). Merck &amp Co, Inc, West Point, PA.
2 Product Information. Diovan (valsartan). Novartis Pharmaceuticals, East Hanover, NJ.
3 Product Information. Trikafta (elexacaftor/ivacaftor/tezacaftor). Vertex Pharmaceuticals, Cambridge, MA.
4 Cerner Multum, Inc. "UK Summary of Product Characteristics.".
5 Gunston GD, Mehta U "Potentially serious drug interactions with grapefruit juice." S Afr Med J 90 (2000): 41. [PMID: 10721388]
6 Product Information. Nexletol (bempedoic acid). Esperion Therapeutics, Ann Arbor, MI.
7 Product Information. Nexlizet (bempedoic acid-ezetimibe). Esperion Therapeutics, Ann Arbor, MI.
8 Product Information. Yupelri (revefenacin). Mylan Specialty, Morgantown, WV.