Drug General Information (ID: DDIIF7CBRP)
Drug Name			Norethisterone		Drug Info		Naratriptan		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Contraceptive Agents				Vasoconstrictor Agents
Structure

Mechanism of Norethisterone-Naratriptan Interaction (Severity Level: Minor)
Decreased renal excretion (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Norethisterone				Naratriptan
Mechanism		Decrease the clearance of naratriptan				Naratriptan
Key Mechanism Factor 1
		Factor Name		Pharmacokinetics
		Factor Description		Alters the excretion of the drug, resulting in changes in the plasma concentration of the drug and affecting the pharmacological effects.
Mechanism Description		Decreased renal excretion of Naratriptan caused by Norethisterone

Recommended Action
Management		The clinician should be aware that the risk of side effects associated with naratriptan is increased if these drugs are given together.

References
1	Bailey DG, Arnold JMO, Spence JD "Grapefruit juice and drugs - how significant is the interaction." Clin Pharmacokinet 26 (1994): 91-8. [PMID: 8162660]
2	Gunston GD, Mehta U "Potentially serious drug interactions with grapefruit juice." S Afr Med J 90 (2000): 41. [PMID: 10721388]
3	Product Information. Amerge (naratriptan). Glaxo Wellcome, Research Triangle Park, NC.