Drug General Information (ID: DDIVC3UDZS)
Drug Name			Norethisterone		Drug Info		Linaclotide		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Contraceptive Agents				Guanylate Cyclase-C Agonists
Structure

Mechanism of Norethisterone-Linaclotide Interaction (Severity Level: Moderate)
Altered absorption (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Norethisterone				Linaclotide
Mechanism		Absorption decreased by vomiting/diarrhea-causing agents				Vomiting/diarrhea-causing agent
Key Mechanism Factor 1
		Factor Name		Pharmacokinetic
		Factor Description		Alters the absorption of the drug, leading to changes in the plasma concentration of the drug and affecting the pharmacological effects.
Mechanism Description		Altered absorption of Norethisterone caused by Linaclotide

Recommended Action
Management		In patients who develop severe diarrhea during treatment with linaclotide, European labeling recommends use of an additional contraceptive method to prevent possible failure of oral contraception.

References
1	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
2	EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports.".
3	Product Information. Linzess (linaclotide). Forest Pharmaceuticals, St. Louis, MO.