Details of Drug

Details of Drug

 Drug General Information (ID: D0929)
  Drug Name
Linaclotide
  Drug Type Small molecule
  Drug Synonymous
Linaclotide (USAN)
    Click to Show/Hide
  Disease Class DD91: Irritable bowel syndrome
  Therapeutic Class Guanylate Cyclase-C Agonists
  Structure Could Not Find 2D Structure
3D Structure 2D Structure
  Formula C59H79N15O21S6
  InChI 1S/C59H79N15O21S6/c1-26-47(82)69-41-25-101-99-22-38-52(87)65-33(13-14-45(80)81)49(84)66-34(16-28-5-9-30(76)10-6-28)50(85)71-40(54(89)72-39(23-97-96-20-32(60)48(83)70-38)53(88)67-35(18-43(61)78)58(93)74-15-3-4-42(74)56(91)63-26)24-100-98-21-37(64-44(79)19-62-57(92)46(27(2)75)73-55(41)90)51(86)68-36(59(94)95)17-29-7-11-31(77)12-8-29/h5-12,26-27,32-42,46,75-77H,3-4,13-25,60H2,1-2H3,(H2,61,78)(H,62,92)(H,63,91)(H,64,79)(H,65,87)(H,66,84)(H,67,88)(H,68,86)(H,69,82)(H,70,83)(H,71,85)(H,72,89)(H,73,90)(H,80,81)(H,94,95)/t26-,27+,32-,33-,34-,35-,36-,37-,38-,39-,40-,41-,42-,46-/m0/s1
  InChIKey KXGCNMMJRFDFNR-WDRJZQOASA-N
  Canonical SMILES CC1C(=O)NC2CSSCC3C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(NC(=O)CNC(=O)C(NC2=O)C(C)O)C(=O)NC(CC4=CC=C(C=C4)O)C(=O)O)C(=O)NC(CSSCC(C(=O)N3)N)C(=O)NC(C(=O)N5CCCC5C(=O)N1)CC(=O)N)CC6=CC=C(C=C6)O)CCC(=O)O
  External Link
Pubchem ID 16158208
CAS Number 851199-59-2
CHEBI ID 68551
TTD ID D00GNJ

Drug-Drug Interaction Network
  Sunburst Graph
AM001  Affected gastrointestinal absorption
AM006  Pharmacodynamic additive effects
BM009  Altered absorption (Unspecific)
BM109  Increased risk of other adverse reactions (Unspecific)
  Relation Graph
 Full list of drugs interacting with Linaclotide
      Affected gastrointestinal absorption
   Altered absorption (Unspecific) Drug Num:  10
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0619
 
Ethinylestradiol
 
C20H24O2
 
5991 
Moderate    Inter Info   
[1], [2], [3]
D0626
 
Etonogestrel
 
C22H28O2
 
6917715 
Moderate    Inter Info   
[1], [4], [3]
D0922
 
Levonorgestrel
 
C21H28O2
 
13109 
Moderate    Inter Info   
[1], [4], [3]
D0925
 
Levothyroxine
 
C15H11I4NO4
 
5819 
Moderate    Inter Info   
[1], [4]
D0485
 
Dienogest
 
C20H25NO2
 
68861 
Moderate    Inter Info   
[1], [2], [3]
D1157
 
Norgestrel
 
C21H28O2
 
13109 
Moderate    Inter Info   
[1], [4], [3]
D1577
 
Thyroid, porcine
 
NA
 
NA
Moderate    Inter Info   
[1], [2], [6]
D0935
 
Liotrix
 
C30H21I7N2Na2O8
 
71371 
Moderate    Inter Info   
[1], [4]
D1011
 
Mestranol
 
C21H26O2
 
6291 
Moderate    Inter Info   
[1], [2], [3]
D1154
 
Norethisterone
 
C20H26O2
 
6230 
Moderate    Inter Info   
[1], [2], [3]
      Pharmacodynamic additive effects
   Increased risk of other adverse reactions (Unspecific) Drug Num:  45
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0789
 
Idelalisib
 
C22H18FN7O
 
11625818 
Moderate    Inter Info   
[5]
D0210
 
Bromfenac
 
C15H12BrNO3
 
60726 
Minor    Inter Info   
[2], [3]
D0458
 
Dexlansoprazole
 
C16H14F3N3O2S
 
9578005 
Minor    Inter Info   
[2], [3]
D0476
 
Diclofenac
 
C14H11Cl2NO2
 
3033 
Minor    Inter Info   
[2], [3]
D0603
 
Esomeprazole
 
C17H19N3O3S
 
9568614 
Minor    Inter Info   
[2], [3]
D0624
 
Etodolac
 
C17H21NO3
 
3308 
Minor    Inter Info   
[2], [3]
D0645
 
Fenoprofen
 
C15H14O3
 
3342 
Minor    Inter Info   
[2], [3]
D0680
 
Flurbiprofen
 
C15H13FO2
 
3394 
Minor    Inter Info   
[2], [3]
D0786
 
Ibuprofen
 
C13H18O2
 
3672 
Minor    Inter Info   
[2], [3]
D0800
 
Indomethacin
 
C19H16ClNO4
 
3715 
Minor    Inter Info   
[2], [3]
D1820
 
Inulin
 
C228H382O191
 
24763 
Minor    Inter Info   
[2], [3]
D0881
 
Ketoprofen
 
C16H14O3
 
3825 
Minor    Inter Info   
[2], [3]
D0882
 
Ketorolac
 
C15H13NO3
 
3826 
Minor    Inter Info   
[2], [3]
D0888
 
Lactulose
 
C12H22O11
 
11333 
Minor    Inter Info   
[2], [3]
D0892
 
Lansoprazole
 
C16H14F3N3O2S
 
3883 
Minor    Inter Info   
[2], [3]
D0184
 
Bisacodyl
 
C22H19NO4
 
2391 
Minor    Inter Info   
[2], [3]
D0269
 
Castor oil
 
C57H104O9
 
14030006 
Minor    Inter Info   
[2], [3]
D0512
 
Docusate
 
C20H38O7S
 
11339 
Minor    Inter Info   
[2], [3]
D0701
 
Frangula purshiana bark
 
NA
 
NA
Minor    Inter Info   
[2], [3]
D0731
 
Glycerin
 
C3H8O3
 
753 
Minor    Inter Info   
[2], [3]
D0970
 
Magnesium citrate
 
C12H10Mg3O14
 
6099959 
Minor    Inter Info   
[2], [3]
D0973
 
Magnesium hydroxide
 
H2MgO2
 
14791 
Minor    Inter Info   
[2], [3]
D1034
 
Methylcellulose
 
C29H54O16
 
44263857 
Minor    Inter Info   
[2], [3]
D1059
 
Microcrystalline cellulose
 
H2
 
783 
Minor    Inter Info   
[2], [3]
D1069
 
Mineral oil
 
NA
 
NA
Minor    Inter Info   
[2], [3]
D1287
 
Picosulfuric acid
 
C18H15NO8S2
 
5243 
Minor    Inter Info   
[2], [3]
D1303
 
Plantago seed
 
NA
 
NA
Minor    Inter Info   
[2], [3]
D1308
 
Polyethylene glycol (3350 with electrolytes)
 
C2H6O2
 
174 
Minor    Inter Info   
[2], [3]
D1309
 
Polyethylene glycol (3350)
 
C2H6O2
 
174 
Minor    Inter Info   
[2], [3]
D1486
 
Sodium phosphate, monobasic
 
NA
 
NA
Minor    Inter Info   
[2], [3]
D0975
 
Magnesium sulfate
 
MgO4S
 
24083 
Minor    Inter Info   
[2], [3]
D0988
 
Meclofenamic acid
 
C14H11Cl2NO2
 
4037 
Minor    Inter Info   
[2], [3]
D0991
 
Mefenamic acid
 
C15H15NO2
 
4044 
Minor    Inter Info   
[2], [3]
D0995
 
Meloxicam
 
C14H13N3O4S2
 
54677470 
Minor    Inter Info   
[2], [3]
D1097
 
Nabumetone
 
C15H16O2
 
4409 
Minor    Inter Info   
[2], [3]
D1109
 
Naproxen
 
C14H14O3
 
156391 
Minor    Inter Info   
[2], [3]
D1179
 
Omeprazole
 
C17H19N3O3S
 
4594 
Minor    Inter Info   
[2], [3]
D1196
 
Oxaprozin
 
C18H15NO3
 
4614 
Minor    Inter Info   
[2], [3]
D1222
 
Pantoprazole
 
C16H15F2N3O4S
 
4679 
Minor    Inter Info   
[2], [3]
D1266
 
Phenolphthalein
 
C20H14O4
 
4764 
Minor    Inter Info   
[2], [3]
D1274
 
Phenylbutazone
 
C19H20N2O2
 
4781 
Minor    Inter Info   
[2], [3]
D1300
 
Piroxicam
 
C15H13N3O4S
 
54676228 
Minor    Inter Info   
[2], [3]
D1373
 
Rabeprazole
 
C18H21N3O3S
 
5029 
Minor    Inter Info   
[2], [3]
D1520
 
Sulindac
 
C20H17FO3S
 
1548887 
Minor    Inter Info   
[2], [3]
D1606
 
Tolmetin
 
C15H15NO3
 
5509 
Minor    Inter Info   
[2], [3]
References
1 Cerner Multum, Inc. "UK Summary of Product Characteristics.".
2 EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports.".
3 Product Information. Linzess (linaclotide). Forest Pharmaceuticals, St. Louis, MO.
4 EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports.".
5 Product Information. Zydelig (idelalisib). Gilead Sciences, Foster City, CA.
6 Wohlt PD, Zheng L, Gunderson S, Balzar SA, Johnson BD, Fish JT "Recommendations for the use of medications with continuous enteral nutrition." Am J Health Syst Pharm 66 (2009): 1438-67. [PMID: 19667002]