Drug General Information (ID: DDI30YHACG)
Drug Name			Linaclotide		Drug Info		Thyroid, porcine		Drug Info
Drug Type		Small molecule				Hormones
Therapeutic Class		Guanylate Cyclase-C Agonists				Thyroid Drugs

Mechanism of Linaclotide-Thyroid, porcine Interaction (Severity Level: Moderate)
Altered absorption (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Linaclotide				Thyroid, porcine
Mechanism		Vomiting/diarrhea-causing agent				Absorption decreased by vomiting/diarrhea-causing agents
Key Mechanism Factor 1
		Factor Name		Pharmacokinetic
		Factor Description		Alters the absorption of the drug, leading to changes in the plasma concentration of the drug and affecting the pharmacological effects.
Mechanism Description		Altered absorption of Thyroid, porcine caused by Linaclotide

Recommended Action
Management		Caution and monitoring for altered efficacy is recommended during concomitant use.

References
1	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
2	EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports.".
3	Wohlt PD, Zheng L, Gunderson S, Balzar SA, Johnson BD, Fish JT "Recommendations for the use of medications with continuous enteral nutrition." Am J Health Syst Pharm 66 (2009): 1438-67. [PMID: 19667002]