Drug General Information (ID: DDIRPZ9037)
Drug Name			Indomethacin		Drug Info		Linaclotide		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antiinflammatory Agents				Guanylate Cyclase-C Agonists
Structure

Mechanism of Indomethacin-Linaclotide Interaction (Severity Level: Minor)
Increased risk of other adverse reactions (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Indomethacin				Linaclotide
Mechanism		Increase the risk of diarrhoea combined with linaclotide				Linaclotide
Key Mechanism Factor 1
		Factor Name		Adverse reactions
		Factor Description		An adverse reaction is an unexpected negative reaction to a medication or treatment that happens even when it's used correctly.
Mechanism Description		Increased risk of adverse reactions by the combination of Indomethacin and Linaclotide

References
1	EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports.".
2	Product Information. Linzess (linaclotide). Forest Pharmaceuticals, St. Louis, MO.