Drug General Information (ID: DDIIODZER1)
Drug Name			Linaclotide		Drug Info		Norgestrel		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Guanylate Cyclase-C Agonists				Contraceptive Agents
Structure

Mechanism of Linaclotide-Norgestrel Interaction (Severity Level: Moderate)
Altered absorption (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Linaclotide				Norgestrel
Mechanism		Vomiting/diarrhea-causing agent				Absorption decreased by vomiting/diarrhea-causing agents
Key Mechanism Factor 1
		Factor Name		Pharmacokinetic
		Factor Description		Alters the absorption of the drug, leading to changes in the plasma concentration of the drug and affecting the pharmacological effects.
Mechanism Description		Altered absorption of Norgestrel caused by Linaclotide

Recommended Action
Management		In patients who develop severe diarrhea during treatment with linaclotide, European labeling recommends use of an additional contraceptive method to prevent possible failure of oral contraception.

References
1	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
2	EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports.".
3	Product Information. Linzess (linaclotide). Forest Pharmaceuticals, St. Louis, MO.