Details of Drug

Drug General Information (ID: D1157)
Drug Name	Norgestrel
Drug Type	Small molecule
Drug Synonymous	norgestrel; 797-63-7; D-Norgestrel; (-)-Norgestrel; Microval; Levonova; Postinor; Mirena; Ovrette; Neogest; Jadelle; Plan B; NORPLANT; Norplant 2; Microlution; Follistrel; Trivora; Monovar; Triciclor; Microgyn; Ovranette; Triagynon; Microlut; Nordet; Trigoa; 18-Methylnorethisterone; Levonorgestrelum; Microgynon CD; Microgest ED; Norplant II; Ovral-Lo; Logynon ED; Levlen ED; Trinordiol 28; Trinordiol 21; Microgynon 28; Microgynon 21; d(-)-Norgestrel; Neogynon 21; Monofeme 28; Nordette 28; Minivlar 30; Stediril 30; Nordette 21; Trifeme; Capronor; DNorgestrel; Levlen; Levonelle; Methylnorethindrone; Microluton; NorLevo; Norgeston; Norgestrel; Norgestrelum; Preven; Tetragynon; LD norgestrel [French]; Ld norgestrel; Levonorgestrel implants; Norgestrel [Progestins]; Norplant System in Plastic Container; Triquilar ED; Microgynon 30 ED; SH 70850; SH 850; Trifeme 28; Triphasil 21; Triphasil 28; Wy 3707; Alpha-Norgestrel; Component of Lo/ovral; Dl-Norgestrel; FH 122-A; LO/Ovral; Levonorgestrelum [INN-Latin]; Levora-21; Levora-28; Mirena (TN); Norgestrelum [INN-Latin]; Norplant (TN); Norplant-2; Ovoplex 30-150; Ovrette (TN); Postinor-2; Rigevidon 21+7; SOH-075; Tri-Levlen 21; Wy-3707; Wy-5104; E-Gen-C; Levonorgestrel [USAN:INN:BAN]; D(-)-Norgestrel; Levonorgestrel (JAN/USP/INN); Norgestrel (JP15/USP/INN); Norgestrel [USAN:BAN:INN:JAN]; Norgestrel [USAN:INN:BAN:JAN]; D-(-)-Norgestrel; Levonelle, D-Norgestrel, Levonova, Levonorgestrel; Norgestrel-(-)-D; Dl-13-beta-Ethyl-17-alpha-ethynyl-19-nortestosterone; 13-BETA-ETHYL-17-ALPHA-ETHYNYL-17-BETA-HYDROXYGON-4-EN-3-ONE; 13-Ehyl-17alpha-ethynyl-17-hydroxygon-4-en-3-one; 13-Ethyl-17-alpha-ethynyl-17-beta-hydroxy-4-gonen-3-one; 13-Ethyl-17-alpha-ethynylgon-4-en-17-beta-ol-3-one; 13-Ethyl-17alpha-ethynylgon-4-en-17beta-ol-3-one; 13-beta-Ethyl-17alpha-ethynyl-17beta-hydroxygon-4-en-3-one; 13beta-Ethyl-17alpha-ethynyl-17beta-hydroxygon-4-en-3-one; 17-Ethynyl-18-methyl-19-nortestosterone; 17-alpha-Ethynyl-13-ethyl-19-nortestosterone; 17alpha-Ethynyl-13-ethyl-19-nortestosterone; 17alpha-Ethynyl-13beta-ethyl-3-oxo-4-estren-17beta-ol; 17alpha-Ethynyl-17-hydroxy-18-methylestr-4-en-3-one; 17alpha-Ethynyl-18-homo-19-nor-testosterone; 17alpha-Ethynyl-18-homo-19-nortestosterone; 17alpha-ethynyl-17beta-hydroxy-18a-homoestr-4-en-3-one; 18,19-Dinor-4-pregnen-20-yn-3-one; 18-Methyl-17-alpha-ethynyl-19-nortestosterone; 72-HOURS Click to Show/Hide
Disease Class	QA21: Contraceptive management
Therapeutic Class	Contraceptive Agents
Structure
Structure	3D Structure		2D Structure
Formula	C21H28O2
InChI	1S/C21H28O2/c1-3-20-11-9-17-16-8-6-15(22)13-14(16)5-7-18(17)19(20)10-12-21(20,23)4-2/h2,13,16-19,23H,3,5-12H2,1H3/t16-,17+,18+,19-,20-,21-/m0/s1
InChIKey	WWYNJERNGUHSAO-XUDSTZEESA-N
Canonical SMILES	CCC12CCC3C(C1CCC2(C#C)O)CCC4=CC(=O)CCC34
External Link
	Pubchem ID	13109
	CAS Number	797-63-7
	CHEBI ID	6443
	TTD ID	D0BA9U
	INTEDE ID	DR0946
	VARIDT ID	DR01186

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM001 Affected gastrointestinal absorption AM004 Affected intra/extra-hepatic metabolism AM005 Affected excretion pathways AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM003 Complex formation BM009 Altered absorption (Unspecific) BM016 Altered formation of CYP450 enzymes BM017 CYP450 enzyme inhibition BM019 UGT inhibition BM020 Decreased metabolism due to hepatotoxicity BM022 CYP450 enzyme induction BM023 UGT induction BM024 Competitive inhibition of metabolic enzyme BM025 Decreased metabolism (Unspecific) BM032 Decreased renal excretion (Unspecific) BM047 Additive thrombogenic effects BM079 Increased risk of skin rash BM086 Antagonize the effect of antidiabetic agents BM089 Antagonize the effect of antihypertensive agents BM107 Attenuated pharmacological effects (Unspecific)
Relation Graph

Full list of drugs interacting with Norgestrel
Affected gastrointestinal absorption
	Complex formation					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0329		Cholestyramine	C27H47ClN2	137699107	Moderate		Inter Info	[141], [142], [127], [143], [144], [145], [146]
D0381		Colesevelam	C31H67Cl3N4O	160051	Moderate		Inter Info	[156]
D0382		Colestipol	C11H28ClN5O	62816	Moderate		Inter Info	[141], [142], [127], [143], [144], [145], [146]
	Altered absorption (Unspecific)					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0929		Linaclotide	C59H79N15O21S6	16158208	Moderate		Inter Info	[38], [175], [176]
D1068		Miltefosine	C21H46NO4P	3599	Moderate		Inter Info	[181]
D1362		Prucalopride	C18H26ClN3O3	3052762	Moderate		Inter Info	[127], [38], [208]
Affected intra/extra-hepatic metabolism
	Altered formation of CYP450 enzymes					Drug Num: 18
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0023		Adalimumab	NA	NA	Moderate		Inter Info	[38], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121]
D0032		Alefacept	NA	NA	Moderate		Inter Info	[38], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121]
D0085		Anakinra	C20H23N5O7S2	146171046	Moderate		Inter Info	[38], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121]
D0246		Canakinumab	NA	NA	Moderate		Inter Info	[38], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121]
D0304		Certolizumab pegol	NA	NA	Moderate		Inter Info	[111], [113], [118]
D0614		Etanercept	NA	NA	Moderate		Inter Info	[38], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121]
D0736		Golimumab	NA	NA	Moderate		Inter Info	[38], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121]
D0802		Infliximab	NA	NA	Moderate		Inter Info	[38], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121]
D0564		Emapalumab	NA	NA	Moderate		Inter Info	[111], [113], [118]
D0747		Guselkumab	NA	NA	Moderate		Inter Info	[38], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121]
D0875		Ixekizumab	NA	NA	Moderate		Inter Info	[38], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121]
D1447		Sarilumab	NA	NA	Moderate		Inter Info	[38], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121]
D1448		Satralizumab	NA	NA	Moderate		Inter Info	[111], [113], [118]
D1403		Rilonacept	NA	NA	Moderate		Inter Info	[38], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121]
D1454		Secukinumab	NA	NA	Moderate		Inter Info	[38], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121]
D1467		Siltuximab	NA	NA	Moderate		Inter Info	[111], [113], [118]
D1599		Tocilizumab	NA	NA	Moderate		Inter Info	[38], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121]
D1671		Ustekinumab	NA	NA	Moderate		Inter Info	[38], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121]
	CYP450 enzyme inhibition					Drug Num: 37
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0692		Fosamprenavir	C25H36N3O9PS	131536	Major		Inter Info	[40], [41], [42]
D0116		Atazanavir	C38H52N6O7	148192	Moderate		Inter Info	[134]
D0349		Clarithromycin	C38H69NO13	84029	Moderate		Inter Info	[127], [38], [4], [147], [148], [139], [149]
D0367		Clotrimazole	C22H17ClN2	2812	Moderate		Inter Info	[151], [152], [153], [154], [155], [52]
D0386		Conivaptan	C32H26N4O2	151171	Moderate		Inter Info	[157]
D0426		Darunavir	C27H37N3O7S	213039	Moderate		Inter Info	[160]
D0497		Diltiazem	C22H26N2O4S	39186	Moderate		Inter Info	[162], [163], [164], [165], [166]
D0597		Erythromycin	C37H67NO13	12560	Moderate		Inter Info	[127], [38], [4], [147], [148], [139], [149]
D0667		Fluconazole	C13H12F2N6O	3365	Moderate		Inter Info	[151], [152], [153], [154], [155], [52]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Moderate		Inter Info	[169], [170]
D0852		Isavuconazonium	C35H35F2N8O5S+	6918606	Moderate		Inter Info	[38], [171]
D0867		Itraconazole	C35H38Cl2N8O4	55283	Moderate		Inter Info	[151], [152], [153], [154], [155], [52]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Moderate		Inter Info	[151], [152], [153], [154], [155], [52]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Moderate		Inter Info	[174]
D0944		Lomitapide	C39H37F6N3O2	9853053	Moderate		Inter Info	[177]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Moderate		Inter Info	[178]
D1050		Metreleptin	NA	NA	Moderate		Inter Info	[179]
D1057		Miconazole	C18H14Cl4N2O	4189	Moderate		Inter Info	[151], [152], [153], [154], [155], [52]
D1117		Nefazodone	C25H32ClN5O2	4449	Moderate		Inter Info	[182]
D0002		Abametapir (topical)	C12H12N2	15664	Moderate		Inter Info	[188]
D0543		Duvelisib	C22H17ClN6O	50905713	Moderate		Inter Info	[189]
D0638		Fedratinib	C27H36N6O3S	16722836	Moderate		Inter Info	[38], [193]
D0699		Fostamatinib	C23H26FN6O9P	11671467	Moderate		Inter Info	[194]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Moderate		Inter Info	[127], [38], [196]
D0899		Lefamulin	C28H45NO5S	25185057	Moderate		Inter Info	[197]
D0906		Letermovir	C29H28F4N4O4	45138674	Moderate		Inter Info	[127], [38], [199]
D1432		Rucaparib	C19H18FN3O	9931954	Moderate		Inter Info	[202]
D1459		Selpercatinib	C29H31N7O3	134436906	Moderate		Inter Info	[203], [204]
D1315		Posaconazole	C37H42F2N8O4	468595	Moderate		Inter Info	[151], [152], [153], [154], [155], [52]
D1444		Saquinavir	C38H50N6O5	441243	Moderate		Inter Info	[210], [211]
D1455		Selegiline	C13H17N	26757	Moderate		Inter Info	[212]
D1505		Stiripentol	C14H18O3	5311454	Moderate		Inter Info	[175]
D1544		Telithromycin	C43H65N5O10	3002190	Moderate		Inter Info	[215], [204], [216]
D1706		Voriconazole	C16H14F3N5O	71616	Moderate		Inter Info	[151], [152], [153], [154], [155], [52]
D0120		Atorvastatin	C33H35FN2O5	60823	Minor		Inter Info	[225]
D0439		Delavirdine	C22H28N6O3S	5625	Minor		Inter Info	[229], [230], [231]
D0799		Indinavir	C36H47N5O4	5362440	Minor		Inter Info	[233]
	Decreased metabolism due to hepatotoxicity					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0113		Asparaginase Erwinia chrysanthemi	NA	NA	Moderate		Inter Info	[127], [38], [133]
D0114		Asparaginase Escherichia coli	NA	NA	Moderate		Inter Info	[127], [38], [133]
D0232		Calaspargase pegol	NA	NA	Moderate		Inter Info	[127], [38], [133]
	CYP450 enzyme induction					Drug Num: 59
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0080		Amprenavir	C25H35N3O6S	65016	Major		Inter Info	[1], [2], [3]
D0178		Bexarotene	C24H28O2	82146	Major		Inter Info	[4], [5]
D0194		Bosentan	C27H29N5O6S	104865	Major		Inter Info	[4], [6]
D0255		Carbamazepine	C15H12N2O	2554	Major		Inter Info	[7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [4], [17], [1], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37]
D0406		Dabrafenib	C23H20F3N5O2S2	44462760	Major		Inter Info	[4], [39]
D0639		Felbamate	C11H14N2O4	3331	Major		Inter Info	[7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [4], [17], [1], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37]
D0697		Fosphenytoin	C16H15N2O6P	56339	Major		Inter Info	[7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [4], [17], [1], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37]
D0741		Griseofulvin	C17H17ClO6	441140	Major		Inter Info	[10], [43], [44], [45], [4], [1], [46], [47], [48], [49], [50], [51], [52]
D0958		Lumacaftor	C24H18F2N2O5	16678941	Major		Inter Info	[38], [53], [54]
D0204		Brigatinib	C29H39ClN7O2P	68165256	Major		Inter Info	[57]
D0569		Encorafenib	C22H27ClFN7O4S	50922675	Major		Inter Info	[58]
D0601		Eslicarbazepine	C15H14N2O2	9881504	Major		Inter Info	[7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [4], [17], [1], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Major		Inter Info	[59], [60], [49]
D1198		Oxcarbazepine	C15H12N2O2	34312	Major		Inter Info	[7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [4], [17], [1], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37]
D1265		Phenobarbital	C12H12N2O3	4763	Major		Inter Info	[7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [4], [17], [1], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37]
D1283		Phenytoin	C15H12N2O2	1775	Major		Inter Info	[7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [4], [17], [1], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37]
D1340		Primidone	C12H14N2O2	4909	Major		Inter Info	[7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [4], [17], [1], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37]
D1399		Rifabutin	C46H62N4O11	135398743	Major		Inter Info	[61], [7], [62], [63], [64], [9], [11], [65], [66], [67], [68], [69], [14], [70], [45], [16], [4], [1], [71], [72], [73], [74], [75], [76], [77], [78], [60], [36], [79], [50], [52], [80]
D1400		Rifampicin	C43H58N4O12	135398735	Major		Inter Info	[63], [76], [79]
D1401		Rifapentine	C47H64N4O12	135403821	Major		Inter Info	[61], [7], [62], [63], [64], [9], [11], [65], [66], [67], [68], [69], [14], [70], [45], [16], [4], [1], [71], [72], [73], [74], [75], [76], [77], [78], [60], [36], [79], [50], [52], [80]
D1502		St. John's Wort	NA	NA	Major		Inter Info	[81], [82], [83], [4], [1], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97]
D1541		Telaprevir	C36H53N7O6	3010818	Major		Inter Info	[53], [100], [101]
D0071		Amobarbital	C11H18N2O3	2164	Moderate		Inter Info	[9], [26], [30]
D0100		Aprepitant	C23H21F7N4O3	135413536	Moderate		Inter Info	[4], [125], [126]
D0106		Armodafinil	C15H15NO2S	9690109	Moderate		Inter Info	[127], [4], [128], [129], [130], [131]
D0108		Artemether	C16H26O5	68911	Moderate		Inter Info	[53], [41], [132]
D0224		Butabarbital	C10H16N2O3	2479	Moderate		Inter Info	[7], [8], [9], [10], [11], [12], [135], [14], [16], [4], [18], [19], [136], [23], [24], [137], [26], [30], [35], [36]
D0300		Cenobamate	C10H10ClN5O2	11962412	Moderate		Inter Info	[7], [62], [8], [64], [9], [11], [65], [67], [68], [44], [12], [13], [135], [14], [45], [16], [82], [4], [18], [85], [86], [138], [20], [22], [23], [72], [24], [47], [73], [137], [74], [25], [91], [139], [93], [78], [60], [36], [95], [49], [79], [50], [51], [52], [37], [80], [140]
D0356		Clobazam	C16H13ClN2O2	2789	Moderate		Inter Info	[4], [150]
D0432		Deferasirox	C21H15N3O4	214348	Moderate		Inter Info	[161]
D0554		Efavirenz	C14H9ClF3NO2	64139	Moderate		Inter Info	[38], [4], [167], [168]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Moderate		Inter Info	[7], [62], [8], [64], [9], [11], [65], [67], [68], [44], [12], [13], [135], [14], [45], [16], [82], [4], [18], [85], [86], [138], [20], [22], [23], [72], [24], [47], [73], [137], [74], [25], [91], [139], [93], [78], [60], [36], [95], [49], [79], [50], [51], [52], [37], [80], [140]
D0693		Fosaprepitant	C23H22F7N4O6P	135413538	Moderate		Inter Info	[4], [125], [126]
D1040		Methylphenobarbital	C13H14N2O3	8271	Moderate		Inter Info	[9], [26], [30]
D1078		Mitotane	C14H10Cl4	4211	Moderate		Inter Info	[7], [62], [8], [64], [9], [11], [65], [67], [68], [44], [12], [13], [135], [14], [45], [16], [82], [4], [18], [85], [86], [138], [20], [22], [23], [72], [24], [47], [73], [137], [74], [25], [91], [139], [93], [78], [60], [36], [95], [49], [79], [50], [51], [52], [37], [80], [140]
D1081		Modafinil	C15H15NO2S	4236	Moderate		Inter Info	[127], [4], [128], [129], [130], [131]
D1099		Nafcillin	C21H22N2O5S	8982	Moderate		Inter Info	[7], [62], [8], [64], [9], [11], [65], [67], [68], [44], [12], [13], [135], [14], [45], [16], [82], [4], [18], [85], [86], [138], [20], [22], [23], [72], [24], [47], [73], [137], [74], [25], [91], [139], [93], [78], [60], [36], [95], [49], [79], [50], [51], [52], [37], [80], [140]
D1119		Nelfinavir	C32H45N3O4S	64143	Moderate		Inter Info	[38], [4], [1], [183]
D1128		Nevirapine	C15H14N4O	4463	Moderate		Inter Info	[186], [4], [187]
D0095		Apalutamide	C21H15F4N5O2S	24872560	Moderate		Inter Info	[7], [62], [8], [64], [9], [11], [65], [67], [68], [44], [12], [13], [135], [14], [45], [16], [82], [4], [18], [85], [86], [138], [20], [22], [23], [72], [24], [47], [73], [137], [74], [25], [91], [139], [93], [78], [60], [36], [95], [49], [79], [50], [51], [52], [37], [80], [140]
D0545		Echinacea	NA	NA	Moderate		Inter Info	[127], [190]
D0555		Elagolix	C32H30F5N3O5	11250647	Moderate		Inter Info	[9], [45], [49]
D0568		Enasidenib	C19H17F6N7O	89683805	Moderate		Inter Info	[40], [41], [192]
D0872		Ivosidenib	C28H22ClF3N6O3	71657455	Moderate		Inter Info	[195]
D0901		Lemborexant	C22H20F2N4O2	56944144	Moderate		Inter Info	[9], [45], [49]
D0905		Lesinurad	C17H14BrN3O2S	53465279	Moderate		Inter Info	[40], [41], [198]
D0953		Lorlatinib	C21H19FN6O2	71731823	Moderate		Inter Info	[7], [62], [8], [64], [9], [11], [65], [67], [68], [44], [12], [13], [135], [14], [45], [16], [82], [4], [18], [85], [86], [138], [20], [22], [23], [72], [24], [47], [73], [137], [74], [25], [91], [139], [93], [78], [60], [36], [95], [49], [79], [50], [51], [52], [37], [80], [140]
D1302		Pitolisant	C17H26ClNO	9948102	Moderate		Inter Info	[38], [4], [201]
D1493		Somapacitan	C54H95N13O20S2	129894493	Moderate		Inter Info	[127], [38], [205]
D1538		Tazemetostat	C34H44N4O4	66558664	Moderate		Inter Info	[41], [206]
D1546		Telotristat ethyl	C27H26ClF3N6O3	25181577	Moderate		Inter Info	[38], [207]
D1248		Pentobarbital	C11H18N2O3	4737	Moderate		Inter Info	[7], [8], [9], [10], [11], [12], [135], [14], [16], [4], [18], [19], [136], [23], [24], [137], [26], [30], [35], [36]
D1433		Rufinamide	C10H8F2N4O	129228	Moderate		Inter Info	[127], [38], [4], [209], [29]
D1453		Secobarbital	C12H18N2O3	5193	Moderate		Inter Info	[9], [26], [30]
D1494		Somatotropin	NA	NA	Moderate		Inter Info	[127], [38], [205]
D1652		Troglitazone	C24H27NO5S	5591	Moderate		Inter Info	[217], [218], [219]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Moderate		Inter Info	[7], [62], [8], [64], [9], [11], [65], [67], [68], [44], [12], [13], [135], [14], [45], [16], [82], [4], [18], [85], [86], [138], [20], [22], [23], [72], [24], [47], [73], [137], [74], [25], [91], [139], [93], [78], [60], [36], [95], [49], [79], [50], [51], [52], [37], [80], [140]
D0208		Brivaracetam	C11H20N2O2	9837243	Minor		Inter Info	[38], [226], [227], [228]
D1294		Pioglitazone	C19H20N2O3S	4829	Minor		Inter Info	[235], [217], [236], [237], [238]
	UGT induction					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1677		Valproic acid	C8H16O2	3121	Moderate		Inter Info	[221], [222], [223], [224]
	Competitive inhibition of metabolic enzyme					Drug Num: 6
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0402		Cyclosporine	C62H111N11O12	5284373	Moderate		Inter Info	[158], [159]
D1127		Netupitant	C30H32F6N4O	6451149	Moderate		Inter Info	[127], [184], [185]
D0696		Fosnetupitant	C31H35F6N4O5P	71544786	Moderate		Inter Info	[127], [184], [185]
D1476		Sirolimus	C51H79NO13	5284616	Moderate		Inter Info	[213], [214]
D1526		Tacrolimus	C44H69NO12	445643	Moderate		Inter Info	[213], [214]
D1549		Temsirolimus	C56H87NO16	6918289	Moderate		Inter Info	[213], [214]
	Decreased metabolism (Unspecific)					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0064		Aminophylline	C16H24N10O4	9433	Moderate		Inter Info	[122], [123], [124]
D1570		Theophylline	C7H8N4O2	2153	Moderate		Inter Info	[122], [123], [124]
D0617		Ethanol	C2H6O	702	Minor		Inter Info	[232]
Affected excretion pathways
	Decreased renal excretion (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1110		Naratriptan	C17H25N3O2S	4440	Minor		Inter Info	[40], [41], [234]
Pharmacodynamic additive effects
	Additive thrombogenic effects					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0261		Carfilzomib	C40H57N5O7	11556711	Major		Inter Info	[38], [4]
D1619		Tranexamic acid	C8H15NO2	5526	Major		Inter Info	[102], [103], [104]
	Increased risk of skin rash					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0558		Elexacaftor	C26H34F3N7O4S	134587348	Moderate		Inter Info	[38], [41], [191]
Pharmacodynamic antagonistic effects
	Antagonize the effect of antidiabetic agents					Drug Num: 34
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0009		Acarbose	C25H43NO18	41774	Moderate		Inter Info	[105], [106], [107]
D0029		Albiglutide	C148H224N40O45	145994868	Moderate		Inter Info	[105], [106], [107]
D0042		Alogliptin	C18H21N5O2	11450633	Moderate		Inter Info	[105], [106], [107]
D0245		Canagliflozin	C24H25FO5S	24812758	Moderate		Inter Info	[105], [106], [107]
D0325		Chlorpropamide	C10H13ClN2O3S	2727	Moderate		Inter Info	[105], [106], [107]
D0418		Dapagliflozin	C21H25ClO6	9887712	Moderate		Inter Info	[105], [106], [107]
D1779		Dulaglutide	NA	NA	Moderate		Inter Info	[105], [106], [107]
D0565		Empagliflozin	C23H27ClO7	11949646	Moderate		Inter Info	[105], [106], [107]
D1784		Exenatide	C184H282N50O60S	45588096	Moderate		Inter Info	[105], [106], [107]
D0727		Glimepiride	C24H34N4O5S	3476	Moderate		Inter Info	[105], [106], [107]
D0728		Glipizide	C21H27N5O4S	3478	Moderate		Inter Info	[105], [106], [107]
D0807		Insulin aspart (aspart protamine)	C256H381N65O79S6	118984445	Moderate		Inter Info	[105], [106], [107]
D0808		Insulin aspart (aspart)	C256H381N65O79S6	118984445	Moderate		Inter Info	[105], [106], [107]
D0810		Insulin detemir	C267H402N64O76S6	16137271	Moderate		Inter Info	[105], [106], [107]
D0811		Insulin glargine	C267H404N72O78S6	118984454	Moderate		Inter Info	[105], [106], [107]
D0812		Insulin glulisine	C258H384N64O78S6	16136701	Moderate		Inter Info	[105], [106], [107]
D0814		Insulin human (inhalation, rapid acting)	C257H383N65O77S6	118984375	Moderate		Inter Info	[105], [106], [107]
D0815		Insulin human (isophane)	C257H383N65O77S6	118984375	Moderate		Inter Info	[105], [106], [107]
D0816		Insulin human (regular)	C257H383N65O77S6	118984375	Moderate		Inter Info	[105], [106], [107]
D0817		Insulin human (zinc extended)	C257H383N65O77S6	118984375	Moderate		Inter Info	[105], [106], [107]
D0818		Insulin human (zinc)	C257H383N65O77S6	118984375	Moderate		Inter Info	[105], [106], [107]
D0819		Insulin lispro	C257H389N65O77S6	16132438	Moderate		Inter Info	[105], [106], [107]
D0820		Insulin lispro (protamine)	C257H389N65O77S6	16132438	Moderate		Inter Info	[105], [106], [107]
D0930		Linagliptin	C25H28N8O2	10096344	Moderate		Inter Info	[105], [106], [107]
D0936		Liraglutide	C172H265N43O51	16134956	Moderate		Inter Info	[105], [106], [107]
D1064		Miglitol	C8H17NO5	441314	Moderate		Inter Info	[105], [106], [107]
D0809		Insulin degludec	C274H411N65O81S6	118984462	Moderate		Inter Info	[105], [106], [107]
D1326		Pramlintide	C171H267N51O53S2	70691388	Moderate		Inter Info	[105], [106], [107]
D1392		Repaglinide	C27H36N2O4	65981	Moderate		Inter Info	[105], [106], [107]
D1429		Rosiglitazone	C18H19N3O3S	77999	Moderate		Inter Info	[105], [106], [107]
D1449		Saxagliptin	C18H25N3O2	11243969	Moderate		Inter Info	[105], [106], [107]
D1477		Sitagliptin	C16H15F6N5O	4369359	Moderate		Inter Info	[105], [106], [107]
D1601		Tolazamide	C14H21N3O3S	5503	Moderate		Inter Info	[105], [106], [107]
D1603		Tolbutamide	C12H18N2O3S	5505	Moderate		Inter Info	[105], [106], [107]
	Antagonize the effect of antihypertensive agents					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1782		Ertugliflozin	C22H25ClO7	44814423	Moderate		Inter Info	[105], [106], [107]
D1887		Semaglutide	C187H291N45O59	56843331	Moderate		Inter Info	[105], [106], [107]
	Attenuated pharmacological effects (Unspecific)					Drug Num: 7
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1094		Mycophenolate mofetil	C23H31NO7	5281078	Major		Inter Info	[41], [55], [56]
D1095		Mycophenolic acid	C17H20O6	446541	Major		Inter Info	[41], [55], [56]
D1894		Sugammadex	C72H112O48S8	6918585	Major		Inter Info	[38], [98], [99]
D0890		Lamotrigine	C9H7Cl2N5	3878	Moderate		Inter Info	[37], [172], [173]
D1063		Mifepristone	C29H35NO2	55245	Moderate		Inter Info	[40], [41], [180]
D1124		Neratinib	C30H29ClN6O3	9915743	Moderate		Inter Info	[200], [127]
D1664		Ulipristal	C28H35NO3	13559281	Moderate		Inter Info	[38], [220], [98]

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195	Product Information. Tibsovo (ivosidenib). Agios Pharmaceuticals, Cambridge, MA.
196	Product Information. Vitrakvi (larotrectinib). Bayer Pharmaceutical Inc, West Haven, CT.
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234	Product Information. Amerge (naratriptan). Glaxo Wellcome, Research Triangle Park, NC.
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238	Product Information. Avandia (rosiglitazone) SmithKline Beecham, Philadelphia, PA.

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