Details of Drug

Drug General Information (ID: D1040)
Drug Name	Methylphenobarbital
Drug Type	Small molecule
Drug Synonymous	Enfenemal; Enphenemal; Enphenemalum; Mebaral; Meberal; Mebroin; Mephobarbital; Mephobarbitone; Mephytal; Methylphenobarbitalum; Methylphenobarbitone; Methylphenobarbitonum; Methylphenolbarbital; Metilfenobarbital; Metilfenobarbitale; Metylfenemal; Metyna; Morbusan; Phemetone; Phemiton; Phemitone; Phenmiton; Prominal; Prominaletten; Prominalum; Mephobarbital [JAN]; Methyl phenobarbitone; Methylphenylbarbituric acid; Metilfenobarbitale [DCIT]; Sanofi Brand of Mephobarbital; Sanofi Synthelabo Brand of Mephobarbital; Isonal (roussel); Mebaral (TN); Menta-Bal; Methyl-calminal; Methylphenobarbital (INN); Methylphenobarbitalum [INN-Latin]; Metilfenobarbital [INN-Spanish]; N-Ethylmethylphenylbarbituric acid; N-Methylethylphenylbarbituric acid; N-Methylphenobarbital; N-Methylphenolbarbitol; Mephobarbital (JAN/USP); N-Methyl-5-phenyl-5-ethylbarbital; 1-Methyl-5-ethyl-5-phenylbarbituric acid; 1-Methyl-5-phenyl-5-ethylbarbituric acid; 1-Methylphenobarbital; 5-Ethyl-1-methyl-5-phenyl-2,4,6(1H,3H,5H)-pyrimidinetrione; 5-Ethyl-1-methyl-5-phenylbarbituric acid; 5-Ethyl-5-phenyl-N-methyl-bartituric acid; 5-Ethyl-N-methyl-5-phenylbarbituric acid; 5-Phenyl-5-ethyl-3-methylbarbituric acid; 5-ethyl-1-methyl-5-phenyl-1,3-diazinane-2,4,6-trione; 5-ethyl-1-methyl-5-phenylpyrimidine-2,4,6(1H,3H,5H)-trione Click to Show/Hide
Disease Class	6B00-6B0Z: Anxiety disorder
Therapeutic Class	Anxiolytics/Sedatives/Hypnotics
Structure
Structure	3D Structure		2D Structure
Formula	C13H14N2O3
InChI	1S/C13H14N2O3/c1-3-13(9-7-5-4-6-8-9)10(16)14-12(18)15(2)11(13)17/h4-8H,3H2,1-2H3,(H,14,16,18)
InChIKey	ALARQZQTBTVLJV-UHFFFAOYSA-N
Canonical SMILES	CCC1(C(=O)NC(=O)N(C1=O)C)C2=CC=CC=C2
External Link
	Pubchem ID	8271
	CAS Number	115-38-8
	CHEBI ID	6758
	TTD ID	D08UMH
	INTEDE ID	DR1026

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM001 Affected gastrointestinal absorption AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM004 Adsorption BM009 Altered absorption (Unspecific) BM016 Altered formation of CYP450 enzymes BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM023 UGT induction BM026 Increased metabolism (Unspecific) BM036 Additive cardiorespiratory depression effects BM038 Additive CNS depression effects BM042 Additive hypotensive effects BM087 Antagonize the effect of antiepileptic agents BM089 Antagonize the effect of antihypertensive agents BM107 Attenuated pharmacological effects (Unspecific)
Relation Graph

Full list of drugs interacting with Methylphenobarbital
Affected gastrointestinal absorption
	Adsorption					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0021		Activated charcoal	C	5462310	Moderate		Inter Info	[131], [132], [133]
	Altered absorption (Unspecific)					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0741		Griseofulvin	C17H17ClO6	441140	Moderate		Inter Info	[111], [112], [113]
D0337		Cimetidine	C10H16N6S	2756	Minor		Inter Info	[342]
Affected intra/extra-hepatic metabolism
	Altered formation of CYP450 enzymes					Drug Num: 18
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0023		Adalimumab	NA	NA	Moderate		Inter Info	[29], [30], [31]
D0032		Alefacept	NA	NA	Moderate		Inter Info	[29], [30], [31]
D0085		Anakinra	C20H23N5O7S2	146171046	Moderate		Inter Info	[29], [30], [31]
D0614		Etanercept	NA	NA	Moderate		Inter Info	[29], [30], [31]
D0802		Infliximab	NA	NA	Moderate		Inter Info	[29], [30], [31]
D0246		Canakinumab	NA	NA	Moderate		Inter Info	[29], [30], [31]
D0304		Certolizumab pegol	NA	NA	Moderate		Inter Info	[29], [30], [31]
D0564		Emapalumab	NA	NA	Moderate		Inter Info	[29], [30], [31]
D0736		Golimumab	NA	NA	Moderate		Inter Info	[29], [30], [31]
D0747		Guselkumab	NA	NA	Moderate		Inter Info	[29], [30], [31]
D0875		Ixekizumab	NA	NA	Moderate		Inter Info	[29], [30], [31]
D1403		Rilonacept	NA	NA	Moderate		Inter Info	[29], [30], [31]
D1447		Sarilumab	NA	NA	Moderate		Inter Info	[29], [30], [31]
D1448		Satralizumab	NA	NA	Moderate		Inter Info	[29], [30], [31]
D1454		Secukinumab	NA	NA	Moderate		Inter Info	[29], [30], [31]
D1467		Siltuximab	NA	NA	Moderate		Inter Info	[29], [30], [31]
D1599		Tocilizumab	NA	NA	Moderate		Inter Info	[29], [30], [31]
D1671		Ustekinumab	NA	NA	Moderate		Inter Info	[29], [30], [31]
	CYP450 enzyme inhibition					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0300		Cenobamate	C10H10ClN5O2	11962412	Moderate		Inter Info	[172]
D0642		Fenofibrate	C20H21ClO4	3339	Moderate		Inter Info	[74], [4], [208]
	CYP450 enzyme induction					Drug Num: 260
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0481		Dicoumarol	C19H12O6	54676038	Major		Inter Info	[8], [9], [10]
D0087		Anisindione	C16H12O3	2197	Major		Inter Info	[8], [9], [10]
D0959		Lumateperone	C24H28FN3O	21302490	Major		Inter Info	[19]
D1383		Ranolazine	C24H33N3O4	56959	Major		Inter Info	[22], [23]
D1706		Voriconazole	C16H14F3N5O	71616	Major		Inter Info	[24], [4], [25]
D1711		Warfarin	C19H16O4	54678486	Major		Inter Info	[8], [9], [10]
D0011		Acetaminophen	C8H9NO2	1983	Moderate		Inter Info	[26], [27], [28]
D0048		Altretamine	C9H18N6	2123	Moderate		Inter Info	[37]
D0068		Amitriptyline	C20H23N	2160	Moderate		Inter Info	[38], [39], [40]
D0069		Amlodipine	C20H25ClN2O5	2162	Moderate		Inter Info	[41], [42], [43]
D0072		Amoxapine	C17H16ClN3O	2170	Moderate		Inter Info	[38], [39], [40]
D0080		Amprenavir	C25H35N3O6S	65016	Moderate		Inter Info	[44], [45], [46]
D0100		Aprepitant	C23H21F7N4O3	135413536	Moderate		Inter Info	[22], [49], [50]
D0172		Betamethasone	C22H29FO5	9782	Moderate		Inter Info	[55], [56], [57]
D0222		Buspirone	C21H31N5O2	2477	Moderate		Inter Info	[60], [61], [62]
D0233		Calcifediol	C27H44O2	5283731	Moderate		Inter Info	[63], [64], [65]
D0234		Calcitriol	C27H44O3	5280453	Moderate		Inter Info	[63], [64], [65]
D0268		Caspofungin	C52H88N10O15	2826718	Moderate		Inter Info	[66], [67]
D0313		Chloramphenicol	C11H12Cl2N2O5	5959	Moderate		Inter Info	[71], [72], [73]
D0328		Cholecalciferol	C27H44O	5280795	Moderate		Inter Info	[63], [64], [65]
D0387		Conjugated estrogens	C18H21NaO5S	45357473	Moderate		Inter Info	[80], [81], [82]
D0402		Cyclosporine	C62H111N11O12	5284373	Moderate		Inter Info	[83], [4], [84]
D0424		Darifenacin	C28H30N2O2	444031	Moderate		Inter Info	[85], [86], [87]
D0439		Delavirdine	C22H28N6O3S	5625	Moderate		Inter Info	[88], [89], [87]
D0494		Dihydroergotamine	C33H37N5O5	10531	Moderate		Inter Info	[74], [4], [90]
D0497		Diltiazem	C22H26N2O4S	39186	Moderate		Inter Info	[91], [92], [93]
D0508		Disopyramide	C21H29N3O	3114	Moderate		Inter Info	[94], [95], [96]
D0516		Donepezil	C24H29NO3	3152	Moderate		Inter Info	[97], [98]
D0530		Doxycycline	C22H24N2O8	54671203	Moderate		Inter Info	[99], [100]
D0554		Efavirenz	C14H9ClF3NO2	64139	Moderate		Inter Info	[101], [93]
D0591		Ergocalciferol	C28H44O	5280793	Moderate		Inter Info	[63], [64], [65]
D0593		Ergotamine	C33H35N5O5	8223	Moderate		Inter Info	[74], [4], [90]
D0595		Erlotinib	C22H23N3O4	176870	Moderate		Inter Info	[102], [22], [103]
D0606		Estradiol	C18H24O2	5757	Moderate		Inter Info	[80], [81], [82]
D0607		Estradiol (topical)	C18H24O2	5757	Moderate		Inter Info	[80], [81], [82]
D0609		Estrone	C18H22O2	5870	Moderate		Inter Info	[80], [81], [82]
D0612		Eszopiclone	C17H17ClN6O3	969472	Moderate		Inter Info	[22], [104], [87]
D0626		Etonogestrel	C22H28O2	6917715	Moderate		Inter Info	[80], [105], [106]
D0671		Fludrocortisone	C21H29FO5	31378	Moderate		Inter Info	[55], [56], [57]
D0713		Gefitinib	C22H24ClFN4O3	123631	Moderate		Inter Info	[102], [22], [110]
D0750		Haloperidol	C21H23ClFNO2	3559	Moderate		Inter Info	[4], [114], [115]
D0773		Hydrocortisone	C21H30O5	5754	Moderate		Inter Info	[55], [56], [57]
D0793		Imatinib	C29H31N7O	5291	Moderate		Inter Info	[116], [74], [117]
D0795		Imipramine	C19H24N2	3696	Moderate		Inter Info	[38], [39], [40]
D0799		Indinavir	C36H47N5O4	5362440	Moderate		Inter Info	[44], [45], [46]
D0845		Irinotecan	C33H38N4O6	60838	Moderate		Inter Info	[118], [119], [120]
D0846		Irinotecan (liposomal)	C33H38N4O6	60838	Moderate		Inter Info	[118], [119], [120]
D0865		Isradipine	C19H21N3O5	3784	Moderate		Inter Info	[41], [42], [43]
D0884		Labetalol	C19H24N2O3	3869	Moderate		Inter Info	[121], [122], [123]
D0922		Levonorgestrel	C21H28O2	13109	Moderate		Inter Info	[80], [105], [106]
D0925		Levothyroxine	C15H11I4NO4	5819	Moderate		Inter Info	[4], [124], [125]
D0934		Liothyronine	C15H12I3NO4	5920	Moderate		Inter Info	[4], [124], [125]
D0990		Medroxyprogesterone acetate	C24H34O4	6279	Moderate		Inter Info	[126], [127], [128]
D0993		Megestrol acetate	C24H32O4	11683	Moderate		Inter Info	[80], [81], [82]
D1037		Methylergometrine	C20H25N3O2	8226	Moderate		Inter Info	[74], [4], [90]
D0006		Abemaciclib	C27H32F2N8	46220502	Moderate		Inter Info	[129]
D0008		Acalabrutinib	C26H23N7O2	71226662	Moderate		Inter Info	[130]
D0010		Acebutolol	C18H28N2O4	1978	Moderate		Inter Info	[121], [122], [123]
D0044		Alpelisib	C19H22F3N5O2S	56649450	Moderate		Inter Info	[134]
D0064		Aminophylline	C16H24N10O4	9433	Moderate		Inter Info	[135], [136], [137]
D0096		Apixaban	C25H25N5O4	10182969	Moderate		Inter Info	[22], [138], [87]
D0099		Apremilast	C22H24N2O7S	11561674	Moderate		Inter Info	[139]
D0105		Aripiprazole	C23H27Cl2N3O2	60795	Moderate		Inter Info	[140], [68]
D0106		Armodafinil	C15H15NO2S	9690109	Moderate		Inter Info	[141], [142], [87]
D0108		Artemether	C16H26O5	68911	Moderate		Inter Info	[74], [4], [143]
D0116		Atazanavir	C38H52N6O7	148192	Moderate		Inter Info	[44], [45], [46]
D0120		Atorvastatin	C33H35FN2O5	60823	Moderate		Inter Info	[144], [145], [146]
D0128		Avanafil	C23H26ClN7O3	9869929	Moderate		Inter Info	[147], [148], [149]
D0129		Avapritinib	C26H27FN10	118023034	Moderate		Inter Info	[4], [150]
D0133		Axitinib	C22H18N4OS	6450551	Moderate		Inter Info	[151], [152]
D0149		Bedaquiline	C32H31BrN2O2	5388906	Moderate		Inter Info	[153]
D0157		Bendamustine	C16H21Cl2N3O2	65628	Moderate		Inter Info	[154]
D0181		Bictegravir	C21H18F3N3O5	90311989	Moderate		Inter Info	[4], [155], [156]
D0192		Boceprevir	C27H45N5O5	10324367	Moderate		Inter Info	[157], [158]
D0195		Bosutinib	C26H29Cl2N5O3	5328940	Moderate		Inter Info	[85], [159], [87]
D0204		Brigatinib	C29H39ClN7O2P	68165256	Moderate		Inter Info	[74], [4], [163]
D0220		Bupropion	C13H18ClNO	444	Moderate		Inter Info	[164], [165]
D0227		Cabazitaxel	C45H57NO14	9854073	Moderate		Inter Info	[166], [149]
D0230		Cabozantinib	C28H24FN3O5	25102847	Moderate		Inter Info	[167], [168], [87]
D0251		Capmatinib	C23H17FN6O	25145656	Moderate		Inter Info	[85], [170], [87]
D0262		Cariprazine	C21H32Cl2N4O	11154555	Moderate		Inter Info	[4], [171]
D0267		Carvedilol	C24H26N2O4	2585	Moderate		Inter Info	[121], [122], [123]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Moderate		Inter Info	[173]
D0361		Clomipramine	C19H23ClN2	2801	Moderate		Inter Info	[38], [39], [40]
D0362		Clonazepam	C15H10ClN3O3	2802	Moderate		Inter Info	[174], [175], [176]
D0376		Cobimetinib	C21H21F3IN3O2	16222096	Moderate		Inter Info	[85], [177], [87]
D0389		Copanlisib	C23H28N8O4	135565596	Moderate		Inter Info	[178]
D0392		Corticotropin	C207H308N56O58S	16132265	Moderate		Inter Info	[55], [56], [57]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Moderate		Inter Info	[179], [4], [180]
D0425		Darolutamide	C19H19ClN6O2	67171867	Moderate		Inter Info	[85], [181], [87]
D0426		Darunavir	C27H37N3O7S	213039	Moderate		Inter Info	[44], [45], [46]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Moderate		Inter Info	[74], [4], [182]
D0446		Desipramine	C18H22N2	2995	Moderate		Inter Info	[38], [39], [40]
D0453		Dexamethasone	C22H29FO5	5743	Moderate		Inter Info	[55], [56], [57]
D0490		Digitoxin	C41H64O13	441207	Moderate		Inter Info	[183], [184]
D0495		Dihydrotachysterol	C28H46O	5311071	Moderate		Inter Info	[63], [64], [65]
D0511		Docetaxel	C43H53NO14	148124	Moderate		Inter Info	[185], [186], [187]
D0518		Doravirine	C17H11ClF3N5O3	58460047	Moderate		Inter Info	[188], [189]
D0525		Doxepin	C19H21NO	667477	Moderate		Inter Info	[38], [39], [40]
D0526		Doxepin (topical)	C19H21NO	667477	Moderate		Inter Info	[38], [39], [40]
D0527		Doxercalciferol	C28H44O2	5281107	Moderate		Inter Info	[63], [64], [65]
D0528		Doxorubicin	C27H29NO11	31703	Moderate		Inter Info	[190], [191], [192]
D0529		Doxorubicin (liposomal)	C27H29NO11	31703	Moderate		Inter Info	[190], [191], [192]
D0534		Dronedarone	C31H44N2O5S	208898	Moderate		Inter Info	[193], [87]
D0536		Drospirenone	C24H30O3	68873	Moderate		Inter Info	[80], [105], [106]
D0543		Duvelisib	C22H17ClN6O	50905713	Moderate		Inter Info	[194]
D0555		Elagolix	C32H30F5N3O5	11250647	Moderate		Inter Info	[195]
D0556		Elbasvir	C49H55N9O7	71661251	Moderate		Inter Info	[196]
D0559		Eliglustat	C23H36N2O4	23652731	Moderate		Inter Info	[197]
D0569		Encorafenib	C22H27ClFN7O4S	50922675	Moderate		Inter Info	[198], [87]
D0577		Entrectinib	C31H34F2N6O2	25141092	Moderate		Inter Info	[4], [199]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Moderate		Inter Info	[22], [200], [87]
D0592		Ergometrine	C19H23N3O2	443884	Moderate		Inter Info	[74], [4], [90]
D0605		Esterified estrogens	NA	NA	Moderate		Inter Info	[80], [81], [82]
D0610		Estrone sulfate	C18H22O5S	3001028	Moderate		Inter Info	[80], [81], [82]
D0619		Ethinylestradiol	C20H24O2	5991	Moderate		Inter Info	[80], [105], [106]
D0628		Etravirine	C20H15BrN6O	193962	Moderate		Inter Info	[202]
D0629		Everolimus	C53H83NO14	6442177	Moderate		Inter Info	[74], [4], [203]
D0630		Exemestane	C20H24O2	60198	Moderate		Inter Info	[204], [22], [87]
D0640		Felodipine	C18H19Cl2NO4	3333	Moderate		Inter Info	[205], [206], [207]
D0655		Fesoterodine	C26H37NO3	6918558	Moderate		Inter Info	[22], [209], [87]
D0692		Fosamprenavir	C25H36N3O9PS	131536	Moderate		Inter Info	[44], [45], [46]
D0693		Fosaprepitant	C23H22F7N4O6P	135413538	Moderate		Inter Info	[22], [49], [50]
D0697		Fosphenytoin	C16H15N2O6P	56339	Moderate		Inter Info	[211], [212]
D0699		Fostamatinib	C23H26FN6O9P	11671467	Moderate		Inter Info	[22], [216], [87]
D0720		Gilteritinib	C29H44N8O3	49803313	Moderate		Inter Info	[22], [217], [87]
D0725		Glasdegib	C21H22N6O	25166913	Moderate		Inter Info	[221], [22], [87]
D0726		Glecaprevir	C38H46F4N6O9S	66828839	Moderate		Inter Info	[222]
D0745		Guanfacine	C9H9Cl2N3O	3519	Moderate		Inter Info	[4], [223], [224]
D0785		Ibrutinib	C25H24N6O2	24821094	Moderate		Inter Info	[4], [225]
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[226]
D0852		Isavuconazonium	C35H35F2N8O5S+	6918606	Moderate		Inter Info	[229]
D0868		Ivabradine	C27H36N2O5	132999	Moderate		Inter Info	[4], [230]
D0869		Ivacaftor	C24H28N2O3	16220172	Moderate		Inter Info	[231], [232], [149]
D0873		Ixabepilone	C27H42N2O5S	6445540	Moderate		Inter Info	[233]
D0874		Ixazomib	C14H19BCl2N2O4	25183872	Moderate		Inter Info	[85], [234], [87]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Moderate		Inter Info	[22], [235], [87]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Moderate		Inter Info	[74], [4], [236]
D0899		Lefamulin	C28H45NO5S	25185057	Moderate		Inter Info	[22], [238], [87]
D0901		Lemborexant	C22H20F2N4O2	56944144	Moderate		Inter Info	[239], [22]
D0905		Lesinurad	C17H14BrN3O2S	53465279	Moderate		Inter Info	[66], [240]
D0906		Letermovir	C29H28F4N4O4	45138674	Moderate		Inter Info	[22], [241], [87]
D0911		Levamlodipine	C20H25ClN2O5	9822750	Moderate		Inter Info	[41], [42], [43]
D0930		Linagliptin	C25H28N8O2	10096344	Moderate		Inter Info	[22], [242], [87]
D0935		Liotrix	C30H21I7N2Na2O8	71371	Moderate		Inter Info	[4], [124], [125]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Moderate		Inter Info	[243], [87]
D0962		Lurbinectedin	C41H44N4O10S	57327016	Moderate		Inter Info	[244]
D0965		Macimorelin	C26H30N6O3	9804938	Moderate		Inter Info	[22], [245], [87]
D0966		Macitentan	C19H20Br2N6O4S	16004692	Moderate		Inter Info	[246], [247]
D0980		Maraviroc	C29H41F2N5O	3002977	Moderate		Inter Info	[74], [248]
D1030		Methoxyflurane	C3H4Cl2F2O	4116	Moderate		Inter Info	[249], [250], [251]
D1041		Methylprednisolone	C22H30O5	6741	Moderate		Inter Info	[55], [56], [57]
D1051		Metronidazole	C6H9N3O3	4173	Moderate		Inter Info	[252], [253], [254]
D1062		Midostaurin	C35H30N4O4	9829523	Moderate		Inter Info	[255], [256]
D1104		Naloxegol	C34H53NO11	56959087	Moderate		Inter Info	[257], [87]
D1114		Nebivolol	C22H25F2NO4	71301	Moderate		Inter Info	[121], [122], [123]
D1134		Nifedipine	C17H18N2O6	4485	Moderate		Inter Info	[41], [42], [43]
D1136		Nilotinib	C28H22F3N7O	644241	Moderate		Inter Info	[22], [258]
D1157		Norgestrel	C21H28O2	13109	Moderate		Inter Info	[80], [105], [106]
D1167		Olaparib	C24H23FN4O3	23725625	Moderate		Inter Info	[74], [4], [259]
D1189		Osilodrostat	C13H10FN3	44139752	Moderate		Inter Info	[22], [260], [87]
D1190		Osimertinib	C28H33N7O2	71496458	Moderate		Inter Info	[22], [261], [87]
D1201		Oxtriphylline	C12H21N5O3	656652	Moderate		Inter Info	[135], [136], [137]
D1212		Paclitaxel	C47H51NO14	36314	Moderate		Inter Info	[262], [263], [264]
D1213		Paclitaxel (protein-bound)	C47H51NO14	36314	Moderate		Inter Info	[262], [263], [264]
D1214		Palbociclib	C24H29N7O2	5330286	Moderate		Inter Info	[74], [4], [265]
D1221		Panobinostat	C21H23N3O2	6918837	Moderate		Inter Info	[22], [266], [87]
D1226		Paricalcitol	C27H44O3	5281104	Moderate		Inter Info	[63], [64], [65]
D1232		Pazopanib	C21H23N7O2S	10113978	Moderate		Inter Info	[22], [267]
D1242		Pemigatinib	C24H27F2N5O4	86705695	Moderate		Inter Info	[268]
D1244		Penbutolol	C18H29NO2	37464	Moderate		Inter Info	[121], [122], [123]
D1290		Pimavanserin	C25H34FN3O2	10071196	Moderate		Inter Info	[22], [270], [87]
D1313		Ponatinib	C29H27F3N6O	24826799	Moderate		Inter Info	[74], [4], [271]
D1330		Praziquantel	C19H24N2O2	4891	Moderate		Inter Info	[272], [74], [273]
D1332		Prednisolone	C21H28O5	5755	Moderate		Inter Info	[55], [56], [57]
D1368		Quetiapine	C21H25N3O2S	5002	Moderate		Inter Info	[74], [274], [275]
D1370		Quinestrol	C25H32O2	9046	Moderate		Inter Info	[80], [81], [82]
D1371		Quinidine	C20H24N2O2	441074	Moderate		Inter Info	[276], [277], [278]
D1392		Repaglinide	C27H36N2O4	65981	Moderate		Inter Info	[279], [280], [281]
D1398		Ribociclib	C23H30N8O	44631912	Moderate		Inter Info	[74], [4], [282]
D1404		Rilpivirine	C22H18N6	6451164	Moderate		Inter Info	[179], [4], [283]
D1408		Riociguat	C20H19FN8O2	11304743	Moderate		Inter Info	[284], [22], [87]
D1409		Ripretinib	C24H21BrFN5O2	71584930	Moderate		Inter Info	[74], [95], [285]
D1417		Rivaroxaban	C19H18ClN3O5S	9875401	Moderate		Inter Info	[286]
D1423		Rolapitant	C25H26F6N2O2	10311306	Moderate		Inter Info	[287]
D1434		Ruxolitinib	C17H18N6	25126798	Moderate		Inter Info	[288]
D1444		Saquinavir	C38H50N6O5	441243	Moderate		Inter Info	[44], [45], [46]
D1449		Saxagliptin	C18H25N3O2	11243969	Moderate		Inter Info	[85], [289], [87]
D1459		Selpercatinib	C29H31N7O3	134436906	Moderate		Inter Info	[22], [290]
D1460		Selumetinib	C17H15BrClFN4O3	10127622	Moderate		Inter Info	[124]
D1466		Silodosin	C25H32F3N3O4	5312125	Moderate		Inter Info	[74], [4], [291]
D1476		Sirolimus	C51H79NO13	5284616	Moderate		Inter Info	[74], [4], [292]
D1491		Solifenacin	C23H26N2O2	154059	Moderate		Inter Info	[22], [293], [87]
D1496		Sonidegib	C26H26F3N3O3	24775005	Moderate		Inter Info	[294]
D1522		Sunitinib	C22H27FN4O2	5329102	Moderate		Inter Info	[74], [4], [295]
D1524		Suvorexant	C23H23ClN6O2	24965990	Moderate		Inter Info	[53]
D1526		Tacrolimus	C44H69NO12	445643	Moderate		Inter Info	[74], [4], [292]
D1536		Tasimelteon	C15H19NO2	10220503	Moderate		Inter Info	[22], [296], [87]
D1538		Tazemetostat	C34H44N4O4	66558664	Moderate		Inter Info	[95], [297]
D1541		Telaprevir	C36H53N7O6	3010818	Moderate		Inter Info	[157], [158]
D1544		Telithromycin	C43H65N5O10	3002190	Moderate		Inter Info	[22], [298], [299]
D1549		Temsirolimus	C56H87NO16	6918289	Moderate		Inter Info	[74], [4], [300]
D1563		Tetracosactide	C136H210N40O31S	16133802	Moderate		Inter Info	[55], [56], [57]
D1577		Thyroid, porcine	NA	NA	Moderate		Inter Info	[4], [124], [125]
D1579		Ticagrelor	C23H28F2N6O4S	9871419	Moderate		Inter Info	[4], [302], [303]
D1587		Tinidazole	C8H13N3O4S	5479	Moderate		Inter Info	[252], [253], [254]
D1592		Tipranavir	C31H33F3N2O5S	54682461	Moderate		Inter Info	[44], [45], [46]
D1600		Tofacitinib	C16H20N6O	9926791	Moderate		Inter Info	[74], [304]
D1608		Tolvaptan	C26H25ClN2O3	216237	Moderate		Inter Info	[4], [305]
D1615		Trabectedin	C39H43N3O11S	108150	Moderate		Inter Info	[4], [306], [307]
D1660		Tucatinib	C26H24N8O2	51039094	Moderate		Inter Info	[22], [308], [87]
D1663		Ubrogepant	C29H26F3N5O3	68748835	Moderate		Inter Info	[309]
D1664		Ulipristal	C28H35NO3	13559281	Moderate		Inter Info	[4], [22], [310]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Moderate		Inter Info	[22], [311], [87]
D1688		Venetoclax	C45H50ClN7O7S	49846579	Moderate		Inter Info	[22], [312]
D1718		Zanubrutinib	C27H29N5O3	135565884	Moderate		Inter Info	[313], [22]
D1730		Zonisamide	C8H8N2O3S	5734	Moderate		Inter Info	[314], [22], [315]
D1043		Methysergide	C21H27N3O2	9681	Moderate		Inter Info	[74], [4], [90]
D1049		Metoprolol	C15H25NO3	4171	Moderate		Inter Info	[121], [122], [123]
D1063		Mifepristone	C29H35NO2	55245	Moderate		Inter Info	[316], [317]
D1081		Modafinil	C15H15NO2S	4236	Moderate		Inter Info	[141], [142], [87]
D1119		Nelfinavir	C32H45N3O4S	64143	Moderate		Inter Info	[44], [45], [46]
D1130		Nicardipine	C26H29N3O6	4474	Moderate		Inter Info	[41], [42], [43]
D1138		Nimodipine	C21H26N2O7	4497	Moderate		Inter Info	[41], [42], [43]
D1141		Nisoldipine	C20H24N2O6	4499	Moderate		Inter Info	[41], [42], [43]
D1143		Nitisinone	C14H10F3NO5	115355	Moderate		Inter Info	[24], [74], [4]
D1154		Norethisterone	C20H26O2	6230	Moderate		Inter Info	[80], [105], [106]
D1158		Nortriptyline	C19H21N	4543	Moderate		Inter Info	[38], [39], [40]
D1283		Phenytoin	C15H12N2O2	1775	Moderate		Inter Info	[211], [212]
D1334		Prednisone	C21H26O5	5865	Moderate		Inter Info	[55], [56], [57]
D1348		Progesterone	C21H30O2	5994	Moderate		Inter Info	[80], [81], [82]
D1349		Progesterone (topical)	C21H30O2	5994	Moderate		Inter Info	[80], [81], [82]
D1357		Propranolol	C16H21NO2	4946	Moderate		Inter Info	[121], [122], [123]
D1361		Protriptyline	C19H21N	4976	Moderate		Inter Info	[38], [39], [40]
D1372		Quinine	C20H24N2O2	3034034	Moderate		Inter Info	[319], [320], [321]
D1415		Ritonavir	C37H48N6O5S2	392622	Moderate		Inter Info	[44], [45], [46]
D1465		Sildenafil	C22H30N6O4S	135398744	Moderate		Inter Info	[322], [323], [324]
D1497		Sorafenib	C21H16ClF3N4O3	216239	Moderate		Inter Info	[22], [325], [87]
D1527		Tadalafil	C22H19N3O4	110635	Moderate		Inter Info	[4], [326], [327]
D1533		Tamoxifen	C26H29NO	2733526	Moderate		Inter Info	[328], [329], [330]
D1570		Theophylline	C7H8N4O2	2153	Moderate		Inter Info	[135], [136], [137]
D1585		Timolol	C13H24N4O3S	33624	Moderate		Inter Info	[121], [122], [123]
D1612		Toremifene	C26H28ClNO	3005573	Moderate		Inter Info	[74], [4], [332]
D1628		Triamcinolone	C21H27FO6	31307	Moderate		Inter Info	[55], [56], [57]
D1647		Trimipramine	C20H26N2	5584	Moderate		Inter Info	[38], [39], [40]
D1690		Verapamil	C27H38N2O4	2520	Moderate		Inter Info	[333], [334], [335]
D0178		Bexarotene	C24H28O2	82146	Minor		Inter Info	[85], [330], [87]
D0193		Bortezomib	C19H25BN4O4	387447	Minor		Inter Info	[4], [336], [337]
D0255		Carbamazepine	C15H12N2O	2554	Minor		Inter Info	[338], [339], [340]
D0308		Cevimeline	C10H17NOS	83898	Minor		Inter Info	[341]
D0420		Dapsone (topical)	C12H12N2O2S	2955	Minor		Inter Info	[343], [147], [149]
D0645		Fenoprofen	C15H14O3	3342	Minor		Inter Info	[344], [345]
D0927		Lidocaine	C14H22N2O	3676	Minor		Inter Info	[346], [347], [348]
D0954		Losartan	C22H23ClN6O	3961	Minor		Inter Info	[349], [350], [351]
D0515		Dolutegravir	C20H19F2N3O5	54726191	Minor		Inter Info	[352], [353]
D0700		Fostemsavir	C25H26N7O8P	11319217	Minor		Inter Info	[22], [354], [87]
D0916		Levobupivacaine	C18H28N2O	92253	Minor		Inter Info	[66], [355]
D1074		Mirabegron	C21H24N4O2S	9865528	Minor		Inter Info	[356]
D1400		Rifampicin	C43H58N4O12	135398735	Minor		Inter Info	[358], [359], [360]
D1078		Mitotane	C14H10Cl4	4211	Minor		Inter Info	[361]
	UGT induction					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0245		Canagliflozin	C24H25FO5S	24812758	Moderate		Inter Info	[74], [4], [169]
	Increased metabolism (Unspecific)					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0688		Folic acid	C19H19N7O6	135398658	Moderate		Inter Info	[107], [108], [109]
D1353		Propafenone	C21H27NO3	4932	Minor		Inter Info	[357]
Pharmacodynamic additive effects
	Additive cardiorespiratory depression effects					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0698		Fospropofol	C13H21O5P	3038498	Moderate		Inter Info	[213], [214], [215]
D1356		Propofol	C12H18O	4943	Moderate		Inter Info	[213], [214], [215]
	Additive CNS depression effects					Drug Num: 145
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0035		Alfentanil	C21H32N6O3	51263	Major		Inter Info	[1]
D0226		Butorphanol	C21H29NO2	5361092	Major		Inter Info	[2], [3], [4]
D0379		Codeine	C18H21NO3	5284371	Major		Inter Info	[1]
D0467		Dextropropoxyphene	C22H29NO2	10100	Major		Inter Info	[5], [6], [7]
D0646		Fentanyl	C22H28N2O	3345	Major		Inter Info	[2], [3], [4]
D0776		Hydromorphone	C17H19NO3	5284570	Major		Inter Info	[1]
D1001		Meperidine	C15H21NO2	4058	Major		Inter Info	[1], [11], [4]
D1017		Methadone	C21H27NO	4095	Major		Inter Info	[2], [3], [4]
D0161		Benzhydrocodone	C25H25NO4	49836084	Major		Inter Info	[2], [3], [4]
D0219		Buprenorphine	C29H41NO4	644073	Major		Inter Info	[12], [13], [14]
D0470		Dezocine	C16H23NO	3033053	Major		Inter Info	[1]
D0493		Dihydrocodeine	C18H23NO3	5284543	Major		Inter Info	[1]
D0617		Ethanol	C2H6O	702	Major		Inter Info	[15], [16], [17]
D0772		Hydrocodone	C18H21NO3	5284569	Major		Inter Info	[2], [3], [4]
D0909		Levacetylmethadol	C23H31NO2	15130	Major		Inter Info	[1]
D1169		Oliceridine	C22H30N2O2S	66553195	Major		Inter Info	[2], [3], [4]
D1208		Oxymorphone	C17H19NO4	5284604	Major		Inter Info	[1]
D1390		Remifentanil	C20H28N2O5	60815	Major		Inter Info	[1]
D1485		Sodium oxybate	C4H7NaO3	23663870	Major		Inter Info	[20], [21], [4]
D1535		Tapentadol	C14H23NO	9838022	Major		Inter Info	[1]
D1089		Morphine	C17H19NO3	5288826	Major		Inter Info	[1]
D1090		Morphine (liposomal)	C17H19NO3	5288826	Major		Inter Info	[1]
D1100		Nalbuphine	C21H27NO4	5311304	Major		Inter Info	[1]
D1203		Oxycodone	C18H21NO4	5284603	Major		Inter Info	[2], [3], [4]
D1247		Pentazocine	C19H27NO	441278	Major		Inter Info	[1]
D1512		Sufentanil	C22H30N2O2S	41693	Major		Inter Info	[1]
D1616		Tramadol	C16H25NO2	33741	Major		Inter Info	[1]
D0030		Aldesleukin	NA	NA	Moderate		Inter Info	[32], [4], [33]
D0097		Apomorphine	C17H17NO2	6005	Moderate		Inter Info	[47], [48]
D0135		Azatadine	C20H22N2	19861	Moderate		Inter Info	[51], [52], [53]
D0143		Baclofen	C10H12ClNO2	2284	Moderate		Inter Info	[51], [52], [53]
D0160		Benzatropine	C21H25NO	1201549	Moderate		Inter Info	[54]
D0183		Biperiden	C21H29NO	2381	Moderate		Inter Info	[54]
D0205		Brimonidine (ophthalmic)	C11H10BrN5	2435	Moderate		Inter Info	[58], [4], [59]
D0206		Brimonidine (topical)	C11H10BrN5	2435	Moderate		Inter Info	[58], [4], [59]
D0214		Brompheniramine	C16H19BrN2	6834	Moderate		Inter Info	[51], [52], [53]
D0259		Carbinoxamine	C16H19ClN2O	2564	Moderate		Inter Info	[51], [52], [53]
D0263		Carisoprodol	C12H24N2O4	2576	Moderate		Inter Info	[51], [52], [53]
D0305		Cetirizine	C21H25ClN2O3	2678	Moderate		Inter Info	[68], [69], [70]
D0317		Chlordiazepoxide	C16H14ClN3O	2712	Moderate		Inter Info	[51], [52], [53]
D0327		Chlorzoxazone	C7H4ClNO2	2733	Moderate		Inter Info	[51], [52], [53]
D0351		Clemastine	C21H26ClNO	26987	Moderate		Inter Info	[51], [52], [53]
D0356		Clobazam	C16H13ClN2O2	2789	Moderate		Inter Info	[51], [52], [53]
D0365		Clorazepic acid	C16H11ClN2O3	2809	Moderate		Inter Info	[51], [52], [53]
D0370		Clozapine	C18H19ClN4	135398737	Moderate		Inter Info	[51], [52], [53]
D0403		Cyproheptadine	C21H21N	2913	Moderate		Inter Info	[51], [52], [53]
D0456		Dexbrompheniramine	C16H19BrN2	16960	Moderate		Inter Info	[51], [52], [53]
D0466		Dextromethorphan	C18H25NO	5360696	Moderate		Inter Info	[51], [52], [53]
D0532		Doxylamine	C17H22N2O	3162	Moderate		Inter Info	[51], [52], [53]
D0533		Dronabinol	C21H30O2	16078	Moderate		Inter Info	[51], [52], [53]
D0535		Droperidol	C22H22FN3O2	3168	Moderate		Inter Info	[51], [52], [53]
D0575		Entacapone	C14H15N3O5	5281081	Moderate		Inter Info	[51], [52], [53]
D0679		Flurazepam	C21H23ClFN3O	3393	Moderate		Inter Info	[51], [52], [53]
D0748		Halazepam	C17H12ClF3N2O	31640	Moderate		Inter Info	[51], [52], [53]
D0957		Loxapine	C18H18ClN3O	3964	Moderate		Inter Info	[51], [52], [53]
D1014		Metaxalone	C12H15NO3	15459	Moderate		Inter Info	[51], [52], [53]
D1023		Methocarbamol	C11H15NO5	4107	Moderate		Inter Info	[51], [52], [53]
D0071		Amobarbital	C11H18N2O3	2164	Moderate		Inter Info	[51], [52], [53]
D0098		Apraclonidine	C9H10Cl2N4	2216	Moderate		Inter Info	[58], [4], [59]
D0112		Asenapine	C17H16ClNO	3036780	Moderate		Inter Info	[51], [52], [53]
D0201		Brexanolone	C21H34O2	92786	Moderate		Inter Info	[160], [161], [162]
D0202		Brexpiprazole	C25H27N3O2S	11978813	Moderate		Inter Info	[51], [52], [53]
D0212		Bromocriptine	C32H40BrN5O5	31101	Moderate		Inter Info	[51], [52], [53]
D0248		Cannabidiol	C21H30O2	644019	Moderate		Inter Info	[51], [52], [53]
D0311		Chloral hydrate	C2H3Cl3O2	2707	Moderate		Inter Info	[51], [52], [53]
D0322		Chlorphenesin	C9H11ClO3	7697	Moderate		Inter Info	[51], [52], [53]
D0323		Chlorpheniramine	C16H19ClN2	2725	Moderate		Inter Info	[51], [52], [53]
D0359		Clofedanol	C17H20ClNO	2795	Moderate		Inter Info	[51], [52], [53]
D0398		Cyclobenzaprine	C20H21N	2895	Moderate		Inter Info	[51], [52], [53]
D0417		Dantrolene	C14H10N4O5	6914273	Moderate		Inter Info	[51], [52], [53]
D0452		Deutetrabenazine	C19H27NO3	73437646	Moderate		Inter Info	[51], [52], [53]
D0471		Diamorphine	C21H23NO5	5462328	Moderate		Inter Info	[51], [52], [53]
D0502		Diphenhydramine	C17H21NO	3100	Moderate		Inter Info	[51], [52], [53]
D0600		Esketamine	C13H16ClNO	182137	Moderate		Inter Info	[68], [201], [162]
D0601		Eslicarbazepine	C15H14N2O2	9881504	Moderate		Inter Info	[51], [52], [53]
D0604		Estazolam	C16H11ClN4	3261	Moderate		Inter Info	[51], [52], [53]
D0632		Ezogabine	C16H18FN3O2	121892	Moderate		Inter Info	[51], [52], [53]
D0662		Flavoxate	C24H25NO4	3354	Moderate		Inter Info	[51], [52], [53]
D0665		Flibanserin	C20H21F3N4O	6918248	Moderate		Inter Info	[68], [210]
D0790		Ifosfamide	C7H15Cl2N2O2P	3690	Moderate		Inter Info	[227], [68], [228]
D0791		Iloperidone	C24H27FN2O4	71360	Moderate		Inter Info	[51], [52], [53]
D0878		Kava	C14H16O3	5281052	Moderate		Inter Info	[51], [52], [53]
D0879		Ketamine	C13H16ClNO	3821	Moderate		Inter Info	[51], [52], [53]
D0897		Lasmiditan	C19H18F3N3O2	11610526	Moderate		Inter Info	[68], [162], [237]
D0917		Levocetirizine	C21H25ClN2O3	1549000	Moderate		Inter Info	[70], [68], [69]
D0940		Lithium carbonate	CLi2O3	11125	Moderate		Inter Info	[51], [52], [53]
D0961		Lurasidone	C28H36N4O2S	213046	Moderate		Inter Info	[51], [52], [53]
D0979		Maprotiline	C20H23N	4011	Moderate		Inter Info	[51], [52], [53]
D1006		Mepyramine	C17H23N3O	4992	Moderate		Inter Info	[51], [52], [53]
D1046		Metoclopramide	C14H22ClN3O2	4168	Moderate		Inter Info	[51], [52], [53]
D1084		Molindone	C16H24N2O2	23897	Moderate		Inter Info	[51], [52], [53]
D1117		Nefazodone	C25H32ClN5O2	4449	Moderate		Inter Info	[51], [52], [53]
D1182		Opicapone	C15H10Cl2N4O6	135565903	Moderate		Inter Info	[51], [52], [53]
D1183		Opium	NA	NA	Moderate		Inter Info	[51], [52], [53]
D1188		Orphenadrine	C18H23NO	4601	Moderate		Inter Info	[51], [52], [53]
D1215		Paliperidone	C23H27FN4O3	115237	Moderate		Inter Info	[51], [52], [53]
D1224		Paraldehyde	C6H12O3	31264	Moderate		Inter Info	[51], [52], [53]
D1252		Pentoxyverine	C20H31NO3	2562	Moderate		Inter Info	[51], [52], [53]
D1253		Perampanel	C23H15N3O	9924495	Moderate		Inter Info	[51], [52], [53]
D1255		Pergolide	C19H26N2S	47811	Moderate		Inter Info	[51], [52], [53]
D1265		Phenobarbital	C12H12N2O3	4763	Moderate		Inter Info	[51], [52], [53]
D1292		Pimozide	C28H29F2N3O	16362	Moderate		Inter Info	[51], [52], [53]
D1367		Quazepam	C17H11ClF4N2S	4999	Moderate		Inter Info	[51], [52], [53]
D1378		Ramelteon	C16H21NO2	208902	Moderate		Inter Info	[51], [52], [53]
D1385		Rasagiline	C12H13N	3052776	Moderate		Inter Info	[51], [52], [53]
D1431		Rotigotine	C19H25NOS	59227	Moderate		Inter Info	[51], [52], [53]
D1433		Rufinamide	C10H8F2N4O	129228	Moderate		Inter Info	[51], [52], [53]
D1464		Sibutramine	C17H26ClN	5210	Moderate		Inter Info	[51], [52], [53]
D1502		St. John's Wort	NA	NA	Moderate		Inter Info	[51], [52], [53]
D1505		Stiripentol	C14H18O3	5311454	Moderate		Inter Info	[51], [52], [53]
D1560		Tetrabenazine	C19H27NO3	6018	Moderate		Inter Info	[51], [52], [53]
D1569		Thalidomide	C13H10N2O4	5426	Moderate		Inter Info	[68], [162], [301]
D1576		Thiothixene	C23H29N3O2S2	941651	Moderate		Inter Info	[51], [52], [53]
D1632		Triazolam	C17H12Cl2N4	5556	Moderate		Inter Info	[51], [52], [53]
D1673		Valbenazine	C24H38N2O4	24795069	Moderate		Inter Info	[51], [52], [53]
D1675		Valerian	NA	NA	Moderate		Inter Info	[51], [52], [53]
D1694		Vigabatrin	C6H11NO2	5665	Moderate		Inter Info	[51], [52], [53]
D1716		Zaleplon	C17H15N5O	5719	Moderate		Inter Info	[51], [52], [53]
D1719		Ziconotide	C102H172N36O32S7	16135415	Moderate		Inter Info	[51], [52], [53]
D1053		Metyrosine	C10H13NO3	441350	Moderate		Inter Info	[51], [52], [53]
D1075		Mirtazapine	C17H19N3	4205	Moderate		Inter Info	[51], [52], [53]
D1096		Nabilone	C24H36O3	5284592	Moderate		Inter Info	[51], [52], [53]
D1166		Olanzapine	C17H20N4S	135398745	Moderate		Inter Info	[51], [52], [53]
D1172		Olopatadine (nasal)	C21H23NO3	5281071	Moderate		Inter Info	[68], [318], [162]
D1198		Oxcarbazepine	C15H12N2O2	34312	Moderate		Inter Info	[51], [52], [53]
D1248		Pentobarbital	C11H18N2O3	4737	Moderate		Inter Info	[51], [52], [53]
D1325		Pramipexole	C10H17N3S	119570	Moderate		Inter Info	[51], [52], [53]
D1335		Pregabalin	C8H17NO2	5486971	Moderate		Inter Info	[51], [52], [53]
D1340		Primidone	C12H14N2O2	4909	Moderate		Inter Info	[51], [52], [53]
D1347		Procyclidine	C19H29NO	4919	Moderate		Inter Info	[54]
D1413		Risperidone	C23H27FN4O2	5073	Moderate		Inter Info	[51], [52], [53]
D1427		Ropinirole	C16H24N2O	5095	Moderate		Inter Info	[51], [52], [53]
D1453		Secobarbital	C12H18N2O3	5193	Moderate		Inter Info	[51], [52], [53]
D1547		Temazepam	C16H13ClN2O2	5391	Moderate		Inter Info	[51], [52], [53]
D1573		Thiopental	C11H18N2O2S	3000715	Moderate		Inter Info	[51], [52], [53]
D1596		Tizanidine	C9H8ClN5S	5487	Moderate		Inter Info	[68], [331], [162]
D1604		Tolcapone	C14H11NO5	4659569	Moderate		Inter Info	[51], [52], [53]
D1624		Trazodone	C19H22ClN5O	5533	Moderate		Inter Info	[51], [52], [53]
D1641		Trihexyphenidyl	C20H31NO	5572	Moderate		Inter Info	[54]
D1644		Trimethobenzamide	C21H28N2O5	5577	Moderate		Inter Info	[51], [52], [53]
D1649		Tripelennamine	C16H21N3	5587	Moderate		Inter Info	[51], [52], [53]
D1650		Triprolidine	C19H22N2	5282443	Moderate		Inter Info	[51], [52], [53]
D1677		Valproic acid	C8H16O2	3121	Moderate		Inter Info	[51], [52], [53]
D1726		Ziprasidone	C21H21ClN4OS	60854	Moderate		Inter Info	[51], [52], [53]
D1729		Zolpidem	C19H21N3O	5732	Moderate		Inter Info	[51], [52], [53]
	Additive hypotensive effects					Drug Num: 9
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0036		Alfuzosin	C19H27N5O4	2092	Moderate		Inter Info	[34], [35], [36]
D0363		Clonidine	C9H9Cl2N3	2803	Moderate		Inter Info	[34], [35], [36]
D0524		Doxazosin	C23H25N5O5	3157	Moderate		Inter Info	[34], [35], [36]
D0138		Azilsartan medoxomil	C30H24N4O8	135409642	Moderate		Inter Info	[34], [35], [36]
D0170		Bepridil	C24H34N2O	2351	Moderate		Inter Info	[34], [35], [36]
D0352		Clevidipine	C21H23Cl2NO6	153994	Moderate		Inter Info	[34], [35], [36]
D0942		Lofexidine	C11H12Cl2N2O	30668	Moderate		Inter Info	[34], [35], [36]
D1545		Telmisartan	C33H30N4O2	65999	Moderate		Inter Info	[34], [35], [36]
D1534		Tamsulosin	C20H28N2O5S	129211	Moderate		Inter Info	[34], [35], [36]
Pharmacodynamic antagonistic effects
	Antagonize the effect of antiepileptic agents					Drug Num: 20
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0320		Chloroquine	C18H26ClN3	2719	Moderate		Inter Info	[74], [75], [76]
D0345		Citalopram	C20H21FN2O	2771	Moderate		Inter Info	[77], [78], [79]
D0539		Duloxetine	C18H19NOS	60835	Moderate		Inter Info	[77], [78], [79]
D0676		Fluoxetine	C17H18F3NO	3386	Moderate		Inter Info	[78], [79], [77]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Moderate		Inter Info	[77], [78], [79]
D1830		Leucovorin	C20H23N7O7	135403648	Moderate		Inter Info	[107], [108], [109]
D0451		Desvenlafaxine	C16H25NO2	125017	Moderate		Inter Info	[77], [78], [79]
D0599		Escitalopram	C20H21FN2O	146570	Moderate		Inter Info	[77], [78], [79]
D0779		Hydroxychloroquine	C18H26ClN3O	3652	Moderate		Inter Info	[74], [75], [76]
D1832		Levoleucovorin	C20H23N7O7	135398559	Moderate		Inter Info	[107], [108], [109]
D1833		Levomefolic acid	C20H25N7O6	135398561	Moderate		Inter Info	[107], [108], [109]
D1834		Levomefolic acid (calcium)	C20H25N7O6	135398561	Moderate		Inter Info	[107], [108], [109]
D0920		Levomilnacipran	C15H22N2O	6917779	Moderate		Inter Info	[78], [79], [77]
D1066		Milnacipran	C15H22N2O	65833	Moderate		Inter Info	[77], [78], [79]
D1243		Pemoline	C9H8N2O2	4723	Moderate		Inter Info	[74], [4], [269]
D1461		Sertraline	C17H17Cl2N	68617	Moderate		Inter Info	[77], [78], [79]
D1696		Vilazodone	C26H27N5O2	6918314	Moderate		Inter Info	[77], [78], [79]
D1708		Vortioxetine	C18H22N2S	9966051	Moderate		Inter Info	[78], [79], [77]
D1229		Paroxetine	C19H20FNO3	43815	Moderate		Inter Info	[77], [78], [79]
D1689		Venlafaxine	C17H27NO2	5656	Moderate		Inter Info	[77], [78], [79]
	Antagonize the effect of antihypertensive agents					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0722		Ginkgo biloba	NA	NA	Moderate		Inter Info	[218], [219], [220]
	Attenuated pharmacological effects (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0752		Hemin	C34H32FeN4O4	26945	Major		Inter Info	[18]

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141	Product Information. Nuvigil (armodafinil). Cephalon Inc, West Chester, PA.
142	Product Information. Provigil (modafinil). Cephalon, Inc, West Chester, PA.
143	Product Information. Coartem (artemether-lumefantrine). Novartis Pharmaceuticals, East Hanover, NJ.
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149	Product Information. Trikafta (elexacaftor/ivacaftor/tezacaftor). Vertex Pharmaceuticals, Cambridge, MA.
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156	Product Information. Viread (tenofovir). Gilead Sciences, Foster City, CA.
157	Product Information. Incivek (telaprevir). Vertex Pharmaceuticals, Cambridge, MA.
158	Product Information. Victrelis (boceprevir). Schering-Plough Corporation, Kenilworth, NJ.
159	Product Information. Bosulif (bosutinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
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168	Product Information. Cometriq (cabozantinib). Exelixis Inc, S San Francisco, CA.
169	Product Information. Invokana (canagliflozin). Janssen Pharmaceuticals, Titusville, NJ.
170	Product Information. Tabrecta (capmatinib). Novartis Pharmaceuticals, East Hanover, NJ.
171	Product Information. Vraylar (cariprazine). Actavis Pharma, Inc., Parsippany, NJ.
172	Product Information. Xcopri (cenobamate). SK Life Science, Inc., Paramus, NJ.
173	Product Information. Zykadia (ceritinib). Novartis Pharmaceuticals, East Hanover, NJ.
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178	Product Information. Aliqopa (copanlisib). Bayer Pharmaceutical Inc, West Haven, CT.
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180	Product Information. Xalkori (crizotinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
181	Product Information. Nubeqa (darolutamide). Bayer HealthCare Pharmaceuticals Inc., Whippany, NJ.
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188	Product Information. Pifeltro (doravirine). Merck &amp Company Inc, Whitehouse Station, NJ.
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190	Product Information. Adriamycin PFS (doxorubicin). Pharmacia and Upjohn, Kalamazoo, MI.
191	Product Information. Doxil (doxorubicin liposomal). Sequis Pharmaceuticals Inc, Menlo Park, CA.
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196	Product Information. Zepatier (elbasvir-grazoprevir). Merck &amp Company Inc, Whitehouse Station, NJ.
197	Product Information. Cerdelga (eliglustat). Genzyme Corporation, Cambridge, MA.
198	Product Information. Braftovi (encorafenib). Array BioPharma Inc., Boulder, CO.
199	Product Information. Rozlytrek (entrectinib). Genentech, South San Francisco, CA.
200	Product Information. Xtandi (enzalutamide). Astellas Pharma US, Inc, Deerfield, IL.
201	Product Information. Spravato (esketamine). Janssen Pharmaceuticals, Titusville, NJ.
202	Product Information. Intelence (etravirine). Ortho Biotech Inc, Bridgewater, NJ.
203	Product Information. Afinitor (everolimus). Novartis Pharmaceuticals, East Hanover, NJ.
204	Product Information. Aromasin (exemestane) Pharmacia &amp Upjohn, Kalamazoo, MI.
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215	Product Information. Lusedra (fospropofol). Eisai Inc, Teaneck, NJ.
216	Product Information. Tavalisse (fostamatinib). Rigel Pharmaceuticals, South San Francisco, CA.
217	Product Information. Xospata (gilteritinib). Astellas Pharma US, Inc, Deerfield, IL.
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222	Product Information. Mavyret (glecaprevir-pibrentasvir). Abbott Pharmaceutical, Abbott Park, IL.
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224	Product Information. Intuniv (guanfacine). Shire US Inc, Florence, KY.
225	Product Information. Imbruvica (ibrutinib). Pharmacyclics Inc, Sunnyvale, CA.
226	Product Information. Zydelig (idelalisib). Gilead Sciences, Foster City, CA.
227	Product Information. Ifex (ifosfamide). Bristol-Myers Squibb, Princeton, NJ.
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229	Product Information. Cresemba (isavuconazonium). Astellas Pharma US, Inc, Deerfield, IL.
230	Product Information. Corlanor (ivabradine). Amgen USA, Thousand Oaks, CA.
231	Product Information. Orkambi (ivacaftor-lumacaftor). Vertex Pharmaceuticals, Cambridge, MA.
232	Product Information. Symdeko 4-Week (ivacaftor-tezacaftor). Vertex Pharmaceuticals, Cambridge, MA.
233	Product Information. Ixempra (ixabepilone). Bristol-Myers Squibb, Princeton, NJ.
234	Product Information. Ninlaro (ixazomib). Takeda Pharmaceuticals America, Lincolnshire, IL.
235	Product Information. Tykerb (lapatinib). Novartis Pharmaceuticals, East Hanover, NJ.
236	Product Information. Vitrakvi (larotrectinib). Bayer Pharmaceutical Inc, West Haven, CT.
237	Product Information. Reyvow (lasmiditan). Lilly, Eli and Company, Indianapolis, IN.
238	Product Information. Xenleta (lefamulin). Nabriva Therapeutics US, Inc., King of Prussia, PA.
239	Product Information. Dayvigo (lemborexant). Eisai Inc, Woodcliff Lake, NJ.
240	Product Information. Zurampic (lesinurad). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
241	Product Information. Prevymis (letermovir). Merck &amp Company Inc, Whitehouse Station, NJ.
242	Product Information. Tradjenta (linagliptin). Boehringer Ingelheim, Ridgefield, CT.
243	Product Information. Zokinvy (lonafarnib). Eiger BioPharmaceuticals, Palo Alto, CA.
244	Product Information. Zepzelca (lurbinectedin). Jazz Pharmaceuticals, Palo Alto, CA.
245	Product Information. Macrilen (macimorelin). Aeterna Zentaris, Charleston, SC.
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248	Product Information. Selzentry (maraviroc). Pfizer U.S. Pharmaceuticals Group, New York, NY.
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257	Product Information. Movantik (naloxegol). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
258	Product Information. Tasigna (nilotinib). Novartis Pharmaceuticals, East Hanover, NJ.
259	Product Information. Lynparza (olaparib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
260	Product Information. Isturisa (osilodrostat). Recordati Rare Diseases Inc, Lebanon, NJ.
261	Product Information. Tagrisso (osimertinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
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263	Product Information. Abraxane (paclitaxel protein-bound). American Pharmaceutical Partners, Schaumberg, IL.
264	Product Information. Taxol (paclitaxel). Bristol-Myers Squibb, Princeton, NJ.
265	Product Information. Ibrance (palbociclib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
266	Product Information. Farydak (panobinostat). Novartis Pharmaceuticals, East Hanover, NJ.
267	Product Information. Votrient (pazopanib). GlaxoSmithKline, Research Triangle Park, NC.
268	Product Information. Pemazyre (pemigatinib). Incyte Corporation, Wilmington, DE.
269	Product Information. Cylert (pemoline). Abbott Pharmaceutical, Abbott Park, IL.
270	Product Information. Nuplazid (pimavanserin). Accelis Pharma, East Windsor, NJ.
271	Product Information. Iclusig (ponatinib). Ariad Pharmaceuticals Inc, Cambridge, MA.
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281	Product Information. Prandin (repaglinide). Novo Nordisk Pharmaceuticals Inc, Princeton, NJ.
282	Product Information. Kisqali (ribociclib). Novartis Pharmaceuticals, East Hanover, NJ.
283	Product Information. Edurant (rilpivirine). Tibotec Pharmaceuticals, Titusville, NJ.
284	Product Information. Adempas (riociguat). Bayer Pharmaceutical Inc, West Haven, CT.
285	Product Information. Qinlock (ripretinib). Deciphera Pharmaceuticals, Waltham, MA.
286	Product Information. Xarelto (rivaroxaban). Bayer Inc, Toronto, IA.
287	Product Information. Varubi (rolapitant). Tesaro Inc., Waltham, MA.
288	Product Information. Jakafi (ruxolitinib). Incyte Corporation, Wilmington, DE.
289	Product Information. Onglyza (saxagliptin). Bristol-Myers Squibb, Princeton, NJ.
290	Product Information. Retevmo (selpercatinib). Lilly, Eli and Company, Indianapolis, IN.
291	Product Information. Rapaflo (silodosin). Watson Pharmaceuticals, Corona, CA.
292	Product Information. Prograf (tacrolimus). Fujisawa, Deerfield, IL.
293	Product Information. VESIcare (solifenacin). GlaxoSmithKline, Research Triangle Park, NC.
294	Product Information. Odomzo (sonidegib). Novartis Pharmaceuticals, East Hanover, NJ.
295	Product Information. Sutent (sunitinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
296	Product Information. Hetlioz (tasimelteon). Vanda Pharmaceuticals Inc, Rockville, MD.
297	Product Information. Tazverik (tazemetostat). Epizyme, Inc, Cambridge, MA.
298	Product Information. Ketek (telithromycin). Aventis Pharmaceuticals, Bridgewater, NJ.
299	European Agency for the Evaluation of Medicinal Products. Committee for Proprietary Medicinal Products "European Public Assessment Report Ketek (telithromycin) (Rev. 2) ".
300	Product Information. Torisel (temsirolimus). Wyeth-Ayerst Laboratories, Philadelphia, PA.
301	Product Information. Thalomid (thalidomide). Celgene Corporation, Warren, NJ.
302	Product Information. Brilinta (ticagrelor). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
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304	Product Information. Xeljanz (tofacitinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
305	Product Information. Samsca (tolvaptan). Otsuka American Pharmaceuticals Inc, Rockville, MD.
306	Machiels JP, Staddon A, Herremans C, et al. "Impact of cytochrome P450 3A4 inducer and inhibitor on the pharmacokinetics of trabectedin in patients with advanced malignancies: open-label, multicenter studies." Cancer Chemother Pharmacol 74 (2014): 729-37. [PMID: 25100135]
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308	Product Information. Tukysa (tucatinib). Seattle Genetics Inc, Bothell, WA.
309	Product Information. Ubrelvy (ubrogepant). Allergan Inc, Irvine, CA.
310	Product Information. ella (ulipristal). Afaxys Inc., Charleston, SC.
311	Product Information. Zelboraf (vemurafenib). Genentech, South San Francisco, CA.
312	Product Information. Venclexta (venetoclax). AbbVie US LLC, North Chicago, IL.
313	Product Information. Brukinsa (zanubrutinib). BeiGene USA, Inc, San Mateo, CA.
314	Nakasa H, Nakamura H, Ono S, Tsutsui M, Kiuchi M, Ohmori S, Kitada M "Prediction of drug-drug interactions of zonisamide metabolism in humans from in vitro data." Eur J Clin Pharmacol 54 (1998): 177-83. [PMID: 9626925]
315	Product Information. Zonegran (zonisamide) Elan Pharmaceuticals, S. San Francisco, CA.
316	Product Information. Korlym (mifepristone). Corcept Therapeutics Incorporated, Menlo Park, CA.
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318	Product Information. Patanase (olopatadine nasal). Alcon Laboratories Inc, Fort Worth, TX.
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