Drug General Information (ID: DDI8TRNL4K)
Drug Name			Methylphenobarbital		Drug Info		Pemoline		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Anxiolytics/Sedatives/Hypnotics				Cns Stimulants
Structure

Mechanism of Methylphenobarbital-Pemoline Interaction (Severity Level: Moderate)
Antagonize the effect of antiepileptic agents Click to Show/Hide Mechanism Graph
Drug Name		Methylphenobarbital				Pemoline
Mechanism		Antiepileptic agent				Lower seizure threshold
Key Mechanism Factor 1
		Factor Name		Antiepileptic agents
		Factor Description		The beneficial effects of antiepileptic drugs may be reduced, leading to an increase in seizure frequency or duration.
Mechanism Description		Antagonize the effect of Methylphenobarbital when combined with Pemoline

Recommended Action
Management		These drugs should be coadministered cautiously with careful clinical monitoring. Patients should be advised to notify their physician if they experience loss of seizure control.

References
1	Cerner Multum, Inc. "Australian Product Information.".
2	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
3	Product Information. Cylert (pemoline). Abbott Pharmaceutical, Abbott Park, IL.