Details of Drug

Drug General Information (ID: D1243)
Drug Name	Pemoline
Drug Type	Small molecule
Disease Class	6A05: Attention deficit hyperactivity disorder
Therapeutic Class	Cns Stimulants
Structure
Structure	3D Structure		2D Structure
Formula	C9H8N2O2
InChI	1S/C9H8N2O2/c10-9-11-8(12)7(13-9)6-4-2-1-3-5-6/h1-5,7H,(H2,10,11,12)
InChIKey	NRNCYVBFPDDJNE-UHFFFAOYSA-N
Canonical SMILES	C1=CC=C(C=C1)C2C(=O)N=C(O2)N
External Link
	Pubchem ID	4723
	CAS Number	2152-34-3
	CHEBI ID	7953
	TTD ID	D0D5GG

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM041 Additive hypertensive effects BM055 Increased risk of hepatotoxicity BM069 Increased risk of lowers seizure threshold BM087 Antagonize the effect of antiepileptic agents BM093 Antagonize the effect of dopaminergic agents
Relation Graph

Full list of drugs interacting with Pemoline
Pharmacodynamic additive effects
	Additive hypertensive effects					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0377		Cocaine (nasal)	C17H21NO4	446220	Major		Inter Info	[16], [17], [18]
D0378		Cocaine (topical)	C17H21NO4	446220	Major		Inter Info	[16], [17], [18]
D0600		Esketamine	C13H16ClNO	182137	Major		Inter Info	[21], [22]
	Increased risk of hepatotoxicity					Drug Num: 21
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0900		Leflunomide	C12H9F3N2O2	3899	Major		Inter Info	[3], [19], [20]
D1073		Mipomersen	C230H324N67O122P19S19	118984467	Major		Inter Info	[28]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Major		Inter Info	[29]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Major		Inter Info	[3], [19], [20]
D0114		Asparaginase Escherichia coli	NA	NA	Moderate		Inter Info	[34], [21], [35]
D0357		Clofarabine	C10H11ClFN5O3	119182	Moderate		Inter Info	[70]
D0554		Efavirenz	C14H9ClF3NO2	64139	Moderate		Inter Info	[71], [72]
D0826		Interferon beta-1a	NA	NA	Moderate		Inter Info	[74], [75], [76], [77]
D0827		Interferon beta-1b	NA	NA	Moderate		Inter Info	[74], [75], [76], [77]
D1025		Methotrexate	C20H22N8O5	126941	Moderate		Inter Info	[16], [81]
D1106		Naltrexone	C20H23NO4	5360515	Moderate		Inter Info	[82]
D1234		Pegaspargase	C14H19NO	436058	Moderate		Inter Info	[83], [34], [84], [21], [16], [85], [86], [87], [88], [89], [90], [35], [91]
D0113		Asparaginase Erwinia chrysanthemi	NA	NA	Moderate		Inter Info	[83], [34], [84], [21], [16], [85], [86], [87], [88], [89], [90], [35], [91]
D0149		Bedaquiline	C32H31BrN2O2	5388906	Moderate		Inter Info	[94]
D0199		Brentuximab vedotin	NA	NA	Moderate		Inter Info	[95]
D0232		Calaspargase pegol	NA	NA	Moderate		Inter Info	[34], [21], [35]
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[96]
D1239		Peginterferon beta-1a	NA	NA	Moderate		Inter Info	[74], [75], [76], [77]
D1389		Remdesivir	C27H35N6O8P	121304016	Moderate		Inter Info	[21], [16], [99], [100], [101]
D1615		Trabectedin	C39H43N3O11S	108150	Moderate		Inter Info	[16], [102]
D1589		Tioguanine	C5H5N5S	2723601	Moderate		Inter Info	[103], [104]
	Increased risk of lowers seizure threshold					Drug Num: 9
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0220		Bupropion	C13H18ClNO	444	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15]
D0833		Iohexol	C19H26I3N3O9	3730	Major		Inter Info	[23], [24], [25], [26], [27]
D0834		Iopamidol	C17H22I3N3O8	65492	Major		Inter Info	[23], [24], [25], [26], [27]
D1616		Tramadol	C16H25NO2	33741	Major		Inter Info	[32], [14], [13], [33]
D0932		Lindane	C6H6Cl6	727	Moderate		Inter Info	[78], [79], [80]
D0054		Amifampridine	C5H7N3	5918	Moderate		Inter Info	[92], [93]
D1287		Picosulfuric acid	C18H15NO8S2	5243	Moderate		Inter Info	[97], [98], [16]
D1308		Polyethylene glycol (3350 with electrolytes)	C2H6O2	174	Moderate		Inter Info	[97], [98], [16]
D1488		Sodium sulfate	Na2O4S	24436	Moderate		Inter Info	[97], [98], [16]
Pharmacodynamic antagonistic effects
	Antagonize the effect of antiepileptic agents					Drug Num: 22
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0255		Carbamazepine	C15H12N2O	2554	Moderate		Inter Info	[21], [16], [36]
D0356		Clobazam	C16H13ClN2O2	2789	Moderate		Inter Info	[21], [16], [36]
D0362		Clonazepam	C15H10ClN3O3	2802	Moderate		Inter Info	[21], [16], [36]
D0365		Clorazepic acid	C16H11ClN2O3	2809	Moderate		Inter Info	[21], [16], [36]
D0473		Diazepam	C16H13ClN2O	3016	Moderate		Inter Info	[21], [16], [36]
D0620		Ethosuximide	C7H11NO2	3291	Moderate		Inter Info	[21], [16], [36]
D0639		Felbamate	C11H14N2O4	3331	Moderate		Inter Info	[21], [16], [36]
D0890		Lamotrigine	C9H7Cl2N5	3878	Moderate		Inter Info	[21], [16], [36]
D0912		Levetiracetam	C8H14N2O2	5284583	Moderate		Inter Info	[21], [16], [36]
D0951		Lorazepam	C15H10Cl2N2O2	3958	Moderate		Inter Info	[21], [16], [36]
D1040		Methylphenobarbital	C13H14N2O3	8271	Moderate		Inter Info	[21], [16], [36]
D1198		Oxcarbazepine	C15H12N2O2	34312	Moderate		Inter Info	[21], [16], [36]
D0208		Brivaracetam	C11H20N2O2	9837243	Moderate		Inter Info	[21], [16], [36]
D0248		Cannabidiol	C21H30O2	644019	Moderate		Inter Info	[21], [16], [36]
D0697		Fosphenytoin	C16H15N2O6P	56339	Moderate		Inter Info	[21], [16], [36]
D1032		Methsuximide	C12H13NO2	6476	Moderate		Inter Info	[21], [16], [36]
D1265		Phenobarbital	C12H12N2O3	4763	Moderate		Inter Info	[21], [16], [36]
D1283		Phenytoin	C15H12N2O2	1775	Moderate		Inter Info	[21], [16], [36]
D1340		Primidone	C12H14N2O2	4909	Moderate		Inter Info	[21], [16], [36]
D1578		Tiagabine	C20H25NO2S2	60648	Moderate		Inter Info	[21], [16], [36]
D1609		Topiramate	C12H21NO8S	5284627	Moderate		Inter Info	[21], [16], [36]
D1677		Valproic acid	C8H16O2	3121	Moderate		Inter Info	[21], [16], [36]
	Antagonize the effect of dopaminergic agents					Drug Num: 9
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1292		Pimozide	C28H29F2N3O	16362	Major		Inter Info	[30], [31]
D0324		Chlorpromazine	C17H19ClN2S	2726	Moderate		Inter Info	[37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [36], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69]
D0678		Fluphenazine	C22H26F3N3OS	3372	Moderate		Inter Info	[37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [36], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69]
D0750		Haloperidol	C21H23ClFNO2	3559	Moderate		Inter Info	[37], [38], [73], [39], [41], [42], [43], [44], [45], [46], [47], [48], [50], [51], [52], [53], [54], [64], [65], [66], [67], [68], [69]
D1010		Mesoridazine	C21H26N2OS2	4078	Moderate		Inter Info	[46], [49], [65]
D1346		Prochlorperazine	C20H24ClN3S	4917	Moderate		Inter Info	[37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [36], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69]
D1352		Promethazine	C17H20N2S	4927	Moderate		Inter Info	[37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [36], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69]
D1574		Thioridazine	C21H26N2S2	5452	Moderate		Inter Info	[46], [49], [65]
D1637		Trifluoperazine	C21H24F3N3S	5566	Moderate		Inter Info	[37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [36], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69]

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103	Product Information. Aubagio (teriflunomide). Genzyme Corporation, Cambridge, MA.
104	Product Information. Tabloid (thioguanine). Prasco Laboratories, Cincinnati, OH.

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