Drug General Information (ID: DDIRLHEN73)
Drug Name			Methylphenobarbital		Drug Info		Hydroxychloroquine		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Anxiolytics/Sedatives/Hypnotics				Antimalarial Agents
Structure

Mechanism of Methylphenobarbital-Hydroxychloroquine Interaction (Severity Level: Moderate)
Antagonize the effect of antiepileptic agents Click to Show/Hide Mechanism Graph
Drug Name		Methylphenobarbital				Hydroxychloroquine
Mechanism		Antiepileptic agent				Lower seizure threshold
Key Mechanism Factor 1
		Factor Name		Antiepileptic agents
		Factor Description		The beneficial effects of antiepileptic drugs may be reduced, leading to an increase in seizure frequency or duration.
Mechanism Description		Antagonize the effect of Methylphenobarbital when combined with Hydroxychloroquine

Recommended Action
Management		The potential risks and benefits should be evaluated prior to initiating chloroquine or hydroxychloroquine in patients on anticonvulsant therapy. In addition, patients with a history of epilepsy should be advised about the risk of chloroquine/hydroxychloroquine-induced seizures. alternative anti-malarial agents may be required. Local treatment guidelines should be consulted.

References
1	Cerner Multum, Inc. "Australian Product Information.".
2	Product Information. Hydroxychloroquine Sulfate (hydroxychloroquine). Prasco Laboratories, Cincinnati, OH.
3	Product Information. Plaquenil (R). (hydroxychloroquine). Sanofi Winthrop Pharmaceuticals, New York, NY.