Drug General Information (ID: DDI9XRDZ67)
Drug Name			Leucovorin		Drug Info		Methylphenobarbital		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Folate Supplements				Anxiolytics/Sedatives/Hypnotics
Structure

Mechanism of Leucovorin-Methylphenobarbital Interaction (Severity Level: Moderate)
Antagonize the effect of antiepileptic agents Click to Show/Hide Mechanism Graph
Drug Name		Leucovorin				Methylphenobarbital
Mechanism		Lower seizure threshold				Antiepileptic agent
Key Mechanism Factor 1
		Factor Name		Antiepileptic agents
		Factor Description		The beneficial effects of antiepileptic drugs may be reduced, leading to an increase in seizure frequency or duration.
Mechanism Description		Antagonize the effect of Methylphenobarbital when combined with Leucovorin

Recommended Action
Management		Caution is advised when folate therapy is coadministered with anticonvulsants. Close monitoring for clinical and laboratory evidence of diminished therapeutic response to both treatments is recommended. Patients should be advised to notify their physician if they experience loss of seizure control.

References
1	Berg MJ, Fischer LJ, Rivey MP, Vern BA, Lantz RK, Schottelius DD "Phenytoin and folic acid interaction: a preliminary report." Ther Drug Monit 5 (1983): 389-94. [PMID: 6659012]
2	Katz M "Potential danger of self-medication with folic acid." N Engl J Med 289 (1973): 1095. [PMID: 4742232]
3	Furlanut M, Benetello P, Avogaro A, Dainese R "Effects of folic acid on phenytoin kinetics in healthy subjects." Clin Pharmacol Ther 24 (1978): 294-7. [PMID: 688723]