Details of Drug

Details of Drug

 Drug General Information (ID: D1830)
  Drug Name
Leucovorin
  Drug Type Small molecule
  Drug Synonymous
folinic acid|leucovorin|5-Formyltetrahydrofolic acid|58-05-9|Folinic acid-SF|Welcovorin|Acide folinique|5-Formyl-5,6,7,8-tetrahydrofolic acid|folinate|N5-Formyltetrahydrofolic acid|10-Formyl-7,8-dihydrofolic acid|Leucal|N5-Formyl-5,6,7,8-tetrahydrofolic acid|5-Formyl-5,6,7,8-tetrahydropteroyl-L-glutamic acid|CHEBI:15640|(2S)-2-[[4-[(2-amino-5-formyl-4-oxo-1,6,7,8-tetrahydropteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid|(5-formyl-5,6,7,8-tetrahydropteroyl)glutamate|HSDB 6544|N-(5-formyl-5,6,7,8-tetrahydropteroyl)-L-glutamic acid|Leucoverin|1492-18-8|[3H]folinic acid|NSC3590|Leucovorinum (acid)|Leucovorin [USAN]|CHEMBL69905|5-Formyl-tetrahydrofolate|Leucovorinum|Levocovorin|5-Formyltetrahydropteroylglutamic acid|Citrovoeum factor|EINECS 200-361-6|L(-)-5-Formyl-5,6,7,8-tetrahydrofolic acid|L-(+)-Folinic acid|Spectrum_000859|Prestwick0_000738|Prestwick1_000738|Prestwick2_000738|Prestwick3_000738|Spectrum2_000116|Spectrum3_000479|Spectrum4_000031|Spectrum5_000910|SCHEMBL8349|CHEMBL1679|5-formyltetrahydro-folic acid|BSPBio_000696|BSPBio_002218|KBioGR_000461|KBioSS_001339|DivK1c_000222|SPBio_000132|SPBio_002635|BPBio1_000766|GTPL4816|GTPL6690|DTXSID0048216|SCHEMBL10068238|KBio1_000222|KBio2_001339|KBio2_003907|KBio2_006475|KBio3_001438|NINDS_000222|DW385|BDBM50039121|MFCD00867488|s5790|AKOS015961207|DB00650|IDI1_000222|AC-13429|HY-17556|L-Glutamic acid, N-(4-(((2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-|SBI-0051427.P003|SD-204098|D93089|BRD-A75919782-238-01-8|Q45435667|(2S)-2-(4-((2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl)methylamino)benzamido)pentanedioic acid|(2S)-2-[(4-{[(2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl)methyl]amino}phenyl)formamido]pentanedioic acid|(2S)-2-[[4-[(2-amino-5-formyl-4-oxo-3,6,7,8-tetrahydropteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid|(S)-2-{4-[(2-Amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydro-pteridin-6-ylmethyl)-amino]-benzoylamino}-pentanedioic acid|2-{4-[(2-Amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydro-pteridin-6-ylmethyl)-amino]-benzoylamino}-pentanedioic acid|Glutamic acid, N-(p-(((2-amino-5-formyl-5,6,7,8-tetrahydro-4-hydroxy-6-pteridinyl)methyl)amino)benzoyl)-, L-|L-Glutamic acid, N-[4-[[(2-amino-5-formyl-3,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-|N-[4-({[2-amino-5-formyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)benzoyl]-L-glutamic acid|N-[4-[[(2-Amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6(RS)-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid
    Click to Show/Hide
  Therapeutic Class Folate Supplements
  Structure Could Not Find 2D Structure
3D Structure 2D Structure
  Formula C20H23N7O7
  InChI 1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32)/t12?,13-/m0/s1
  InChIKey VVIAGPKUTFNRDU-ABLWVSNPSA-N
  Canonical SMILES C1C(N(C2=C(N1)N=C(NC2=O)N)C=O)CNC3=CC=C(C=C3)C(=O)NC(CCC(=O)O)C(=O)O
  External Link
Pubchem ID 135403648
CAS Number CAS 58-05-9
CHEBI ID CHEBI:15640
TTD ID D0R4PS
VARIDT ID DR00238

Drug-Drug Interaction Network
  Sunburst Graph
AM004  Affected intra/extra-hepatic metabolism
AM006  Pharmacodynamic additive effects
AM007  Pharmacodynamic antagonistic effects
BM026  Increased metabolism (Unspecific)
BM083  Potentiated the pharmacological effects (Unspecific)
BM087  Antagonize the effect of antiepileptic agents
BM107  Attenuated pharmacological effects (Unspecific)
  Relation Graph
 Full list of drugs interacting with Leucovorin
      Affected intra/extra-hepatic metabolism
   Increased metabolism (Unspecific) Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1802
 
Glucarpidase
 
Zn4+8
 
21195079 
Moderate    Inter Info   
[13]
      Pharmacodynamic additive effects
   Potentiated the pharmacological effects (Unspecific) Drug Num:  2
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0675
 
Fluorouracil
 
C4H3FN2O2
 
3385 
Major    Inter Info   
[1], [2], [3]
D0249
 
Capecitabine
 
C15H22FN3O6
 
60953 
Major    Inter Info   
[1], [2], [3]
      Pharmacodynamic antagonistic effects
   Antagonize the effect of antiepileptic agents Drug Num:  17
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0255
 
Carbamazepine
 
C15H12N2O
 
2554 
Moderate    Inter Info   
[10], [11], [12]
D0620
 
Ethosuximide
 
C7H11NO2
 
3291 
Moderate    Inter Info   
[10], [11], [12]
D0890
 
Lamotrigine
 
C9H7Cl2N5
 
3878 
Moderate    Inter Info   
[10], [11], [12]
D0601
 
Eslicarbazepine
 
C15H14N2O2
 
9881504 
Moderate    Inter Info   
[10], [11], [12]
D0621
 
Ethotoin
 
C11H12N2O2
 
3292 
Moderate    Inter Info   
[10], [11], [12]
D0639
 
Felbamate
 
C11H14N2O4
 
3331 
Moderate    Inter Info   
[10], [11], [12]
D0697
 
Fosphenytoin
 
C16H15N2O6P
 
56339 
Moderate    Inter Info   
[10], [11], [12]
D1032
 
Methsuximide
 
C12H13NO2
 
6476 
Moderate    Inter Info   
[10], [11], [12]
D1040
 
Methylphenobarbital
 
C13H14N2O3
 
8271 
Moderate    Inter Info   
[10], [11], [12]
D1198
 
Oxcarbazepine
 
C15H12N2O2
 
34312 
Moderate    Inter Info   
[10], [11], [12]
D1265
 
Phenobarbital
 
C12H12N2O3
 
4763 
Moderate    Inter Info   
[10], [11], [12]
D1269
 
Phensuximide
 
C11H11NO2
 
6839 
Moderate    Inter Info   
[10], [11], [12]
D1340
 
Primidone
 
C12H14N2O2
 
4909 
Moderate    Inter Info   
[10], [11], [12]
D1433
 
Rufinamide
 
C10H8F2N4O
 
129228 
Moderate    Inter Info   
[10], [11], [12]
D1003
 
Mephenytoin
 
C12H14N2O2
 
4060 
Moderate    Inter Info   
[10], [11], [12]
D1283
 
Phenytoin
 
C15H12N2O2
 
1775 
Moderate    Inter Info   
[10], [11], [12]
D1677
 
Valproic acid
 
C8H16O2
 
3121 
Moderate    Inter Info   
[10], [11], [12]
   Attenuated pharmacological effects (Unspecific) Drug Num:  3
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0296
 
Ceftriaxone
 
C18H18N8O7S3
 
5479530 
Major    Inter Info   
[4], [5], [6]
D1645
 
Trimethoprim
 
C14H18N4O3
 
5578 
Major    Inter Info   
[7], [8], [9]
D1025
 
Methotrexate
 
C20H22N8O5
 
126941 
Moderate    Inter Info   
[14], [15], [16]
References
1 EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports.".
2 Product Information. Xeloda (capecitabine). Roche Laboratories, Nutley, NJ.
3 Clippe C, Freyer G, Milano G, Trillet-Lenoir V "Lethal toxicity of capecitabine due to abusive folic acid prescription?" Clin Oncol (R Coll Radiol) 15 (2003): 299-300. [PMID: 12924465]
4 Product Information. Rocephin (ceftriaxone). Roche Laboratories, Nutley, NJ.
5 CDER. Center for Drug Evaluation and Research. FDA. U.S. Food and Drug Admninistration "Information for health care professionals: ceftriaxone (marketed as Rocephin and its generics).".
6 Bradley JS, Wassel RT, Lee L, Nambiar S "Intravenous Ceftriaxone and Calcium in the Neonate: Assessing the Risk for Cardiopulmonary Adverse Events." Pediatrics (2009):. [PMID: 19289450]
7 Bozzette SA, Forthal D, Sattler FR, Kemper C, Richman DD, Tilles JG, Leedom J, Mccutchan JA "The tolerance for zidovudine plus thrice weekly or daily trimethoprim-sulfamethoxazole with and without leucovorin for primary prophylaxis in advanced HIV disease." Am J Med 98 (1995): 177-82. [PMID: 7847434]
8 Product Information. Levoleucovorin (levoleucovorin). Spectrum Chemical, Gardena, CA.
9 Razavi B, Lund B, Allen BL, Schlesinger L "Failure of trimethoprim/sulfamethoxazole prophylaxis for Pneumocystis carinii pneumonia with concurrent leucovorin use." Infection 30 (2002): 41-2. [PMID: 11876516]
10 Berg MJ, Fischer LJ, Rivey MP, Vern BA, Lantz RK, Schottelius DD "Phenytoin and folic acid interaction: a preliminary report." Ther Drug Monit 5 (1983): 389-94. [PMID: 6659012]
11 Katz M "Potential danger of self-medication with folic acid." N Engl J Med 289 (1973): 1095. [PMID: 4742232]
12 Furlanut M, Benetello P, Avogaro A, Dainese R "Effects of folic acid on phenytoin kinetics in healthy subjects." Clin Pharmacol Ther 24 (1978): 294-7. [PMID: 688723]
13 Product Information. Voraxaze (glucarpidase). BTG International Inc, West Conshohocken, PA.
14 Cerner Multum, Inc. "Australian Product Information.".
15 Cerner Multum, Inc. "UK Summary of Product Characteristics.".
16 Product Information. Methotrexate Sodium (methotrexate). Teva Pharmaceuticals (formerly IVAX), Miami, FL.