Drug General Information (ID: DDI6MXNEW9)
Drug Name			Methotrexate		Drug Info		Leucovorin		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antimetabolites				Folate Supplements
Structure

Mechanism of Methotrexate-Leucovorin Interaction (Severity Level: Moderate)
Attenuated pharmacological effects (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Methotrexate				Leucovorin
Mechanism		Antifolate effects				Folate derivatives
Key Mechanism Factor 1
		Factor Name		Pharmacodynamics
		Factor Description		Reduced pharmacological effects leading to insufficient efficacy and/or treatment failure.
Mechanism Description		Attenuated pharmacological effects of  Methotrexate when combined with Leucovorin

Recommended Action
Management		Although folic acid or folinic acid are frequently used along with methotrexate to reduce adverse effects or as an antidote to high dose methotrexate therapy, patients receiving methotrexate should be advised to avoid the inadvertent use of vitamin preparations containing folic acid or its derivatives.

References
1	Cerner Multum, Inc. "Australian Product Information.".
2	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
3	Product Information. Methotrexate Sodium (methotrexate). Teva Pharmaceuticals (formerly IVAX), Miami, FL.