Drug General Information (ID: DDIQ384DE6)
Drug Name			Methylphenobarbital		Drug Info		Activated charcoal		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Anxiolytics/Sedatives/Hypnotics				Antidotes
Structure

Mechanism of Methylphenobarbital-Activated charcoal Interaction (Severity Level: Moderate)
Adsorption Click to Show/Hide Mechanism Graph
Drug Name		Methylphenobarbital				Activated charcoal
Mechanism		Adsorbed by activated charcoal				Activated charcoal
Key Mechanism Factor 1
		Factor Name		Adsorption
		Factor Description		Adsorption is a direct drug interaction, usually through adsorption on its surface, resulting in reduced absorption of concomitantly administered drugs in the gastrointestinal tract.
Mechanism Description		Decreased absorption of Methylphenobarbital due to adsorption of Activated charcoal

Recommended Action
Management		The regular ingestion of charcoal should be avoided by patients requiring maintenance medications. If concomitant use is necessary, the dosage or route of administration may need to be altered.

References
1	Ilkhanipour K, Yealy DM, Krenzelok EP "Activated charcoal surface area and its role in multiple-dose charcoal therapy." Am J Emerg Med 11 (1993): 583-5. [PMID: 8240556]
2	Naveau S, Bonhomme L, Preaux N, Chaput JC "A pure charcoal suspension for colonoscopic tattoo." Gastrointest Endosc 37 (1991): 624-5. [PMID: 1756921]
3	Reed MD "Oral activated charcoal therapy." Am J Emerg Med 6 (1988): 318. [PMID: 3370115]