Details of Drug

Drug General Information (ID: D1035)
Drug Name	Methyldopa
Drug Type	Small molecule
Drug Synonymous	AMD; Aldometil; Aldomin; Alphamethyldopa; Baypresol; Becanta; Dopamet; Dopamethyperpax; Dopatec; Dopegit; Dopegyt; Dopergit; Grospisk; Hyperpax; Hypolag; Medomet; Medopa; Medopal; Medopren; Methoplain; Methyldopum; Metildopa; Novomedopa; Presinol; Presolisin; Sedometil; Sembrina; Alpha medopa; Methyl dopa; Methyldopa anhydrous; Aldoril D30; Aldoril D50; Bayer 1440 L; LT00847269; MK 351; Aldomet (TN); Aldoril (TN); Alpha-Methyl dopa; Alpha-Methyldihydroxyphenylalanine; Alpha-Methyldopa; Apo-Methyldopa; Dopamet (TN); Dopegyt (TN); L-Methyl Dopa; L-Methyldopa; METHYL DOPA (SEE ALSO METHYL DOPA SESQUIHYDRATE); MK-351; Methyldopa (INN); Methyldopa (anhydrous); Methyldopum [INN-Latin]; Metildopa [INN-Spanish]; Mk. b51; Nr.C 2294; Nu-Medopa; Alpha-Methyldopa (VAN); L-alpha-Methyl DOPA; L-alpha-Methyldopa; Methyl-L-dopa; Aldoril, Dopamet, Dopegyt, Methyldopa; L-(alpha-Md); Methyldopa (L,-); Alpha-Methyl-L-3,4-dihydroxyphenylalanine; L-alpha-Methyl-3,4-dihydroxyphenylalanine; L-3-(3,4-Dihydroxyphenyl)-2-methylalanine; Levo-3-(3,4-Dihydroxyphenyl)-2-methylalanine; Alpha-Methyl-beta-(3,4-dihydroxyphenyl)-L-alanine; L(-)-beta-(3,4-Dihydroxyphenyl)-alpha-methylalanine; L-2-Amino-2-methyl-3-(3,4-dihydroxyphenyl)propionic acid; L-(-)-3-(3,4-Dihydroxyphenyl)-2-methylalanine; L-(-)-alpha-Methyl-beta-(3,4-dihydroxyphenyl)alanine; (-)-3-(3,4-Dihydroxyphenyl)-2-Methyl-L-Alanine Sesqui-Hydrate; (2S)-2-amino-3-(3,4-dihydroxyphenyl)-2-methylpropanoic acid; (S)-(-)-alpha-Methyldopa; 3-(3,4-DIHYDROXYPHENYL)-2-METHYL-L-ALANINE; 3-Hydroxy-.alpha.-methyl-L-tyrosine; 3-Hydroxy-alpha-methyl-L-tyrosine Click to Show/Hide
Disease Class	BA00-BA04: Hypertension
Therapeutic Class	Antihypertensive Agents
Structure
Structure	3D Structure		2D Structure
Formula	C10H13NO4
InChI	1S/C10H13NO4/c1-10(11,9(14)15)5-6-2-3-7(12)8(13)4-6/h2-4,12-13H,5,11H2,1H3,(H,14,15)/t10-/m0/s1
InChIKey	CJCSPKMFHVPWAR-JTQLQIEISA-N
Canonical SMILES	CC(CC1=CC(=C(C=C1)O)O)(C(=O)O)N
External Link
	Pubchem ID	38853
	CAS Number	555-30-6
	CHEBI ID	61058
	TTD ID	D0BA6T
	INTEDE ID	DR1051
	VARIDT ID	DR00596

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM001 Affected gastrointestinal absorption AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM003 Complex formation BM018 Non-CYP450 enzyme inhibition BM025 Decreased metabolism (Unspecific) BM038 Additive CNS depression effects BM042 Additive hypotensive effects BM049 Increased risk of atrioventricular block BM051 Increased risk of bradycardia BM055 Increased risk of hepatotoxicity BM067 Increased risk of hyponatremia BM075 Increased risk of photosensitivity reactions BM089 Antagonize the effect of antihypertensive agents BM107 Attenuated pharmacological effects (Unspecific) BM109 Increased risk of other adverse reactions (Unspecific)
Relation Graph

Full list of drugs interacting with Methyldopa
Affected gastrointestinal absorption
	Complex formation					Drug Num: 6
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0649		Ferrous fumarate	C4H2FeO4	6433164	Moderate		Inter Info	[306], [307], [308]
D0650		Ferrous gluconate	C12H22FeO14	23616740	Moderate		Inter Info	[306], [307], [308]
D0651		Ferrous sulfate anhydrous	FeO4S	24393	Moderate		Inter Info	[306], [307], [308]
D0847		Iron	Fe	23925	Moderate		Inter Info	[306], [307], [308]
D0849		Iron protein succinylate	NA	NA	Moderate		Inter Info	[306], [307], [308]
D1566		Tetraferric tricitrate decahydrate	C18H32Fe4O31	90478690	Moderate		Inter Info	[306], [307], [308]
Affected intra/extra-hepatic metabolism
	Non-CYP450 enzyme inhibition					Drug Num: 13
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0933		Linezolid	C16H20FN3O4	441401	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D0853		Isocarboxazid	C12H13N3O2	3759	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D1036		Methylene blue	C16H18ClN3S	6099	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D1211		Ozanimod	C23H24N4O3	52938427	Major		Inter Info	[14], [15], [16], [17], [18], [19], [20], [21], [1], [22], [2], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [3], [38], [4], [39], [5], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [6], [54], [55], [56], [57], [58], [7], [8], [59]
D1345		Procarbazine	C12H19N3O	4915	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D1385		Rasagiline	C12H13N	3052776	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D1437		Safinamide	C17H19FN2O2	131682	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D1455		Selegiline	C13H17N	26757	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D1263		Phenelzine	C8H12N2	3675	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D1620		Tranylcypromine	C9H11N	19493	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D0575		Entacapone	C14H15N3O5	5281081	Moderate		Inter Info	[283], [284], [285], [286]
D1182		Opicapone	C15H10Cl2N4O6	135565903	Moderate		Inter Info	[283], [284], [285], [286]
D1604		Tolcapone	C14H11NO5	4659569	Moderate		Inter Info	[283], [284], [285], [286]
	Decreased metabolism (Unspecific)					Drug Num: 7
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0013		Acetohexamide	C15H20N2O4S	1989	Minor		Inter Info	[339]
D0325		Chlorpropamide	C10H13ClN2O3S	2727	Minor		Inter Info	[339]
D0727		Glimepiride	C24H34N4O5S	3476	Minor		Inter Info	[339]
D0728		Glipizide	C21H27N5O4S	3478	Minor		Inter Info	[339]
D0730		Glyburide	C23H28ClN3O5S	3488	Minor		Inter Info	[339]
D1603		Tolbutamide	C12H18N2O3S	5505	Minor		Inter Info	[339]
D1601		Tolazamide	C14H21N3O3S	5503	Minor		Inter Info	[339]
Pharmacodynamic additive effects
	Additive CNS depression effects					Drug Num: 11
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0345		Citalopram	C20H21FN2O	2771	Moderate		Inter Info	[93], [94], [95]
D0201		Brexanolone	C21H34O2	92786	Moderate		Inter Info	[301]
D0208		Brivaracetam	C11H20N2O2	9837243	Moderate		Inter Info	[93], [94], [95]
D0300		Cenobamate	C10H10ClN5O2	11962412	Moderate		Inter Info	[93], [94], [95]
D0323		Chlorpheniramine	C16H19ClN2	2725	Moderate		Inter Info	[93], [94], [95]
D0359		Clofedanol	C17H20ClNO	2795	Moderate		Inter Info	[93], [94], [95]
D0879		Ketamine	C13H16ClNO	3821	Moderate		Inter Info	[93], [94], [95]
D0897		Lasmiditan	C19H18F3N3O2	11610526	Moderate		Inter Info	[311]
D0901		Lemborexant	C22H20F2N4O2	56944144	Moderate		Inter Info	[93], [94], [95]
D1433		Rufinamide	C10H8F2N4O	129228	Moderate		Inter Info	[93], [94], [95]
D1616		Tramadol	C16H25NO2	33741	Moderate		Inter Info	[93], [94], [95]
	Additive hypotensive effects					Drug Num: 78
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1596		Tizanidine	C9H8ClN5S	5487	Major		Inter Info	[61]
D0030		Aldesleukin	NA	NA	Moderate		Inter Info	[62]
D0097		Apomorphine	C17H17NO2	6005	Moderate		Inter Info	[63], [64], [65]
D0098		Apraclonidine	C9H10Cl2N4	2216	Moderate		Inter Info	[40], [44], [66]
D0188		Bisoprolol	C18H31NO4	2405	Moderate		Inter Info	[17], [18], [79]
D0205		Brimonidine (ophthalmic)	C11H10BrN5	2435	Moderate		Inter Info	[40], [44], [66]
D0206		Brimonidine (topical)	C11H10BrN5	2435	Moderate		Inter Info	[40], [44], [66]
D0265		Carteolol	C16H24N2O3	2583	Moderate		Inter Info	[17], [80], [81]
D0324		Chlorpromazine	C17H19ClN2S	2726	Moderate		Inter Info	[82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92]
D0370		Clozapine	C18H19ClN4	135398737	Moderate		Inter Info	[82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92]
D0459		Dexmedetomidine	C13H16N2	5311068	Moderate		Inter Info	[17], [276], [277]
D0533		Dronabinol	C21H30O2	16078	Moderate		Inter Info	[278], [279], [280]
D0644		Fenoldopam	C16H16ClNO3	3341	Moderate		Inter Info	[288], [289]
D0678		Fluphenazine	C22H26F3N3OS	3372	Moderate		Inter Info	[82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92]
D0772		Hydrocodone	C18H21NO3	5284569	Moderate		Inter Info	[278], [279], [280]
D0884		Labetalol	C19H24N2O3	3869	Moderate		Inter Info	[17], [80], [81]
D0957		Loxapine	C18H18ClN3O	3964	Moderate		Inter Info	[82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92]
D1010		Mesoridazine	C21H26N2OS2	4078	Moderate		Inter Info	[82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92]
D1019		Methdilazine	C18H20N2S	14677	Moderate		Inter Info	[82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92]
D0037		Alimemazine	C18H22N2S	5574	Moderate		Inter Info	[86], [88], [90]
D0055		Amifostine	C5H15N2O3PS	2141	Moderate		Inter Info	[63], [288], [295]
D0067		Amisulpride	C17H27N3O4S	2159	Moderate		Inter Info	[82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92]
D0105		Aripiprazole	C23H27Cl2N3O2	60795	Moderate		Inter Info	[82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92]
D0112		Asenapine	C17H16ClNO	3036780	Moderate		Inter Info	[82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92]
D0128		Avanafil	C23H26ClN7O3	9869929	Moderate		Inter Info	[296], [297], [298]
D0161		Benzhydrocodone	C25H25NO4	49836084	Moderate		Inter Info	[278], [279], [280]
D0202		Brexpiprazole	C25H27N3O2S	11978813	Moderate		Inter Info	[82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92]
D0245		Canagliflozin	C24H25FO5S	24812758	Moderate		Inter Info	[17], [18], [302]
D0262		Cariprazine	C21H32Cl2N4O	11154555	Moderate		Inter Info	[82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92]
D0267		Carvedilol	C24H26N2O4	2585	Moderate		Inter Info	[17], [80], [81]
D0418		Dapagliflozin	C21H25ClO6	9887712	Moderate		Inter Info	[17], [18], [302]
D0498		Dimenhydrinate	C24H28ClN5O3	10660	Moderate		Inter Info	[278], [279], [280]
D0565		Empagliflozin	C23H27ClO7	11949646	Moderate		Inter Info	[17], [18], [302]
D0586		Epoprostenol	C20H32O5	5282411	Moderate		Inter Info	[18], [304], [305]
D0745		Guanfacine	C9H9Cl2N3O	3519	Moderate		Inter Info	[17], [18], [309]
D0791		Iloperidone	C24H27FN2O4	71360	Moderate		Inter Info	[82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92]
D0792		Iloprost	C22H32O4	5311181	Moderate		Inter Info	[18], [304], [305]
D0942		Lofexidine	C11H12Cl2N2O	30668	Moderate		Inter Info	[18], [318], [319]
D0959		Lumateperone	C24H28FN3O	21302490	Moderate		Inter Info	[82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92]
D0961		Lurasidone	C28H36N4O2S	213046	Moderate		Inter Info	[82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92]
D0980		Maraviroc	C29H41F2N5O	3002977	Moderate		Inter Info	[320]
D1006		Mepyramine	C17H23N3O	4992	Moderate		Inter Info	[278], [279], [280]
D1026		Methotrimeprazine	C19H24N2OS	72287	Moderate		Inter Info	[82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92]
D1084		Molindone	C16H24N2O2	23897	Moderate		Inter Info	[82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92]
D1098		Nadolol	C17H27NO4	39147	Moderate		Inter Info	[17], [80], [81]
D1114		Nebivolol	C22H25F2NO4	71301	Moderate		Inter Info	[17], [18], [79]
D1117		Nefazodone	C25H32ClN5O2	4449	Moderate		Inter Info	[321], [322], [319]
D1148		Nitrous acid	HNO2	24529	Moderate		Inter Info	[323], [324], [325]
D1169		Oliceridine	C22H30N2O2S	66553195	Moderate		Inter Info	[278], [279], [280]
D1215		Paliperidone	C23H27FN4O3	115237	Moderate		Inter Info	[82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92]
D1244		Penbutolol	C18H29NO2	37464	Moderate		Inter Info	[17], [80], [81]
D1352		Promethazine	C17H20N2S	4927	Moderate		Inter Info	[82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92]
D1368		Quetiapine	C21H25N3O2S	5002	Moderate		Inter Info	[82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92]
D1408		Riociguat	C20H19FN8O2	11304743	Moderate		Inter Info	[329]
D1457		Selexipag	C26H32N4O4S	9913767	Moderate		Inter Info	[18], [304], [305]
D1485		Sodium oxybate	C4H7NaO3	23663870	Moderate		Inter Info	[278], [279], [280]
D1576		Thiothixene	C23H29N3O2S2	941651	Moderate		Inter Info	[82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92]
D1096		Nabilone	C24H36O3	5284592	Moderate		Inter Info	[278], [279], [280]
D1166		Olanzapine	C17H20N4S	135398745	Moderate		Inter Info	[82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92]
D1251		Pentoxifylline	C13H18N4O3	4740	Moderate		Inter Info	[333]
D1257		Perphenazine	C21H26ClN3OS	4748	Moderate		Inter Info	[82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92]
D1293		Pindolol	C14H20N2O2	4828	Moderate		Inter Info	[17], [80], [81]
D1346		Prochlorperazine	C20H24ClN3S	4917	Moderate		Inter Info	[82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92]
D1351		Promazine	C17H20N2S	4926	Moderate		Inter Info	[82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92]
D1355		Propiomazine	C20H24N2OS	4940	Moderate		Inter Info	[82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92]
D1357		Propranolol	C16H21NO2	4946	Moderate		Inter Info	[17], [80], [81]
D1413		Risperidone	C23H27FN4O2	5073	Moderate		Inter Info	[82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92]
D1465		Sildenafil	C22H30N6O4S	135398744	Moderate		Inter Info	[296], [297], [298]
D1498		Sotalol	C12H20N2O3S	5253	Moderate		Inter Info	[17], [80], [81]
D1572		Thiethylperazine	C22H29N3S2	5440	Moderate		Inter Info	[82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92]
D1574		Thioridazine	C21H26N2S2	5452	Moderate		Inter Info	[82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92]
D1585		Timolol	C13H24N4O3S	33624	Moderate		Inter Info	[17], [80], [81]
D1625		Treprostinil	C23H34O5	6918140	Moderate		Inter Info	[18], [304], [305]
D1638		Triflupromazine	C18H19F3N2S	5568	Moderate		Inter Info	[82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92]
D1682		Vardenafil	C23H32N6O4S	135400189	Moderate		Inter Info	[296], [297], [298]
D1726		Ziprasidone	C21H21ClN4OS	60854	Moderate		Inter Info	[82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92]
D0711		Garlic	NA	NA	Minor		Inter Info	[340], [341]
D1527		Tadalafil	C22H19N3O4	110635	Minor		Inter Info	[342], [343]
	Increased risk of atrioventricular block					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0363		Clonidine	C9H9Cl2N3	2803	Moderate		Inter Info	[97]
	Increased risk of bradycardia					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1600		Tofacitinib	C16H20N6O	9926791	Moderate		Inter Info	[17], [330]
	Increased risk of hepatotoxicity					Drug Num: 24
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0900		Leflunomide	C12H9F3N2O2	3899	Major		Inter Info	[9], [10], [11]
D0944		Lomitapide	C39H37F6N3O2	9853053	Major		Inter Info	[12]
D1073		Mipomersen	C230H324N67O122P19S19	118984467	Major		Inter Info	[13]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Major		Inter Info	[60]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Major		Inter Info	[9], [10], [11]
D0114		Asparaginase Escherichia coli	NA	NA	Moderate		Inter Info	[67], [68], [69], [17], [18], [70], [71], [72], [73], [74], [75], [76], [77]
D0357		Clofarabine	C10H11ClFN5O3	119182	Moderate		Inter Info	[96]
D0554		Efavirenz	C14H9ClF3NO2	64139	Moderate		Inter Info	[281], [282]
D0584		Epirubicin	C27H29NO11	41867	Moderate		Inter Info	[17], [18], [287]
D0826		Interferon beta-1a	NA	NA	Moderate		Inter Info	[290], [291], [292], [293]
D0827		Interferon beta-1b	NA	NA	Moderate		Inter Info	[290], [291], [292], [293]
D1025		Methotrexate	C20H22N8O5	126941	Moderate		Inter Info	[18], [294]
D0113		Asparaginase Erwinia chrysanthemi	NA	NA	Moderate		Inter Info	[67], [68], [69], [17], [18], [70], [71], [72], [73], [74], [75], [76], [77]
D0149		Bedaquiline	C32H31BrN2O2	5388906	Moderate		Inter Info	[299]
D0199		Brentuximab vedotin	NA	NA	Moderate		Inter Info	[300]
D0232		Calaspargase pegol	NA	NA	Moderate		Inter Info	[67], [68], [69], [17], [18], [70], [71], [72], [73], [74], [75], [76], [77]
D0248		Cannabidiol	C21H30O2	644019	Moderate		Inter Info	[18], [303]
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[310]
D1239		Peginterferon beta-1a	NA	NA	Moderate		Inter Info	[290], [291], [292], [293]
D1389		Remdesivir	C27H35N6O8P	121304016	Moderate		Inter Info	[17], [18], [326], [327], [328]
D1615		Trabectedin	C39H43N3O11S	108150	Moderate		Inter Info	[18], [331]
D1106		Naltrexone	C20H23NO4	5360515	Moderate		Inter Info	[332]
D1234		Pegaspargase	C14H19NO	436058	Moderate		Inter Info	[67], [68], [69], [17], [18], [70], [71], [72], [73], [74], [75], [76], [77]
D1589		Tioguanine	C5H5N5S	2723601	Moderate		Inter Info	[336], [337]
	Increased risk of hyponatremia					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0449		Desmopressin	C46H64N14O12S2	5311065	Moderate		Inter Info	[17], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168], [169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204], [205], [206], [207], [208], [209], [210], [211], [212], [213], [214], [215], [216], [217], [218], [219], [220], [221], [222], [223], [224], [225], [226], [227], [228], [229], [230], [231], [232], [233], [18], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246], [247], [248], [249], [250], [251], [252], [253], [254], [255], [256], [257], [258], [259], [260], [261], [262], [263], [264], [265], [266], [267], [268], [269], [270], [9], [271], [272], [273], [274], [275]
D1683		Vasopressin	C46H65N15O12S2	644077	Moderate		Inter Info	[17], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168], [169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204], [205], [206], [207], [208], [209], [210], [211], [212], [213], [214], [215], [216], [217], [218], [219], [220], [221], [222], [223], [224], [225], [226], [227], [228], [229], [230], [231], [232], [233], [18], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246], [247], [248], [249], [250], [251], [252], [253], [254], [255], [256], [257], [258], [259], [260], [261], [262], [263], [264], [265], [266], [267], [268], [269], [270], [9], [271], [272], [273], [274], [275]
	Increased risk of photosensitivity reactions					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1314		Porfimer sodium	C68H74N8O11	135577896	Moderate		Inter Info	[334], [18], [335]
	Increased risk of other adverse reactions (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0940		Lithium carbonate	CLi2O3	11125	Moderate		Inter Info	[315], [316], [317]
Pharmacodynamic antagonistic effects
	Antagonize the effect of antihypertensive agents					Drug Num: 13
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0172		Betamethasone	C22H29FO5	9782	Moderate		Inter Info	[18], [78]
D0671		Fludrocortisone	C21H29FO5	31378	Moderate		Inter Info	[18], [78]
D0773		Hydrocortisone	C21H30O5	5754	Moderate		Inter Info	[18], [78]
D0215		Budesonide	C25H34O6	5281004	Moderate		Inter Info	[18], [78]
D0392		Corticotropin	C207H308N56O58S	16132265	Moderate		Inter Info	[18], [78]
D0436		Deflazacort	C25H31NO6	189821	Moderate		Inter Info	[18], [78]
D0453		Dexamethasone	C22H29FO5	5743	Moderate		Inter Info	[18], [78]
D0926		Licorice	C42H62O16Zn	163463	Moderate		Inter Info	[312], [313], [314]
D1563		Tetracosactide	C136H210N40O31S	16133802	Moderate		Inter Info	[18], [78]
D1041		Methylprednisolone	C22H30O5	6741	Moderate		Inter Info	[18], [78]
D1332		Prednisolone	C21H28O5	5755	Moderate		Inter Info	[18], [78]
D1334		Prednisone	C21H26O5	5865	Moderate		Inter Info	[18], [78]
D1628		Triamcinolone	C21H27FO6	31307	Moderate		Inter Info	[18], [78]
	Attenuated pharmacological effects (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1691		Verteporfin	C82H84N8O16	11980904	Moderate		Inter Info	[338], [288]

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287	Product Information. Ellence (epirubicin) Pharmacia and Upjohn, Kalamazoo, MI.
288	Product Information. Xatral (alfuzosin). Sanofi-Synthelabo Canada Inc, Markham, ON.
289	Product Information. Corlopam (fenoldopam). Neurex, Menlo Park, CA.
290	Product Information. Avonex (interferon beta-1a). Biogen, Cambridge, MA.
291	Product Information. Betaseron (interferon beta-1b). Berlex, Richmond, CA.
292	Product Information. Plegridy (peginterferon beta-1a). Biogen Idec Inc, Cambridge, MA.
293	Product Information. Rebif (interferon beta-1a). Serono Laboratories Inc, Norwell, MA.
294	Product Information. Methotrexate (methotrexate). Lederle Laboratories, Wayne, NJ.
295	Product Information. Ethyol (amifostine). Alza, Palo Alto, CA.
296	Product Information. Levitra (vardenafil). Bayer, West Haven, CT.
297	Product Information. Stendra (avanafil). Vivus Inc, Mountain View, CA.
298	Product Information. Viagra (sildenafil). Pfizer US Pharmaceuticals, New York, NY.
299	Product Information. Sirturo (bedaquiline). Janssen Pharmaceuticals, Titusville, NJ.
300	Product Information. Adcetris (brentuximab vedotin). Seattle Genetics Inc, Bothell, WA.
301	Product Information. Zulresso (brexanolone). Sage Therapeutics, Inc., Cambridge, MA.
302	Product Information. Jardiance (empagliflozin). Boehringer Ingelheim, Ridgefield, CT.
303	Product Information. Epidiolex (cannabidiol). Greenwich Biosciences Inc, Carlsbad, CA.
304	Product Information. Flolan (epoprostenol). Glaxo Wellcome, Research Triangle Park, NC.
305	Product Information. Remodulin (treprostinil). United Therapeutics Corp, Silver Spring, MD.
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310	Product Information. Zydelig (idelalisib). Gilead Sciences, Foster City, CA.
311	Product Information. Reyvow (lasmiditan). Lilly, Eli and Company, Indianapolis, IN.
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318	Product Information. Lucemyra (lofexidine). US WorldMeds LLC, Louisville , KY.
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321	Product Information. Fycompa (perampanel). Eisai Inc, Teaneck, NJ.
322	Product Information. Serzone (nefazodone). Bristol-Myers Squibb, Princeton, NJ.
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331	Product Information. Yondelis (trabectedin). Janssen Pharmaceuticals, Titusville, NJ.
332	Product Information. ReVia (naltrexone). DuPont Pharmaceuticals, Wilmington, DE.
333	Product Information. Trental (pentoxifylline). Hoechst Marion-Roussel Inc, Kansas City, MO.
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335	Product Information. Photofrin (porfimer). Sanofi Winthrop Pharmaceuticals, New York, NY.
336	Product Information. Aubagio (teriflunomide). Genzyme Corporation, Cambridge, MA.
337	Product Information. Tabloid (thioguanine). Prasco Laboratories, Cincinnati, OH.
338	Product Information. Visudyne (verteporfin) Valeant Pharmaceuticals, Costa Mesa, CA.
339	Gachalyi B, Tornyossy, Vas A, Kaldor A "Effect of alphamethyldopa on the half-lives of antipyrine, tolbutamide and D-glucaric acid excretion in man." Int J Clin Pharmacol Ther Toxicol 18 (1980): 133-5. [PMID: 6103880]
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342	Product Information. Cialis (tadalafil). Lilly, Eli and Company, Indianapolis, IN.
343	Product Information. Rapaflo (silodosin). Watson Pharmaceuticals, Corona, CA.

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