Drug General Information (ID: DDI36SIZNO)
  Drug Name Methyldopa Drug Info Glipizide Drug Info
  Drug Type Small molecule Small molecule
  Therapeutic Class Antihypertensive Agents Antidiabetic Agents
  Structure

 Mechanism of Methyldopa-Glipizide Interaction (Severity Level: Minor)
     Decreased metabolism (Unspecific) Click to Show/Hide Mechanism Graph
      Drug Name Methyldopa Glipizide
      Mechanism Inhibit the metabolism of sulfonylurea Sulfonylurea
      Key Mechanism Factor 1
Factor Name Pharmacokinetics
Factor Description Alters the metabolism of the drug, leading to changes in the plasma concentration of the drug and affecting the pharmacological effects.
      Mechanism Description
  • Decreased metabolism of Glipizide caused by Methyldopa 

References
1 Gachalyi B, Tornyossy, Vas A, Kaldor A "Effect of alphamethyldopa on the half-lives of antipyrine, tolbutamide and D-glucaric acid excretion in man." Int J Clin Pharmacol Ther Toxicol 18 (1980): 133-5. [PMID: 6103880]