Drug General Information (ID: DDIUR9LJKZ)
  Drug Name Tolazamide Drug Info Methyldopa Drug Info
  Drug Type Small molecule Small molecule
  Therapeutic Class Antidiabetic Agents Antihypertensive Agents
  Structure

 Mechanism of Tolazamide-Methyldopa Interaction (Severity Level: Minor)
     Decreased metabolism (Unspecific) Click to Show/Hide Mechanism Graph
      Drug Name Tolazamide Methyldopa
      Mechanism Sulfonylurea Inhibit the metabolism of sulfonylurea
      Key Mechanism Factor 1
Factor Name Pharmacokinetics
Factor Description Alters the metabolism of the drug, leading to changes in the plasma concentration of the drug and affecting the pharmacological effects.
      Mechanism Description
  • Decreased metabolism of Tolazamide caused by Methyldopa 

References
1 Gachalyi B, Tornyossy, Vas A, Kaldor A "Effect of alphamethyldopa on the half-lives of antipyrine, tolbutamide and D-glucaric acid excretion in man." Int J Clin Pharmacol Ther Toxicol 18 (1980): 133-5. [PMID: 6103880]