Details of Drug

Drug General Information (ID: D1018)
Drug Name	Methazolamide
Drug Type	Small molecule
Drug Synonymous	Methazolamide (oral, sustained release) Click to Show/Hide
Disease Class	9C61: Glaucoma
Therapeutic Class	Carbonic Anhydrase Inhibitors
Structure
Structure	3D Structure		2D Structure
Formula	C5H8N4O3S2
InChI	1S/C5H8N4O3S2/c1-3(10)7-4-9(2)8-5(13-4)14(6,11)12/h1-2H3,(H2,6,11,12)
InChIKey	FLOSMHQXBMRNHR-UHFFFAOYSA-N
Canonical SMILES	CC(=O)N=C1N(N=C(S1)S(=O)(=O)N)C
External Link
	Pubchem ID	4100
	CAS Number	554-57-4
	CHEBI ID	6822
	TTD ID	D0C2II
	VARIDT ID	DR00599

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM001 Affected gastrointestinal absorption AM003 Affected organization distribution AM005 Affected excretion pathways AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM009 Altered absorption (Unspecific) BM013 Competitive binding of plasma proteins BM014 Interference of cell/tissue uptake BM029 Altered urine pH BM038 Additive CNS depression effects BM042 Additive hypotensive effects BM044 Additive myelosuppressive effects BM045 Additive neuromuscular blocking effects BM065 Increased risk of hypokalemia BM066 Increased risk of hypomagnesemia BM067 Increased risk of hyponatremia BM070 Increased risk of metabolic acidosis BM072 Increased risk of nephrotoxicity BM076 Increased risk of prolong QT interval BM081 Increased risk of ventricular arrhythmias BM086 Antagonize the effect of antidiabetic agents BM089 Antagonize the effect of antihypertensive agents BM107 Attenuated pharmacological effects (Unspecific) BM109 Increased risk of other adverse reactions (Unspecific)
Relation Graph

Full list of drugs interacting with Methazolamide
Affected gastrointestinal absorption
	Altered absorption (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1340		Primidone	C12H14N2O2	4909	Moderate		Inter Info	[172]
Affected organization distribution
	Competitive binding of plasma proteins					Drug Num: 5
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0017		Acetylsalicylic acid	C9H8O4	2244	Major		Inter Info	[15], [16], [17]
D0187		Bismuth subsalicylate	C7H6BiO4	16682734	Major		Inter Info	[22], [3], [4], [5], [15], [23], [24], [12], [25], [26], [27], [16], [17]
D0331		Choline salicylate	C12H19NO4	54686350	Major		Inter Info	[22], [3], [4], [5], [15], [23], [24], [12], [25], [26], [27], [16], [17]
D1439		Salicylic acid (sodium)	C7H6O3	338	Major		Inter Info	[15], [16], [17]
D1442		Salsalate	C14H10O5	5161	Major		Inter Info	[22], [3], [4], [5], [15], [23], [24], [12], [25], [26], [27], [16], [17]
	Interference of cell/tissue uptake					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1818		Indium In-111 pentetate	C14H20InN3O10	76967078	Moderate		Inter Info	[154]
D0326		Chlorthalidone	C14H11ClN2O4S	2732	Minor		Inter Info	[177], [178]
Affected excretion pathways
	Altered urine pH					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1020		Methenamine	C6H12N4	4101	Moderate		Inter Info	[159], [160], [161], [162], [163]
D1371		Quinidine	C20H24N2O2	441074	Moderate		Inter Info	[173], [174], [175]
D0998		Memantine	C12H21N	4054	Minor		Inter Info	[184]
Pharmacodynamic additive effects
	Additive CNS depression effects					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1596		Tizanidine	C9H8ClN5S	5487	Moderate		Inter Info	[176]
	Additive hypotensive effects					Drug Num: 25
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0030		Aldesleukin	NA	NA	Moderate		Inter Info	[37]
D0156		Benazepril	C24H28N2O5	5362124	Moderate		Inter Info	[44], [4], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65]
D0567		Enalapril	C20H28N2O5	5388962	Moderate		Inter Info	[44], [4], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65]
D0695		Fosinopril	C30H46NO7P	55891	Moderate		Inter Info	[44], [4], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65]
D0097		Apomorphine	C17H17NO2	6005	Moderate		Inter Info	[144], [145], [146]
D0128		Avanafil	C23H26ClN7O3	9869929	Moderate		Inter Info	[147], [148], [149]
D0254		Captopril	C9H15NO3S	44093	Moderate		Inter Info	[44], [4], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65]
D0586		Epoprostenol	C20H32O5	5282411	Moderate		Inter Info	[5], [150], [151]
D0644		Fenoldopam	C16H16ClNO3	3341	Moderate		Inter Info	[31], [153]
D0792		Iloprost	C22H32O4	5311181	Moderate		Inter Info	[5], [150], [151]
D0918		Levodopa	C9H11NO4	6047	Moderate		Inter Info	[144], [145], [155]
D0938		Lisinopril	C21H31N3O5	5362119	Moderate		Inter Info	[44], [4], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65]
D1117		Nefazodone	C25H32ClN5O2	4449	Moderate		Inter Info	[123], [164], [165]
D1148		Nitrous acid	HNO2	24529	Moderate		Inter Info	[166], [167], [168]
D1256		Perindopril	C19H32N2O5	107807	Moderate		Inter Info	[44], [4], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65]
D1369		Quinapril	C25H30N2O5	54892	Moderate		Inter Info	[44], [4], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65]
D1457		Selexipag	C26H32N4O4S	9913767	Moderate		Inter Info	[5], [150], [151]
D1682		Vardenafil	C23H32N6O4S	135400189	Moderate		Inter Info	[147], [148], [149]
D1082		Moexipril	C27H34N2O7	91270	Moderate		Inter Info	[44], [4], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65]
D1379		Ramipril	C23H32N2O5	5362129	Moderate		Inter Info	[44], [4], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65]
D1465		Sildenafil	C22H30N6O4S	135398744	Moderate		Inter Info	[147], [148], [149]
D1618		Trandolapril	C24H34N2O5	5484727	Moderate		Inter Info	[44], [4], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65]
D1625		Treprostinil	C23H34O5	6918140	Moderate		Inter Info	[5], [150], [151]
D0711		Garlic	NA	NA	Minor		Inter Info	[182], [183]
D1527		Tadalafil	C22H19N3O4	110635	Minor		Inter Info	[185], [186]
	Additive myelosuppressive effects					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0370		Clozapine	C18H19ClN4	135398737	Moderate		Inter Info	[12], [123], [124]
	Additive neuromuscular blocking effects					Drug Num: 12
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0343		Cisatracurium	C53H72N2O12+2	62887	Moderate		Inter Info	[66], [67], [68]
D0122		Atracurium	C53H72N2O12+2	47319	Moderate		Inter Info	[66], [67], [68]
D0522		Doxacurium	C56H78N2O16+2	60169	Moderate		Inter Info	[66], [67], [68]
D1047		Metocurine	C40H48N2O6+2	21233	Moderate		Inter Info	[66], [67], [68]
D1080		Mivacurium	C58H80N2O14+2	5281042	Moderate		Inter Info	[66], [67], [68]
D1219		Pancuronium	C35H60N2O4+2	441289	Moderate		Inter Info	[66], [67], [68]
D1295		Pipecuronium	C35H62N4O4+2	50192	Moderate		Inter Info	[66], [67], [68]
D1384		Rapacuronium	C37H61N2O4+	5311399	Moderate		Inter Info	[66], [67], [68]
D1420		Rocuronium	C32H53N2O4+	441290	Moderate		Inter Info	[66], [67], [68]
D1659		Tubocurarine	C37H41N2O6+	6000	Moderate		Inter Info	[66], [67], [68]
D1684		Vecuronium	C34H57N2O4+	39765	Moderate		Inter Info	[66], [67], [68]
D1510		Succinylcholine	C14H30N2O4+2	5314	Moderate		Inter Info	[66], [67], [68]
	Increased risk of hypokalemia					Drug Num: 30
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0075		Amphotericin B	C47H73NO17	5280965	Moderate		Inter Info	[5]
D0076		Amphotericin B (cholesteryl sulfate)	C47H73NO17	5280965	Moderate		Inter Info	[5]
D0077		Amphotericin B (lipid complex)	C47H73NO17	5280965	Moderate		Inter Info	[5]
D0078		Amphotericin B (liposomal)	C47H73NO17	5280965	Moderate		Inter Info	[5]
D0148		Beclomethasone dipropionate	C28H37ClO7	21700	Moderate		Inter Info	[41], [42], [43]
D0172		Betamethasone	C22H29FO5	9782	Moderate		Inter Info	[41], [42], [43]
D0491		Digoxin	C41H64O14	2724385	Moderate		Inter Info	[128], [129], [130], [131], [132], [133], [134], [135], [136], [137]
D0671		Fludrocortisone	C21H29FO5	31378	Moderate		Inter Info	[41], [42], [43]
D0854		Isoetharine	C13H21NO3	3762	Moderate		Inter Info	[138], [139], [140]
D0103		Arformoterol	C19H24N2O4	3083544	Moderate		Inter Info	[138], [139], [140]
D0392		Corticotropin	C207H308N56O58S	16132265	Moderate		Inter Info	[41], [42], [43]
D0436		Deflazacort	C25H31NO6	189821	Moderate		Inter Info	[41], [42], [43]
D0453		Dexamethasone	C22H29FO5	5743	Moderate		Inter Info	[41], [42], [43]
D0490		Digitoxin	C41H64O13	441207	Moderate		Inter Info	[128], [129], [130], [131], [132], [133], [134], [135], [136], [137]
D0691		Formoterol	C19H24N2O4	3410	Moderate		Inter Info	[138], [139], [140]
D0773		Hydrocortisone	C21H30O5	5754	Moderate		Inter Info	[41], [42], [43]
D0797		Indacaterol	C24H28N2O3	6918554	Moderate		Inter Info	[138], [139], [140]
D0924		Levosalbutamol	C13H21NO3	123600	Moderate		Inter Info	[138], [139], [140]
D0926		Licorice	C42H62O16Zn	163463	Moderate		Inter Info	[156], [157], [158]
D1041		Methylprednisolone	C22H30O5	6741	Moderate		Inter Info	[41], [42], [43]
D1171		Olodaterol	C21H26N2O5	11504295	Moderate		Inter Info	[138], [139], [140]
D1185		Orciprenaline	C11H17NO3	4086	Moderate		Inter Info	[138], [139], [140]
D1298		Pirbuterol	C12H20N2O3	4845	Moderate		Inter Info	[138], [139], [140]
D1332		Prednisolone	C21H28O5	5755	Moderate		Inter Info	[41], [42], [43]
D1438		Salbutamol	C13H21NO3	2083	Moderate		Inter Info	[138], [139], [140]
D1440		Salmeterol	C25H37NO4	5152	Moderate		Inter Info	[138], [139], [140]
D1554		Terbutaline	C12H19NO3	5403	Moderate		Inter Info	[138], [139], [140]
D1695		Vilanterol	C24H33Cl2NO5	10184665	Moderate		Inter Info	[138], [139], [140]
D1334		Prednisone	C21H26O5	5865	Moderate		Inter Info	[41], [42], [43]
D1628		Triamcinolone	C21H27FO6	31307	Moderate		Inter Info	[41], [42], [43]
	Increased risk of hyponatremia					Drug Num: 15
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0345		Citalopram	C20H21FN2O	2771	Moderate		Inter Info	[69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122]
D0539		Duloxetine	C18H19NOS	60835	Moderate		Inter Info	[69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122]
D0676		Fluoxetine	C17H18F3NO	3386	Moderate		Inter Info	[69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Moderate		Inter Info	[69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122]
D0451		Desvenlafaxine	C16H25NO2	125017	Moderate		Inter Info	[69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122]
D0599		Escitalopram	C20H21FN2O	146570	Moderate		Inter Info	[69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122]
D0601		Eslicarbazepine	C15H14N2O2	9881504	Moderate		Inter Info	[152]
D0920		Levomilnacipran	C15H22N2O	6917779	Moderate		Inter Info	[69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122]
D1066		Milnacipran	C15H22N2O	65833	Moderate		Inter Info	[69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122]
D1229		Paroxetine	C19H20FNO3	43815	Moderate		Inter Info	[69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122]
D1461		Sertraline	C17H17Cl2N	68617	Moderate		Inter Info	[69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122]
D1464		Sibutramine	C17H26ClN	5210	Moderate		Inter Info	[69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122]
D1696		Vilazodone	C26H27N5O2	6918314	Moderate		Inter Info	[69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122]
D1708		Vortioxetine	C18H22N2S	9966051	Moderate		Inter Info	[69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122]
D1689		Venlafaxine	C17H27NO2	5656	Moderate		Inter Info	[69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122]
	Increased risk of metabolic acidosis					Drug Num: 5
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1015		Metformin	C4H11N5	4091	Major		Inter Info	[9], [10], [11]
D0012		Acetazolamide	C4H6N4O3S2	1986	Major		Inter Info	[12], [13], [14]
D0479		Diclofenamide	C6H6Cl2N2O4S2	3038	Major		Inter Info	[12], [13], [14]
D1730		Zonisamide	C8H8N2O3S	5734	Major		Inter Info	[12], [13], [14]
D1609		Topiramate	C12H21NO8S	5284627	Major		Inter Info	[12], [13], [14]
	Increased risk of nephrotoxicity					Drug Num: 14
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0472		Diatrizoate	C11H9I3N2O4	2140	Moderate		Inter Info	[125], [126], [127]
D0831		Iodipamide	C20H14I6N2O6	3739	Moderate		Inter Info	[125], [126], [127]
D0832		Iodixanol	C35H44I6N6O15	3724	Moderate		Inter Info	[125], [126], [127]
D0833		Iohexol	C19H26I3N3O9	3730	Moderate		Inter Info	[125], [126], [127]
D0834		Iopamidol	C17H22I3N3O8	65492	Moderate		Inter Info	[125], [126], [127]
D0836		Iopromide	C18H24I3N3O8	3736	Moderate		Inter Info	[125], [126], [127]
D0837		Iothalamic acid	C11H9I3N2O4	3737	Moderate		Inter Info	[125], [126], [127]
D0838		Ioversol	C18H24I3N3O9	3741	Moderate		Inter Info	[125], [126], [127]
D0839		Ioxilan	C18H24I3N3O8	3743	Moderate		Inter Info	[125], [126], [127]
D0441		Demeclocycline	C21H21ClN2O8	54680690	Minor		Inter Info	[179], [180], [181]
D0530		Doxycycline	C22H24N2O8	54671203	Minor		Inter Info	[179], [180], [181]
D1070		Minocycline	C23H27N3O7	54675783	Minor		Inter Info	[179], [180], [181]
D1564		Tetracycline	C22H24N2O8	54675776	Minor		Inter Info	[179], [180], [181]
D1209		Oxytetracycline	C22H24N2O9	54675779	Minor		Inter Info	[179], [180], [181]
	Increased risk of prolong QT interval					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0535		Droperidol	C22H22FN3O2	3168	Major		Inter Info	[3], [4], [5], [6], [7], [8]
	Increased risk of ventricular arrhythmias					Drug Num: 8
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0342		Cisapride	C23H29ClFN3O4	6917698	Major		Inter Info	[1]
D0513		Dofetilide	C19H27N3O5S2	71329	Major		Inter Info	[2]
D0066		Amiodarone	C25H29I2NO3	2157	Major		Inter Info	[18], [19]
D0107		Arsenic trioxide	As2O3	14888	Major		Inter Info	[20], [21]
D0534		Dronedarone	C31H44N2O5S	208898	Major		Inter Info	[28]
D0909		Levacetylmethadol	C23H31NO2	15130	Major		Inter Info	[29], [30], [31]
D1292		Pimozide	C28H29F2N3O	16362	Major		Inter Info	[32]
D1726		Ziprasidone	C21H21ClN4OS	60854	Major		Inter Info	[33]
	Increased risk of other adverse reactions (Unspecific)					Drug Num: 14
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0888		Lactulose	C12H22O11	11333	Moderate		Inter Info	[141], [142], [143]
D0184		Bisacodyl	C22H19NO4	2391	Moderate		Inter Info	[141], [142], [143]
D0269		Castor oil	C57H104O9	14030006	Moderate		Inter Info	[141], [142], [143]
D0701		Frangula purshiana bark	NA	NA	Moderate		Inter Info	[141], [142], [143]
D0731		Glycerin	C3H8O3	753	Moderate		Inter Info	[141], [142], [143]
D0887		Lactitol	C12H24O11	157355	Moderate		Inter Info	[141], [142], [143]
D0970		Magnesium citrate	C12H10Mg3O14	6099959	Moderate		Inter Info	[141], [142], [143]
D0973		Magnesium hydroxide	H2MgO2	14791	Moderate		Inter Info	[141], [142], [143]
D1069		Mineral oil	NA	NA	Moderate		Inter Info	[141], [142], [143]
D1266		Phenolphthalein	C20H14O4	4764	Moderate		Inter Info	[141], [142], [143]
D1287		Picosulfuric acid	C18H15NO8S2	5243	Moderate		Inter Info	[169], [170], [171]
D1308		Polyethylene glycol (3350 with electrolytes)	C2H6O2	174	Moderate		Inter Info	[169], [170], [171]
D1309		Polyethylene glycol (3350)	C2H6O2	174	Moderate		Inter Info	[141], [142], [143]
D1488		Sodium sulfate	Na2O4S	24436	Moderate		Inter Info	[169], [170], [171]
Pharmacodynamic antagonistic effects
	Antagonize the effect of antidiabetic agents					Drug Num: 39
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0009		Acarbose	C25H43NO18	41774	Moderate		Inter Info	[34], [35], [36]
D0013		Acetohexamide	C15H20N2O4S	1989	Moderate		Inter Info	[34], [35], [36]
D0325		Chlorpropamide	C10H13ClN2O3S	2727	Moderate		Inter Info	[34], [35], [36]
D0727		Glimepiride	C24H34N4O5S	3476	Moderate		Inter Info	[34], [35], [36]
D0811		Insulin glargine	C267H404N72O78S6	118984454	Moderate		Inter Info	[34], [35], [36]
D0813		Insulin human	C257H383N65O77S6	118984375	Moderate		Inter Info	[34], [35], [36]
D0814		Insulin human (inhalation, rapid acting)	C257H383N65O77S6	118984375	Moderate		Inter Info	[34], [35], [36]
D0815		Insulin human (isophane)	C257H383N65O77S6	118984375	Moderate		Inter Info	[34], [35], [36]
D0816		Insulin human (regular)	C257H383N65O77S6	118984375	Moderate		Inter Info	[34], [35], [36]
D0817		Insulin human (zinc extended)	C257H383N65O77S6	118984375	Moderate		Inter Info	[34], [35], [36]
D0818		Insulin human (zinc)	C257H383N65O77S6	118984375	Moderate		Inter Info	[34], [35], [36]
D0819		Insulin lispro	C257H389N65O77S6	16132438	Moderate		Inter Info	[34], [35], [36]
D0820		Insulin lispro (protamine)	C257H389N65O77S6	16132438	Moderate		Inter Info	[34], [35], [36]
D0029		Albiglutide	C148H224N40O45	145994868	Moderate		Inter Info	[34], [35], [36]
D0042		Alogliptin	C18H21N5O2	11450633	Moderate		Inter Info	[34], [35], [36]
D0245		Canagliflozin	C24H25FO5S	24812758	Moderate		Inter Info	[34], [35], [36]
D0418		Dapagliflozin	C21H25ClO6	9887712	Moderate		Inter Info	[34], [35], [36]
D0565		Empagliflozin	C23H27ClO7	11949646	Moderate		Inter Info	[34], [35], [36]
D0728		Glipizide	C21H27N5O4S	3478	Moderate		Inter Info	[34], [35], [36]
D0730		Glyburide	C23H28ClN3O5S	3488	Moderate		Inter Info	[34], [35], [36]
D0807		Insulin aspart (aspart protamine)	C256H381N65O79S6	118984445	Moderate		Inter Info	[34], [35], [36]
D0808		Insulin aspart (aspart)	C256H381N65O79S6	118984445	Moderate		Inter Info	[34], [35], [36]
D0809		Insulin degludec	C274H411N65O81S6	118984462	Moderate		Inter Info	[34], [35], [36]
D0810		Insulin detemir	C267H402N64O76S6	16137271	Moderate		Inter Info	[34], [35], [36]
D0812		Insulin glulisine	C258H384N64O78S6	16136701	Moderate		Inter Info	[34], [35], [36]
D0930		Linagliptin	C25H28N8O2	10096344	Moderate		Inter Info	[34], [35], [36]
D0936		Liraglutide	C172H265N43O51	16134956	Moderate		Inter Info	[34], [35], [36]
D0941		Lixisenatide	C215H347N61O65S	90472060	Moderate		Inter Info	[34], [35], [36]
D1112		Nateglinide	C19H27NO3	5311309	Moderate		Inter Info	[34], [35], [36]
D1294		Pioglitazone	C19H20N2O3S	4829	Moderate		Inter Info	[34], [35], [36]
D1326		Pramlintide	C171H267N51O53S2	70691388	Moderate		Inter Info	[34], [35], [36]
D1392		Repaglinide	C27H36N2O4	65981	Moderate		Inter Info	[34], [35], [36]
D1449		Saxagliptin	C18H25N3O2	11243969	Moderate		Inter Info	[34], [35], [36]
D1477		Sitagliptin	C16H15F6N5O	4369359	Moderate		Inter Info	[34], [35], [36]
D1601		Tolazamide	C14H21N3O3S	5503	Moderate		Inter Info	[34], [35], [36]
D1603		Tolbutamide	C12H18N2O3S	5505	Moderate		Inter Info	[34], [35], [36]
D1064		Miglitol	C8H17NO5	441314	Moderate		Inter Info	[34], [35], [36]
D1429		Rosiglitazone	C18H19N3O3S	77999	Moderate		Inter Info	[34], [35], [36]
D1652		Troglitazone	C24H27NO5S	5591	Moderate		Inter Info	[34], [35], [36]
	Antagonize the effect of antihypertensive agents					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1779		Dulaglutide	NA	NA	Moderate		Inter Info	[34], [35], [36]
D1782		Ertugliflozin	C22H25ClO7	44814423	Moderate		Inter Info	[34], [35], [36]
D1887		Semaglutide	C187H291N45O59	56843331	Moderate		Inter Info	[34], [35], [36]
	Attenuated pharmacological effects (Unspecific)					Drug Num: 16
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0045		Alprazolam	C17H13ClN4	2118	Moderate		Inter Info	[38], [39], [40]
D0317		Chlordiazepoxide	C16H14ClN3O	2712	Moderate		Inter Info	[38], [39], [40]
D0356		Clobazam	C16H13ClN2O2	2789	Moderate		Inter Info	[38], [39], [40]
D0365		Clorazepic acid	C16H11ClN2O3	2809	Moderate		Inter Info	[38], [39], [40]
D0679		Flurazepam	C21H23ClFN3O	3393	Moderate		Inter Info	[38], [39], [40]
D0951		Lorazepam	C15H10Cl2N2O2	3958	Moderate		Inter Info	[38], [39], [40]
D0362		Clonazepam	C15H10ClN3O3	2802	Moderate		Inter Info	[38], [39], [40]
D0473		Diazepam	C16H13ClN2O	3016	Moderate		Inter Info	[38], [39], [40]
D0604		Estazolam	C16H11ClN4	3261	Moderate		Inter Info	[38], [39], [40]
D0748		Halazepam	C17H12ClF3N2O	31640	Moderate		Inter Info	[38], [39], [40]
D1197		Oxazepam	C15H11ClN2O2	4616	Moderate		Inter Info	[38], [39], [40]
D1367		Quazepam	C17H11ClF4N2S	4999	Moderate		Inter Info	[38], [39], [40]
D1391		Remimazolam	C21H19BrN4O2	9867812	Moderate		Inter Info	[38], [39], [40]
D1632		Triazolam	C17H12Cl2N4	5556	Moderate		Inter Info	[38], [39], [40]
D1060		Midazolam	C18H13ClFN3	4192	Moderate		Inter Info	[38], [39], [40]
D1547		Temazepam	C16H13ClN2O2	5391	Moderate		Inter Info	[38], [39], [40]

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