Drug General Information (ID: DDIUO3IPGF)
  Drug Name Chlorthalidone Drug Info Methazolamide Drug Info
  Drug Type Small molecule Small molecule
  Therapeutic Class Antihypertensive Agents Carbonic Anhydrase Inhibitors
  Structure

 Mechanism of Chlorthalidone-Methazolamide Interaction (Severity Level: Minor)
     Interference of cell/tissue uptake Click to Show/Hide Mechanism Graph
Could Not Find 2D Structure
      Drug Name Chlorthalidone Methazolamide
      Mechanism Chlorthalidone Inhibit the binding or uptake of chlorthalidone in erythrocytes
      Key Mechanism Factor 1
Factor Name Pharmacokinetics
Factor Description Alters the distribution of the drug, leading to changes in the plasma concentration of the drug and affecting the pharmacological effects.
      Mechanism Description
  • Interference of cell/tissue uptake of Chlorthalidone by Methazolamide 

References
1 Beermann B, Hellstrom K, Lindstrom B, Rosen A "Binding-site interaction of chlorthalidone and acetazolamide, two drugs transported by red blood cells." Clin Pharmacol Ther 17 (1975): 424-32. [PMID: 804371]
2 Lettieri JT, Portelli ST. Effects of competitive red blood cell binding and reduced hematocrit on the blood and plasma levels of [14C]Indapamide in the rat. J Pharmacol Exp Ther. 1983;224(2):269-272. [PMID: 6822954]