Details of Drug-Drug Interaction
| Drug General Information (ID: DDI9ZB0QW6) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Drug Name | Clozapine | Drug Info | Methazolamide | Drug Info | |||||
| Drug Type | Small molecule | Small molecule | |||||||
| Therapeutic Class | Antipsychotic Agents | Carbonic Anhydrase Inhibitors | |||||||
| Structure | |||||||||
| Mechanism of Clozapine-Methazolamide Interaction (Severity Level: Moderate) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Additive myelosuppressive effects Click to Show/Hide Mechanism Graph | |||||||||
 |
|||||||||
| Drug Name | Clozapine | Methazolamide | |||||||
| Mechanism | Myelosuppressive effects | Increase the risk of neutropenia combined with clozapine | |||||||
| Key Mechanism Factor 1 | |||||||||
| Factor Name | Myelosuppressive effects | ||||||||
| Factor Description | Myelosuppression, also known as bone marrow suppression, is a decrease in bone marrow activity that leads to a decrease in the production of blood cells. Some blood cell disorders include: erythrocytopenia (anemia), leukopenia (neutropenia), and thrombocytopenia (thrombocytopenia). | ||||||||
| Mechanism Description |
|
||||||||
| Recommended Action | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Management | Close monitoring is advisable during concomitant use. White blood cell (WBC) counts and absolute neutrophil counts (ANC) should be measured regularly according to official recommendations, and clozapine should be discontinued if cell counts fall below critical limits. Patients should be counseled to notify their doctor immediately if they experience influenza-like symptoms, fever, or a sore throat. | ||||||||